Article
Chemistry, Multidisciplinary
Xiaoqing Wei, Dan Mu, Yingping Li, Jingya Zhao, Shaobing Zhou
Summary: Researchers have developed a magnetic exosome that responds to bacteria associated with tumors, enabling sensitive tumor imaging. The magnetic exosome can rapidly respond in the tumor microenvironment and release iron oxide nanoparticles for dynamic MRI of tumors. After MRI, the iron oxide nanoparticles can be eliminated through renal clearance to avoid potential toxicity.
Article
Materials Science, Multidisciplinary
Yiwei Zhang, Xinxin Li, Xing Chen, Yingfan Zhang, Yun Deng, Yanhua Yu, Bing Wang, Yanan Xue, Yulun Huang, Min Liu
Summary: In this study, a 0-cyclodextrin-modified ultrasmall gold nanoparticle was prepared as a functional core, and contrast agents and folate were anchored on its surface to give it the ability to target tumor cells. Compared to clinical contrast agents, this nanocomposite exhibited higher longitudinal relaxivity and excellent biocompatibility. In vivo studies showed that it could accumulate in the tumor region and acquire high-resolution MRI images.
MATERIALS & DESIGN
(2022)
Article
Nanoscience & Nanotechnology
Rong Tu, Xiaoguang You, Zhichao Ding, Huanyu Wu, Linlu Zhao, Zhi Qiu, Junjie Wei, Xiaofeng Yang
Summary: The development of imaging methods that can detect target molecules is of great importance for non-invasive molecular diagnosis. In this study, a magnetic resonance contrast agent was created by coupling a polypeptide with a Gd(DOTA) complex, which is capable of binding to the target molecule. The results showed that this contrast agent exhibited high targeting ability and image enhancement.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Acoustics
Shrishti Singh, Giovanni Giammanco, Chih-Hsiang Hu, Joshua Bush, Leandro Soto Cordova, Dylan J. Lawrence, Jeffrey L. Moran, Parag V. Chitnis, Remi Veneziano
Summary: Near-infrared photoacoustic imaging (NIR-PAI) combines optical and ultrasound imaging to provide high-resolution anatomical and functional information of tissues. However, the limited availability of NIR contrast agents hinders its widespread use. J-aggregates (JA) made of indocyanine green dye (ICG) are a promising type of contrast agents for PAI. In this study, we present a simple synthesis method that combines ICG and ICG-azide dyes to produce contrast agents with tunable size and targetability. The ICG-JA platform exhibits a strong PA signal in vitro and enhanced visualization of liver and spleen in vivo.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ray R. Zhang, Cynthia Choi, Christina L. Brunnquell, Reinier Hernandez, Anatoly N. Pinchuk, Joseph G. Grudzinski, Paul A. Clark, Alan B. McMillan, Anjon Audhya, Justin Jeffrey, John S. Kuo, Jamey P. Weichert
Summary: The research team developed a new broad-spectrum, tumor-targeted Gd chelate, Gd-NM600, which exhibits high T1 relaxivity, excellent tumor uptake, and prolonged tumor retention. This chelate demonstrates broad-spectrum tumor-specific uptake in various human cancer models.
INVESTIGATIVE RADIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Yiwen Zheng, Mengyao Liu, Lixin Jiang
Summary: Molecular imaging is a valuable technology in oncology for precise diagnosis and treatment. Photoacoustic imaging, a novel imaging technique, utilizes the photoacoustic effect to obtain internal tissue information. Currently, photoacoustic imaging combined with targeted photoacoustic contrast agents is widely used in tumor molecular imaging research.
FRONTIERS IN CHEMISTRY
(2022)
Article
Engineering, Biomedical
Min Wu, Kai Xiao, Xingang Liu, Yudan Yang, Gousheng Song, Gelei Xiao, Qing Liu, Jian Yuan, Bin Liu
Summary: Traditional GBM cell lines cannot maintain the complexity of the original tumor, limiting their usefulness in GBM theranostics. In this study, a new type of tumor-targeting nanoparticle TCFNP@iRGD was designed and evaluated for GBM detection using PA imaging. The results showed that TCFNP@iRGD demonstrated excellent tumor-specific mapping performance, indicating its promising potential in the clinical diagnosis of GBM.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yanan Feng, Yongsheng Hao, Yuanyuan Wang, Weijian Song, Shanxin Zhang, Dong Ni, Fei Yan, Litao Sun
Summary: In this study, a nanoscale acoustic probe based on gas vesicles (GVs) was developed by conjugating ZD2 peptides to the biosynthetic GVs. The resulting ZD2-GVs showed excellent binding capability to tumor cells and demonstrated strong penetration ability in tumor tissues. This study suggests that ZD2-GVs can serve as a potential UMI probe for early diagnosis of bladder cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Medicinal
Sanu Karan, Mi Young Cho, Hyunseung Lee, Hye Sun Park, Eun Hee Han, Youngkyu Song, Youlee Lee, Mina Kim, Jee-Hyun Cho, Jonathan L. Sessler, Kwan Soo Hong
Summary: A bimodal probe based on molecular antenna was developed for enhanced imaging of solid tumors under hypoxic conditions. The probe exhibited both magnetic resonance and optical signals, allowing for improved tumor detection and monitoring.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Staszak, Karolina Wieszczycka, Anna Bajek, Maciej Staszak, Bartosz Tylkowski, Krzysztof Roszkowski
Summary: According to the World Health Organization (WHO), cancer is the second leading cause of death globally. This review focuses on recent developments of chemical compounds in cancer angiogenesis imaging and monitoring, providing insights into active agents structures involved in various imaging techniques. The aim is to provide the journal audience with a comprehensive understanding of chemistry policy in tumor angiogenesis imaging.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Nanoscience & Nanotechnology
Huiquan Yang, Jing Zhao, Dongdong Li, Yuyu Cao, Fan Li, Jing Ma, Peidang Liu
Summary: This study successfully prepared chitosan-coated silver nanotriangles with strong x-ray attenuation capability, which showed better contrast effect compared to iohexol. Larger sized AgNTs demonstrated higher x-ray attenuation coefficient, indicating potential application as efficient tumor CT contrast agents.
Article
Chemistry, Multidisciplinary
Hao Li, Dong Luo, Chaonan Yuan, Xinning Wang, Jing Wang, James P. Basilion, Thomas J. Meade
Summary: PSMA is a transmembrane protein highly expressed in aggressive prostate cancer, utilized in various imaging modalities as a biomarker. MR imaging provides detailed information but requires development of molecular contrast agents for improved sensitivity. In this study, targeted and activatable MR contrast agents were successfully used to differentiate between PSMA+ and PSMA- prostate cancer cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Nanoscience & Nanotechnology
Yongjie Xiong, Yi Qu, Zhe Min, Jun Wu, Suming Zhang, Zheng Xue
Summary: This study developed a novel MRI contrast agent by coupling ultrasmall superparamagnetic iron oxide nanoparticles with a functional protein. The contrast agent successfully penetrated biological membranes and bound to Aβ deposits, allowing for the visualization of Aβ deposits in Alzheimer's disease animal models by MRI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Mingjie Wei, Manlin Lai, Jiaqi Zhang, Xiaoqing Pei, Fei Yan
Summary: The rugby-ball-shaped GVs isolated from Halobacteria NRC-1 exhibit excellent ultrasound contrast imaging properties and show potential for future molecular imaging and image-guided drug delivery. They can produce stable and strong contrast signals in murine liver tumors, and have a higher penetration ability compared to traditional microbubbles in ischemic regions of tumors.
Article
Pharmacology & Pharmacy
Vassily Vorobiev, Souad Adriouach, Lindsey A. Crowe, Sebastien Lenglet, Aurelien Thomas, Anne-Sophie Chauvin, Eric Allemann
Summary: This study presents mixed micelles as a potential formulation for molecular imaging of atheroma and cancer cells using MRI. The micelles are characterized by their size, zeta potential, stability, relaxivity, and toxicity, and showed promising results in target binding and internalization assays.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Mathematics
Jim Agler, John E. McCarthy
TRANSACTIONS OF THE AMERICAN MATHEMATICAL SOCIETY
(2016)
Article
Neurosciences
Timothy O. Laumann, Abraham Z. Snyder, Anish Mitra, Evan M. Gordon, Caterina Gratton, Babatunde Adeyemo, Adrian W. Gilmore, Steven M. Nelson, Jeff J. Berg, Deanna J. Greene, John E. McCarthy, Enzo Tagliazucchi, Helmut Laufs, Bradley L. Schlaggar, Nico U. F. Dosenbach, Steven E. Petersen
Article
Mathematics
John E. McCarthy, Orr Moshe Shalit
ISRAEL JOURNAL OF MATHEMATICS
(2017)
Article
Mathematics
Alexandru Aleman, Michael Hartz, John E. McCarthy, Stefan Richter
JOURNAL OF THE LONDON MATHEMATICAL SOCIETY-SECOND SERIES
(2017)
Article
Mathematics
John E. McCarthy, James E. Pascoe
MATHEMATISCHE ANNALEN
(2018)
Article
Multidisciplinary Sciences
John E. McCarthy, Barry D. Dewitt, Bob A. Dumas, Myles T. McCarthy
Summary: The text discusses a risk model for COVID-19, estimating infection risks in various activities by enumerating components and infection routes. It aims to assist government and industry decisions by providing insights into relative risk rankings.
Article
Mathematics, Applied
Eleftherios Kastis, Derek Kitson, John E. McCarthy
Summary: In this paper, we prove a variant of the well-known result that intertwiners for the bilateral shift on l(2)(Z) are unitarily equivalent to multiplication operators on L-2(T). This allows us to unify and extend fundamental aspects of rigidity theory for bar-joint frameworks with an abelian symmetry group. Specifically, we formulate the symbol function for a wide class of frameworks and demonstrate how to construct generalised rigid unit modes in various new contexts.
JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Patrick M. Winter
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Mathematics
Meric Augat, John E. McCarthy
Summary: This article establishes a theory of noncommutative functions on a certain class of von Neumann algebras and proves that the directional derivative of any NC function is a linear homogeneous polynomial in its directions. These results have important implications for the approximation and realization of NC functions.
CANADIAN MATHEMATICAL BULLETIN-BULLETIN CANADIEN DE MATHEMATIQUES
(2023)
Editorial Material
Mathematics
John E. McCarthy
MATHEMATICAL INTELLIGENCER
(2022)
Article
Mathematics
Jim Agler, Lukasz Kosinski, John E. McCarthy
Summary: This study demonstrates the existence of a pseudoconvex domain G in a pseudoconvex domain Omega, containing an analytic set V, where every bounded holomorphic function on V can be extended to G as a bounded holomorphic function with the same norm. Some specific cases are identified where such a G can be found. Furthermore, when Omega is an operhedron, a norm on holomorphic functions on V can always be preserved by extensions to Omega.
JOURNAL OF FUNCTIONAL ANALYSIS
(2022)
Article
Mathematics
Alexandru Aleman, Michael Hartz, John E. McCarthy, Stefan Richter
Summary: We study the common range of adjoints of cyclic multiplication operators on the Drury-Arveson space, and find that a function belongs to this range if and only if its Taylor coefficients satisfy a simple decay condition. To do this, we introduce the uniform Smirnov class on the ball and determine its dual space. We show that the dual space of the uniform Smirnov class equals the dual space of the smaller Smirnov class of the Drury-Arveson space, which in turn equals the common range of adjoints of cyclic multiplication operators.
JOURNAL D ANALYSE MATHEMATIQUE
(2023)
Article
Mathematics
Jim Agler, John E. E. McCarthy
Summary: We prove that the invariant subspaces of the Hardy operator on L-2[0, 1] are the limit spaces of sequences of finite dimensional spaces spanned by monomial functions.
ACTA SCIENTIARUM MATHEMATICARUM
(2023)
Article
Mathematics
John E. McCarthy, James E. Pascoe
ACTA SCIENTIARUM MATHEMATICARUM
(2017)
Proceedings Paper
Physics, Applied
Michael S. Hughes, John E. McCarthy, Paul J. Bruillard, Jon N. Marsh, Samuel A. Wickline
42ND ANNUAL REVIEW OF PROGRESS IN QUANTITATIVE NONDESTRUCTIVE EVALUATION: INCORPORATING THE 6TH EUROPEAN-AMERICAN WORKSHOP ON RELIABILITY OF NDE
(2016)
