Article
Engineering, Environmental
Shaochen Pang, Yue Gao, Yanwu Wang, Xinglei Yao, Mengxi Cao, Yong Liang, Maoyong Song, Guibin Jiang
Summary: TBBPA exposure disrupts early embryonic development, perturbing cell fate decisions along the DV axis and leading to impaired organogenesis. This highlights the potential ecological and health risks associated with TBBPA.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jana Slovakova, Mateusz Sikora, Feyza Nur Arslan, Silvia Caballero-Mancebo, S. F. Gabriel Krens, Walter A. Kaufmann, Jack Merrin, Carl-Philipp Heisenberg
Summary: The tension of the actomyosin cell cortex is crucial in determining the growth and size of cell-cell contact. This relationship increases proportionally within a certain range of tension, but inversely scales above a critical threshold. This switch is caused by cortical tension promoting the anchoring of E-cadherin to the actomyosin cytoskeleton, thereby increasing clustering and stability of E-cadherin at the contact.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biotechnology & Applied Microbiology
Jinpeng Yao, Yuanhua Cai, Zhixiang Chen, Xuechun Wang, Xiaolin Lai, Lili Pan, Yang Li, Shaoyuan Wang
Summary: This study revealed a new role for DHX15 in zebrafish intestinal development. We found intestinal defects, decreased proliferation, and increased apoptosis in dhx15 knockout zebrafish. RNA genome wide analysis and qRT-PCR analysis showed down-regulation of the Wnt signaling pathway in dhx15 knockout zebrafish. Therefore, we concluded that dhx15 regulates zebrafish intestinal development through the Wnt signaling pathway. This study provides new insights into the role of dhx15 in intestinal development beyond its well-characterized role in intestinal immunity.
Article
Biochemistry & Molecular Biology
Yin-Hua Cheng, Ni-Chin Tsai, Yun-Ju Chen, Pei-Ling Weng, Yun-Chiao Chang, Jai-Hong Cheng, Jih-Yang Ko, Hong-Yo Kang, Kuo-Chung Lan
Summary: For the prevention and treatment of intrauterine adhesion, extracorporeal shockwave therapy (ESWT) and platelet-rich plasma (PRP) transplantation have shown promising effects. These treatments can promote endometrial recovery and angiogenesis, reduce fibrosis, and inhibit inflammatory response. Additionally, in the preventive stage, these treatments can also increase the expression levels of vascular endothelial growth factor and progesterone receptor, while in the therapeutic stage, they can increase the expression levels of progesterone receptor, insulin-like growth factor 1, and interleukin 4.
Article
Microbiology
Courtney M. Klappenbach, Nicholas M. Negretti, Jesse Aaron, Teng-Leong Chew, Michael E. Konkel
Summary: Our study reveals that C. jejuni infection alters the size and topology of focal adhesions in epithelial cells, leading to changes in cell adhesion strength and motility. The increased phosphorylation of paxillin and altered turnover at focal adhesions may contribute to the effects on cell behavior. Additionally, inhibiting protein synthesis or using specific mutants of C. jejuni can partially reverse these effects, suggesting a potential mechanism for the observed restricted intestinal repair in infected animals.
Review
Cell Biology
Dorothee Bornhorst, Salim Abdelilah-Seyfried
Summary: Hippo signaling plays crucial roles in regulating the growth and morphogenesis of the zebrafish heart, including influencing the number of cardiac progenitor cells, restricting epicardial growth, and guiding trabeculation formation. Myocardial chamber dimensions serve as a blueprint for endocardial growth dependent on Hippo signaling. Components of the Hippo pathway interact with various signaling pathways involved in embryonic zebrafish heart development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Dorothee Bornhorst, Salim Abdelilah-Seyfried
Summary: The heart is comprised of multiple tissues that contribute to its physiological functions, and during development, the growth of myocardium and endocardium is coupled. Hippo signaling plays a significant role in the growth and morphogenesis of the zebrafish heart.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shiela C. C. Samson, Akib M. M. Khan, Michelle C. C. Mendoza
Summary: The RAS-ERK pathway is crucial in promoting cell migration and invasion, with steady-state ERK activity playing a role in promoting both single cell and collective migration and invasion. ERK drives actin polymerization and adhesion turnover for edge protrusion, while cell contraction stimulates cell movement in epithelial sheets.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Mao Kondo, Koki Kimura, Jingjing Kobayashi -Sun, Shiori Yamamori, Makoto Taniguchi, David Traver, Isao Kobayashi
Summary: The zebrafish is a unique model for studying hematopoietic niches, and it has been found that sinusoidal endothelium plays a crucial role in the zebrafish kidney. Loss of the junctional adhesion molecule 1a (Jam1a) leads to a reduction in sinusoids and a defect in hematopoietic niches, indicating the importance of Jam1a in the formation of sinusoids and hematopoietic niches in the zebrafish kidney.
Article
Developmental Biology
Koji Ando, Yu-Huan Shih, Lwaki Ebarasi, Ann Grosse, Daneal Portman, Ayano Chiba, Kenny Mattonet, Claudia Gerri, Didier Y. R. Stainier, Naoki Mochizuki, Shigetomo Fukuhara, Christer Betsholtz, Nathan D. Lawson
Summary: The study demonstrates that Pdgfrb signaling plays a critical role in mural cells in zebrafish, and its absence can lead to issues such as cranial hemorrhage and vessel dilation. Similar to mice, pdgfrb mutant zebrafish also show defects in the structure of glomerulus, but normal development of hepatic stellate cells.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Environmental
Congcong Wang, Meng Li, Wanying Gui, Haochun Shi, Peng Wang, Jierong Chen, Karl Fent, Kun Zhang, Jiayin Dai, Xi Li, Yanbin Zhao
Summary: This study examined the effects of the synthetic glucocorticoid prednisolone on zebrafish embryos. The results showed that prednisolone at low concentrations accelerated the embryonic development of zebrafish. Further analysis revealed changes in signaling pathways involved in tissue/organ growth and development, confirming the potential environmental risks of glucocorticoids.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Matthew R. Hawkins, Rebecca A. Wingert
Summary: Retinoic acid, a metabolite of vitamin A, plays a significant role in development, influencing differentiation, patterning, and organogenesis. The conservation of RA and its pathways from zebrafish to humans makes zebrafish a valuable translational model for investigating the functions of RA and associated diseases. This review explores both foundational and recent studies using zebrafish to understand RA at the molecular and organismal level.
Article
Multidisciplinary Sciences
Liam P. Dow, Guido Gaietta, Yair Kaufman, Mark F. Swift, Moara Lemos, Kerry Lane, Matthew Hopcroft, Armel Bezault, Cecile Sauvanet, Niels Volkmann, Beth L. Pruitt, Dorit Hanein
Summary: The authors developed a micropatterning workflow that allows control of cell positioning and morphology. By characterizing the nanoscale details of protein micropatterns on electron microscopy grids, they were able to study the structural changes governing cell-cell signaling.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Zofia Ostrowska-Podhorodecka, Isabel Ding, Masoud Norouzi, Christopher A. McCulloch
Summary: Vimentin plays a role in regulating cell attachment to the ECM and modulating collagen deposition and ECM structure, thus impacting cell migration and ECM remodeling. It interacts with cell adhesion proteins to regulate integrin-dependent adhesions and cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
William Tyler Frantz, Sharanya Iyengar, James Neiswender, Alyssa Cousineau, Rene Maehr, Craig J. Ceol
Summary: Tissue-resident stem and progenitor cells play important roles in maintaining organ homeostasis and repairing damage. However, the mechanisms governing their renewal and differentiation are not well understood, especially in non-hematopoietic tissues. In this study, melanocyte progenitors in adult zebrafish skin were identified and analyzed to uncover the mechanisms underlying melanocyte regeneration. It was revealed that KIT signaling through the RAS/MAPK pathway regulates direct differentiation and asymmetric division of melanocyte progenitors.