Review
Oncology
Andrea Grego, Alberto Friziero, Simone Serafini, Amanda Belluzzi, Lucia Moletta, Luca Maria Saadeh, Cosimo Sperti
Summary: Postoperative pancreatic fistula (POPF) after resection for pancreatic ductal adenocarcinoma (PDAC) is significantly associated with worse overall and disease-free survival.
Review
Oncology
Florentine E. F. Timmer, Bart Geboers, Sanne Nieuwenhuizen, Evelien A. C. Schouten, Madelon Dijkstra, Jan J. J. de Vries, M. Petrousjka van den Tol, Martijn R. Meijerink, Hester J. Scheffer
Summary: Metastatic pancreatic ductal adenocarcinoma (mPDAC) has a poor prognosis, but in selected patients, locoregional therapy may improve survival. Radical-intent local therapy for primary and metastatic sites showed superior survival compared to chemotherapy, but further research and randomized controlled trials are needed for definitive recommendations.
Review
Oncology
Nadia N. Khan, Tennille Lewin, Amy Hatton, Charles Pilgrim, Liane Ioannou, Luc te Marvelde, John Zalcberg, Sue Evans
Summary: This systematic review examines the relationship between pancreatic cancer patients and health service utilization, identifying factors such as age, race, socioeconomic status, education level, location, and comorbidities that are associated with healthcare utilization. The study also found factors associated with treatment use and hospital readmissions.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Medicine, General & Internal
Francesco Serra, Isabella Bonaduce, Elena Giulia Rossi, Nicola De Ruvo, Nicola Cautero, Roberta Gelmini
Summary: POPF is a feared complication of pancreatic surgery, and sealants have been used as an option to reduce its occurrence. However, the routine use of sealants in clinical practice still needs validation.
ANNALS OF MEDICINE AND SURGERY
(2021)
Review
Surgery
Isabel Jaen-Torrejimeno, Diego Lopez-Guerra, Adela Rojas-Holguin, Noelia De-Armas-Conde, Gerardo Blanco-Fernandez
Summary: Surgical treatment of pancreatic metastasis from lung cancer is rare but potentially beneficial for selected patients, although limited evidence is available due to the small number of published articles.
UPDATES IN SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Umberto Bracale, Roberto Peltrini, Biancamaria Iacone, Mirko Martirani, Daniele Sannino, Antonio Gargiulo, Francesco Corcione, Raffaele Serra, Umberto Marcello Bracale
Summary: This study aimed to investigate the relationship between extracellular matrix disorders and abdominal wall hernias (AWHs) and the levels of matrix metalloproteinases (MMPs). The results showed that AWHs may be a disease of the extracellular matrix, supported by increased levels of MMPs in patients with AWHs. The study also highlighted the impact of tissue inhibitors of metalloproteinases (TIMPs) on AWHs. More prospective studies are needed to confirm the relationship between these biomarkers and the risk of AWHs.
Article
Polymer Science
Maha Ibrahim AlGhannam, Mana'a Saleh AlAbbas, Jumanah Abdulla AlJishi, Muath Abdulrahman AlRuwaili, Jehan AlHumaid, Maria Salem Ibrahim
Summary: The effectiveness of incorporating remineralizing agents into resin-based sealants has been confirmed by studies, but the interpretation of these results should be cautious due to variations in study settings and assessments.
Article
Surgery
Pietro Gentile, Simone Garcovich
Summary: This article reviews the literature on the efficacy of autologous activated platelet-rich plasma (PRP) and nonactivated PRP injection for facial rejuvenation. Eleven out of twelve studies showed improved results, despite differences in study design and outcome measures. However, further randomized controlled trials and systematic reviews are needed to confirm the efficacy of PRP injection in facial rejuvenation.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Review
Oncology
James M. Halle-Smith, Lewis Hall, Lois A. Daamen, James Hodson, Rupaly Pande, Alastair Young, Nigel B. Jamieson, Angela Lamarca, Hjalmar C. van Santvoort, Izaak Quintus Molenaar, Juan W. Valle, Keith J. Roberts
Summary: Routine surveillance after surgery for PDAC may lead to detection of more asymptomatic recurrences, higher rates of treatment, and longer overall survival for patients.
Review
Surgery
Bathiya Ratnayake, Sayali A. Pendharkar, Saxon Connor, Jonathan Koea, Diana Sarfati, Elizabeth Dennett, Sanjay Pandanaboyana, John A. Windsor
Summary: Contemporary literature confirms a strong relationship between patient volume and clinical outcomes for pancreatic cancer resection, with high-volume centers showing lower mortality, morbidity, failure-to-rescue, and positive resection margin rates.
Review
Radiology, Nuclear Medicine & Medical Imaging
Sohee Park, Jong Keon Jang, Jae Ho Byun, Jin Hee Kim, Seung Soo Lee, Hyoung Jung Kim, Seung Baek Hong, Seong Ho Park
Summary: The study systematically evaluated the diagnostic accuracy of CT-determined resectability after neoadjuvant treatment for predicting margin-negative resection in patients with PDAC. The research found that the ordinary criterion for resectability on CT was highly specific but insensitive in predicting R0 resection, while the extended criterion increased sensitivity but decreased specificity. Further investigations using quantitative parameters may improve the identification of R0 resection.
EUROPEAN RADIOLOGY
(2021)
Review
Oncology
Stefano Crippa, Claudio Ricci, Giovanni Guarneri, Carlo Ingaldi, Giulia Gasparini, Stefano Partelli, Riccardo Casadei, Massimo Falconi
Summary: The oncological benefit of achieving a negative pancreatic neck margin through re-resection after a positive frozen section (FS) is debated. Results suggest that a negative neck margin after primary resection or re-resection of a positive FS is associated with improved survival outcomes for patients with ductal adenocarcinoma.
Review
Biochemistry & Molecular Biology
Giuseppe Filiberto Serraino, Federica Jiritano, Davide Costa, Nicola Ielapi, Desiree Napolitano, Pasquale Mastroroberto, Umberto Marcello Bracale, Michele Andreucci, Raffaele Serra
Summary: Hypertrophic cardiomyopathy (HCM) is a genetic condition characterized by altered collagen turnover of the extracellular matrix. Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are abnormally released in patients with HCM. This systematic review found that MMP levels, particularly MMP2, were higher in HCM patients compared to healthy subjects. MMPs can be used as biomarkers for HCM and for monitoring treatment outcomes.
Review
Surgery
Nasreen Akter, Bathiya Ratnayake, Daniel B. Joh, Sara-Jane Chan, Emily Bonner, Sanjay Pandanaboyana
Summary: This systematic review compared the use of epidural analgesia (EDA), patient controlled analgesia (PCA), and transabdominal wound catheters (TAWC) in pancreatic surgery. The results showed that EDA, PCA, and TAWC are comparable in providing pain relief and perioperative outcomes.
WORLD JOURNAL OF SURGERY
(2021)
Review
Chemistry, Physical
Saad Saeed AlShahrani, Mana'a Saleh AlAbbas, Isadora Martini Garcia, Maha Ibrahim AlGhannam, Muath Abdulrahman AlRuwaili, Fabricio Mezzomo Collares, Maria Salem Ibrahim
Summary: This study evaluated the antimicrobial effects of various antibacterial agents/compounds in resin-based dental sealants. Compounds like zinc, tin, Selenium, chitosan, chlorhexidine, fluoride, and methyl methacrylate were found to be effective in reducing bacterial growth. Aging time did not significantly affect the antibacterial effect.
Article
Surgery
Leonard W. F. Seelen, Anne Floortje van Oosten, Lilly J. H. Brada, Vincent P. Groot, Lois A. Daamen, Marieke S. Walma, Bastiaan F. van der Lek, Mike S. L. Liem, Gijs A. Patijn, Martijn W. J. Stommel, Ronald M. van Dam, Bas Groot Koerkamp, Olivier R. Busch, Ignace H. J. T. de Hingh, Casper H. J. van Eijck, Marc G. Besselink, Richard A. Burkhart, Inne H. M. Borel Rinkes, Christopher L. Wolfgang, Izaak Quintus Molenaar, Jin He, Hjalmar C. van Santvoort
Summary: The objective of this study was to establish a evidence-based cutoff and predictors for early recurrence in patients with resected locally advanced pancreatic cancer (LAPC). After analyzing long-term follow-up data, a cutoff time of 6 months was determined to differentiate between early and late recurrence, and early recurrence was associated with poor survival. Preoperative predictors included post-induction therapy carbohydrate antigen (CA) 19-9 level, tumor differentiation and postoperative predictors included poor tumor differentiation and lack of adjuvant chemotherapy. These findings are valuable for guiding and counseling patients with LAPC before and after resection.
Article
Surgery
Simone Augustinus, Anouk E. J. A. Latenstein, Bert R. Bonsing, Olivier Busch, Bas Groot Koerkamp, Ignace H. J. T. E. de Hingh, Vincent de Meijer, I. Quintus C. Molenaar, Hjalmar van Santvoort, Judith H. de Vos-Geelen, Casper G. van Eijck, Marc Besselink, Dutch Pancreatic Canc Grp
Summary: This study aimed to assess the clinical impact and risk factors of chyle leak (CL) after pancreatoduodenectomy. The nationwide Dutch Pancreatic Cancer Audit was used to include consecutive patients from all 19 centers. The rate of CL was 7.0% and it was associated with prolonged hospital stay. Vascular resection and open surgery were identified as predictors of CL.
Article
Surgery
Hester M. Timmerhuis, Sven A. van Dijk, Robbert S. Hollemans, Devica J. Umans, Christina G. Sperna Weiland, Marc Besselink, Stefan A. W. J. Bouwense, Marco Bruno, Peter van Duijvendijk, Casper H. J. van Eijck, Yama Issa, J. Sven D. Mieog, I. Quintus Molenaar, Martijn W. J. L. Stommel, Thomas P. Bollen, Rogier C. Voermans, Robert C. Verdonk, Hjalmar van Santvoort, Dutch Pancreatitis Study Group
Summary: The aim of this study was to explore the incidence, risk factors, clinical course and treatment of gastrointestinal tract perforation and fistula in patients with necrotizing pancreatitis. The results showed that the incidence rate was 16%, with the stomach and duodenum being the most commonly affected sites. High C-reactive protein and early organ failure were identified as risk factors. Treatment varied depending on the affected site.
Article
Oncology
Jelle C. van Dongen, Eva Versteijne, Bert A. Bonsing, J. Sven D. Mieog, Ignace H. J. T. de Hingh, Sebastiaan Festen, Gijs A. Patijn, Ronald van Dam, Erwin van der Harst, Jan H. Wijsman, Koop Bosscha, Marion van der Kolk, Vincent E. de Meijer, Mike S. L. Liem, Olivier R. Busch, Marc G. H. Besselink, Geertjan van Tienhoven, Bas Groot Koerkamp, Casper H. J. van Eijck, Mustafa Suker
Summary: This study aimed to evaluate the value of staging laparoscopy in detecting occult metastases in patients with resectable or borderline resectable pancreatic cancer. The results showed that staging laparoscopy could detect occult metastases in about 10% of patients, and these patients were more likely to receive palliative systemic chemotherapy.
Article
Gastroenterology & Hepatology
Nadine C. M. van Huijgevoort, Sanne A. M. Hoogenboom, Selma J. Lekkerkerker, Olivier R. Busch, Marco Del Chiaro, Paul Fockens, Inne Somers, Joanne Verheij, Rogier P. Voermans, Marc G. Besselink, Jeanin E. van Hooft
Summary: Background: Follow-up in patients with intraductal papillary mucinous neoplasm (IPMN) aims to detect advanced neoplasia (high-grade dysplasia/cancer) in an early stage. The 2015 American Gastroentero-logical Association (AGA), 2017 International Association of Pancreatology (IAP), and the 2018 European Study Group on Cystic tumours of the Pancreas (European) guidelines differ in their recommendations on indications for surgery. However, it remains unclear which guideline is most accurate in predicting advanced neoplasia in IPMN. Methods: Patients who underwent surgery were extracted from a prospective database (January 2006-January 2021). In patients with IPMN, final pathology was compared with the indication for surgery according to the guidelines. ROC-curves were calculated to determine the diagnostic accuracy for each guideline. Results: Overall, 247 patients underwent surgery for cystic lesions. In 145 patients with IPMN, 52 had advanced neoplasia, of which the AGA guideline would have advised surgery in 14 (27%), the IAP and European guideline in 49 (94%) and 50 (96%). In 93 patients without advanced neoplasia, the AGA, IAP, and European guidelines would incorrectly have advised surgery in 8 (8.6%), 77 (83%) and 71 (76%). Conclusion: The European and IAP guidelines are clearly superior in detecting advanced neoplasia in IPMN as compared to the AGA, albeit at the cost of a higher rate of unnecessary surgery. To harmonize care and to avoid confusion caused by conflicting statements, a global evidence-based guideline for PCN in collaboration with the various guidelines groups is required once the current guidelines require an update. (c) 2023 Published by Elsevier B.V. on behalf of IAP and EPC.
Article
Oncology
Nynke Michiels, Deesje Doppenberg, Jesse V. Groen, Eran van Veldhuisen, Bert A. Bonsing, Olivier R. Busch, A. Stijn L. P. Crobach, Otto M. van Delden, Susan van Dieren, Arantza Farina, Ignace H. J. T. de Hingh, Rob Hurks, Joost Nederend, Shirin Shahbazi Feshtali, Yeliz Tank, A. L. Vahrmeijer, Martin Wasser, Marc G. Besselink, J. Sven D. Mieog
Summary: Intraoperative ultrasound (IOUS) can provide real-time additional information during surgery for pancreatic cancer with vascular involvement, and it has been found to change the resectability status in over one-third of patients, facilitating progress during surgical exploration. This finding should be confirmed by larger studies.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Simone Augustinus, Pascale J. M. V. Schafrat, Boris A. Janssen, Bert Bonsing, Lodewijk A. A. R. Brosens, Olivier Busch, Stijn Crobach, Michail H. Doukas, Casper van Eijck, Lydia G. M. van der Geest, Bas Groot Koerkamp, Ignace H. J. T. de Hingh, G. Mihaela C. Raicu, Hjalmar van Santvoort, Marie-Louise van Velthuysen, Joanne G. Verheij, Marc Besselink, Arantza Farina Sarasqueta
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Jeffrey W. Chen, Tess M. E. van Ramshorst, Sanne Lof, Bilal Al-Sarireh, Bergthor Bjornsson, Ugo Boggi, Fernando Burdio, Giovanni Butturini, Riccardo Casadei, Andrea Coratti, Mathieu D'Hondt, Safi Dokmak, Bjorn Edwin, Alessandro Esposito, Jean M. Fabre, Giovanni Ferrari, Fadhel S. Fteriche, Giuseppe K. Fusai, Bas Groot Koerkamp, Thilo Hackert, Asif Jah, Jin-Young Jang, Emanuele F. Kauffmann, Tobias Keck, Alberto Manzoni, Marco Marino, Quintus Molenaar, Elizabeth Pando Rau, Patrick Pessaux, Andrea Pietrabissa, Zahir Soonawalla, Robert P. Sutcliffe, Lea Timmermann, Steven White, Vincent S. Yip, Alessandro Zerbi, Mohammad Abu Hilal, Marc G. Besselink
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
J. Annelie Suurmeijer, Anouk M. Emmen, Bert A. Bonsing, Olivier R. Busch, Freek Daams, Casper H. van Eijck, Susan van Dieren, Ignace H. de Hingh, Tara M. Mackay, J. Sven Mieog, I. Quintus Molenaar, Martijn W. Stommel, Vincent E. de Meijer, Hjalmar C. van Santvoort, Bas Groot Koerkamp, Marc G. Besselink, Dutch Pancreat Canc Grp
Summary: This study aimed to validate the International Study Group of Pancreatic Surgery risk classification for postoperative pancreatic fistula after pancreatoduodenectomy. The study found that a simplified 3-tier classification system can achieve similar predictive value compared to the original 4-tier classification system.
Review
Medicine, General & Internal
Mark Ramaekers, Christiaan G. A. Viviers, Boris V. Janssen, Terese A. E. Hellstrom, Lotte Ewals, Kasper van der Wulp, Joost Nederend, Igor Jacobs, Jon R. Pluyter, Dimitrios Mavroeidis, Fons van der Sommen, Marc G. Besselink, Misha D. P. Luyer, EMTIC Oncology Collaborative Grp
Summary: Radiological imaging is crucial for detecting and treating pancreatic ductal adenocarcinoma (PDAC), but there are challenges in using these techniques in daily clinical practice. AI-based computer-aided detection (CAD) has shown promise in improving the radiological detection of cancer, but widespread adoption in clinical practice has not yet occurred.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Simone Augustinus, Gajanan Thurairajah, Marc G. Besselink, Hanneke W. M. van Laarhoven, Martijn G. H. van Oijen, Tara M. Mackay, Johanna W. Wilmink
Summary: Due to increased use of imaging, more advanced stages of cancer are being diagnosed in an early, asymptomatic phase. The optimal timing of chemotherapy in asymptomatic patients with advanced cancer is still uncertain, and there is a lack of systematic reviews on this topic.
Article
Surgery
Sanne Lof, Linda Claassen, Gerjon Hannink, Bilal Al-Sarireh, Bergthor Bjornsson, Ugo Boggi, Fernando Burdio, Giovanni Butturini, Giovanni Capretti, Riccardo Casadei, Safi Dokmak, Bjorn Edwin, Alessandro Esposito, Jean M. Fabre, Giovanni Ferrari, Asmund A. Fretland, Fadhel S. Fteriche, Giuseppe K. Fusai, Alessandro Giardino, Bas Groot Koerkamp, Mathieu D'Hondt, Asif Jah, Sivesh K. Kamarajah, Emanuele F. Kauffmann, Tobias Keck, Stijn van Laarhoven, Alberto Manzoni, Marco V. Marino, Ravi Marudanayagam, Izaak Q. Molenaar, Patrick Pessaux, Edoardo Rosso, Roberto Salvia, Zahir Soonawalla, Regis Souche, Steven White, Frans van Workum, Alessandro Zerbi, Camiel Rosman, Martijn W. J. Stommel, Mohammed Abu Hilal, Marc G. Besselink
Summary: Understanding the learning curve of MIDP is important in reducing patient harm. This multicenter study analyzed data from 26 European centers to evaluate the length of the learning curve. The findings suggest that 85 procedures are needed to achieve optimal outcomes, while earlier mastery can be achieved for conversion rate, operation time, and intraoperative blood loss.
Article
Surgery
Deesje Doppenberg, Jacob L. van Dam, Youngmin Han, Bert A. Bonsing, Olivier R. Busch, Sebastiaan Festen, Erwin van der Harst, Ignace H. de Hingh, Marjolein Y. Homs, Wooil Kwon, Mirang Lee, Daan J. Lips, Vincent E. de Meijer, I. Quintus Molenaar, Joost J. Nuyttens, Gijs A. Patijn, Stijn van Roessel, George P. van der Schelling, Mustafa Suker, Eva Versteijne, Judith de Vos-Geelen, Johanna W. Wilmink, Casper H. J. van Eijck, Geertjan van Tienhoven, Jin-Young Jang, Marc G. Besselink, Bas Groot Koerkamp
Summary: Two randomized controlled trials (RCTs) have shown that neoadjuvant chemoradiotherapy (CRT) is associated with better survival in patients with resectable and borderline resectable pancreatic cancers compared to upfront surgery. The baseline serum CA19-9 level does not affect the treatment effect of neoadjuvant CRT, indicating that it should not be withheld based on CA19-9 concentration.
BRITISH JOURNAL OF SURGERY
(2023)
Review
Surgery
Aagje J. M. Pronk, Anne Roelofs, David R. Flum, H. Jaap Bonjer, Mohammed Abu Hilal, Marcel G. W. Dijkgraaf, Marc G. Besselink, Usama Ahmed Ali
Summary: This systematic review analyzed 1188 surgical randomized controlled trials (RCTs) from three different years (1999, 2009, and 2019) and found that the global volume of published surgical RCTs remained stable in the past decade, but the proportion of RCTs with low risk of bias increased from 14.7% to 22.1%. Asia saw an increase in surgical RCTs, while Europe saw a decrease.
BRITISH JOURNAL OF SURGERY
(2023)
Correction
Surgery
J. Annelie Suurmeijer, Eline C. Soer, Mark P. G. Dings, Yongsoo Kim, Marin Strijker, Bert A. Bonsing, Lodewijk A. A. Brosens, Olivier R. Busch, Jesse Groen, Johannes B. Halfwerk, Robbert A. E. Slooff, Hanneke W. M. van Laarhoven, I. Quintus Molenaar, G. Johan A. Offerhaus, Hans Morreau, Marc J. van de Vijver, Arantza Farina Sarasqueta, Joanne Verheij, Marc G. Besselink, Maarten F. Bijlsma, Frederike Dijk
BRITISH JOURNAL OF SURGERY
(2023)
