Article
Biochemistry & Molecular Biology
Daniela Denis Di Martino, Chiara Maria Soldavini, Gabriele Rossi, Maria Chiara Lonardoni, Gabriele Tine, Agnese Caneschi, Francesco D'Ambrosi, Enrico Ferrazzi
Summary: This study aimed to evaluate the sFlt-1/PlGF ratio in pregnancies complicated by COVID-19 and gestational diabetes (GD) and found that patients with both GD and SARS-CoV-2 infection had a higher sFlt-1/PlGF ratio, along with a higher incidence of obesity and hypertensive disorders of pregnancy.
Article
Peripheral Vascular Disease
Rugina Neuman, Langeza Saleh, Koen Verdonk, Anton H. van den Meiracker, Henk Russcher, Herold J. Metselaar, Willy Visser, A. H. Jan Danser
Summary: The study indicates that PlGF production is significantly upregulated in AFLP patients, mainly originating from the placenta. Compared to other disease groups, AFLP patients have significantly elevated levels of PlGF, which rapidly decline postpartum.
Article
Medicine, General & Internal
Katarzyna Kosinska-Kaczynska, Ewa Malicka, Iwona Szymusik, Norbert Dera, Michal Pruc, Stepan Feduniw, Zubaid Rafique, Lukasz Szarpak
Summary: COVID-19 infection in pregnant women is associated with an increased risk of adverse pregnancy outcomes, including preeclampsia. This meta-analysis found that pregnant women with COVID-19 have higher sFlt-1/PlGF ratios compared to those without COVID-19. Severe COVID-19 and SARS-CoV-2 infection in hypertensive pregnant women were also associated with significantly higher sFlt-1/PlGF ratios.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Birgitte Mitlid-Mork, Sophie Bowe, Anne Cathrine Staff, Meryam Sugulle
Summary: The study found that the increase in sFlt-1 and sFlt-1/PlGF ratio before labor onset is more rapid in pregnancies with placental syndromes. This rapid antiangiogenic shift might indicate a pregnancy more prone to acute placental failure and more prepared for labor onset. The induction of labor was not affected by placental dysfunction.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Obstetrics & Gynecology
Shuyuan Xue, Ying Feng, Wei Li, Guifeng Ding
Summary: This study demonstrates that sFlt-1/PLGF ratio has better predictive and diagnostic value for preeclampsia, with improved auxiliary efficiency compared to just considering sFlt-1 levels.
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
(2022)
Article
Environmental Sciences
Magdalena Bednarek-Jedrzejek, Sylwia Dzidek, Piotr Tousty, Ewa Kwiatkowska, Aneta Cymbaluk-Ploska, Tomasz Gora, Bartosz Czuba, Andrzej Torbe, Sebastian Kwiatkowski
Summary: This study found a significant correlation between uric acid levels and LBW, particularly in pregnant women with placental insufficiency. Uric acid can be used to improve the prediction of LBW, and when combined with other biophysical and biochemical parameters, better results can be achieved in prognosis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Obstetrics & Gynecology
Oriane Tasta, Olivier Parant, Safouane M. Hamdi, Mickael Allouche, Christophe Vayssiere, Paul Guerby
Summary: The sFlt-1/PlGF ratio is a valuable tool for predicting adverse maternofetal outcomes in early-onset preeclampsia, which can help anticipate and prevent severe complications.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Clinical Neurology
John C. Morris, Michael Weiner, Chengjie Xiong, Laurel Beckett, Dean Coble, Naomi Saito, Paul S. Aisen, Ricardo Allegri, Tammie L. S. Benzinger, Sarah B. Berman, Nigel J. Cairns, Maria C. Carrillo, Helena C. Chui, Jasmeer P. Chhatwal, Carlos Cruchaga, Anne M. Fagan, Martin Farlow, Nick C. Fox, Bernardino Ghetti, Alison M. Goate, Brian A. Gordon, Neill Graff-Radford, Gregory S. Day, Jason Hassenstab, Takeshi Ikeuchi, Clifford R. Jack, William J. Jagust, Mathias Jucker, Johannes Levin, Parinaz Massoumzadeh, Colin L. Masters, Ralph Martins, Eric McDade, Hiroshi Mori, James M. Noble, Ronald C. Petersen, John M. Ringman, Stephen Salloway, Andrew J. Saykin, Peter R. Schofield, Leslie M. Shaw, Arthur W. Toga, John Q. Trojanowski, Jonathan Voeglein, Stacie Weninger, Randall J. Bateman, Virginia D. Buckles
Summary: This study compared biomarker changes in individuals with autosomal dominant Alzheimer's disease and late onset Alzheimer's disease and found similarities in their pathophysiology, suggesting a shared pathobiological construct.
Article
Biochemistry & Molecular Biology
Luis M. Garcia-Puente, Oscar Fraile-Martinez, Cielo Garcia-Montero, Julia Bujan, Juan A. De Leon-Luis, Coral Bravo, Patrocinio Rodriguez-Benitez, Pilar Pintado, Francisco Javier Ruiz-Labarta, Melchor alvarez-Mon, Natalio Garcia-Honduvilla, Maria J. Cancelo, Miguel A. Saez, Miguel A. Ortega
Summary: Pre-eclampsia is a harmful condition during pregnancy, characterized by hypertension and proteinuria. Inflammation in the placenta may play a role in its development, and this study suggests that the NLRP3 inflammasome is potentially involved in the pathophysiology of late-onset pre-eclampsia.
Article
Medicine, General & Internal
Agathi Thomaidou, Olga Deda, Olga Begou, Artemis Lioupi, Angeliki Kontou, Helen Gika, Eleni Agakidou, Georgios Theodoridis, Kosmas Sarafidis
Summary: This study evaluated the metabolic profile of neonates with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC). The results revealed significant differences in the metabolic profile of neonates with LOS or NEC compared to controls, suggesting that certain phospholipids and their derivatives could be used as biomarkers for early detection of these diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Claus Z. Simonsen, Thabele M. Leslie-Mazwi, Gotz Thomalla
Summary: Reperfusion therapy has been shown to be effective for stroke with unknown time of onset, but challenges in clinical practice exist due to variability in data and different imaging paradigms. Physicians need to consider which imaging approach to use when guiding reperfusion treatment for these patients.
Article
Obstetrics & Gynecology
Manisha Kumar, Kirti Balyan, Ekta Debnath, Shivangi Shankar, Aryahi Apte, Shreeja Jha
Summary: This study evaluated the role of angiogenic biomarkers in predicting severe adverse materno-fetal outcomes among women at high risk of preeclampsia. It found that an increased sFlt-1/PlGF ratio was a good predictive marker, especially for those who developed complications before 34 weeks.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Obstetrics & Gynecology
Manisha Kumar, Kirti Balyan, Ekta Debnath, Ben Himtsoe, Surbhi Sapna, Arunav Kumar
Summary: The study validates the predictive value of sFlt-1/PlGF ratio for risk stratification in high-risk pregnant women and suggests that testing at 28-30 weeks may be the optimal time for prediction of preeclampsia.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2023)
Article
Pediatrics
Serife Kurul, Famke L. M. Beckers, Marijn J. Vermeulen, Jill Suurland, Jasmin E. Hasbek, Christian R. B. Ramakers, Sinno H. P. Simons, Irwin K. M. Reiss, H. Rob Taal
Summary: The association between inflammatory biomarkers (CRP, PCT, IL-6) and sepsis severity (nSOFA) and neurodevelopmental outcomes at 2 years in preterm neonates was investigated. High CRP concentrations and sepsis severity were found to be associated with neurodevelopmental outcomes in survivors at the age of 2 years.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Hubert Wolski, Marcin Ozarowski, Grazyna Kurzawinska, Anna Bogacz, Marlena Wolek, Malgorzata Luszczynska, Krzysztof Drews, Aleksandra E. Mrozikiewicz, Przemyslaw L. Mikolajczak, Radoslaw Kujawski, Boguslaw Czerny, Tomasz M. Karpinski, Agnieszka Seremak-Mrozikiewicz
Summary: This study found significantly lower levels of LXRA mRNA and LXRA protein in the placenta of women with late-onset preeclampsia compared to healthy pregnant women. These nuclear receptors may play a role in the development of preeclampsia through disturbances of lipid metabolism.
JOURNAL OF CLINICAL MEDICINE
(2022)