Article
Obstetrics & Gynecology
Robin Tuytten, Argyro Syngelaki, Gregoire Thomas, Ana Panigassi, Leslie W. Brown, Paloma Ortea, Kypros H. Nicolaides
Summary: This study aimed to verify metabolite biomarkers as preterm preeclampsia predictors early in pregnancy in all women and across body mass index groups. The results showed that certain metabolites and ratios of amino acids were associated with preterm preeclampsia risk, but their predictive performance varied according to body mass index classification.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Faith Andres, Natalie J. Hannan, Susan P. Walker, Teresa M. MacDonald, Georgia P. Wong, Ciara Murphy, Ping Cannon, Manju Kandel, Joshua Masci, Tuong-Vi Nguyen, Alison Abboud, Danica Idzes, Valerie Kyritsis, Natasha Pritchard, Stephen Tong, Tuuhevaha J. Kaituu-Lino
Summary: This study found that EPCR levels were significantly increased in both the placenta and circulation of patients with preterm preeclampsia and fetal growth restriction. Hypoxia may be associated with the elevation of placental EPCR. These findings have important implications for understanding the mechanisms underlying these conditions.
Article
Obstetrics & Gynecology
Daniel L. Rolnik, Roshan J. Selvaratnam, Dagmar Wertaschnigg, Simon Meagher, Euan Wallace, Jon Hyett, Fabricio da Silva Costa, Andrew McLennan
Summary: This study aimed to assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia. Women who underwent combined screening were less likely to experience preeclampsia, preterm birth, and other pregnancy complications compared to those who received standard care. The screening identified a population at high risk of adverse pregnancy outcomes and low-risk women suitable for less intensive antenatal care.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Acoustics
I. Dhaifalah, E. Magalova, D. Studnykova, J. Havalova, E. Slintakova, H. Cuckle
Summary: This study assesses the performance and impact of first-trimester preterm pre-eclampsia screening in a single center. The results show a high detection rate but further evaluation is needed to determine the impact on the condition.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Cell Biology
Claudia Melina Robellada-Zarate, Janelly Estefania Luna-Palacios, Carlos Agustin Zapata Caballero, Juan Pablo Acuna-Gonzalez, Irlando Lara-Pereyra, Diego Ivan Gonzalez-Azpeitia, Ricardo Josue Acuna-Gonzalez, Elsa Romelia Moreno-Verduzco, Hector Flores-Herrera, Mauricio Osorio-Caballero
Summary: A study found that elevated levels of 60 and 70-KDa extracellular heat shock proteins (eHsp) and decreased levels of eHsp-27 in the first trimester are associated with the development of preeclampsia (PE). These findings suggest that first-trimester eHsp levels may serve as early biomarkers for predicting PE.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Anita Subramanian, Doria Weiss, Kate Nyhan, Andrew Dewan, Anne Marie Z. Jukic
Summary: This systematic review summarizes the miRNAs associated with early placentation and pregnancy complications, identifying seven potential early biomarkers. These miRNAs can facilitate early detection and interventions for pregnancy complications.
Article
Nanoscience & Nanotechnology
Lilly Synan, Saman Ghazvini, Saji Uthaman, Gabriel Cutshaw, Che-Yu Lee, Joshua Waite, Xiaona Wen, Soumik Sarkar, Eugene Lin, Mark Santillan, Donna Santillan, Rizia Bardhan
Summary: Preterm birth is a major cause of infant mortality globally. Current clinical measures often fail to identify women who may deliver preterm, making accurate screening tools essential. This study uses Raman spectroscopy to predict preterm birth by examining differences in the maternal metabolome. Fifteen statistically significant metabolites were identified as predictors of preterm birth. The integration of Raman and clinical data with machine learning achieved an unprecedented 85.1% accuracy in risk stratification of preterm birth in the first trimester.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Jiajin Hu, Meihui Li, Chuang Li, Shaowei Yin, Lin Tao, Lin Li, Ningyu Wan, Yilin Liu, Borui Liu, Lu Zheng, Xiaochuan Wang, Zhe Yang, Yanan Ma, Chong Qiao, Deliang Wen, Caixia Liu
Summary: This study aimed to investigate the relationship between maternal dietary patterns during pregnancy and the risk of preterm birth (PTB). It found that adherence to different dietary patterns during different trimesters was associated with varying risks of PTB. Specifically, following a fish-seafood pattern during the first trimester increased the risk of PTB and iatrogenic preterm birth, while following the same pattern during the second trimester decreased the risk of PTB. Additionally, adherence to a dairy-egg pattern during the second or third trimester increased the risks of PTB and iatrogenic preterm birth.
Article
Acoustics
V. GIORGIONE, O. QUINTERO MENDEZ, A. PINAS, W. ANSLEY, B. THILAGANATHAN
Summary: Preterm birth (PTB) is a major public health issue worldwide, and this study aimed to investigate whether there is a shared uteroplacental etiology in PTB subtypes during the first trimester of pregnancy. The analysis found that factors used to predict preterm PE risk could also be used to predict PTB at < 33 weeks, suggesting a shared etiological pathway for preterm births.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carl P. Weiner, Helen Zhou, Howard Cuckle, Argyro Syngelaki, Kypros H. Nicolaides, Mark L. Weiss, Yafeng Dong
Summary: The prediction of spontaneous preterm birth (sPTB) in the first trimester has been difficult. Currently, screening relies heavily on obstetric history, but this is not applicable to nullipara who are at a higher risk for sPTB <= 32 weeks. A panel of maternal plasma cell-free RNAs has been tested for prediction at 16-20 weeks, but its applicability in the first trimester for nullipara is still uncertain due to a small sample size in this study.
Article
Multidisciplinary Sciences
Sakita K. Moungmaithong, Angel H. S. Kwan, Ada W. Tse, Natalie K. C. Wong, Michelle S. S. Lam, Jing Wang, Liona C. Poon, Daljit S. Sahota
Summary: International professional organizations recommend aspirin prophylaxis to women at high risk for preterm preeclampsia (PE) in the first trimester. However, the UK Fetal Medicine Foundation (FMF) screening test using mean arterial pressure (MAP), uterine artery pulsatility index (UTPI), and placental growth factor (PlGF) has shown lower detection rates (DRs) in Asian population studies. Additional biomarkers are needed in Asian women to improve screening for preterm and term PE.
Article
Medicine, General & Internal
Tamar Wainstock, Ruslan Sergienko, Eyal Sheiner
Summary: The study revealed that complications during the first pregnancy may increase the risk of preterm delivery in subsequent pregnancies. Therefore, the first pregnancy, even if carried to term, could be a crucial period for identifying women at risk for future preterm deliveries.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Developmental Biology
Rik H. J. Beernink, Eva F. Zwertbroek, Joost H. N. Schuitemaker, Thomas I. F. H. Cremers, Sicco A. Scherjon
Summary: This study aimed to discover novel biomarkers for early onset, preterm onset, and PE at term, and found that some proteins are differently expressed in different PE subtypes which may play a role in the development of PE.
Article
Pharmacology & Pharmacy
Y. -H. Zhang, M. -H. Zhen, Y. -F. Zeng, L. Lao, W. AI
Summary: This study aimed to assess the differences in peripheral complete blood count between women with spontaneous preterm birth and age-matched controls with healthy pregnancies in the first trimester. The results showed that white blood count, platelet, lymphocyte, monocyte, and lymphocyte-monocyte ratio were higher in the sPTB group, while platelet-lymphocyte ratio and neutrophil-lymphocyte ratio were lower. Lymphocyte count had the highest predictive value, with an AUROC of 0.853.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Obstetrics & Gynecology
Chaelin Lee, Seung Mi Lee, Dong Jun Byun, So Yeon Kim, Hugh Kim, Do Yup Lee, Young Mi Jung, Chan-Wook Park, Joong Shin Park, Man Ho Choi
Summary: Increased levels of tetrahydrocortisol and decreased levels of 21-deoxycortisol were observed in pregnant women carrying small-for-gestational-age (SGA) fetuses. The combination of 21-deoxycortisol concentration and two metabolic ratios of cortisol/21-deoxycortisol and tetrahydrocortisol/cortisol can serve as potential biomarkers for predicting SGA in the first trimester.
REPRODUCTIVE SCIENCES
(2022)
Editorial Material
Pediatrics
Paula L. Hedley, Marie Baekvad-Hansen, Gitte Hedermann, Henrik Hjalgrim, David M. Hougaard, Mads Melbye, Morten Breindahl, Lone Krebs, Anders Hviid, Ulrik Lausten-Thomsen, Michael Christiansen
Review
Obstetrics & Gynecology
Herman A. Sorensen, Josephine Obel, Jeppe B. Schroll, Lone Krebs
Summary: This study assessed the impact of singleton vaginal breech delivery (VBD) and cesarean breech delivery (CBD) on neonatal and maternal mortality and morbidity in low- and lower-middle-income settings. The results showed that VBD increased the risk of perinatal mortality and 5-minute Apgar score below 7 compared to CBD. On the other hand, CBD was associated with a higher risk of hospitalization and postpartum bleeding.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Anna J. M. Aabakke, Tanja G. Petersen, Karen Wojdemann, Mette H. Ibsen, Fjola Jonsdottir, Elisabeth Ronneberg, Charlotte S. Andersen, Anne Hammer, Tine D. Clausen, Julie Milbak, Lars Burmester, Rikke Zethner, Birgitte Lindved, Annette Thorsen-Meyer, Mohammed R. Khalil, Birgitte Henriksen, Lisbeth Jonsson, Lise L. T. Andersen, Kamilla K. Karlsen, Monica L. Pedersen, Gitte Hedermann, Marianne Vestgaard, Dorthe Thisted, Agnethe N. Fallesen, Josephine N. Johansson, Ditte C. Moller, Greta Dubietyte, Charlotte B. Andersson, Richard Farlie, Ane-Kersti Skaarup Knudsen, Lea Hansen, Lone Hvidman, Anne N. Sorensen, Sidsel L. Rathcke, Katrine H. Rubin, Lone K. Petersen, Jan S. Jorgensen, Lone Krebs, Mette Bliddal
Summary: This study analyzed the risk factors and outcomes of SARS-CoV-2 infection during pregnancy using national health registers and medical records in Denmark. The results showed that pregnant women infected with SARS-CoV-2 were more likely to develop hypertensive disorders in pregnancy, early pregnancy loss, preterm delivery, and have children small for gestational age. The Danish national registers had acceptable accuracy in identifying SARS-CoV-2 infection during pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Public, Environmental & Occupational Health
Veronica N. E. Malange, Gitte Hedermann, Ulrik Lausten-Thomsen, Steen Hoffmann, Marianne Voldstedlund, Anna J. M. Aabakke, Anna K. K. Eltvedt, Jorgen S. Jensen, Morten Breindahl, Lone Krebs, Michael Christiansen, Paula L. L. Hedley
Summary: In the past decade, there have been numerous infectious disease outbreaks worldwide, which have had significant effects on perinatal health, including increased risk of preterm delivery and the delivery of low birth weight or small for gestational age babies. Severe perinatal outcomes, such as perinatal and infant death, have also been observed in relation to various infectious diseases. It is important to monitor perinatal health and collect systematic data to understand the implications of these diseases for pregnant women and their unborn infants.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
Mads Langager Larsen, Veronika Schreiber, Lone Krebs, Christina Engel Hoei-Hansen, Sailesh Kumar
Summary: This study analyzed the relationship between the magnitude of decline in fetal growth and stillbirth, perinatal mortality, and adverse neonatal outcomes. The findings showed a significant increase in stillbirth and perinatal mortality when the decline in fetal growth was more than 50th percentile. These results provide guidance for identifying late fetal growth restriction in prenatal diagnosis.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Obstetrics & Gynecology
Anne K. Ortqvist, Maria C. Magnus, Anna J. M. Aabakke, Stine Kjaer Urhoj, Anne Vinkel Hansen, Anne-Marie Nybo Andersen, Lone Krebs, Karin Pettersson, Siri E. Haberg, Olof Stephansson
Summary: This study aimed to explore the characteristics of pregnant women admitted to the ICU with severe COVID-19, including maternal factors, pregnancy outcomes, vaccination status, and virus variants. The results showed that unvaccinated pregnant women of non-Scandinavian origin and lower socioeconomic status were at higher risk of ICU admission. Additionally, pregnant women admitted to the ICU for COVID-19 had a higher risk of adverse pregnancy outcomes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Gastroenterology & Hepatology
Yun Huang, Sara E. Stinson, Helene Baek Juel, Morten A. V. Lund, Louise Aas Holm, Cilius E. Fonvig, Trine Nielsen, Niels Grarup, Oluf Pedersen, Michael Christiansen, Elizaveta Chabanova, Henrik S. Thomsen, Aleksander Krag, Stefan Stender, Jens-Christian Holm, Torben Hansen
Summary: This study investigated the effects of eight previously reported genome-wide significant steatogenic variants on liver and cardiometabolic traits in children and adolescents. The results showed that these variants were associated with higher liver fat and distinct patterns of plasma lipids. The genetic risk score (GRS) based on these variants was also associated with higher prevalence of hepatic steatosis and had potential clinical utility for risk stratification.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Victoria de Knegt, Paula Hedley, Gitte N. Hedermann, Casper Wilstrup, Marie Baekvad-Hansen, Ida Thagaard, Henrik M. Hjalgrim, Jorgen Kanters, Mads Melbye, David Hougaard, Anders Hviid, Lone Krebs, Morten Breindahl, Ulrik Lausten-Thomsen, Michael Christiansen
Summary: A nationwide COVID-19 lockdown in Denmark resulted in a reduced prevalence of extremely preterm or extremely low birthweight births. This study aimed to investigate the impact of the lockdown on term birthweights in Denmark. The findings showed a small but significant increase in birthweight during the lockdown period, primarily driven by an increase in birthweight in gestational weeks 40 and 41. Additionally, the proportion of infants with a large-for-gestational-age (LGA) increased during the lockdown.
Article
Obstetrics & Gynecology
Sandra Maria Behnke Gerdes, Charlotte Kvist Ekelund, Line Rode, Caroline Borregaard Miltoft, Julie Midtgaard, Finn Stener Jorgensen, Kasper Pihl, Ann Tabor, Iben Riishede
Summary: This questionnaire study aimed to investigate Danish pregnant women's motivation to participate in a first trimester screening for preeclampsia. The study found that most women had a positive attitude towards the screening and expressed willingness to participate in the risk assessment. These findings are important for the potential implementation of the screening in Denmark.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Orthopedics
Paula L. Hedley, Ulrik Lausten-Thomsen, Kristin M. Conway, Klaus Hindso, Paul A. Romitti, Michael Christiansen
Summary: This study used publicly available data to investigate the prevalence and co-occurring anomalies of clubfoot in Denmark from 1994 to 2021. The findings showed that the prevalence of nonsyndromic clubfoot remained stable during the study period, and the reduction in maternal smoking rates did not significantly impact the prevalence. These results support the suspected multifactorial etiopathogenesis of clubfoot and provide a valuable population-based resource for future investigations.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Obstetrics & Gynecology
Maria Jeppegaard, Steen C. Rasmussen, Jacob Anhoj, Lone Krebs
Summary: The purpose of this study was to investigate the seasonal variation in placenta-mediated pregnancy complications. The researchers found a significant seasonal variation in the risk of hypertensive disorders during pregnancy, with the highest risk in pregnancies conceived in the spring and summer season. However, there was no apparent seasonality in other placenta-mediated complications.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Simon Foged Victor, Maria Jeppegaard, Steen Christian Rasmussen, Marie Hoygaard Larsen, Lone Krebs
Summary: The study aimed to develop placental weight percentile curves adjusted by gestational age and stratified by major maternal comorbidities. The results showed that diabetic placentas generally had higher weight, while hypertensive placentas had lower weight.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Rebecka Hansen, Veronika Markova Sommer, Anja Pinborg, Lone Krebs, Lars Lykke Thomsen, Torben Moos, Charlotte Holm
Summary: This study aims to compare the efficacy of intravenous iron and oral iron in the treatment of persistent iron deficiency in pregnant women. The results showed that intravenous iron was superior to oral iron in preventing anemia and also improved fatigue and quality of life.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Simon Foged Victor, Diana Bottcher Brondum Bach, Anna Carolina Hvelplund, Carsten Nickelsen, Jens Lyndrup, Charlotte Wilken-Jensen, Lise Jul Scharff, Tom Weber, Niels Jorgen Secher, Lone Krebs
Summary: Intrapartum monitoring with cardiotocography (CTG) in combination with ST analysis (STAN) did not reduce the incidence of neonatal metabolic acidosis compared to CTG in combination with fetal blood sampling (FBS). However, CTG + STAN was associated with an increased risk of operative vaginal delivery and a reduced use of FBS.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Amalie Birkmose Thams, Marie Hoygaard Larsen, Steen Christian Rasmussen, Maria Jeppegaard, Lone Krebs
Summary: This study examined the incidence and risk factors for postpartum hemorrhage (PPH), and found that women who had previous PPH had an increased risk of PPH in subsequent deliveries. Additionally, labor induction increased the risk of recurrent PPH, while planned cesarean section reduced the risk. Personalized counseling based on risk factors, labor history, and maternal preferences is recommended for preventing recurrent PPH.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
