Continuous production of redispersible and rapidly-dissolved fenofibrate nanoformulation by combination of microfluidics and spray drying

Slow dissolution rate is responsible for poor oral bioavailability of fenofibrate. This work aimed at synthesizing a redispersible and rapidly-dissolved fenofibrate nanoformulation by combination of antisolvent precipitation-in-microfluidics and spray drying. 196-296 nm fenofibrate nanoparticles (NPs) were achieved by the developed process. Increasing the volume ratio of the antisolvent water to drug ethanolic solution, flow rate or drug concentration resulted in the formation of smaller particles. Fenofibrate nanoformulation exhibited good redispersibility and much faster dissolution rate in comparison with the raw drug. (C) 2014 Elsevier B.V. All rights reserved.