Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 14, Issue -, Pages 623-633Publisher
ELSEVIER
DOI: 10.1016/j.jff.2015.02.030
Keywords
Black soybean testa; Anthocyanin; Adipogenesis; Lipogenesis; Lipolysis; Inflammation
Categories
Funding
- Cooperative Research Program for Agriculture, Science, and Technology Development [PJ907089]
- Technology Commercialization Support Program, Ministry for Food, Agriculture, Forestry, and Fisheries, Republic of Korea [811003031SU000]
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Black soybeans have been known as medicinal food with anti-obesity, anti-inflammation and anti-oxidative stress effects, and the testa of Cheongja #3 black soybeans is especially rich in anthocyanins. Forty-one male C57BL/6N mice were randomly assigned into four groups after 10-week-period of diet-induced obesity: a control group, a high-fat diet group, a high-fat diet group with the ethanol extract from black soybean testa (BBC), and a high-fat diet group with orlistat; BBC was orally administered for 12 weeks. BBC treatment significantly decreased food intake, fat accumulation, and the expression of lipogenesis genes (acetylCoA carboxylase and CCAAT-enhancer-binding protein alpha), and increased the levels of lipolysis proteins (lipoprotein lipase, hormone-sensitive lipase, and AMP-activated protein kinase) in mesenteric fat. BBC also showed successful anti-inflammatory effects through regulation of tumor necrosis factor-alpha, interleukin-6 and interleukin-10. These findings provide scientific support for using anthocyanin-rich black soybean as functional food in prevention of obesity and inflammation-induced diseases. (C) 2015 Elsevier Ltd. All rights reserved.
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