Article
Pharmacology & Pharmacy
Kangming Zhou, Zeng Liu, Renyu Fan, Mengtao Zhao, Linxiu Luo, Yuting Wang, Yanling Jiang, Zheng Lu, Jincao Tang, Anqi Luo, Tianbing Guan, Huimin Sun, Taigang Zhou, Chuanyun Dai
Summary: The mechanism of interaction between binder and powder with different sugar content in high shear wet granulation (HSWG) was studied on the molecular level using experiment analysis and molecular dynamics (MD) simulation. It was found that for sticky powder with high sugar content, ethanol in the binder played a crucial role in dispersing water into powders, and the amount of water determined the growth of granules. In the saturating stage, the reduction of sugar content facilitated the penetration of ethanol molecules. The concentration of ethanol determined the uniform blending of the mixture in the merging stage. The simulation results are consistent with the actual situation and explain the competition mechanism of interaction with binder and powder. Therefore, this research offers an efficient strategy for understanding the HSWG process with sticky powder and provides guidelines for the practical application of Traditional Chinese Medicine (TCM) granule preparation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Dejian Zhang, Satoko Takase, Gyoko Nagayama
Summary: This study developed an electrochemical impedance method to evaluate the effective wetting area at a hydrophobic solid-liquid interface, finding a positive correlation between electrochemical impedance and surface hydrophobicity, and a negative correlation with effective wetting area. Patterned Si surfaces exhibited an intermediate wetting state, with the predicted effective wetting area matching well with the partial wetting model.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Chemical
Chen Li, Yuzhou Zhang, Ning Zhu, Heather N. Emady, Lifeng Zhang
Summary: This study successfully captured the dynamic wet granulation process of pharmaceutical powders using synchrotron in-situ imaging technique, and quantitatively described the movement of liquid binders in the powder beds with a new parameter rm. The results showed that the properties of liquid binders and operation parameters significantly impact the dynamic granulation process.
Article
Pharmacology & Pharmacy
Lara Heidrich, Ayat Abdelkader, Jan Ornik, Enrique Castro-Camus, Cornelia M. Keck, Martin Koch
Summary: The study investigates paper tablets as drug delivery systems, using cellulose-based paper matrices loaded with norfloxacin. Wet granulation is introduced to improve the flowability of solids, essential for industrial scale production. THz TDS proves to be more effective than XRD in assessing crystallinity changes of the API after wet granulation.
Article
Engineering, Chemical
Martin Krov, Ondrej Rychecky, Maximilian Prachar, Ales Zadrazil, Rudolf Sramek, Frantisek Stepanek
Summary: This article introduces a new device for continuous production of liquid marbles with high reproducibility and precise size distribution. The device has potential applications in various fields such as food, cosmetics, and pharmaceutics. Experimental data is provided to guide the production process.
Article
Pharmacology & Pharmacy
Selina Ramm, Ruwen Fulek, Veronika Anna Eberle, Christian Kiera, Ulrich Odefey, Miriam Pein-Hackelbusch
Summary: Pellet production is a multi-step manufacturing process, with liquid requirement being the most important parameter in wet granulation. Through experiments, we found that compression density can serve as an alternative parameter for liquid requirement and successfully predicted the liquid requirement for unknown formulations. This prediction allowed the production of high-quality pellets.
Article
Chemistry, Physical
Youqing Sun, Ensieh Yousefi, Anil Kunwar, Nele Moelans, David Seveno, Muxing Guo
Summary: This study investigated the wettability behavior of liquid aluminum on solid nickel at high temperatures, revealing the formation of Al3Ni phase as the primary phase and its significant influence on wetting behavior. Experimental and theoretical analyses confirmed the limited effect of Ni dissolution into Al at temperatures below 950 degrees C on wetting dynamics.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Roozbeh Abidnejad, Marco Beaumont, Blaise L. Tardy, Bruno D. Mattos, Orlando J. Rojas
Summary: The study introduces a synergetic combination of colloids to stabilize complex fluids at the interface, which is beneficial for preparing lightweight materials; the strong interactions between high aspect ratio and hydrophilic fibrillated cellulose (CNF) with low aspect ratio hydrophobic particles can significantly increase foamability and extend the foam lifetime; the formation of a fibrillar network by CNF in wet foam regulates interparticle interactions, delaying or preventing drainage, coarsening, and bubble coalescence, leading to the transformation into lightweight and strong architectures after drying.
Article
Engineering, Chemical
Ziqi Wang, Guiru Zhu, Qi Wang, Kaiyue Ding, Yunbo Tong, Congjie Gao
Summary: The improvement of the molding process of adsorbent powders, utilizing the liquid marble phenomenon, leads to the successful preparation of millimeter-sized spherical particles SSG, which shows significant progress in the practical application of uranium adsorption. SSG demonstrates high adsorption capacity and shows behavior consistent with the pseudo-second-order model and Langmuir model. Moreover, SSG proves its capability in uranium extraction, offering a new approach for practical applications.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Mechanics
Kevin R. Murphy, Jonathan B. Boreyko
Summary: When a sessile droplet contacts an opposing solid surface, the droplet can transfer based on wettabilities and surface velocity. This study used high-speed imaging to capture the transfer process from a solid substrate to a porous surface, varying parameters such as wettability, pore size, droplet volume, and working fluid. The transfer process is divided into wetting and wicking regimes, with wicking being significantly longer than wetting. The wetting regime has two sub-regimes, donor-independent and donor-dependent, while the wicking regime follows Darcy's law to complete the transfer.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Pharmacology & Pharmacy
Suye Li, Hengqian Wu, Yanna Zhao, Ruiyan Zhang, Zhengping Wang, Jun Han
Summary: The study focused on the influence of water on the polymorphic conversion of fexofenadine hydrochloride (FXD) and its impact on the quality and performance of the drug. It was found that water facilitated the rapid transformation of FXD into Form II, with the addition of excipients delaying this conversion. The relationship between water content and phase transformation was investigated, with implications for scale-up during wet granulation processes.
Article
Pharmacology & Pharmacy
LiangFeng Wang, LiJie Zhao, YanLong Hong, Lan Shen, Xiao Lin
Summary: This study examines the effect of diluent types and granulation liquids on granule properties and tablet quality for high shear wet granulation and tableting (HSWG-T) and studies the attribute transmission in the process. The impact of diluents is more dominant than that of granulation liquids. The study provides some guides for achieving high-quality tablets via HSWG-T.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Vladimir Borman, Anton Belogorlov, Vladimir Tronin
Summary: The study focuses on the non-wetting liquid transport in nanoporous medium, examining the interacting modes of spontaneous filling and rapid compression filling to propose a mechanism of liquid transport. The research reveals a new dynamic filling threshold and explains the slow mode of impact compression in the filling of porous medium. The theoretical model based on kinetic equations accurately describes the experimental data, highlighting the positive feedback in suspension response to impact.
Article
Chemistry, Physical
Carina Waldner, Alfons Ritzer, Ulrich Hirn
Summary: Spreading and absorption of liquid drops on porous substrates have a significant impact on the printed dot area in inkjet printing. This study evaluates the printed dot area for 140 paper-liquid pairings and finds that the wettability of the liquid-substrate pairing and penetration speed are the main factors affecting the dot area.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Physical
Hironori Nakajima, Shintaro Iwasaki, Tatsumi Kitahara
Summary: Microporous layers (MPLs) are applied in the catalyst layer (CL) of gas diffusion layers (GDLs) in polymer electrolyte fuel cells to reduce liquid water accumulation and facilitate oxygen transport. A pore network model (PNM) is used to simulate the three-dimensional porous structure of a hydrophobic MPL and evaluate air permeability and oxygen diffusivity. The model is validated through experimental tests and can be used to design optimal pore size distributions for practical cells.
JOURNAL OF POWER SOURCES
(2023)
Article
Engineering, Chemical
P. L. Xiao, S. Mansouri, V. Suriya Hena, Y. K. Bong, K. Hapgood, M. W. Woo
Article
Engineering, Chemical
Amanda Lum, Nicholas Cardamone, Ron Beliavski, Shahnaz Mansouri, Karen Hapgood, Meng Wai Woo
JOURNAL OF FOOD ENGINEERING
(2019)
Article
Engineering, Chemical
George A. Mutch, Karen P. Hapgood, Rui Shen, Cordelia Selomulya
Article
Engineering, Chemical
Amanda Lum, Nicholas Cardamone, Ron Beliavski, Shahnaz Mansouri, Karen Hapgood, Meng Wai Woo
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2019)
Article
Engineering, Chemical
Narendra Akiti, Yuen Sin Cheong, Karen P. Hapgood, Devang Khakhar
ADVANCED POWDER TECHNOLOGY
(2020)
Article
Engineering, Chemical
Jun Zhang, Negin Amini, David A. Morton, Karen P. Hapgood
ADVANCED POWDER TECHNOLOGY
(2020)
Article
Engineering, Chemical
Ruihuan Ge, Mojtaba Ghadiri, Tina Bonakdar, Qijun Zheng, Zongyan Zhou, Ian Larson, Karen Hapgood
CHEMICAL ENGINEERING SCIENCE
(2020)
Article
Engineering, Chemical
Jun Zhang, Negin Amini, David A. V. Morton, Karen P. Hapgood
Summary: The study investigates the printing of powder granules using binder jetting technique, exploring the influence of different parameters on granule strength and surface roughness through structural property characterization. By establishing the relationship between print settings, structure, and strength, it demonstrates the potential for AM powder granules with controlled strengths to serve as ideal calibration particles for various industrial applications.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Engineering, Chemical
Jun Zhang, Negin Amini, David A. Morton, Karen P. Hapgood
Summary: 3D printing has been widely applied in various research fields, driving innovations in particle technology. This review outlines established 3D printing processes, advantages, limitations, and introduces different particulate systems as printing feedstock materials. It aims to provide valuable information for individuals, researchers, and companies in the AM industry.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shishir Shekhar, Negin Amini, David A. Morton, Karen P. Hapgood, Alexander Russell
Summary: Simulation using DEM enhances understanding of single-particle interactions in pharmaceutical unit operations, aiding in mitigating challenges during formulation and process development with minimal use of active drug material. This study highlights the potential of DEM for a rapid preliminary assessment of mechanistic attributes in tablet and capsule drug products based on MUPS.
Article
Engineering, Chemical
Jun Zhang, Josh Tuohey, Negin Amini, David A. Morton, Karen P. Hapgood
Summary: This study used artificial models to represent porous particle beds and found that the porous structure has a more significant effect on liquid capillary rise than material surface wettability. The experimental results also pave the way for a new production method for reproducible models of irregular powder beds.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Engineering, Chemical
Rechana Remadevi, David A. Morton, Karen Hapgood, Nigar Rashida, Rangam Rajkhowa
Summary: In this study, a novel approach to engineer silk into composite micro-sized particles was described. The combination of wet milling and homogenization followed by co-spray drying with L-leucine was used. The results showed that the co-spray dried silk powders had modified bulk properties and the level of L-leucine addition affected their behavior. Furthermore, the co-spray drying process reduced the cohesiveness and improved the stability and flowability of the silk powders.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Engineering, Chemical
Negin Amini, Josh Tuohey, John M. Long, Jun Zhang, David A. Morton, Karen E. Daniels, Farnaz Fazelpour, Karen P. Hapgood
Summary: The study presents a method combining X-ray computed tomography, 3D printing, and traditional photoelastic analysis for visualizing strain in complex particles. Different types of particles were analyzed, ranging from simple discs to 3D-printed coffee beans with internal voids. The relative orientation of print layers and loading force can influence the optical response of the particles without affecting their mechanical properties. Furthermore, a semi-quantitative measurement method for generated stresses within 3D-printed complex particles is introduced.
Article
Engineering, Chemical
A. Antic, J. Zhang, N. Amini, D. A. V. Morton, K. P. Hapgood
Summary: Binder jetting is an additive manufacturing technique that is used in various industries, including pharmaceuticals, and has the potential to create new products. However, there are limitations and challenges in terms of powder technology expertise and 3D printing processes that need to be addressed in order to optimize the use of this technique.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Engineering, Chemical
M. G. Lee, Jajaei P. Mansouri, S. Mansouri, K. Hapgood, M. W. Woo
Article
Engineering, Chemical
Ri Zhang, Shasha Zhang, Mengyan Ding
Summary: A thin liquid film method is proposed to evaluate sand erosion in annular flow. This method considers the direct interaction between the liquid film and gas core, as well as the entrainment and deposition of droplets. The erosion rate is calculated by considering the effects of liquid entrainment and particle velocity decay. The method is fully verified by comparing with experimental data.
Article
Engineering, Chemical
Yu Suo, Xianheng Su, Wenyuan He, Xiaofei Fu, Zhejun Pan
Summary: This research investigates the mechanical properties of sandstone-shale composite through orthogonal experimental method and discrete element simulation. The results show that different lithologies and thickness ratios can affect the strength and fracture mode of the composite rock samples.
Article
Engineering, Chemical
Maurizio Troiano, Andrea El Hassanin, Roberto Solimene, Alessia Teresa Silvestri, Fabrizio Scala, Antonino Squillace, Piero Salatino
Summary: This study investigates the potential of Fluidized Bed Finishing (FBF) for square flat AlSi10Mg specimens manufactured via Laser-Powder Bed Fusion (L-PBF) additive manufacturing technology. The results show that good finishing can be achieved using rotation-assisted tests, with a maximum reduction of surface roughness by 67%. Steel particles are found to be the most effective bed material.
Review
Engineering, Chemical
Ningbo Song, Wanzhong Yin, Jin Yao
Summary: Seawater's dissolved salts and minerals have various effects on the flotation process, including influencing the characteristics and behavior of flotation factors, as well as affecting the surface of sulfide minerals. In most cases, seawater has adverse effects on the flotation of sulfide minerals, but these effects can be mitigated by adjusting the reagents.
Article
Engineering, Chemical
Kaiqiao Wu, Shuxian Jiang, Victor Francia, Marc-Olivier Coppens
Summary: In rectangular and cylindrical annular fluidized beds, pulsating gas flow can create regular bubble patterns, overcoming challenges seen in conventional units. This study provides new opportunities for modularization of fluidized bed operations.
Article
Engineering, Chemical
Shuo Li, Huili Zhang, Jan Baeyens, Miao Yang, Zehao Li, Yimin Deng
Summary: The paper assesses the behavior of cohesive Geldart C-type particles when fluidized by air with the aid of vibration. It determines that mechanical vibration is a simple and effective method to improve the fluidity of cohesive particles during fluidization.
Article
Engineering, Chemical
Zhenfei Feng, Qingyuan Zhang, Shanpan Liang, Zhenzhou Li, Fangwen Guo, Jinxin Zhang, Ding Yuan
Summary: A new micro/mini-channel heat sink (MCHS) with a combined structure of longitudinal and transverse vortex generators is designed, using Al2O3 nanofluid as the working medium. The study explores the effects of transverse vortex generator shape and longitudinal vortex generator angle on the hydraulic and thermal characteristics, comprehensive performance, entropy generation, and exergy efficiency. The results show that the triangular transverse vortex generator improves the comprehensive performance and exergy efficiency. Combined with the longitudinal vortex generator, the MCHS achieves the best comprehensive performance, entropy generation, and exergy efficiency when the Reynolds number is 742.
Article
Engineering, Chemical
Kostas Giannis, Christoph Thon, Guoqing Yang, Arno Kwade, Carsten Schilde
Summary: This study presents a 3D convolutional neural network (3D-CNN) methodology for generating realistic 3D models of particles. The method trains on 2D projections of particle images to predict their 3D shapes, and evaluates the accuracy of the predictions using Fourier shape descriptors (FSDs). This methodology has wide applications in particle shape analysis.
Article
Engineering, Chemical
Zheng-qing Zhou, Lu-jia Chai, Yu-long Zhang, Ya-bin Wang, Ze-chen Du, Tian-yi Wang, Yu-zhe Liu
Summary: The dynamic oxidation and shell-breaking processes of aluminum nanoparticles (ANPs) during heating were studied using in situ transmission electron microscopy. The results revealed that the changes in shell thickness can be divided into three stages, and the active aluminum content of ANP decreased before shell-breaking.
Article
Engineering, Chemical
Fulei Chen, Huaqing Ma, Zihan Liu, Lianyong Zhou, Yongzhi Zhao
Summary: A particle breakage model based on the particle replacement scheme, using the polyhedral model to describe particles, is proposed in this work to accurately describe the breakage of a large number of particles. Additionally, a fast-cutting algorithm is proposed to reproduce the size distribution of progeny particles determined by the breakage model. The validation and simulation results show satisfactory accuracy, efficiency, and stability of the algorithm.
Review
Engineering, Chemical
Matteo Errigo, Christopher Windows-Yule, Massimiliano Materazzi, Dominik Werner, Paola Lettieri
Summary: Gas-solid fluidized-bed systems have advantages in terms of chemical reaction efficiency and temperature control, making them widely used in industrial applications. However, the design, scale-up, and optimization of these complex units are limited by the lack of deep physical understanding. Non-invasive and non-intrusive diagnostic techniques provide a way for researchers to study these systems without affecting the flow field or directly contacting the medium under study.
Article
Engineering, Chemical
Saeed Fateh, Mohammad Behshad Shafii, Mohammad Najafi, Cyrus Aghanajafi
Summary: Applying a magnetic field to ferrofluids alters their flow characteristics and enhances heat transfer. Through visualization and quantitative investigation, it is found that the magnetic field influences the flow patterns and velocity profiles, improving fluid mixing and vorticity magnitude.
Article
Engineering, Chemical
Lei Gao, Bingbing Wei, Xiaochuan Hu, Zaifeng Yao, Yiwen Fang, Xuejian Gao
Summary: In this study, a numerical model of sand triaxial test was established using discrete element software PFC3D, and an indoor triaxial test was conducted to calibrate the numerical model. The influence of microscopic parameters on the macroscopic mechanical response of sand was analyzed. The results showed that the friction coefficient had the greatest impact on the peak strength and residual strength of the sand's stress-strain curve, and it was positively correlated. The normal tangential stiffness ratio was negatively correlated, while the porosity and boundary flexibility stiffness had minimal influence on it.
Article
Engineering, Chemical
Xuan Liu, Jie Gong, Kai Jiang, Xiaojuan Lai, Yu Tian, Kang Zhang
Summary: This study aimed to improve the performance of lignite coal water slurries (CWSs) by synthesizing a series of three-arm amphiphilic block copolymers. By controlling the relative molecular weight, hydrophilic/hydrophobic ratio, and ionic group content, the apparent viscosity of CWSs was significantly reduced and the static stability was improved. Thermogravimetric testing and XPS analysis were conducted to reveal the mechanism behind the improved performance.
Article
Engineering, Chemical
Lanka Dinushke Weerasiri, Daniel Fabijanic, Subrat Das
Summary: Fluidization at low pressure offers significant benefits for the fine chemical industry. This study investigates the behavior of bubbles and bed expansion under low pressure conditions. It is found that lower pressure leads to larger bubbles, increased bubble quantity, and higher aspect ratio. The predictability is affected by the inhomogeneous fluidization, but low pressure fluidization can generate similar bubble sizes with lower fluidizing mass compared to atmospheric pressure.