Journal
POULTRY SCIENCE
Volume 91, Issue 10, Pages 2517-2522Publisher
OXFORD UNIV PRESS
DOI: 10.3382/ps.2012-02334
Keywords
influenza virus; H9N2; Lactobacillus fermentum; CJL; chicken
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Funding
- Ministry of Health & Welfare, Republic of Korea [A103001]
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The aim of this study was to determine whether intranasal administration of Lactobacillus sp. could prevent horizontal transmission of H9N2 avian influenza virus (AIV) in specific-pathogen-free chickens. Three-week-old chickens received 500 mu L of 1.5 x 10(9) cfu of Lactobacillus fermentum CJL-112 strain (CM) intranasally for 7 d before and 14 d after a challenge. Challenged chickens, each inoculated with H9N2 AIV, were kept in either direct or indirect contact with naive chickens, and morbidity and viral shedding were monitored. We demonstrated that the intranasal administration of CJL significantly decreased the number of chickens with viral shedding from the gastrointestinal tract in the indirect contact chickens (P < 0.001) and also significantly reduced viral shedding from the respiratory tract in the challenged (P < 0.05) and the direct contact chickens (P < 0.001) than those in the control group. Hence, the use of this lactobacilli strain may constitute a novel and effectively plausible alternative to prevent and control H9N2 AIV infection in chickens.
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