Article
Biochemistry & Molecular Biology
Tianjiao Li, Wei Guo, Zhanxiang Zhou
Summary: Understanding the regulation of ATGL in the liver is crucial for understanding lipid and glucose homeostasis and developing targeted therapies for hepatic metabolic disorders.
Article
Oncology
Julie Cremer, Laura Brohee, Laura Dupont, Camille Lefevre, Raphael Peiffer, Alicia M. Saarinen, Olivier Peulen, Laure Bindels, Jun Liu, Alain Colige, Christophe F. Deroanne
Summary: Bidirectional interactions between cancer cells and adipocytes in the microenvironment play a critical role in tumor progression. Acidification of the extracellular medium induced by cancer cells promotes preadipocyte lipolysis, which affects the phenotype of cancer cells and their response to chemotherapy. G0S2 is identified as the main regulator of cancer-induced lipolysis, and its adipocyte-specific overexpression inhibits mammary tumor growth and lung metastasis.
Article
Endocrinology & Metabolism
Jiesi Xu, Zhenglong Liu, Jianxin Zhang, Siyu Chen, Wei Wang, Xuefan Zhao, Mei Zhen, Xun Huang
Summary: Cellular lipid storage is regulated by the balance of lipogenesis and lipolysis. In this study, we showed that the protein stability of ATGL is regulated by the N-end rule in cultured cells and in mice. Our findings reveal the N-end rule-mediated proteasomal regulation of ATGL, which may have potential implications for the treatment of obesity.
Article
Nutrition & Dietetics
Zhizheng Fang, Lu Wei, Yanping Lv, Tongsheng Wang, Hamizah Shahirah Hamezah, Rongchun Han, Xiaohui Tong
Summary: This study investigates the impact of Phillyrin on obesity-related metabolic dysfunctions. It was found that Phillyrin reduces circulating level of glycerol, hepatic steatosis, and improves insulin sensitivity in obese mice. Phillyrin also attenuates obesity-related inflammation and IL-6 production in adipose tissue. Furthermore, Phillyrin inhibits IL-6-initiated basal lipolysis and expression of adipose triglyceride lipase (ATGL) in adipose tissue. These findings suggest that Phillyrin can be a potential candidate in the treatment of obesity-associated complications.
FRONTIERS IN NUTRITION
(2022)
Editorial Material
Endocrinology & Metabolism
Melissa A. Linden, Susan J. Burke, Humza A. Pirzadah, Tai-Yu Huang, Heidi M. Batdorf, Walid K. Mohammed, Katarina A. Jones, Sujoy Ghosh, Shawn R. Campagna, J. Jason Collier, Robert C. Noland
Summary: Glucocorticoid therapy can cause iatrogenic diabetes, and activating lipolysis plays a crucial role in its development. Inhibiting lipolysis can reduce glucocorticoid-induced obesity and hyperglycemia. The role of lipolysis differs between skeletal muscle and liver.
MOLECULAR METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yusuke Nakatsu, Takeshi Yamamotoya, Mizuki Okumura, Tetsuhiro Ishii, Mayu Kanamoto, Miki Naito, Mikako Nakanishi, Shunya Aoyama, Yasuka Matsunaga, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Hiraku Ono, Tomoichiro Asano
Summary: Deleting the Pin1 gene in epiWAT promotes lipolysis and increases ATGL protein expression. Pin1 directly associates with ATGL, enhancing its degradation through the ubiquitin proteasome system. AdipoPin1 KO mice under a high fat diet exhibit higher lipolytic activity and improved glucose metabolism.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Agriculture, Dairy & Animal Science
Jun Li, Yaling Wang, Pengkun Yang, Haoyuan Han, Guizhi Zhang, Huifen Xu, Kai Quan
Summary: Overexpression of ATGL in goat mammary epithelial cells (GMECs) can decrease lipid droplet accumulation and cellular TG content by accelerating lipolysis, thus affecting lipid metabolism.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Miriam Livier Llamas-Garcia, Edgar D. Paez-Perez, Claudia G. Benitez-Cardoza, Gabriela M. Montero-Moran, Samuel Lara-Gonzalez
Summary: CGI-58 interacts with PLIN1 to regulate lipolysis, and the phosphorylation controls the release of CGI-58. Mutants 3WA and 3WA/S237E affect the stability and binding ability of CGI-58, with the latter showing improved solubility and proper folding.
Article
Biochemistry & Molecular Biology
L. Riegler-Berket, L. Wechselberger, I. K. Cerk, K. M. Padmanabha Das, R. Viertlmayr, N. Kulminskaya, C. F. Rodriguez Gamez, M. Schweiger, R. Zechner, R. Zimmermann, M. Oberer
Summary: The protein encoded by the G0/G1 switch gene 2 (G0S2) is an important regulator of intracellular lipolysis as it inhibits adipose triglyceride lipase (ATGL). Through mutagenesis and truncation studies, the minimal sequence required for ATGL inhibition was determined to range from amino acids 20 to 44, with specific residues within this sequence playing a substantial role in inhibition. Additionally, it was found that unspecific interactions of the N-terminal part further facilitate the interaction between G0S2 and ATGL.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Pharmacology & Pharmacy
Zhang-Hong Ke, Ai-Li Yu, Xue-Fen Cai, Yan Sun, Hui-Ling Xu, Meng Chen, Chen-Xi Chen, Bei-Hong Zheng
Summary: Using a rat model, this study found that neonatal exposure to BPA can lead to abnormal lipid metabolism in adulthood. The increased lipolysis in visceral adipose tissue may be one of the underlying mechanisms.
Article
Multidisciplinary Sciences
Rucha Patel, Anna Santoro, Peter Hofer, Dan Tan, Monika Oberer, Andrew T. Nelson, Srihari Konduri, Dionicio Siegel, Rudolf Zechner, Alan Saghatelian, Barbara B. Kahn
Summary: In this study, the researchers identified adipose triglyceride lipase (ATGL) as the first biosynthetic enzyme for the formation of the FAHFA ester bond in mammals. They found that ATGL uses transacylase activity to esterify hydroxy fatty acids (HFAs) with fatty acids (FAs) from triglycerides (TGs) or diglycerides (DGs) to produce FAHFAs. The expression of ATGL and the activity of DGAT were found to be closely associated with FAHFA biosynthesis.
Article
Immunology
Kang Liu, Songsong Liu, Chou Wu, Yuwei Wang, Yurou Zhang, Jingsu Yu, Siqi Liu, Xiangling Li, Xinyu Qi, Songtao Su, Xinyi Qi, Lei Zhou, Yixing Li
Summary: Hepatic fat metabolism is disrupted in overnutrition and obesity, resulting in the development of NAFLD. Plant alkaloids, including rhynchophylline (RHY), show potential for NAFLD prevention and treatment. RHY was found to reduce triglyceride accumulation, increase energy metabolism, and alleviate oxidative stress in cell models of high-fat diet (HFD). In mice fed an HFD, RHY improved liver steatosis, reduced fat deposition, promoted energy metabolism, and improved glucose metabolism. Mechanistically, RHY interacted with lipases and increased lipase activity and lipolysis. Overall, RHY ameliorated HFD-induced NAFLD and its complications by enhancing lipase activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Fisheries
Xiufei Cao, Wei Fang, Jiamin Li, Wencong Lai, Kangsen Mai, Qinghui Ai
Summary: This study reveals the involvement of antisense lncRNA LTCONS_00091578 and atgl in hepatic lipolysis in rainbow trout. The function of lncRNA in fish lipid metabolism needs further investigation.
Article
Biochemistry & Molecular Biology
Huijuan Zhou, Jie Zhang, ZhongKang Yan, Min Qu, Gaojian Zhang, Jianxiong Han, Feifei Wang, Kai Sun, Lili Wang, Xingyuan Yang
Summary: DECR1 promotes cancer cell growth by enhancing lipolysis and releasing energy stores to support cell proliferation and migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Review
Biochemistry & Molecular Biology
Marek Wilhelm, Lenka Rossmeislova, Michaela Siklova
Summary: This article reviews the characteristics of lipogenic and lipolytic enzymes and the methods available for measuring their activity. It evaluates the applicability of these methods to different biological samples and discusses the advantages and disadvantages of these methods in vivo, ex vivo, and in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Jesper Tessin, Judith Rohde, Arne Jung, Nicole Kemper, Jochen Schulz
Summary: In this study, samples from poultry house environment and culled birds were collected, and E. cecorum was successfully isolated. The principle of isolating the pathogen by streaking on a chromogenic agar may motivate researchers to investigate transmission routes and optimize biosecurity measures.
Article
Agriculture, Dairy & Animal Science
Junqin Zhang, Zimin Xie, Yanlin Pan, Zuoxin Chen, Yunzhen Huang, Linlin Li, Jiawen Dong, Yong Xiang, Qi Zhai, Minhua Sun, Xingying Li, Shujian Huang, Ming Liao
Summary: In recent years, there has been an increase in the occurrence of fowl adenovirus 2 (FAdV-2) in China, posing a significant threat to the poultry industry. This study investigated the epidemiology, phylogenetic relationship, genomic characteristics, and pathogenicity of FAdV-2. The results showed that FAdV-2 was the most commonly detected serotype among various FAdV serotypes. Genetic analysis revealed that these FAdV-2 strains formed a distinct branch within the FAdV-D group and had a high nucleotide similarity with reference strains. Recombination analysis identified recombination events between FAdV-2 and FAdV-11 in some strains. Pathogenicity experiments demonstrated that a recombinant FAdV-2 strain caused a high mortality rate and more severe disease in chickens. These findings contribute to our understanding of FAdV-2 and provide a basis for vaccine development.
Article
Agriculture, Dairy & Animal Science
Ebtsam Iraqi, Ali Abdel Hady, Nadia Elsayed, Hanaa Khalil, Amina El-Saadany, Karim El-Sabrout
Summary: Thermal manipulation during egg incubation, particularly at 12 to 18 days, has positive effects on embryonic development, hatching characteristics, chick quality, as well as posthatch thermotolerance and performance.
Article
Agriculture, Dairy & Animal Science
Yong Liu, Mingxin Song, He Bai, Chunhua Wang, Fei Wang, Qi Yuan
Summary: Dietary curcumin supplementation can significantly improve egg quality of quails in the late laying period, primarily by improving lipid metabolism and selectively regulating the intestinal microbial community.
Article
Agriculture, Dairy & Animal Science
Lei Zhang, Zhixuan Song, Peiyao Li, Xingju Song, Xinming Tang, Dandan Hu
Summary: This study evaluated the vaccine potential of recombinant proteins for avian coccidiosis caused by Eimeria. The results showed that the rEten5-B protein can trigger immune protection against E. tenella and may be a potential and effective subunit vaccine for the control of coccidiosis in poultry.
Article
Agriculture, Dairy & Animal Science
Milan Kumar Sharma, Amit Kumar Singh, Doyun Goo, Venkata Sesha Reddy Choppa, Hanseo Ko, Hanyi Shi, Woo Kyun Kim
Summary: The study investigates the effect of Eimeria infection on gastrointestinal physiology, growth performance, and egg production of Hy-Line W-36 laying hens during peak production. Results show that Eimeria infection negatively affects body weight, feed intake, immune response, and nutrient transporter gene expression. Egg production temporarily ceases in hens infected with high and medium-high dosages of Eimeria.
Article
Agriculture, Dairy & Animal Science
Elwy A. Ashour, Mahmoud Kamal, Hayman A. A. Altaie, Ayman A. Swelum, Gamaleldin M. Suliman, Guillermo Tellez-Isaias, Mohamed E. Abd El-Hack
Summary: This study evaluated the effects of CP and ME on the performance and nutritional value of Japanese quail lay chicken. The results showed that protein and energy levels significantly influenced all productive outcomes except feed conversion ratio. The combination of dietary energy and protein levels had a substantial effect on all egg quality trials evaluated. It is recommended to feed layer Japanese quail between the ages of 8 and 20 weeks during the summer with a dietary energy content of 2,900 kcal ME/kg and 20% CP.
Article
Agriculture, Dairy & Animal Science
J. E. Doornweerd, R. F. Veerkamp, B. de Klerk, M. van der Sluis, A. C. Bouwman, E. D. Ellen, G. Kootstra
Summary: Tracking group-housed individual broilers using video can provide valuable information on their health, welfare, and performance. This study conducted a comprehensive analysis on broiler tracking on video and potential tracking errors, highlighting the potential and challenges of phenotyping broiler locomotion. The results emphasized the importance of addressing tracking errors, potential algorithm improvements, and the need for an external animal identification system for efficient locomotion phenotyping.
Article
Agriculture, Dairy & Animal Science
Jiayu Wu, Yanan Wang, Yu An, Changyu Tian, Lingfeng Wang, Zuhong Liu, Desheng Qi
Summary: This study compared the gene expression differences in liver tissues of laying hens at different ages using RNA sequencing, and found that the transport and metabolism of amino acids changed during the growing period, which influenced the growth and development of the hens.
Article
Agriculture, Dairy & Animal Science
J. Raabe, G. Raveendran, W. Otten, K. Homeyer, T. Bartels
Summary: This study investigated the effects of different flicker frequencies on the behavior, performance, and stress response in male turkeys. The results showed that flicker frequencies of 165 Hz or higher had no detrimental effect on growth performance, injurious pecking, or endocrine stress response in the turkeys.
Article
Agriculture, Dairy & Animal Science
Adamu Mani Isa, Yanyan Sun, Yuanmei Wang, Yunlei Li, Jingwei Yuan, Aixin Ni, Hui Ma, Lei Shi, Hailai Hagos Tesfay, Yunhe Zong, Panlin Wang, Pingzhuang Ge, Jilan Chen
Summary: This study sequenced mRNAs and lncRNAs in the ovary stroma of specific chicken breeds and their reciprocal crossbreds to understand the molecular mechanism of heterosis for egg production. Results showed that genes with nonadditive expression were related to follicle growth and atresia as well as oxidative stress in the crossbred hens.
Article
Agriculture, Dairy & Animal Science
Zhepeng Wang, Qiu Chen, Yiwei Wang, Yulu Wang, Ruifang Liu
Summary: The study investigates the functional variants associated with chicken eggshell color in the SLCO1B3 gene by measuring the eggshell color of Lueyang black-boned chickens and analyzing the genetic data. It identifies 15 variants in SLCO1B3 that are significantly associated with eggshell color. However, the functional analysis shows that one specific variant, 1B3_SNP108, does not have a significant effect on promoter activity. This study highlights the importance of SLCO1B3 and its variants in breeding eggshell color.
Article
Agriculture, Dairy & Animal Science
P. Yin, Q. Tong, B. M. Li, W. C. Zheng, Y. Wang, H. Q. Peng, X. L. Xue, S. Q. Wei
Summary: This study investigated the welfare and health of laying hens in a multitier system. The results showed that the spatial distribution of hens changed with increasing age, and lower-ranking hens preferred to stay in lower tiers to avoid competition but still had access to resources. This improved the welfare and health of the hens near the end of the laying cycle.
Article
Agriculture, Dairy & Animal Science
Wenwen Liang, Siqiong Jie, Yiqin Wang, Xiaowei Wen, Yanling Xiong, Xiaoxi Lin, Zhengrong Lv
Summary: This study examined the effect of risk perceptions on preventive behavior among vendors in the live poultry wholesale market and the live poultry retail market in Guangdong Province using the health belief model and structural equation modeling. The results showed that perceived severity and perceived benefits positively influenced vendors' self-efficacy in the wholesale market, while perceived barriers negatively affected self-efficacy in both the wholesale and retail markets. Moreover, cues to action mediated the relationship between perceived severity, perceived benefits, and self-efficacy, and also mediated the effect of perceived susceptibility among wholesale market vendors.
Article
Agriculture, Dairy & Animal Science
Shreeya Sharma, Raveendra R. Kulkarni, Shayan Sharif, Hosni Hassan, Mohammadali Alizadeh, Scott Pratt, Khaled Abdelaziz
Summary: The study investigates the impact of exposing chick embryos to antigens via in ovo delivery of poultry-specific lactobacilli on the expression of genes associated with early bursal development and maturation. Results indicate that the supplementation of poultry-specific lactobacilli to chick embryos can accelerate the development and immunological maturation of the bursa of Fabricius.