Article
Oncology
Ke Gao, Xiaoshun Li, Jianxin Ni, Bin Wu, Jiaheng Guo, Rui Zhang, Guojun Wu
Summary: This article introduces the roles of dysregulation of different subclasses of non-coding RNAs (ncRNAs) in the development of castration-resistant prostate cancer (CRPC) progression and Enzalutamide (Enz) resistance. The mechanisms of Enz resistance, including AR-splice variant-7 (AR-V7), mutations, circRNAs, and lncRNAs that act as miRNA sponges, are discussed. The contributions of epithelial-mesenchymal transition and glucose metabolism to Enz resistance are also highlighted. The article summarizes the different mechanisms of miRNAs, lncRNAs, and circRNAs in the progression of CRPC and Enz resistance, and discusses future therapeutic strategies against Enz resistance.
Article
Pharmacology & Pharmacy
Sisi Qin, Huanyao Gao, Wootae Kim, Huan Zhang, Yayun Gu, Krishna R. Kalari, Jason P. Sinnwell, Jodi A. Scholz, Fang Xie, Ping Yin, Jia Yu, Bo Qin, Yongxian Zhuang, Lixuan Wei, Winston Tan, Alan H. Bryce, Richard M. Weinshilboum, Liewei Wang
Summary: This study identified three drugs that could potentially be alternative treatments for abiraterone nonresponders in patients with metastatic castration-resistant prostate cancer. Additionally, eleven genes targeted by these drugs were associated with worse outcomes in both PROMOTE and Stand Up To Cancer cohorts. Further clinical investigation is needed to determine the efficacy of these alternative therapies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Yuanyuan Wang, Jiyuan Chen, Zhengjie Wu, Weihong Ding, Shen Gao, Yuan Gao, Chuanliang Xu
Summary: This review examines the emerging information on resistance mechanisms to enzalutamide in castration-resistant prostate cancer, including various signaling pathways and metabolic effects, and suggests potential therapeutic strategies for overcoming enzalutamide resistance.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eunjeong Seo, Byula Jee, Jae Hoon Chung, Wan Song, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Minyong Kang
Summary: In this study, the researchers discovered that the AR-V7/YAP1/TAZ axis represses the expression of SLC22A3, leading to resistance to enzalutamide (ENZ) in metastatic castration-resistant prostate cancer (mCRPC). This finding provides new insights into potential treatment targets for prostate cancer.
Article
Medical Laboratory Technology
Maibritt Norgaard, Marianne T. Bjerre, Jacob Fredsoe, Soren Vang, Jorgen B. Jensen, Bram De Laere, Henrik Groenberg, Michael Borre, Johan Lindberg, Karina D. Sorensen
Summary: The clinical utility of low-pass whole-genome sequencing (LPWGS) of circulating tumor DNA (ctDNA) for prognostication in metastatic castration-resistant prostate cancer (mCRPC) was examined. The study found that high ctDNA% and high copy number alteration (CNA) burden at baseline were associated with poor treatment response, progression-free survival (PFS), and overall survival (OS). These findings were confirmed in an independent cohort.
CLINICAL CHEMISTRY
(2023)
Article
Cell Biology
Mithila Sawant, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Jingqin Luo, Vandna Kukshal, Joseph M. Jez, Myung Sik Jeon, Bo Zhang, Tiandao Li, Bin Fang, Yunting Luo, Nicholas J. Lawrence, Harshani R. Lawrence, Felix Y. Feng, Nupam P. Mahajan
Summary: Resistance to enzalutamide in castration-resistant prostate cancer (CRPC) is a common issue without effective therapeutic options. This study reveals that acetylation at Lys(609) in the DNA binding domain of androgen receptor (AR) allows AR translocation and confers enzalutamide insensitivity. The acetylation is mediated by ACK1 kinase-mediated AR Y267 phosphorylation, which leads to positive feedback loops at both transcriptional and posttranslational levels. Inhibiting ACK1 kinase with a small-molecule inhibitor compromises enzalutamide-resistant CRPC xenograft tumor growth.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mamta Parikh, Chengfei Liu, Chun-Yi Wu, Christopher P. Evans, Marc Dall'Era, Daniel Robles, Primo N. Lara, Neeraj Agarwal, Allen C. Gao, Chong-Xian Pan
Summary: The study aimed to evaluate the efficacy and tolerability of a novel reformulated orally-bioavailable niclosamide in combination with abiraterone and prednisone for castration-resistant prostate cancer. The results showed that this combination therapy demonstrated good tolerability and treatment response in patients, warranting further research.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jing Wei, Lijuan Yin, Jingjing Li, Jing Wang, Tianjie Pu, Peng Duan, Tzu-Ping Lin, Allen C. Gao, Boyang Jason Wu
Summary: The study reveals a reciprocal regulatory circuit between MAOA and AR in prostate cancer, with implications for cancer development and growth, particularly CRPC. Targeting MAOA may enhance the efficacy of AR-targeted therapies.
Article
Pharmacology & Pharmacy
Yi-Ting Lin, Yen-Chun Huang, Chih-Kuan Liu, Tian-Shyug Lee, Mingchih Chen, Yu-Ning Chien
Summary: Secondary hormone therapy with abiraterone and enzalutamide has significantly improved outcomes for mCRPC patients. Enzalutamide was found to be superior to abiraterone in terms of overall survival, and there was no statistically significant difference in the development of new comorbidities between the two groups. The Charlson comorbidity index score, rather than individual items, was a statistically significant predictor for overall survival.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Marc Wiesehoefer, Benedikt Bernhard Gereon Raczinski, Caroline Wiesehoefer, Jaroslaw Thomas Dankert, Elena Dilara Czyrnik, Martin Spahn, Marianna Kruithof-de Julio, Gunther Wennemuth
Summary: This study reveals an increased expression of epiregulin in prostate cancer cells and tissues, which correlates with tumor recurrence, metastasis, and increased grading. The regulation of epiregulin involves different mechanisms and it could be a potential diagnostic tool and therapeutic target for patients with castration-resistant prostate cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Zeyuan Zheng, Jinxin Li, Yankuo Liu, Zhiyuan Shi, Zuodong Xuan, Kunao Yang, Chunlan Xu, Yang Bai, Meiling Fu, Qiaohong Xiao, Huimin Sun, Chen Shao
Summary: This review summarizes the mechanisms and biological behaviors of AR-V7 in enzalutamide resistance of castration-resistant prostate cancer (CRPC), providing novel insights for CRPC therapy.
Article
Oncology
Felix Y. Feng, Shibu Thomas, Fred Saad, Michael Gormley, Margaret K. Yu, Deborah S. Ricci, Brendan Rooney, Sabine Brookman-May, Sharon McCarthy, David Olmos, Simon Chowdhury, Boris Hadaschik, Yang Liu, Elai Davicioni, Matthew R. Smith, Eric J. Small
Summary: The GC score and basal-luminal subtype derived from archived tumor specimens could be potential biomarkers for predicting response to apalutamide+ADT in nmCRPC patients. Although the addition of apalutamide to ADT was beneficial overall, higher-risk and luminal subtypes appeared to benefit most.
Article
Chemistry, Multidisciplinary
Jia-Luo Huang, Xue-Long Yan, Wei Li, Run-Zhu Fan, Shen Li, Jianghe Chen, Zhenhua Zhang, Jun Sang, Lu Gan, Gui-Hua Tang, Hongwu Chen, Junjian Wang, Sheng Yin
Summary: This study identified a highly potent importin-beta 1 inhibitor DD1, which selectively inhibited the growth and survival of CRPC cells and completely blocked tumor growth. Mechanistic studies showed that DD1 reduced the nuclear accumulation of key CRPC drivers, shutting down their downstream oncogenic signaling. These findings suggest that importin-beta 1 is an effective therapeutic target in CRPC and DD1 can be developed as a potential treatment for this disease.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Oncology
Yu-Ting Hsieh, Bing-Juin Chiang, Chia-Chang Wu, Chun-Hou Liao, Chia-Da Lin, Chung-Hsin Chen
Summary: The study in Taiwanese mCRPC patients receiving enzalutamide revealed that high tumor burden (HTB) was associated with reduced PSA response rate, radiological response rate, and progression-free survival duration. HTB patients had lower disease control rate compared to low tumor burden (LTB) patients after treatment with enzalutamide.
Article
Pharmacology & Pharmacy
Masaki Hirabatake, Hiroaki Ikesue, Yuna Iwama, Kei Irie, Shintaro Yoshino, Toshinari Yamasaki, Tohru Hashida, Mutsushi Kawakita, Nobuyuki Muroi
Summary: The study investigated the efficacy of a collaborative management program between pharmacists and urologists for CRPC patients receiving enzalutamide, and found that collaborative management was useful for prolonging the time to enzalutamide discontinuation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wijdan H. Ramadan, Wissam K. Kabbara, Rosa M. Abilmona
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2016)
Correction
Environmental Sciences
May A. Massoud, N. Makarem, Wijdan H. Ramadan, R. Nakkash
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2016)
Article
Respiratory System
Wijdan H. Ramadan, Aline T. Sarkis
CHRONIC RESPIRATORY DISEASE
(2017)
Article
Infectious Diseases
Wissam K. Kabbara, Mohamad M. Meski, Wijdan H. Ramadan, Dina S. Maaliki, Pascale Salameh
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2018)
Article
Medicine, General & Internal
Wissam K. Kabbara, Hani Dimassi, Marwan Sheikh-Taha
CURRENT MEDICAL RESEARCH AND OPINION
(2018)
Article
Infectious Diseases
Wissam K. Kabbara, Ghada El-Khoury, Nour R. Chamas
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
(2018)
Review
Respiratory System
Wijdan H. Ramadan, Sarah Al Masri, John Rizk
CLINICAL RESPIRATORY JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Wissam K. Kabbara, Shinn Azar-Atallah
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2019)
Article
Pharmacology & Pharmacy
Wijdan H. Ramadan, Aline Sarkis, Sandrine Sarine Aderian, Aline Milane
Article
Medicine, Research & Experimental
Rony M. Zeenny, Hanine Mansour, Wissam K. Kabbara, Nibal Chamoun, Myriam Audi, Yasmina Yared, Pascale Salameh
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2020)
Article
Education & Educational Research
Diana Maddah, Souheil Hallit, Wissam Kabbara, Marwan Akel, Keith Bowen, Zeinab Hasan, Tamar Kabakian Khasholian, Nael H. Alami, Pascale Salameh
Summary: Despite the lack of a valid Arabic measure of Life Skills (LS) among youth, this study successfully validated an Arabic Life Skills Scale (A-LSS) to evaluate the effectiveness of life skills interventions. The scale was found to have high reliability and validity among Lebanese university students, making it a useful tool for measuring the effectiveness of life skills health promotion interventions.
Article
Education & Educational Research
Stephanie Atallah, Hanine Mansour, Hani Dimassi, Wissam K. Kabbara
Summary: This study evaluated the impact of social media education on spreading antimicrobial stewardship awareness among healthcare students and residents. The results showed a significant improvement in knowledge about antimicrobial stewardship after the intervention.
BMC MEDICAL EDUCATION
(2023)
Article
Health Policy & Services
Ghada El Khoury, Wijdan Ramadan, Nadine Zeeni
JOURNAL OF COMMUNITY HEALTH
(2016)
Article
Endocrinology & Metabolism
Ghada El Khoury, Hanine Mansour, Wissam K. Kabbara, Nibal Chamoun, Nadim Atallah, Pascale Salameh
CURRENT DIABETES REVIEWS
(2019)