Article
Immunology
Pui-Ying Leong, Tsu-Man Chiu, James Cheng-Chung Wei, An-Ping Huo
Summary: This case report presents a rare occurrence of psoriasis combined with vitiligo in an Asian boy under the age of 6, and demonstrates that symptom improvement can be achieved with the use of methotrexate, indicating shared immune pathways between the two diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Jasna Grzelj, Irena Mlinaric-Rascan, Pij B. Marko, Maruska Marovt, Tanja Gmeiner, Alenka Smid
Summary: Genetic polymorphisms, especially in GNMTrs10948059, DNMT3b rs2424913, and BHMT rs3733890, are associated with efficacy and toxicity of low-dose methotrexate treatment for psoriasis. Further studies are needed to validate these pharmacogenetic markers.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Elizabeth Benites, Esmeralda Carrillo, Martha Heras
Summary: This study evaluated the effects of methotrexate and etanercept treatment in psoriasis and verified their response to the PASI index. The results showed that treatment with etanercept and methotrexate had favorable effects on moderate and severe psoriasis.
Article
Dermatology
Richard G. Langley, Yves Poulin, Bhaskar Srivastava, Kimberly Parnell Lafferty, Steven Fakharzadeh, Wayne Langholff, Matthias Augustin
Summary: Biologic therapy was found to be associated with reduced mortality risk in patients with moderate to severe psoriasis, regardless of treatment duration. Methotrexate only reduced mortality risk after at least 1 year of exposure.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Dermatology
L. Thomas, J. Azad, A. Takwale
Summary: Nail involvement is common in patients with psoriasis and can lead to pain, functional impairment, and social stigma, significantly impacting quality of life. Managing nail psoriasis is challenging and often overlooked by physicians, highlighting the need for simplified disease severity scores and effective treatments.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Dermatology
Zhijia Fan, Zhenghua Zhang, Qiong Huang, Ling Han, Xu Fang, Ke Yang, Siyuan Wu, Zhizhong Zheng, Nikhil Yawalkar, Zhicheng Wang, Kexiang Yan
Summary: The study found significant associations between ANxA6 gene SNPs and the severity of psoriasis, with the CC genotype of rs11960458 and GG genotype of rs960709 showing better responses to MTX therapy. This suggests that genetic variations in ANxA6 gene may serve as potential predictors for the clinical efficacy of MTX.
Article
Immunology
Bing Wang, Zhicheng Wang, Wenjing Yang, Ling Han, Qiong Huang, Nikhil Yawalkar, Zhenghua Zhang, Yu Yao, Kexiang Yan
Summary: This study found that patients with the GG genotype of B7-H4 rs1935780 had a poorer response to MTX, and low expression of B7-H4 protein in platelets correlated with better clinical outcomes of MTX in psoriasis.
Article
Biotechnology & Applied Microbiology
Tingjun Tao, Yan Chen, Bochen Lai, Jinhua Wang, Weiliang Wang, Weimian Xiao, Xushan Cha
Summary: This study aimed to investigate the inhibitory effects of shikonin combined with methotrexate on psoriasis progression by regulating macrophage polarization. The results showed that this combination treatment reduced erythema and PASI scores, decreased backer score and epidermal thickness, and regulated macrophage polarization, providing protective effects against psoriasis.
Review
Dermatology
Andrea Luengas-Martinez, Ralf Paus, Helen S. Young
Summary: Chronic plaque psoriasis is an inflammatory skin disease influenced by genetic predisposition and environmental factors. Current treatment strategies targeting the immune system may not satisfy all patients' needs. Vascular endothelial growth factor-A (VEGF-A) is upregulated in plaques and plasma of patients, suggesting that anti-angiogenesis therapies could be a potential treatment option for psoriasis.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cristina Membrive-Jimenez, Sayleth Vieira-Maroun, Noelia Marquez-Pete, Yasmin Cura, Cristina Perez-Ramirez, Jesus Tercedor-Sanchez, Alberto Jimenez-Morales, Maria del Carmen Ramirez-Tortosa
Summary: This study found that polymorphisms in ABCC1, ABCG2, and FOXP3 genes are associated with the development of MTX toxicity in PS patients. These polymorphisms may serve as biomarkers for predicting toxicity risk in MTX treatment.
Article
Dermatology
Mie S. Liljendahl, Nikolai Loft, Tri-Long Nguyen, Lone Skov, Alexander Egeberg
Summary: This study provides the first estimation of the proportion of patients with moderate-to-severe psoriasis in Denmark who are eligible for systemic therapy but do not receive it. The results showed that a large number of patients with moderate-to-severe psoriasis are candidates for systemic therapy but do not receive it. Furthermore, the study found that the time on conventional systemic therapy has become shorter and more patients are initiating biologics as second-line therapy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
A. B. Gottlieb, J. F. Merola, K. Reich, F. Behrens, P. Nash, C. E. M. Griffiths, W. Bao, P. Pellet, L. Pricop, I. B. McInnes
Summary: This study compared the efficacy of Secukinumab and adalimumab in patients with PsA and concomitant moderate-to-severe plaque psoriasis. The results showed that Secukinumab demonstrated consistently higher responses across skin endpoints compared to adalimumab.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Maria Tereza Carneiro Paschoal Bernardes, Sandra Barbosa Neder Agostini, Gislaine Ribeiro Pereira, Laila Pereira da Silva, Jessica Bassi da Silva, Marcos Luciano Bruschi, Romulo Dias Novaes, Flavia Chiva Carvalho
Summary: Psoriasis is a chronic skin disease characterized by increased cell growth and inflammation. A study evaluated two different vehicles for methotrexate (MTX) in psoriasis treatment and found that a hydrogel based on alkylated carbomer showed better drug delivery and bioadhesion, with greater effectiveness in reducing inflammation compared to liquid crystal systems.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biology
Sheikh Abdur Rashid, Sajid Bashir, Faiza Naseem, Arshad Farid, Irfan A. Rather, Khalid Rehman Hakeem
Summary: Psoriasis, a chronic inflammatory illness, is linked to other life-threatening diseases. Methotrexate nanoemulsion gel formulation showed effectiveness in treating psoriasis and reducing symptoms, potentially providing a new treatment option.
Article
Dermatology
Anne-Claire Fougerousse, Laure Mery-Bossard, Josiane Parier, Charles Taieb, Antoine Bertolotti, Francois Maccari
Summary: The survey revealed that there are significant variations in prescription patterns and practices when dermatologists in France treat moderate to severe psoriasis with methotrexate, with the majority of practitioners prescribing folic acid alongside the medication. Some physicians have already switched from oral to injectable methotrexate due to issues with tolerance, lack of efficacy, or compliance. The COVID-19 pandemic has also impacted prescription behaviors, with some dermatologists either not initiating or reducing their prescriptions as a result.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2021)
