Article
Health Care Sciences & Services
Floriana Mandracchia, Lucia Tarro, Elisabet Llaurado, Rosa M. Valls, Rosa Sola
Summary: This study described the development and evaluation of the Healthy Meals web app designed for professionals related to food. The app was found to have good usability and quality among professionals, and was effective for assessing the nutritional content and food allergens of dishes.
Article
Nutrition & Dietetics
Elizabeth Yakaboski, Lacey B. Robinson, Anna Arroyo, Janice A. Espinola, Ruth J. Geller, Ashley F. Sullivan, Susan A. Rudders, Carlos A. Camargo
Summary: This study suggests that early introduction of egg and peanut is associated with decreased risk of developing food allergy. It also indicates that early introduction of peanut was uncommon before 2015.
Review
Nutrition & Dietetics
Kristina A. Malsagova, Arthur T. Kopylov, Alexandra A. Sinitsyna, Alexander A. Stepanov, Alexander A. Izotov, Tatyana V. Butkova, Konstantin Chingin, Mikhail S. Klyuchnikov, Anna L. Kaysheva
Summary: An athlete's diet is influenced by various factors, and it is important to follow recommendations from physicians and nutritionists before training and competition. Studying nutritional strategies and trends used by athletes can help optimize training outcomes and minimize negative symptoms associated with food consumption. Future clinical trials may be conducted to identify specific foods beneficial for athletes.
Review
Food Science & Technology
Xiaowen Pi, Yili Yang, Yuxue Sun, Qiang Cui, Yin Wan, Guiming Fu, Hongbing Chen, Jianjun Cheng
Summary: The increasing prevalence of food allergies poses a significant challenge to global food health and safety. Fermentation has unique advantages in reducing allergenicity and may represent a new trend in preventing food-induced allergies. It is an efficient approach for reducing or eliminating food allergenicity, while improving the nutritional value and physicochemical properties of food materials. Combination of mixed strain fermentation with additional processing methods can efficiently reduce allergenicity of various foods and preserve their taste and nutritional components, which is significant for patients with allergies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Mario Bezerra, Miguel Ribeiro, Gilberto Igrejas
Summary: Tree nuts, including almonds, are important in healthy diets but can be a common source of severe food allergies. Almond allergies, part of the Big Eight food allergens, are persistent and life-threatening, necessitating further research for understanding and management.
Article
Nutrition & Dietetics
Jenny van Odijk, Adina Weisheit, Monica Arvidsson, Nicolae Miron, Bright Nwaru, Linda Ekerljung
Summary: This study aimed to describe the distribution of DAO in a large representative cohort of adults and determine the association between DAO activity and possible associated factors. The results showed that only a few subjects presented reactions upon histamine intake, while 44% had DAO levels below the suggested normal cut-off values. BMI and age were found to have an impact on DAO activity in women, while only increasing age affected DAO levels in men. No association was found between DAO levels and reported symptoms to histamine-rich foods.
Review
Medicine, General & Internal
Alina Kanikowska, Susanne Janisz, Dorota Mankowska-Wierzbicka, Marcin Gabryel, Agnieszka Dobrowolska, Piotr Eder
Summary: The incidence of food hypersensitivity has increased dramatically in both children and adults. It is important for gastroenterologists and other healthcare professionals to be aware of the symptoms, diagnosis, and treatment possibilities of food hypersensitivity. Diagnosis is primarily based on medical history and sensitivity tests. Elimination diet and pharmacologic treatment are common therapeutic approaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Domenico Gargano, Ramapraba Appanna, Antonella Santonicola, Fabio De Bartolomeis, Cristiana Stellato, Antonella Cianferoni, Vincenzo Casolaro, Paola Iovino
Summary: The narrative review discusses the differences between immune and non-immune adverse reactions to food, emphasizing the importance of correct diagnosis and nutritional control in improving patients' quality of life.
Article
Allergy
Riccardo Asero, Renato Ariano, Arianna Aruanno, Claudio Barzaghi, Paolo Borrelli, Moira Busa, Giorgio Celi, Massimo Cinquini, Gabriele Cortellini, Francesca D'Auria, Marco De Carli, Camilla Di Paolo, Giulia Garzi, Fabio Lodi Rizzini, Monica Magnani, Giuseppina Manzotti, Alessandro Marra, Stefano Miceli Sopo, Francesco Murzilli, Eleonora Nucera, Elena Pinter, Valerio Pravettoni, Federica Rivolta, Angela Rizzi, Nicoletta Saporiti, Enrico Scala, Danilo Villalta, Mona-Rita Yacoub, Giuliana Zisa
Summary: The study found that systemic reactions induced by PR-10 and profilin are facilitated by PPI, ingestion of large amounts of unprocessed foods, and fasting. Soybean beverages represent a risk for PR-10 hypersensitive patients.
Review
Food Science & Technology
Meijia Huang, Huming Shao, Zhongliang Wang, Hongbing Chen, Xin Li
Summary: The goal of food allergy prevention and treatment is to induce oral tolerance (OT). Nutritional interventions play a crucial role in inducing OT to food allergens. This review discusses the mechanism of OT, emphasizes the importance of early nutritional interventions, and summarizes specific nutritional factors that promote the development of OT for food allergies, such as proteins, vitamins, fatty acids, saccharides, and probiotics.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Muhamad Hafiz Abd Rahim, Nur Hazlin Hazrin-Chong, Hanis Hazeera Harith, Wan Abd Al Qadr Imad Wan-Mohtar, Rashidah Sukor
Summary: This review explores the effects and roles of fermented foods on allergic responses, focusing on milk, plant, and meat sources. Fermented foods have been shown to alleviate and aggravate allergic responses, with positive outcomes attributed to microbial hydrolysis of food allergens, improvement in gut microbiota, and modulation of the immune system. Plant-based, non-protein rich fermented foods tend to show more favorable results compared to meat-based or protein-rich options. The use of specific starter cultures and sufficient fermentation time is important in alleviating allergic responses. However, there is a possibility of new allergens being formed through the fermentation process of certain meat-based foods or the use of specific fermenting microbes. Therefore, the combination of starter cultures and food substrates should be considered to prevent or eliminate allergic responses. This review provides valuable insights for consumers in making informed decisions when consuming fermented food.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Chemistry, Applied
Stefan Kabasser, Kunal Pratap, Sandip Kamath, Aya C. Taki, Thanh Dang, Jennifer Koplin, Kirsten Perrett, Karin Hummel, Christian Radauer, Heimo Breiteneder, Andreas L. Lopata, Merima Bublin
Summary: Macadamia nut is a popular choice for a healthy diet, but it is also a potent allergen. Research has identified four IgE-binding proteins in sera from individuals allergic to macadamia nut, with three of them successfully purified and characterized. These newly discovered allergens have the potential to improve molecular diagnostics for macadamia nut allergy.
Article
Chemistry, Applied
Stephanie C. Filep, Kristina Reid Black, Bryan R. E. Smith, Denise S. Block, Anna Kuklinska-Pijanka, Max Bermingham, Maria A. Oliver, Catherine M. Thorpe, Zachary P. Schuhmacher, Sayeh Agah, Sabina Wuenschmann, Martin D. Chapman
Summary: The aim of this study was to develop a fluorescent multiplex array for simultaneously measuring regulated food allergens. The method used specific allergen protein molecules and microspheres coupled to monoclonal antibodies for allergen detection, and showed good accuracy and sensitivity. This method has applications in risk assessment of food allergies and standardization of therapeutic products.
Article
Food Science & Technology
Mingfei Pan, Jingying Yang, Kaixin Liu, Xiaoqian Xie, Liping Hong, Shan Wang, Shuo Wang
Summary: Food allergies are a major global health concern that have been increasing at an alarming rate. Irradiation is an effective method to reduce the allergenicity of food, showing great potential in improving food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2021)
Review
Food Science & Technology
Qin Geng, Ying Zhang, Min Song, Xiaoya Zhou, Yu Tang, Zhihua Wu, Hongbing Chen
Summary: Food allergies, particularly peanut allergies, are a global concern in food safety. This review focuses on the mechanisms, management, and structures of allergens associated with peanut allergies. Epitope localization methods are summarized to aid in the discovery of allergenicity-dependent structures. Efforts to reduce the allergenicity of peanuts include analysis of hypoallergens produced during processing. Identifying and modifying conformational epitopes will lead to improved strategies for managing and preventing peanut allergies, with a potential for application in other food allergies as well.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Paula Wroblewska-Luczka, Aneta Grabarska, Magdalena Florek-Luszczki, Zbigniew Plewa, Jarogniew J. Luszczki
Summary: The study found that osthole and xanthotoxol have the strongest anticancer properties, reducing the median inhibitory concentration (IC50) values of melanoma cells. Compared to osthole, the combination of CDDP and xanthotoxol showed additive effects on melanoma cells. Isobolographic analysis allows for the selection of potential candidates for cancer drugs among natural substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Drabik, Mariusz Gluszak, Paula Wroblewska-Luczka, Zbigniew Plewa, Marek Jankiewicz, Justyna Kozinska, Magdalena Florek-Luszczki, Tomasz Plech, Jarogniew J. Luszczki
Summary: The novel antiepileptic drug TPL-16 showed protective effects in mice models and synergistic interaction with valproate, making it a promising candidate for further experimental and clinical testing. The combination of TPL-16 with carbamazepine, phenobarbital and phenytoin produced additive interaction in protecting mice from tonic-clonic seizures. There were no significant changes in total brain concentrations of classic AEDs after TPL-16 administration in mice.
NEUROCHEMICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Pawel Marzeda, Paula Wroblewska-Luczka, Malgorzata Drozd, Magdalena Florek-Luszczki, Katarzyna Zaluska-Ogryzek, Jarogniew J. Luszczki
Summary: Cannabidiol (CBD) has antiepileptic, antipsychotic, anti-inflammatory, and anxiolytic properties. Recent studies have found that CBD has anticancer effects on melanoma and additive interactions with mitoxantrone (MTX). However, CBD has an antagonistic interaction when combined with cisplatin (CDDP).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Danuta Krasowska, Agnieszka Gerkowicz, Paula Wroblewska-Luczka, Aneta Grabarska, Katarzyna Zaluska-Ogryzek, Dorota Krasowska, Jarogniew J. Luszczki
Summary: Amantadine has anti-melanoma properties and can alleviate symptoms of Parkinson's disease. Amantadine combined with CDDP showed additive interaction in some melanoma cell lines, while its combination with MTO exhibited synergistic interaction in one cell line.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Malgorzata Bernatek, Wioletta Zukiewicz-Sobczak, Sabina Lachowicz-Wisniewska, Jacek Piatek
Summary: The current research aims to evaluate the parameters that influence the effectiveness of probiotic products on the market. The study finds that probiotic formulations in acid-resistant capsules have the highest survival rate in low pH environment, and products with a greater diversity of bacterial strains show better antimicrobial activity against common gastrointestinal pathogens.
Article
Chemistry, Medicinal
Sabina Lachowicz-Wisniewska, Anubhav Pratap-Singh, Ireneusz Kapusta, Angelika Kruszynska, Andrzej Rapak, Ireneusz Ochmian, Tomasz Cebulak, Wioletta Zukiewicz-Sobczak, Pawel Rubinski
Summary: The present study assessed the biological potential of polyphenolic compounds in different parts of Stachys palustris L. It identified 89 polyphenolic compounds and explored their antioxidant, digestive enzyme inhibitory, and antiproliferative activities. The study found that flowers and leaves of S. palustris L. contained the highest amount of polyphenolic compounds and exhibited the strongest effects.
Article
Biochemistry & Molecular Biology
Paula Wroblewska-Luczka, Justyna Cabaj, Weronika Bak, Julia Bargiel, Aneta Grabarska, Agnieszka Goralczyk, Jarogniew J. Luszczki
Summary: Betulinic acid significantly inhibits the growth of melanoma cell lines in vitro and shows no cytotoxic effect on normal human keratinocytes. Combination therapy of betulinic acid with taxanes generates desirable drug-drug interactions, enhancing the therapeutic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sylwia Nakonieczna, Aneta Grabarska, Kinga Gawel, Paula Wroblewska-Luczka, Arkadiusz Czerwonka, Andrzej Stepulak, Wirginia Kukula-Koch
Summary: This study investigated the anti-cancer effects of compounds from Coptis chinensis on gastric cancer cells and found that coptisine showed the highest efficacy. The combination of coptisine with cisplatin exhibited synergistic and additive interactions in vitro, and coptisine was safe for developing zebrafish in vivo. Further studies are warranted to explore the detailed mechanisms of these bioactive compounds in inhibiting gastric cancer cell survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Daniel Tokarski, Irena Ickiewicz, Wioletta Zukiewicz-Sobczak, Pawel Wolinski
Summary: This manuscript explores the analysis and identification of microorganisms, specifically mold fungi, that can be a threat to human health in historical buildings. The study investigates the use of biochar as a supplementary layer in building partitions to reduce the contamination and development of harmful mold fungi. The research shows that the addition of biochar significantly inhibits the presence and growth of mold fungi, improving indoor air quality and protecting the health of both professionals and visitors in historical buildings.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Pawel Marzeda, Paula Wroblewska-Luczka, Magdalena Florek-Luszczki, Malgorzata Drozd, Agnieszka Goralczyk, Jarogniew J. Luszczki
Summary: The drugs Arvanil and Olvanil have the ability to stimulate both TPRV1 and CB1 receptors due to their unique structures, making them interesting candidates for carcinoma treatment. This study investigated the effects of Arvanil and Olvanil alone and in combination with cisplatin (CDDP) and mitoxantrone (MTX) on malignant melanoma cell lines. The results showed that both Arvanil and Olvanil inhibited the viability and proliferation of melanoma cells, with additive interactions observed with MTX and antagonistic interactions observed with CDDP. It is suggested that the combination of Arvanil or Olvanil with MTX may be a potential multi-drug therapy for melanoma, while caution should be taken when combining these compounds with CDDP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Paula Wroblewska-Luczka, Agnieszka Goralczyk, Jarogniew J. Luszczki
Summary: This study evaluated the anticancer effects of esculetin and its pharmacodynamic interactions with six commonly used cytostatic drugs. Esculetin showed inhibitory effects on malignant melanoma cell viability and proliferation, and exhibited additive, antagonistic, or synergistic interactions with different drugs. The combination of esculetin with mitoxantrone displayed synergy and may be a beneficial combination in anticancer therapy.
Article
Cell Biology
Paula Wroblewska-Luczka, Agnieszka Goralczyk, Jarogniew J. Luszczki
Summary: This study evaluates the anticancer potential of daphnetin and its combinations with five different cytostatic drugs for metastatic or drug-resistant melanoma. Results show that daphnetin exhibits anticancer activity against melanoma and demonstrates synergistic effects when combined with mitoxantrone and docetaxel, while antagonistic effects are observed when combined with vemurafenib and epirubicin.
Review
Nutrition & Dietetics
Oskar Wojciech Wisniewski, Bartlomiej Czyzniewski, Wioletta Zukiewicz-Sobczak, Magdalena Gibas-Dorna
Summary: COVID-19 is associated with hyperinflammation and immune cell dysfunction. Adequate nutrition may play a role in combating the negative consequences of SARS-CoV-2 infection. The COVID-19 pandemic has led to unhealthy eating behaviors and a decline in physical activity. Poor eating habits persist as a post-COVID negative consequence.
Review
Green & Sustainable Science & Technology
Pawel Sobczak, Jozef Grochowicz, Patrycja Lusiak, Wioletta Zukiewicz-Sobczak
Summary: Epidemiological studies, changing dietary trends, and climate change are the main factors influencing consumer choices. Despite food overproduction and overconsumption, proper nutrition poses a problem. Traditional protein sources are no longer attractive due to changing dietary trends, leading to a shift towards alternative protein sources. Scientific research is targeting previously underestimated alternative raw materials and products, and their biological activity often astonishes researchers.
Article
Biochemistry & Molecular Biology
Paula Wroblewska-Luczka, Aneta Grabarska, Agnieszka Goralczyk, Pawel Marzeda, Jarogniew J. Luszczki
Summary: Malignant melanoma is a highly aggressive and deadly form of skin cancer. The development of drug resistance and early metastases in melanoma necessitate the exploration of new therapeutic approaches. This study evaluated the cytotoxic and antiproliferative effects of scoparone and fraxetin, alone and in combination with three cytostatics, on human melanoma cell lines. Fraxetin exhibited inhibitory effects on cell proliferation, particularly in certain cell lines, and showed additive interactions when combined with cisplatin and mitoxantrone. However, the combination of fraxetin with docetaxel seemed to have an antagonistic effect, potentially limiting its therapeutic value in melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
