Article
Spectroscopy
Dineshkumar Sengottuvelu, Muthusamy Athianna, Anand Siddeswaran
Summary: A series of azomethine diol monomers containing naphthalene moiety were oxidatively polymerized in aqueous alkaline medium using NaOCl as oxidant. The polymers exhibit high thermal stability and good spectroscopic properties.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Polymer Science
Na Xue, Xiaoming Hou, Xing-Ping Qiu, Xiaotao Song, Qingguo Feng, Xiaozhi Liu
Summary: This study synthesized a new amphiphilic polyoxazoline polymer, FPIPOZ, and investigated its self-assembly behavior in aqueous solution and under vapor annealing conditions. Compared to its precursor N(3)PIPOZ, FPIPOZ showed different thermal properties and surface assembly behavior.
Article
Polymer Science
Jean-Richard, Evgeniya Korchagina, Francoise M. Winnik
Summary: Two different approaches, coupling-onto (CO) and core-first (CF), were used to prepare a series of star poly(2-isopropyl-2-oxazolines) (S-PIPOZ). High-sensitivity microcalorimetry analyses (HS-DSC) were shown to be powerful tools in combination with commonly used analytical techniques for refinement and elucidation of the microstructure of architecturally complex thermosensitive polymers such as star polymers. The results highlighted a discrepancy in synthesis completeness between the core-first and coupling-onto approaches, with the latter showing better correlation and consistency in the results.
Article
Polymer Science
Xinyi Wang, Yewon L. Jeong, Christopher Love, Holly A. Stretz, Gila E. Stein, Brian K. Long
Summary: This study explored the modification of the service window of unfunctionalized vinyl-addition polynorbornene (VAPNB) through the use of norbornene monomers bearing alkyl, aryl, and aryl ether substituents. The resulting VAPNBs exhibited high T'(g)s and large service windows, comparable to other commercial engineering thermoplastics. The feasibility of melt processing was demonstrated by successfully extruding and molding a functionalized VAPNB material, indicating potential for compatibility with traditional processing techniques and emerging technologies.
Article
Polymer Science
Francisco J. Arraez, Xiaowen Xu, Mariya Edeleva, Paul H. M. Van Steenberge, Yoshi W. Marien, Valentin-Victor Jerca, Richard Hoogenboom, Dagmar R. D'hooge
Summary: Cationic ring-opening polymerization (CROP) is an interesting synthesis technique for obtaining well-defined polymers with narrow molar mass distribution. By combining experimental data recording and kinetic Monte Carlo modeling, a detailed understanding of the relationship between reaction conditions and molecular properties of poly(2-oxazoline)s (PAOx) can be obtained for optimization of the synthesis of well-defined PAOx building blocks. The validated model provides insights into the type of macrospecies present and allows differentiation between different coupling reactions.
Article
Chemistry, Physical
Sara Del Galdo, Carlo Andrea De Filippo, Luca Stefanuto, Simona Sennato, Tecla Gasperi, Ester Chiessi, Barbara Capone
Summary: Poly(2-oxazoline)s (POAs) are biocompatible polymers with thermoresponsiveness, making them important in the biomedical field. This study simulated poly(2-isopropyl-2-oxazoline) (PiPOx) and found its thermoresponsive behavior and liquid-liquid phase separation. The study also hinted at the presence of a liquid crystalline phase in the polymer-rich region.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Florica Adriana Jerca, Valentin Victor Jerca, Richard Hoogenboom
Summary: PiPOx shows different hydrolytic stability under different pH conditions, with good stability in neutral and basic conditions, and low stability in acidic conditions, forming a water-soluble structure under acidic conditions.
Article
Polymer Science
Dimitrios Selianitis, Stergios Pispas
Summary: This work introduces a series of novel multi-responsive hyperbranched copolymers which self-organize in aqueous media. The copolymers, prepared by RAFT polymerization, exhibit responsiveness to changes in solution temperature and pH, and are able to encapsulate hydrophobic drugs like curcumin. These hyperbranched copolymers show potential as candidates for drug delivery and bio-imaging applications, as they demonstrate stability in the presence of serum proteins.
Review
Polymer Science
Somdeb Jana, Richard Hoogenboom
Summary: Poly(2-alkyl/aryl-2-oxazoline)s have gained significant attention in the polymer research community due to their ease of synthesis, customizable properties, and potential applications in medical and biological fields. This review provides an overview of recent advancements in the structures and side-chain-dependent properties of PAOx, discussing the design strategies, limitations, and thermal and solution properties.
POLYMER INTERNATIONAL
(2022)
Article
Polymer Science
Shu Wang, Purushottam Poudel, Felix H. Schacher, Leonid I. Kaberov
Summary: In this work, a method for synthesizing temperature and light-responsive copolymers by introducing azobenzene fragments in the side chain of poly(2-oxazoline)s is proposed. The obtained copolymers exhibited thermo-responsive behavior and reversible isomerization of azobenzene units under UV and visible light exposure. The presence of nanoparticles in the aqueous solutions of the copolymers was confirmed, and the size of these nanoparticles changed in response to UV irradiation.
Article
Polymer Science
Yanyao Zhang, Yusheng Tang, Junliang Zhang, Simon Harrisson
Summary: The fluorescence properties of the copolymer can be adjusted by rationally designing the copolymer structure. The asymmetric diblock copolymer shows a gradual increase in fluorescent intensity as the environmental pH decreases, in contrast to the limited and stepwise change of its symmetric block counterpart.
Article
Polymer Science
Fabio Blaschke, Philipp Marx, Stefan Hirner, Inge Muehlbacher, Karin Wewerka, Frank Wiesbrock
Summary: The dielectric and physicochemical properties of renewable POx networks were compared with fossil-based PA 12 networks. POx showed lower shrinkage and reduced defects when SOE was added. The development of a thermally triggered dual-cure system resulted in lower density for the fully-cured POx networks with relative expansion during curing.
Article
Materials Science, Multidisciplinary
Xiangkun Li, Lu Wang, Ying Liu, Jinwen Ye
Summary: This research investigates the effect of VC on the microstructure, high-temperature mechanical properties, and thermal conductivity of WC-10Co-0.8Cr(3)C(2). It is found that the addition of 0.2 wt% VC results in excellent high-temperature mechanical properties, including a transverse rupture strength of 2170 MPa, a fracture toughness of 17.78 MPa.m(1/2), and a hardness of 1370HV5 at 800°C, surpassing most commonly used WC-10C(o) cemented carbides. Moreover, the thermal conductivity is almost unaffected by the addition of VC. This work provides a new perspective on preparing WC-Co cemented carbide with excellent cutting potential.
INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS
(2023)
Article
Polymer Science
Lucca Trachsel, Matteo Romio, Marcy Zenobi-Wong, Edmondo M. Benetti
Summary: Cyclic macromolecules exhibit enhanced mechanical strength and greater hydration in hydrogels, compared to their linear counterparts, due to the higher effective intramolecular repulsion between polymer segments and the topology effects.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Esra Altay, Yoon-Jung Jang, Xiang Qi Kua, Marc A. Hillmyer
Summary: This study demonstrates that incorporating methyl groups into PGA polymers can widen the window between crystallization/degradation temperatures and melting temperatures while maintaining overall thermal stability. The distribution of methyl groups in copolymers affects the resulting gas barrier properties.
Article
Biochemistry & Molecular Biology
Shubhashis Datta, Annamaria Jutkova, Petra Sramkova, Lenka Lenkayska, Veronika Huntosova, Dusan Chorvat, Pavol Miskovsky, Daniel Jancura, Juraj Kronek
Article
Polymer Science
Ramasubba Reddy Palem, Shimoga D. Ganesh, Nabanita Saha, Juraj Kronek, Petr Saha
JOURNAL OF POLYMER RESEARCH
(2018)
Article
Chemistry, Multidisciplinary
Dusana Trel'ova, Alice Rita Salgarella, Leonardo Ricotti, Guido Giudetti, Annarita Cutrone, Petra Sramkova, Anna Zahoranova, Dusan Chorvat, Daniel Hasko, Claudio Canale, Silvestro Micera, Juraj Kronek, Arianna Menciassi, Igor Lacik
Correction
Polymer Science
Ramasubba Reddy Palem, Shimoga D. Ganesh, Nabanita Saha, Juraj Kronek, Petr Saha
JOURNAL OF POLYMER RESEARCH
(2018)
Article
Polymer Science
Vladimir Raus, Ana Holos, Juraj Kronek, Jaroslav Mosnacek
Article
Polymer Science
Emi Haladjova, Maros Smolicek, Iva Ugrinova, Denitsa Momekova, Pavletta Shestakova, Zuzana Kronekov, Juraj Kronek, Stanislav Rangelov
JOURNAL OF APPLIED POLYMER SCIENCE
(2020)
Article
Chemistry, Physical
Alena Opalkova Siskova, Erika Kozma, Andrej Opalek, Zuzana Kronekova, Angela Kleinova, Stefan Nagy, Juraj Kronek, Joanna Rydz, Anita Eckstein Andicsova
Article
Chemistry, Physical
Ema Paulovicova, Zuzana Kronekova, Lucia Paulovicova, Monika Majercikova, Juraj Kronek
Summary: Poly(2-isopropenyl-2-oxazoline) (PIPOx) is a functional polymer with high potential for drug delivery, tissue engineering, and immunomodulation. In vitro studies have shown the immunomodulatory efficiency of PIPOx formulation on various immune cell responses, including the production of specific cytokines and cell phagocytosis. The results demonstrate the bioavailability of PIPOx and its capability to induce immune cell responses, highlighting its potential for future biomedical applications.
Article
Polymer Science
Monika Majercikova, Peter Nadazdy, Dusan Chorvat, Leonid Satrapinskyy, Helena Valentova, Zuzana Kronekova, Peter Siffalovic, Juraj Kronek, Anna Zahoranova
Summary: This study investigated the influence of dexamethasone on the thermoresponsive behavior of diblock copolymers, revealing that the addition of dexamethasone lowered the cloud point temperature of one copolymer and resulted in the formation of microparticles. The characteristics of the microparticles were influenced by the structure and concentration of the copolymer, the drug concentration, and the temperature.
Article
Biochemistry & Molecular Biology
Veronika Huntosova, Shubhashis Datta, Lenka Lenkavska, Mariana Macajova, Boris Bilcik, Barbora Kundekova, Ivan Cavarga, Juraj Kronek, Annamaria Jutkova, Pavol Miskovsky, Daniel Jancura
Summary: This study investigates the effects of self-assembly of gradient copolymers and loading of hypericin on polymeric nanoparticles, showing that different copolymer structures can lead to variations in the size of formed nanoparticles. The release rate of hypericin from nanoparticles plays a crucial role in their effectiveness. Furthermore, the nanoparticles entering cells via endocytosis can decrease the effectiveness of PDT induced by hypericin.
Article
Oncology
Barbora Kundekova, Mariana Macajova, Majlinda Meta, Ivan Cavarga, Veronika Huntosova, Shubhashis Datta, Pavol Miskovsky, Juraj Kronek, Boris Bilcik
Summary: Amphiphilic gradient copoly(2-oxazoline)s have been extensively studied in the field of drug delivery, showing promise as a drug transport system. In this study, nanoparticles loaded with a hydrophobic drug were tested on a Japanese quail chorioallantoic membrane (CAM) model. The results showed that the nanoparticles were biocompatible, non-toxic, and effectively altered the fluorescence of the drug. Additionally, the nanoparticles demonstrated a potential anti-angiogenic effect, which could be advantageous for photodynamic therapy in tumor treatment.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Pharmacology & Pharmacy
Shubhashis Datta, Veronika Huntosova, Annamaria Jutkova, Robert Seliga, Juraj Kronek, Adriana Tomkova, Lenka Lenkavska, Mariana Macajova, Boris Bilcik, Barbora Kundekova, Ivan Cavarga, Ewa Pavlova, Miroslav Slouf, Pavol Miskovsky, Daniel Jancura
Summary: Due to their simple preparation method and potential applications in biomedical research, amphiphilic gradient copoly(2-oxazoline)s have attracted increasing interest. This study investigated the solubilization ability of a series of these copolymers with different length of hydrophobic side-chains for curcumin. The results showed that the length of hydrophobic side-chain played a crucial role in curcumin loading onto the self-assembled nanoparticles. The kinetic stability of the nanoparticles was studied using FRET and a correlation between their integrity and cellular uptake was observed in human glioblastoma cells.
Proceedings Paper
Nanoscience & Nanotechnology
Petra Sramkova, Jakub Kelar, Richard Krumpolec, Zlata Tucekova, Monika Stupavska, Juraj Kronek, Dusan Kovacik, Mirko Cernak
10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2018 (R))
(2019)
Proceedings Paper
Nanoscience & Nanotechnology
Martin Cvek, Miroslav Mrlik, Marketa Ilcikova, Jaroslav Mosnacek, Juraj Kronek, Michal Sedlacik
9TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2017)
(2018)
Article
Chemistry, Multidisciplinary
Lukas Hrdlicka, Petra Sramkova, Josef Prousek, Juraj Kronek
Article
Polymer Science
Zhongming Yuan, Hiroko Yamamoto, Shinji Kanehashi, Takeshi Shimomura
Summary: This study reports the synthesis of a flexible light-emitting polymer film using a solution blending method. The selective positioning of MEH-PPV molecules in the PS phase of the film was confirmed. The film exhibited a nanometer-scale luminescent domain with low aggregation quenching and showed good elastomeric characteristics.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2024)