Journal
POLYMERS FOR ADVANCED TECHNOLOGIES
Volume 21, Issue 10, Pages 720-725Publisher
WILEY-BLACKWELL
DOI: 10.1002/pat.1495
Keywords
amphiphiles; self-assembly; solution properties; thermo-sensitive; N-vinylcaprolactam
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Funding
- National Natural Science Foundation [20474044, 20644002]
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Thermo-sensitive amphiphilic copolymers, PVCL-PTrpAMT and PVCL-PVP-PTrpAMT of hydrophilic N-vinylcaprolactam (VCL), N-vinylpyrrolidone (NVP), and hydrophobic N-t-Boc-tryptophanamido-N'-methacryl thioureas (TrpAMT) monomers, were synthesized and characterized by (1)H NMR, UV-spectroscopy, and GPC-MALLS. The cloud point (CP) measurement showed that hydrophobic PTrpAMT and hydrophilic PVP segments significantly altered the phase transition temperature of PVCL with comparable molecular weight in aqueous solution. The CP of PVP-PTrpAMT solution was 38.0 degrees C, lower by 5.0 degrees C than that of unmodified PVCL. In the presence of phosphate buffer saline (PBS), the CP value of the PVCL polymer decreased by similar to 2.0 degrees C in comparison to that of the aqueous solution. Fluorescent spectroscopy and TEM studies revealed that PVCL-PTrpAMT and PVCL-PVP-PTrpAMT self-assembled into the spherical micelles, 30-70 nm in diameter, at concentrations over their CMCs in an aqueous solution. Cytotoxicity tests demonstrated that the PVCL copolymers were not harmful to cell viability, which may favor the use of the copolymers as potential thermo-sensitive polymers in pharmaceutical applications. Copyright (c) 2009 John Wiley & Sons, Ltd.
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