Review
Biotechnology & Applied Microbiology
Hao Wu, Kaili Lin, Cancan Zhao, Xudong Wang
Summary: Silk fibroin (SF) scaffolds offer excellent biocompatibility and mechanical properties, making them promising candidates for bone regeneration. Further research on fabrication techniques and modifications to enhance osteogenesis show great potential for improving clinical translation and outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Characterization & Testing
Fei-Fan Shuang, Chen-Chen Wang, Wei-Jun Zhu, Tao Chen, Xiao-Hui Yao, Dong-Yang Zhang, Wei-Guo Zhao
Summary: This study presents a robust silk fibroin (SF) scaffold with a reinforced concrete structure, where silk nanofibers serve as the skeleton. The scaffold is prepared using a CaCl2-formic acid dissolving system combined with freeze-drying method, ensuring minimal silk loss and shorter preparation time. Additionally, the scaffold retains the nanofibers of silk, preserving their mechanical toughness. The prepared scaffolds exhibit good biocompatibility and biodegradability. The findings provide a new strategy for manufacturing SF scaffolds and hold great potential for the development of silk fibroin materials in tissue engineering.
Article
Engineering, Biomedical
Shujun Zhang, Jing Wang, Zhaozhu Zheng, Jia Yan, Li Zhang, Yi Li, Jiaheng Zhang, Gang Li, Xiaoqin Wang, David Kaplan
Summary: Porous nerve guidance conduits (NGCs) reinforced by a braided composite structure consisting of silk/magnesium filaments provide appropriate physio-mechanical guidance and stability during early-stage nerve regeneration. The S/Mg-SF/CS NGC demonstrated sufficient mechanical properties and biocompatibility, promoting the growth of damaged nerves and showing potential in artificial nerve transplantation. The manufacturing process involves multidisciplinary engineering, including textile technologies, biomaterial engineering, and medical science.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Ji-Xin Li, Shu-Xiang Zhao, Yu-Qing Zhang
Summary: This paper describes the use of silk protein for the clean degumming of silk and the preparation of silk protein bioinks for 3D printing of various composite scaffolds. The techniques described here allow for the recycling and utilization of sericin, a waste product of silk processing. The resulting composite scaffolds exhibit improved properties such as enhanced compressive strength and resistance to protease hydrolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Peng Pan, Cheng Hu, Ahui Liang, Xueping Liu, Mengqi Fang, Shanlong Yang, Yadong Zhang, Mingzhong Li
Summary: The study developed a hybrid scaffold with antibacterial and healing-guiding functions. Results showed that the scaffold exhibited significant antibacterial activity against bacteria when the PHMB/SF ratio was greater than 1/100, and promoted cell adhesion, spreading, and proliferation when the ratio was less than 2/100.
Article
Materials Science, Ceramics
Hajar Maleki, Nicola Huesing
Summary: Silk fibroin is incorporated into silica aerogels through either a one-step or two-step sol-gel reaction. The hybridization process is regulated by organosilane concentration and SF to silane mass fractions. Both approaches result in materials with promising mechanical properties for a wide range of applications, with the one-step process showing better compressibility and the two-step process potentially leading to aerogels with lower shrinkage.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoying Zha, Xingliang Xiong, Cheng Chen, Yang Li, Lingqin Zhang, Haojiang Xie, Qifeng Jiang
Summary: This study developed a functionalized silk fibroin cutaneous scaffold incorporated with a natural medicine, usnic acid, which showed significant potential in promoting wound healing and could be a promising treatment for chronic wounds.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Zohre Montaseri, Samira Sadat Abolmaali, Ali Mohammad Tamaddon, Fakhrossadat Farvadi
Summary: Cartilage tissue engineering requires an appropriate microenvironment for chondrocyte proliferation. Composite silk fibroin hydrogels have shown strong potential and advantages for cartilage regeneration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Xinyi Li, Mengjie Ye, Yong-E. Gao, Shengxin Hou, Peng Jia, Peng Xue, Yuejun Kang, Zhigang Xu
Summary: Nanoparticle-based theranostics have become a preferential technology for the diagnosis and treatment of diseases. This study introduces a drug delivery system based on natural silk fibroin (SF NPs). It has been evaluated and found to have high stability, universal drug delivery ability, and good biosafety both in vitro and in vivo.
ADVANCED FIBER MATERIALS
(2022)
Article
Biophysics
Yankuan Tian, Qinting Wu, Fang Li, Yuhang Zhou, Di Huang, Ruijuan Xie, Xiaoqin Wang, Zhaozhu Zheng, Gang Li
Summary: The study prepared a porous SF/WK composite scaffold with good biocompatibility and mechanical properties for cartilage tissue engineering, showing potential in this field.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Sanaz Khademolqorani, Hossein Tavanai, Fatemeh Ajalloueian
Summary: The appropriate mechanical properties in longitudinal and circumferential directions are important for tissue engineering support. The study on silk fibroin scaffolds showed that lower stitch density increased porosity and surface porosity, while higher density decreased large pore size. Cell-cultured scaffolds exhibited higher strength and strain, indicating potential for bladder tissue engineering studies.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Materials Science, Multidisciplinary
Chenxi Zhao, Yawen Liu, Zhuochen Lv, Leitao Cao, Jing Ren, Zhengzhong Shao, Shengjie Ling
Summary: This study developed a silk protein-based nacre with mechanical properties superior to natural nacre by imitating the structure of natural nacre. The silk fibroin nacre can be used for structural engineering and biomedical applications, thanks to its good processability and tunable coloration.
ADVANCED FIBER MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Jiwen Chen, Huajun Wang, Yunjun Wu, Youjie Liu, Yiwan Shi, Changshun Chen, Huige Hou, Zhengang Zha, Xiaofei Zheng, Tingting Wu
Summary: A novel scaffold material with good mechanical and biocompatible properties was fabricated in this study. It can promote proliferation and osteogenic differentiation of bone cells, making it a promising biomaterial for the treatment of bone defects.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Kazuharu Arakawa, Nobuaki Kono, Ali D. Malay, Ayaka Tateishi, Nao Ifuku, Hiroyasu Masunaga, Ryota Sato, Kousuke Tsuchiya, Rintaro Ohtoshi, Daniel Pedrazzoli, Asaka Shinohara, Yusuke Ito, Hiroyuki Nakamura, Akio Tanikawa, Yuya Suzuki, Takeaki Ichikawa, Shohei Fujita, Masayuki Fujiwara, Masaru Tomita, Sean J. Blamires, Jo-Ann Chuah, Hamish Craig, Choon P. Foong, Gabriele Greco, Juan Guan, Chris Holland, David L. Kaplan, Kumar Sudesh, Biman B. Mandal, Y. Norma-Rashid, Nur A. Oktaviani, Rucsanda C. Preda, Nicola M. Pugno, Rangam Rajkhowa, Xiaoqin Wang, Kenjiro Yazawa, Zhaozhu Zheng, Keiji Numata
Summary: This study conducted transcriptome assemblies of 1098 species of spiders and measured the mechanical properties of the dragline silks of 446 species, revealing the essential contributions of multicomponent structures and numerous amino acid motifs to the performance limits of industrial fibers.
Article
Biotechnology & Applied Microbiology
Lina Guo, Ziqing Zhu, Chuanzhou Gao, Kaiwen Chen, Shenzhou Lu, Hexin Yan, Wenming Liu, Mingqi Wang, Yanfang Ding, Lin Huang, Xiuli Wang
Summary: By developing SF-collagen I composite scaffolds with improved physical and chemical properties, a more biomimetic hepatic lobule-like model was successfully bioengineered, allowing iHepLPCs to differentiate into mature hepatocytes with enhanced liver functions and facilitating the arrangement of hepatocyte-endothelial cell interphase with improved polarity and bile capillary formation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Zhongming Yuan, Hiroko Yamamoto, Shinji Kanehashi, Takeshi Shimomura
Summary: This study reports the synthesis of a flexible light-emitting polymer film using a solution blending method. The selective positioning of MEH-PPV molecules in the PS phase of the film was confirmed. The film exhibited a nanometer-scale luminescent domain with low aggregation quenching and showed good elastomeric characteristics.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2024)
