Article
Thermodynamics
Zhixu Li, Yiming Ma, Jiawei Lin, Peng Shi, Songgu Wu, Dandan Han, Junbo Gong
Summary: The solubility of 2,2-Bis(hydroxymethyl)propionic acid (DMPA) in 12 mono solvents was investigated at various temperatures and the results were correlated with different models, with the Apelblat model showing the best fitting performance. The NRTL model revealed that solvation is a spontaneous and entropy-driven mixing process in solvents. It was also found that the polarity and hydrogen bond acceptor propensities of solvents play crucial roles in determining the solubility of DMPA. Molecular dynamic simulations were used to further study the solvent effect on the solubility of DMPA. The results showed a good correlation between solute-solvent interactions and solubility order.
JOURNAL OF CHEMICAL THERMODYNAMICS
(2022)
Review
Engineering, Biomedical
Imran Ansari, Prabhjeet Singh, Anupama Mittal, Ram Mahato, Deepak Chitkara
Summary: Bis-MPA derived cyclic carbonates have garnered significant attention for their versatile applications in the field of grafted biodegradable polymers. They have evolved into a multi-functional platform with diverse applications in various fields.
Article
Chemistry, Applied
Samiran Morang, Nishant Biswakarma, Ramesh Chandra Deka, Niranjan Karak
Summary: This study explores the use of glycerol ester of citric acid (GECA) as a biobased emulsifier for preparing high-performance anionic polyurethane dispersions (PUDs). The results show that GECA has comparable reactivity to conventional emulsifiers and the synthesized PUD films exhibit outstanding physical and chemical properties, as well as biodegradability under microbial exposure.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Polymer Science
Aurora Pacini, Andrea Nitti, Guido Sangiovanni, Marcello Vitale, Dario Pasini
Summary: This study presents the synthesis and characterization of two aliphatic AB(2) monomers containing one alkyne group and two azide functionalities, with adjustable distance between polymerizable groups to meet steric demands during polymerization. The monomers polymerize through the Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC reaction), yielding hyperbranched polymers with good yields, molecular weights, and moderate degrees of branching.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Energy & Fuels
Mingyu Shin, Seunghye Oh, Hayoung Jeong, Chanho Noh, Yongjin Chung, Jeong Woo Han, Yongchai Kwon
Summary: In this study, an all-iron aqueous redox flow battery using Fe(BIS-TRIS) and Fe(CN)(6) as redox couples is proposed. Fe(BIS-TRIS) exhibits good activity and stability without side reactions, while Fe(CN)(6) is suitable for the catholyte due to its excellent redox reactivity and low cost. Flow battery tests confirm that the battery using Fe(BIS-TRIS) shows outstanding performance and stability.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Tsvetan Kardashliev, Sven Panke, Martin Held
Summary: In this study, a novel one-pot biocatalytic process was demonstrated using recombinant microbial whole cells as catalysts to prepare a versatile chemical intermediate 2,6-bis(hydroxymethyl)pyridine from naturally-occurring 2,6-lutidine. After scale up, bioconversion achieved titers exceeding 12 g L-1 with a space-time yield of 0.8 g L-1 h(-1), offering a simpler and more sustainable alternative to multistep organic synthesis protocols.
Article
Engineering, Environmental
Mingyu Shin, Chanho Noh, Yongchai Kwon
Summary: This study determines the optimal electrolyte condition for an alkaline aqueous redox flow battery (ARFB) using Fe(BIS-TRIS) and Ferrocyanide as the redox couple. By controlling the mixing ratio of metal to ligand and the concentration of KOH, the stability of the anolyte is improved. The performance of the ARFB using the optimized anolyte shows high energy efficiency and discharging capacities, comparable to conventional vanadium RFB.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Silvana Alfei
Summary: Gene therapy is a realistic and promising therapeutic approach for treating inherited and acquired diseases by repairing defective genes. Viruses, with their excellent transfection efficiency, have been extensively used as carriers, but nonviral cationic materials, such as dendrimers, are attractive alternative options. Among dendrimers, those derived from 2,2-bis(hydroxymethyl)propanoic acid (b-HMPA) are particularly interesting due to their biodegradability in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Tomas A. Garcia Cambon, Cecilia Samaniego Lopez, Natalie Hanheiser, Sumati Bhatia, Katharina Achazi, M. Veronica Rivas, Carla C. Spagnuolo
Summary: This study introduced benzoxaborole into chitosan for the first time by amidation of the amino groups of chitosan, improving solubility and introducing cis-diol recognition at physiological pH. The chemical structures and physical properties of the novel chitosan-benzoxaborole (CS-Bx) were characterized using various spectroscopic and analytical techniques. The solubilized CS-Bx showed potential as a boronated material derived from polysaccharides. The study also investigated the dynamic covalent interaction between boronated chitosan and model affinity ligands, and discussed the application of fluorescence microscale thermophoresis for analyzing the interactions of the modified polysaccharide.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Szymon Kapuscinski, Bindushree Anand, Paulina Bartos, Jose M. Garcia Fernandez, Piotr Kaszynski
Summary: This paper presents a synthetic method for accessing spin-labeled compounds by synthesizing 7-CF3-1,4-dihydrobenzo[e][1,2,4]triazin-4-yl radicals containing different substituents and converting them into tosylates and phosphates. The obtained tosylates were used to obtain disulfides and azides. The Blatter radical containing an azido group showed good reactivity in a copper(I)-catalyzed azide-alkyne cycloaddition reaction, indicating its potential for grafting onto other molecular objects via the CuAAC click reaction.
Article
Chemistry, Multidisciplinary
Durairaj Siva, Subramanian Abinaya, Durairaj Rajesh, Govindaraju Archunan, Parasuraman Padmanabhan, Balazs Gulyas, Shanmugam Achiraman
Summary: This study investigates the possible mechanism of doxorubicin-mediated cardiotoxicity and explores the use of chitosan nanoparticles conjugated with doxorubicin and supplemented with propionic acid to reduce the cardiotoxicity. The results show that DCNPs and propionic acid have a protective effect against doxorubicin-induced cardiotoxicity.
Article
Biochemistry & Molecular Biology
Sadaf Rauf, Agata Trzesowska-Kruszynska, Tomasz Sieranski, Marcin Swiatkowski
Summary: Three new copper coordination compounds were synthesized from dmpa and hmta, and their crystal structures were determined. The structural diversity among the compounds was a result of the multiple coordination modes of the ligands used. Characterization of the compounds in terms of absorption and thermal properties provided insights into the relationships between structural features and properties.
Article
Chemistry, Applied
Alexander S. Edgar, Camille H. Wong, Kitmin Chen, David A. Langlois, Dali Yang
Summary: The presence of DNPOH in aged NP as a degradation product through hydrolysis has been identified for the first time using LC-QTOF analysis. It is shown that water can stabilize NP against hydrolysis and reduce acidity by slowing HONO decomposition.
PROPELLANTS EXPLOSIVES PYROTECHNICS
(2022)
Article
Biotechnology & Applied Microbiology
Kseniia V. Vikanova, Marina S. Chernova, Elena A. Redina, Gennady Kapustin, Olga P. Tkachenko, Leonid M. Kustov
Summary: The study demonstrates that ultra-low-loaded supported Pt catalysts exhibit extremely high activity in the selective hydrogenation of 5-HMF, with 0.1% Pt/CeO2-ZrO2 catalyst showing the highest yield and selectivity for BHMF without the need for alkali or other additives.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tadeja Katan, Rupert Kargl, Tamilselvan Mohan, Tobias Steindorfer, Miran Mozetic, Janez Kovac, Karin Stana Kleinschek
Summary: Stable chitosan thin films can serve as promising substrates for creating nanometric peptide-bound polyglucosamine layers, with structural similarities to bacterial peptidoglycans. Various characterization techniques were employed to investigate the surface chemistry and confirm the acetylation and coupling of peptides on the chitosan films, indicating potential to mimic bacterial cell wall structures.
Article
Chemistry, Physical
Inna Klimenko, Elena A. Trusova, Alexander N. Shchegolikhin, Anton Lobanov, Lubov Jurina
Summary: The study utilized the unique physical properties of graphene to stabilize the AlClPc complex and prevent its agglomeration, while also developing a sonochemical method for preparing stable suspensions of oxygen-free graphene. By employing molecular design techniques, hybrid structures based on AlClPc and graphene were successfully synthesized, leading to new possibilities for drug delivery and early diagnosis platforms.
FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
(2022)
Article
Materials Science, Multidisciplinary
T. S. Demina, T. N. Popyrina, E. D. Minaeva, A. A. Dulyasova, S. A. Minaeva, R. Tilkin, V. Yusupov, C. Grandfils, T. A. Akopova, N. Minaev, P. S. Timashev
Summary: Surface-selective laser sintering (SSLS) is a method to fabricate 3D structures with well-defined architectonic by selectively melting the surface of microparticles. This method uses water as the laser radiation absorber and relies on the specific surface properties of the microparticles to absorb and sinter the laser irradiation.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
T. S. Demina, P. Y. Bikmulina, A. Birdibekova, A. S. Kuryanova, A. A. Frolova, P. Koteneva, N. A. Aksenova, N. Kosheleva, T. M. Khlebnikova, T. A. Akopova, P. S. Timashev
Summary: This study evaluated the effect of low-frequency plasma treatment on the surface properties of chitosan films and its impact on the adhesion and proliferation of human keratinocytes. The results showed that plasma treatment resulted in the formation of polar oxygen-containing groups on the surface, reduced surface roughness, and increased surface hydrophilicity. The chitosan films exhibited cytocompatibility and supported keratinocyte viability in extract or cell cultivation applications. Plasma treatment enhanced the adhesion properties of chitosan films to cells and stimulated keratinocyte proliferation, which is crucial for the use of chitosan-containing materials as wound dressings.
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
(2022)
Article
Chemistry, Physical
E. D. Minaeva, A. S. Kuryanova, A. A. Dulyasova, S. A. Minaeva, N. Minaev, S. Kostjuk, T. S. Demina, T. A. Akopova, P. S. Timashev
Summary: The influence of mid-IR laser radiation on the morphology of polylactide and polycaprolactone nonwoven materials obtained by electrospinning has been studied. It has been found that laser irradiation can achieve local structuring of the nonwoven materials, including fusing fibers together, straightening them, and creating breaks. The influence of laser irradiation parameters and additional wetting on the structure of the nonwovens has also been determined.
HIGH ENERGY CHEMISTRY
(2022)
Article
Polymer Science
Olga Yu. Kochetkova, Tatiana S. Demina, Olga Yu. Antonova
Summary: Several variants of hybrid polyelectrolyte microcapsules were designed and produced, demonstrating high efficiency of carrying hydrophilic and hydrophobic compounds. The microcarriers showed high storage stability and no apparent toxic effects on live cells. Interaction with macrophages resulted in deformation and degradation of the microcapsules, accompanied by release of their contents. These results highlight the functional efficiency and potential of these novel hybrid microcarriers in delivering drugs with different properties in complex therapy.
Review
Biochemistry & Molecular Biology
Tatiana A. Akopova, Tatiana N. Popyrina, Tatiana S. Demina
Summary: This study reviews the application of mechanochemical approaches to modify polysaccharides. The considered approach is characterized by the ability to avoid toxic solvents, initiators, or catalysts, aligning with current global trends. Examples using various polysaccharides and their derivatives are used to analyze the mechanisms of chemical transformations, the structure and properties of the products, their solubility and swelling in different media, and their ability to self-organize and stabilize nanodispersed inorganic particles and biologically active substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Tatiana N. Popyrina, Tatiana S. Demina, Tatiana A. Akopova
Summary: The wider application of naturally derived polysaccharides in the food packaging industry is of great importance as it provides additional functionality such as antibacterial and antioxidant properties, making them suitable for functional food products.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Polymer Science
Nikita Minaev, Svetlana A. Minaeva, Anastasia A. Sherstneva, Tatiana Chernenok, Yulia K. Sedova, Ekaterina D. Minaeva, Vladimir Yusupov, Tatiana A. Akopova, Peter S. Timashev, Tatiana S. Demina
Summary: This study presents the fabrication of polyester/hydroxyapatite microparticles without surfactants, using hydroxyapatite nanoparticles for stabilization, resulting in microparticles with varying characteristics. Processing conditions such as polymer properties, polymer/nHA ratio, and ultrasound treatment all influence the yield, size distribution, surface morphology, and chemical structure of the particles.
Article
Polymer Science
Tatiana S. Demina, Mikhail S. Piskarev, Aisylu Birdibekova, Nadezhda N. Veryasova, Anastasia Shpichka, Nastasia Kosheleva, Andrey K. Gatin, Elena A. Skryleva, Elena Istranova, Alla B. Gilman, Tatiana A. Akopova, Peter S. Timashev
Summary: This study compares the effects of different methods of collagen deposition on polylactide films in terms of surface chemical structure, morphology, hydrophilicity, and the ability to support adhesion and growth of human mesenchymal stromal cells.
Article
Polymer Science
Tatiana S. Demina, Evgeniy N. Bolbasov, Maria A. Peshkova, Yuri M. Efremov, Polina Y. Bikmulina, Aisylu V. Birdibekova, Tatiana N. Popyrina, Nastasia V. Kosheleva, Sergei I. Tverdokhlebov, Peter S. Timashev, Tatiana A. Akopova
Summary: This work aims to develop fibrous scaffolds from a multicomponent polymeric system for tissue engineering. The fibrous materials were fabricated using different methods and their morphology and properties were evaluated. The cytocompatibility of the fabricated mats was confirmed using in vitro cell analysis. The electro-assisted solution blow spinning technology resulted in the formation of multifilament fibers with the highest number of cell-cell contacts.
Article
Polymer Science
Tatiana Tolstova, Maria Drozdova, Tatiana Popyrina, Diana Matveeva, Tatiana Demina, Tatiana Akopova, Elena Andreeva, Elena Markvicheva
Summary: Novel matrices based on chitosan-g-oligo (L,L-/L,D-lactide) copolymers were developed in this study. 2D films were fabricated by solvent casting and 3D macroporous hydrogels were obtained by lyophilization. These copolymer-based matrices showed interconnected macropore structures with an average size of 150 μm. The Chit-LD matrices exhibited superior osteodifferentiation properties compared to Chit-LL matrices, suggesting that film composition affects osteogenesis.
Article
Polymer Science
Maria Drozdova, Marina Vodyakova, Tatiana Tolstova, Marina Chernogortseva, Nikita Sazhnev, Tatiana Demina, Nadezhda Aksenova, Peter Timashev, Nataliya Kildeeva, Elena Markvicheva
Summary: The study aimed to develop two methods for preparing macroporous composite chitosan/hyaluronic acid (Ch/HA) hydrogels and evaluate their potential as biodegradable matrices for tissue engineering. The hydrogels were prepared by crosslinking chitosan with genipin or glutaraldehyde, and the distribution of hyaluronic acid within the hydrogel was controlled by different modification methods. The results showed that the Ch/HA hydrogels with low molecular weight HA exhibited enhanced cell growth compared to the Ch matrices, and the hydrogels prepared by bulk modification promoted better cell adhesion, growth, and proliferation.
Article
Nanoscience & Nanotechnology
E. A. Svidchenko, E. S. Solomatina, T. S. Demina, S. A. Uspenskii, N. M. Surin, A. N. Zelenetskii
Summary: The process of ultrasonic dispersion of hydroxyapatite nanoparticles in sodium hyaluronate solutions was studied using UV spectrophotometry, dynamic light scattering, and viscometry. The optimal parameters for obtaining stable dispersions were determined, including the concentration of hydroxyapatite nanoparticles, concentration of sodium hyaluronate solution, and the ratio of the components. Film materials were obtained by casting, and the uniformity of filler distribution in the polymer matrix was evaluated using UV spectrophotometry and microscopy.
NANOBIOTECHNOLOGY REPORTS
(2022)