Journal
POLYMER INTERNATIONAL
Volume 64, Issue 2, Pages 275-283Publisher
WILEY
DOI: 10.1002/pi.4787
Keywords
wound dressing; silver nanoparticles; alginate; gelatin; bead; drug delivery system
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Funding
- Research, Development and Engineering (RDAMP
- E) fund through the National Nanotechnology Center (NANOTEC)
- National Science and Technology Development Agency (NSTDA), Thailand [P-11-00986]
- Thailand Graduate Institute of Science and Technology (TGIST) [TG-55-99-55-048 M]
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Silver nanoparticles (AgNPs)-loaded calcium alginate beads embedded in gelatin scaffolds were developed to sustain and maintain the release of silver (Ag+) ions over an extended time period. The UV irradiation technique was used to reduce Ag+ ions in alginate solution to AgNPs. The average sizes of AgNPs ranged between ca 20 and ca 22nm. The AgNPs-loaded calcium alginate beads were prepared by electrospraying of a sodium alginate solution containing AgNPs into calcium chloride (CaCl2) solution. The AgNPs-loaded calcium alginate beads were then embedded into gelatin scaffolds. The release characteristics of Ag+ ions from both the AgNPs-loaded calcium alginate beads and the AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were determined in either deionized water or phosphate buffer solution at 37 degrees C for 7 days. Moreover, the AgNPs-loaded calcium alginate beads embedded in gelatin scaffolds were tested for their antibacterial activity and cytotoxicity. (c) 2014 Society of Chemical Industry
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