Article
Multidisciplinary Sciences
Malika Sammari, Yanis Inglebert, Norbert Ankri, Michael Russier, Salvatore Incontro, Dominique Debanne
Summary: This study reveals that brain oscillations at specific frequencies can induce both synaptic and intrinsic potentiation in O-LM interneurons, contrary to the typical response seen in glutamatergic neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Wonseok Chang, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, Sun Seek Min
Summary: Trans-anethole has neuroprotective effects and can positively influence synaptic plasticity, which suggests its potential for improving cognitive impairment caused by neurodegenerative diseases.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Neurosciences
Margarita Anisimova, Bas van Bommel, Rui Wang, Marina Mikhaylova, Joern Simon Wiegert, Thomas G. Oertner, Christine E. Gee
Summary: The study uses optogenetic stimulation to induce STDP and observes timing-dependent depression and potentiation. This study does not require electrodes and results suggest that synaptic depression after anticausal activation is a transient phenomenon.
Article
Cell Biology
Yongchuan Zhu, Marco Uytiepo, Eric Bushong, Matthias Haberl, Elizabeth Beutter, Frederieke Scheiwe, Weiheng Zhang, Lyanne Chang, Danielle Luu, Brandon Chui, Mark Ellisman, Anton Maximov
Summary: The study shows that experience is not necessary for the development of synaptic morphology and the arrangement of different connections in local networks is stochastic. Loss of activity increases the variability in synaptic structure size, but does not disrupt their alignment. These results demonstrate that mechanisms for the structural diversity of neuronal synapses are intrinsic.
Article
Neurosciences
Alen Eapen, Diego Fernandez-Fernandez, John Georgiou, Zuner A. Bortolotto, Stafford Lightman, David E. Jane, Arturas Volianskis, Graham L. Collingridge
Summary: The study demonstrates the involvement of GluN2D-containing NMDARs in both short-term potentiation (STP) and long-term potentiation (LTP) in the mouse hippocampus, highlighting the important role of GluN2D subunits in synaptic plasticity.
Article
Cell Biology
Egor Byvaltcev, Mahraz Behbood, Jan-Hendrik Schleimer, Thomas Gensch, Alexey Semyanov, Susanne Schreiber, Ulf Strauss
Summary: Extracellular potassium [K+]o elevation during synaptic activity retrogradely modifies presynaptic release and astrocytic uptake of glutamate. Hence, local K+ clearance and replenishment mechanisms are crucial regulators of glutamatergic transmission and plasticity. Based on recordings of astrocytic inward rectifier potassium current IKir and K+-sensitive electrodes as sensors of [K+]o as well as on in silico modeling, we demonstrate that the neuronal K+-Cl- co-transporter KCC2 clears local perisynaptic [K+]o during synaptic excitation by operating in an activity-dependent reversed mode.
Article
Pharmacology & Pharmacy
Li-Qiang Chen, Xue-Jing Lv, Qing-Huan Guo, Su-Su Lv, Ning Lv, Wen-Dong Xu, Jin Yu, Yu-Qiu Zhang
Summary: This study found that trigeminal neuralgia patients often experience anxiety and depression symptoms. It was also discovered that microglia-mediated neuroinflammation plays a role in the development of neuropathic pain and anxiodepression. Additionally, the study revealed that activation of hippocampal microglia is associated with anxiety and depression caused by trigeminal neuralgia.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biology
Tzitzitlini Alejandre-Garcia, Samuel Kim, Jesus Perez-Ortega, Rafael Yuste
Summary: Neuronal ensembles are coactive groups of cortical neurons that play a role in perception and behavior. In this study, we replicated an in vivo optogenetic protocol in brain slices to investigate the mechanisms involved in ensemble formation. We found that coactivated neurons showed increased correlated activity and biphasic changes in presynaptic plasticity. Furthermore, stimulation induced significant increases in spontaneous EPSPs and neuronal excitability.
Article
Neurosciences
Nan Jiang, Dario Cupolillo, Noelle Grosjean, Emeline Muller, Severine Deforges, Christophe Mulle, Thierry Amedee
Summary: The study found that female APP/PS1 mice displayed early deficits in hippocampus-dependent memory tasks and heightened intrinsic excitability of DG granule cells as early as 3 months of age, which may be attributed to impaired synaptic plasticity induced by HFS.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Luis A. Marquez, Ernesto Griego, Carolina Lopez Rubalcava, Emilio J. Galvan
Summary: Blocking NMDARs with MK-801 during early postnatal development impairs NMDAR-dependent long-term plasticity in the hippocampus, mimicking behavioral and neurophysiological abnormalities of schizophrenia. This study demonstrates that transient hypofunction of NMDARs also affects other forms of hippocampal plasticity, such as AMPAR-mediated short- and long-term potentiation.
Article
Clinical Neurology
Benjamin Clennell, Tom G. J. Steward, Kaliya Hanman, Tom Needham, Janette Benachour, Mark Jepson, Meg Elley, Nathan Halford, Kate Heesom, Eunju Shin, Elek Molnar, Bruce W. Drinkwater, Daniel J. Whitcomb
Summary: This study reveals the regulation of neuronal excitability and synaptic function by ultrasound stimulation. Ultrasound stimulation can increase whole-cell potassium currents and excitatory synaptic transmission. Activation of ionotropic glutamate receptors is required for ultrasound-induced modulation of neuronal potassium currents. These findings have important implications for the application of ultrasound stimulation in experimental and therapeutic settings, but further research is needed to understand the underlying molecular mechanisms.
Article
Multidisciplinary Sciences
Kif Liakath-Ali, Jai S. Polepalli, Sung-Jin Lee, Jean-Francois Cloutier, Thomas C. Sudhof
Summary: This study reveals the crucial role of presynaptic neurexin-ligand cerebellin-4 (Cbln4) in long-term potentiation (LTP) at EC -> DG synapses. Binding of presynaptic Cbln4 to postsynaptic neogenin-1 enables the EC -> DG synapses to undergo LTP, but is not necessary for the establishment or function of these synapses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Federico Brandalise, Stefano Carta, Roberta Leone, Fritjof Helmchen, Anthony Holtmaat, Urs Gerber
Summary: In this study, dendritic patch-clamp recordings and calcium imaging were used to investigate the integrative properties of single dendrites. It was found that local hyperpolarization of a single dendritic segment can prevent NMDA spikes, their associated calcium transients, and LTP in a branch-specific manner. This finding provides direct evidence that a single dendritic branch operates as a functional unit in regulating CA3 pyramidal cell plasticity.
Article
Biochemistry & Molecular Biology
Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdak, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W. Mozrzymas
Summary: This study demonstrates that MMP3 plays a key role in iLTP mechanisms, affecting behaviors that in part depend on GABAergic plasticity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Katarzyna Terejko, Michal A. Michalowski, Anna Dominik, Anna Andrzejczak, Jerzy W. Mozrzymas
Summary: Recent studies have shown that the activation of pLGICs is associated with coordinated subunit twisting in the membrane plane, indicating a crucial role of intersubunit interactions in receptor activation, especially in preactivation and opening processes. The underlying mechanisms of this intersubunit cross-talk outside the top-down pathway remain largely unknown.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Terejko, Michal A. Michalowski, Ilona Izykowska, Anna Dominik, Aleksandra Brzostowicz, Jerzy W. Mozrzymas
Summary: GABA type A receptors play a crucial role in mediating inhibition in the adult mammalian brain and have a complex gating mechanism involving openings/closings, preactivation, and desensitization. The ligand binding sites affect the receptor's gating mechanism, suggesting shared structural determinants for distinct conformational transitions.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Michal A. Michalowski, Marta M. Czyzewska, Ilona Izykowska, Jerzy W. Mozrzymas
Summary: The pH sensitivity of the GABA-A receptor can be altered by mutating the beta 2E155 residue, affecting its modulation by protons.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soumyendu Sekhar Bandyopadhyay, Anup Kumar Halder, Monika Zareba-Koziol, Anna Bartkowiak-Kaczmarek, Aviinandaan Dutta, Piyali Chatterjee, Mita Nasipuri, Tomasz Wojtowicz, Jakub Wlodarczyk, Subhadip Basu
Summary: The study introduces a consensus strategy for predicting palmitoylated cysteine sites on synaptic proteins, which significantly improves prediction performance in mouse datasets through efficient feature selection and a three-star quality consensus strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Marcin Wyroslak, Katarzyna Lebida, Jerzy W. Mozrzymas
Summary: The study examined the plasticity of tonic inhibition in hippocampal pyramidal neurons under NMDAR-dependent GABAergic inhibitory long-term potentiation (iLTP) induction protocol. It was found that alpha 5-containing GABA(A)Rs played a key role in mediating the plastic change in tonic current during this process.
Review
Cell Biology
Grzegorz Wiera, Jerzy W. Mozrzymas
Summary: Long-term synaptic plasticity is regulated by the controlled reorganization of the synaptic proteome, including the crucial role of extracellular matrix metalloproteinases (MMPs) such as MMP9 and MMP3 in excitatory synapses. These enzymes are also implicated in memory, learning deficits, and psychiatric disorders. Research into the role of extracellular proteolysis in inhibitory synapses is just beginning.
Article
Pharmacology & Pharmacy
Karol Klopotowski, Marta M. Czyzewska, Jerzy W. Mozrzymas
Summary: Recent studies have shown that phenylalanine 64 (alpha 1F64) located at loop D of GABA(A) receptors plays a crucial role in the conformational transitions of the receptor, with mutations of alpha 1F64 dramatically altering gating properties.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Izabela Figiel, Ewa Baczynska, Tomasz Wojtowicz, Marta Magnowska, Anna Buszka, Monika Bijata, Jakub Wlodarczyk
Summary: This study reveals that the deletion of DG in rat hippocampal cell cultures leads to significant changes in the density and morphology of dendritic spines, accompanied by a decrease in laminin and aquaporin 4. However, silencing of DG does not affect synaptic transmission or Psd-95 protein expression, suggesting the existence of unknown mechanisms to maintain proper synaptic signaling despite impaired structure of dendritic spines. Presumably, astrocytes are involved in these processes.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Grzegorz Wiera, Patrycja Brzdak, Anna Maria Lech, Katarzyna Lebida, Jadwiga Jablonska, Przemyslaw Gmerek, Jerzy W. Mozrzymas
Summary: This study provides the first evidence that integrins play a key role in regulating the endogenous modulatory mechanisms of GABAergic inhibition and plasticity in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Przemyslaw T. Kaczor, Michal A. Michalowski, Jerzy W. Mozrzymas
Summary: Cys-loop receptors are important in mammalian CNS signaling. Little is known about the GABAA receptor's activation mechanisms. Recent studies have provided structural insights into the GABAA receptor, enabling further molecular functional studies. The interface region between the transmembrane and extracellular domains plays a crucial role in transmitting conformational changes. A highly conserved proline residue within this interface is involved in regulating receptor gating.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Marek Brodzki, Jerzy W. Mozrzymas
Summary: This study investigated the role of the beta(2)P273 residue in the gating transitions of GABA(A) receptors. The results showed that mutations of this residue impaired macroscopic desensitization and accelerated current deactivation. Furthermore, the mutations also affected the intraburst open probability of the receptors. The findings suggest that beta(2)P273 is a crucial element in regulating the receptor's ability to undergo late gating transitions and could be a potential target for pharmacological tools affecting GABA(A)R-mediated inhibition.
Review
Cell Biology
Anna Buszka, Agata Pytys, Domnic Colvin, Jakub Wlodarczyk, Tomasz Wojtowicz
Summary: Protein lipidation, specifically S-palmitoylation, is a common post-translational modification that regulates protein trafficking in membranes and has essential roles in human physiology and brain function. Recent experimental studies have shed light on the discrete molecular switch function of protein S-palmitoylation within minutes to hours, expanding protein functions and subcellular localization. This review focuses on the impact of protein palmitoylation on functional changes in synapses associated with neuronal activity and plasticity, highlighting its crucial role in learning, memory, and cognitive functions.
Article
Multidisciplinary Sciences
Patrycja Brzdak, Katarzyna Lebida, Marcin Wyroslak, Jerzy W. Mozrzymas
Summary: GABAergic transmission onto pyramidal neurons shows different forms of plasticity, and plasticity at inhibitory interneurons remains largely unknown. This study investigated the impact of integrins on the long-term plasticity of GABAergic synapses on specific inhibitory interneurons. The results revealed interneuron-specific plasticity and differences in the underlying integrin-dependent mechanisms.
SCIENTIFIC REPORTS
(2023)