Article
Neurosciences
Bryan McClarty, Guadalupe Rodriguez, Hongxin Dong
Summary: The study showed that the HDAC inhibitor CI-994 at different doses could reduce motor and memory side effects induced by haloperidol in aged mice. A dose of 20 mg/kg was effective in improving motor coordination and mitigating memory impairment in aged mice. Biochemical analyses indicated an increase in histone acetylation and expression of the dopamine 2 receptor gene in aged mice after administration of CI-994 at 20 mg/kg.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Chemistry, Medicinal
Mauricio T. Tavares, Alan P. Kozikowski, Sida Shen
Summary: Histone deacetylase 6 (HDAC6) is a zinc-dependent enzyme that regulates the acetylation of non-histone substrates, impacting various cellular processes. The discovery of mercaptoacetamide (MCA)-based HDAC6 inhibitors has shown promising potential due to their selectivity and lack of mutagenicity. Further research on the structure-activity relationships, selectivity, and pharmacological properties of MCA-based HDAC6 inhibitors could lead to improved drug-like properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Vincenza Capone, Laura Della Torre, Daniela Carannante, Mehrad Babaei, Lucia Altucci, Rosaria Benedetti, Vincenzo Carafa
Summary: Histone modifications play a crucial role in the pathogenesis of diseases, including cancer, and acetylation is a reversible epigenetic process with important functions in cell life. HAT1 has been found to regulate molecular pathways, including those involved in cancer. This review summarizes the current knowledge and recent advances of HAT1 in the pathogenesis of cancer.
Article
Biotechnology & Applied Microbiology
Nando D. Das, Jen-Chien Chang, Chung-Chau Hon, S. Thomas Kelly, Shinsuke Ito, Marina Lizio, Bogumil Kaczkowski, Hisami Watanabe, Keisuke Katsushima, Atsushi Natsume, Haruhiko Koseki, Yutaka Kondo, Aki Minoda, Takashi Umehara
Summary: This study found that H4K5acK8ac and H3K27ac signals have some overlap in binding to the super-enhancer transcription factor BRD4 at higher levels, but they also have distinct specificities, especially in glioblastoma stem-like cell lines. Deletion of H4K5acK8ac-preferred super-enhancers associated with MYCN and NFIC resulted in a reduction in stem-like properties.
Review
Biochemistry & Molecular Biology
Leisheng Wang, Yue Tao, Jingbo Zhai, Mengzhou Xue, Chunfu Zheng, Hao Hu
Summary: The rapid progress in epigenetic study has brought new hope for cancer treatment. The ac4C acetylation modification and N-acetyltransferase 10 are important factors in various biological processes and have high expression in malignant tumors. This review aims to introduce NAT10, summarize the impact of ac4C acetylation on tumor growth, and discuss the potential therapeutic targeting of NAT10 and future research directions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Disha Agarwal, Ruchika Kumari, Ashal Ilyas, Shweta Tyagi, Rajnish Kumar, Nitesh Kumar Poddar
Summary: Epigenetics has opened a new dimension in exploring unanswered questions in genetics, particularly in neurodegenerative diseases like Alzheimer's and cancers. The alterations in DNA methylation levels, histone acetylation, and methylation play a significant role in conditions such as Alzheimer's disease. Studying the interplay between the mTOR regulatory pathway and epigenetic machinery may lead to early diagnosis and novel therapeutic strategies for Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Genetics & Heredity
Merrick S. Fallah, Dora Szarics, Clara M. Robson, James H. Eubanks
Summary: Epigenetic processes play a critical role in regulating gene expression patterns in neurodevelopment, including the dynamic network of post-translational histone modifications. Mutations in histone-modifying enzymes can disrupt this system and lead to developmental consequences. This review examines neurodevelopmental conditions associated with histone methylation and acetylation, discussing clinical phenotypes, genetic bases, and model systems for studying pathological mechanisms.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Giordano Proietti, Yali Wang, Chiara Punzo, Jasmin Mecinovic
Summary: KAT8 is capable of acetylating selective lysine analogues with subtle changes in side chains and main chains, in addition to natural lysine. This study contributes to the design of new chemical probes targeting KAT8 and other members of the histone lysine acetyltransferase family.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Soumya Banerjee, Samuel Vernon, Wei Jiao, Ben Jiwon Choi, Evelyne Ruchti, Jamshid Asadzadeh, Olivier Burri, R. Steven Stowers, Brian D. McCabe
Summary: The decline of synaptic structures and functions during ageing can be mitigated by enhancing miniature neurotransmission, which is essential for maintaining and prolonging motor ability in adult organisms.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Qian Xiang, Yongzhao Zhao, Jialiang Lin, Shuai Jiang, Weishi Li
Summary: This study systematically discusses the different epigenetic modifications and their potential functions in the process of spinal ligament aging.
AGEING RESEARCH REVIEWS
(2022)
Article
Psychiatry
Anil Srivastava, Oluwagbenga Dada, Jessica Qian, Nzaar Al-Chalabi, Ali Bani Fatemi, Philip Gerretsen, Ariel Graff, Vincenzo De Luca
Summary: Schizophrenia is a chronic psychotic disorder that significantly impacts behavior, thought, and cognition, with possible contributions from both genetic and epigenetic factors. Current research focuses on DNA methylation, histone modification, and non-coding RNA, offering potential new avenues for diagnosis and treatment of schizophrenia. Limitations in current knowledge and potential future research directions are also discussed.
PSYCHIATRY RESEARCH
(2021)
Article
Environmental Sciences
Chongdan Xiang, Haibo Chen, Xiaolin Liu, Yao Dang, Xin Li, Yunjiang Yu, Bei Li, Xintong Li, Yanan Sun, Ping Ding, Guocheng Hu
Summary: This study examines the adverse effects of virgin and aged polystyrene microplastics (PS-MPs) on zebrafish larvae. Exposure to PS-MPs reduces swimming speed and aged PS-MPs have stronger behavioral effects. PS-MPs accumulate in zebrafish tissues and increase neurotransmitter levels, resulting in neurotoxicity. These findings underscore the importance of the neurotoxicity of aged PS-MPs in zebrafish for risk assessment and ecosystem conservation.
Article
Biochemistry & Molecular Biology
Viacheslav V. Trush, Christian Feller, Alice Shi Ming Li, Abdellah Allali-Hassani, Magdalena M. Szewczyk, Irene Chau, Mohammad S. Eram, Boya Jiang, Raymond Luu, Fangfei Zhang, Dalia Barsyte-Lovejoy, Ruedi Aebersold, Cheryl H. Arrowsmith, Masoud Vedadi
Summary: Posttranslational modification of histones, including methylation and acetylation, plays a critical role in regulating gene expression by establishing transcriptionally active or repressive chromatin states. Acetylation of nucleosomes can create better substrates for specific HMTs, leading to significant increases in catalytic efficiencies of SETDB1, G9a, and SUV420H2 in vitro.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Immunology
Chen Xi Yang, Emma Schon, Ma'en Obeidat, Michael S. Kobor, Lisa McEwen, Julie MacIsaac, David Lin, Richard M. Novak, Fleur Hudson, Hartwig Klinker, Nila Dharan, Steve Horvath, Jean Bourbeau, Wan Tan, Don D. Sin, S. F. Paul Man, Ken Kunisaki, Janice M. Leung
Summary: This study found evidence of advanced methylation aging in persons living with HIV (PLWH) before the initiation of antiretroviral therapy (ART) and with preserved immune status. Compared to HIV-negative controls, PLWH had significantly higher methylation age, with black race, low CD4 and high CD8 T-cell counts, and duration of HIV being risk factors for age acceleration.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Reproductive Biology
Naiara Z. Saraiva, Clara S. Oliveira, Nathalia N. C. Almeida, Marivaldo R. Figueiro, Carolina C. R. Quintao, Joaquim M. Garcia
Summary: This study investigated the epigenetic changes resulting from the use of histone deacetylase inhibitors in the maturation of bovine oocytes and subsequent embryo development. The results showed that the treatment with histone deacetylase inhibitors promoted the development of bovine oocytes and had a positive impact on embryo development.