Journal
POLYMER DEGRADATION AND STABILITY
Volume 98, Issue 1, Pages 44-51Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymdegradstab.2012.10.030
Keywords
Poly(epsilon-caprolactone); Hydrolytic degradation; Solvent-casting; Melt-compression; Electrospinning; Supercritical fluid
Categories
Funding
- FCT (Fundacao para a Ciencia e a Tecnologia) [SFRH/BD/30198/2006]
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Films, fibers, sponges and disks, based on poly(e-caprolactone), PCL were prepared using solvent-casting, electrospinning, supercritical fluid processing and melt-compression, respectively. The extent of degradation was determined by measuring the change in morphology, crystallinity and molecular weight (MW). The influence of processing method, MW and drug presence on degradation rate was also evaluated. The different processing techniques produced samples of various morphology and crystallinity. Nevertheless, the differences in degradation rate were not so significant during the advanced stage (18 36 months), while some differences existed during the initial stage (up to 18 months). MW had an important effect on degradation rate, while drug did not. The low MW disks had a degradation rate that was lower by one order of magnitude than high MW constructs. (C) 2012 Elsevier Ltd. All rights reserved.
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