Article
Polymer Science
Rushabh Patel, Davide Monticone, Mingyuan Lu, Lisbeth Grondahl, Han Huang
Summary: The long-term hydrolytic degradation of SLS PHBV bone scaffolds was explored by incubating them in PBS solution for 20 weeks. The degradation occurred predominantly by bulk degradation, leading to reduction in molecular weight and compressive stiffness while increasing crystallinity. The weight loss was minimal in the first 8 weeks, with gradual increase thereafter, and the concentration of COOH groups on the scaffold surface initially increased before declining due to surface erosion from hydrolysis.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Chemistry, Physical
Mariangela Guastaferro, Lucia Baldino, Stefano Cardea, Ernesto Reverchon
Summary: Polycaprolactone-based aerogels were prepared by supercritical CO2 drying. Addition of polyethylene glycol improved the morphology of the scaffolds and prolonged drug release. The drug release process was controlled by drug diffusion and polymer erosion.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Review
Biochemistry & Molecular Biology
Brian Amsden
Summary: This review examines the mechanisms by which aliphatic polycarbonates (APCs) and functionalized APCs degrade in vivo, aiming to provide guidance for the continued development of these polymers as biomaterials.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Engineering, Environmental
Monica Elvira Mendoza-Duarte, Jorge Alberto Roacho-Perez, Adriana G. Quiroz- Reyes, Elsa N. Garza-Trevino, Celia N. Sanchez-Dominguez, Perla Elvia Garcia-Casillas, Alejandro Vega-Rios
Summary: This study investigated the hydrolytic degradation and safety of ternary blends in medical devices. The results showed that the blends had good mechanical stability and biocompatibility, making them suitable for use in medical devices.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Amaury Bossion, Chen Zhu, Lea Guerassimoff, Julie Mougin, Julien Nicolas
Summary: The authors demonstrate a system based on acrylamide and cyclic ketene acetals to obtain copolymers with faster degradation rates, which have potential applications in drug release and environmental fields.
NATURE COMMUNICATIONS
(2022)
Article
Polymer Science
Chengkai Liu, Zhengyi Han, Xiangyu Yan, Jinshuo Yu, Qiao Zhang, Dongmei Wang, Yan Zhao, Huiliang Zhang
Summary: In this study, a novel and environmentally friendly PBSA/sc-PLA blend was obtained by melt-blending equimolar amounts of PLLA and PDLA with PBSA. The formation of sc-PLA in the PBSA matrix was confirmed by differential scanning calorimetry and wide-angle X-ray diffractometry, and the sc-PLA was uniformly dispersed in the PBSA matrix. The addition of sc-PLA increased the strength, heat resistance, and hydrolytic degradation resistance of the PBSA matrix, providing an effective strategy to improve the performance and expand the application scope of PBSA materials.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Elham Khodaverdi, Mohammad Reza Abbaspour, Fatemeh Oroojalian, Negar Omidkhah, Samir Hossein-nezahd, Hossein Kamali, Farzin Hadizadeh
Summary: The triblock copolymers of PEG-PCL-PEG (PEGCL) were fabricated using ring-opening polymerization (ROP) of epsilon-caprolactone. The scaffolds with adjustable structure and morphology were constructed using the scCO(2) gas foaming method to provide controlled release of dexamethasone loaded in PEGCL.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Inari Lyyra, Nina Sandberg, Vijay Singh Parihar, Markus Hannula, Heini Huhtala, Jari Hyttinen, Jonathan Massera, Minna Kellomaki
Summary: Polylactides (PLAs) have been extensively studied for biomedical engineering applications, but their rigidity limits their use. Blending them with more flexible polymers, such as polybutylene succinate (PBSu), results in softer materials and expands their potential applications. Bioactivity is a limitation of biopolymers, which can be improved by adding bioactive glass. Blending and compounding PLA/PBSu blends with bioactive glass enables the production of materials with a wide range of mechanical properties, suitable for tissue engineering applications.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Xiangyu Yan, Chengkai Liu, Liting He, Chentao Li, Dongmei Wang, Guangfeng Wu, Junjia Bian, Yan Zhao, Huiliang Zhang
Summary: In this study, poly(L-lactic acid) (PLLA) and poly(D-lactic acid) (PDLA) were blended with PBST to form stereocomplex poly(lactic acid) (sc-PLA) in situ during melt blending process. The PBST/sc-PLA blends showed improved mechanical properties and heat resistance compared to neat PBST. Additionally, the hydrolytic degradation of the PBST/sc-PLA blends was enhanced.
JOURNAL OF MATERIALS SCIENCE
(2023)
Review
Polymer Science
Stanko Kramer, Neil R. Cameron, Peter Krajnc
Summary: This review highlights the importance and versatility of high internal phase emulsions (HIPEs) and the resulting porous polymers (polyHIPEs) in biomedical applications. The focus is on the use of polyHIPEs as scaffolds for biological cell growth and tissue regeneration, along with their preparation methods and interactions with biological systems. Additionally, it touches upon the use of combined techniques and advanced applications in this field.
Article
Materials Science, Biomaterials
Huanhuan Yan, Chen Wang, Qingxia Zhang, Pengfei Yu, Yuwei Xiao, Chunhua Wang, Peibiao Zhang, Guige Hou
Summary: Injectable conductive porous scaffolds were fabricated by incorporating camphor sulfonic acid-doped polyaniline (PANI) into hydroxyapatite/poly-(lactide-co-glycolide) (HA/PLGA) scaffolds. These scaffolds exhibited excellent electroactivity, conductivity, hydrophilicity, antibacterial properties, and biocompatibility. Controlling the degradation behavior through PANI content regulation could promote bone ingrowth and restoration in conductive porous scaffolds.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Polymer Science
Yu-Ting Guo, Changxia Shi, Tian-Yi Du, Xiang-Yue Cheng, Fu-Sheng Du, Zi-Chen Li
Summary: The design and synthesis of closed-loop recyclable polymers using ring-opening polymerization (ROP) is a promising solution to address plastic pollution and economic loss. The resulting poly(ester-amide)s (PEAs) exhibit tunable mechanical properties, good thermal stability, and excellent recyclability.
Article
Polymer Science
Ina Keridou, Lourdes Franco, Luis J. del Valle, Juan C. Martinez, Lutz Funk, Pau Turon, Jordi Puiggali
Summary: The hydrolytic and enzymatic degradation of poly(4-hydroxybutyrate) films under different pH values and temperatures have been studied, along with their effects on thermal properties and crystallinity. Enzymatic degradation selectively eliminates amorphous regions and highlights the spherulitic morphology, with Rhizopus oryzae identified as the most suitable enzyme for cropping out the spherulites.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Materials Science, Biomaterials
Minqi Lu, Liangyan Sun, Jinrong Yao, Bingjiao Zhao, Yuehua Liu, Zhengzhong Shao, Xin Chen
Summary: This study introduced LAPONITE(R) into regenerated silk fibroin porous scaffolds, resulting in RSF/LAP 3D porous scaffolds with good biocompatibility and biodegradability. In vitro and in vivo experiments demonstrated the potential of RSF/LAP 3D porous scaffolds in bone tissue engineering.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Metallurgy & Metallurgical Engineering
Qiangsheng Dong, Yang Li, Huiqin Jiang, Xingxing Zhou, Huan Liu, Mengmeng Lu, Chenglin Chu, Feng Xue, Jing Bai
Summary: In this study, 3D-cubic interconnected porous Mg-xZn-0.3Ca scaffolds were prepared, showing high porosity and a pore structure similar to human cancellous bone, with good compression properties. However, the scaffolds exhibited undesirable degradation behavior in Hank's solution, indicating the need for surface modifications to control degradation.
JOURNAL OF MAGNESIUM AND ALLOYS
(2021)
Article
Polymer Science
Tetsu Sato, Mariko Takahashi, Takeshi Saito, Masahito Toyonaga, Itsuo Tanuma, Rie Yamada, Satoru Hosoda
Summary: An automatic evaluation system for photooxidation has been developed and successfully applied to assess the photo-OIT of LDPE samples containing photooxidation stabilizers. The system allows independent setting of various measurement conditions and provides detailed information on the photooxidation process.
POLYMER DEGRADATION AND STABILITY
(2024)
Article
Polymer Science
Zongzheng Zuo, Shuxue Zhou
Summary: In this study, three fluoroalkyl trimethoxysilane (FATMS) additives with different chain lengths were incorporated into a two-component polyurethane clearcoat to improve its hydrophobic durability. The coatings modified with FATMS maintained their surface hydrophobicity under various conditions, but quickly lost it when exposed to both UV irradiation and/or high temperature with water. The results suggest that the FATMS route is more suitable for indoor applications at room temperature.
POLYMER DEGRADATION AND STABILITY
(2024)
Article
Polymer Science
Song Li, Feng Zhao, Xueya Wang, Zhihua Liu, Jingze Guo, Yutong Li, Shuangmei Tan, Zhenxiang Xin, Shuai Zhao, Lin Li
Summary: Green flame retardants have garnered attention for their environmental friendliness, but current options fall short in achieving high flame retardancy for flammable polymers and maintaining environmental protection. This study takes a two-pronged approach to address flame retardants and the flame-retardant process. An eco-friendly bio-based synergistic flame retardant (PAU), synthesized using phytic acid (PA) and urea (U), is used to create a flame retardant coating that can be directly applied to any surface shape using polydopamine as an adhesive. The resulting EPS-PAU exhibits excellent flame retardancy, smoke suppression, and light weight while only slightly increasing the density.
POLYMER DEGRADATION AND STABILITY
(2024)