Article
Biochemistry & Molecular Biology
Panpan Song, Nannan Song, Li Li, Minghao Wu, Zhongxia Lu, Xia Zhao
Summary: A pH/reduction-sensitive carboxymethyl chitosan nanogel modified by targeting peptide angiopep-2 loaded with doxorubicin shows promising potential for targeted chemotherapy of glioblastoma. The targeted nanogel exhibited good stability, biocompatibility, and enhanced BBB penetration and tumor targeting ability, leading to higher drug uptake and stronger antitumor activity compared to nontargeted nanogels. This innovative nanogel platform with pH/reduction dual-stimuli response may hold great significance for GBM-targeted therapy.
Review
Pharmacology & Pharmacy
Pearl Moharil, Zhuoya Wan, Apurva Pardeshi, Jiang Li, Haozhe Huang, Zhangyi Luo, Sanjay Rathod, Ziqian Zhang, Yuang Chen, Bei Zhang, Christian A. Fernandez, Jingjing Sun, Song Li
Summary: Combining passive targeting with active targeting is a promising approach to improve the therapeutic efficacy of nanotherapy. In this study, ultra-small-sized gemcitabine-based nanoparticles were combined with folic acid conjugation for enhanced dual targeted delivery to tumor cells and tumor-associated macrophages. The co-delivery system showed small particle size and achieved significant reduction of tumor growth in a breast cancer model.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Ru Zhang, Yunying Jiang, Linkun Hao, Yang Yang, Ying Gao, Ningning Zhang, Xuecheng Zhang, Yimin Song
Summary: In this study, a novel PLGA-based micelle was synthesized, which effectively delivered the antitumor drug DOX and reduced its toxic and side effects. The micelles showed good physicochemical properties and biocompatibility, and demonstrated stronger cytotoxicity and apoptosis in tumor cells through the double receptor-mediated endocytosis pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Libin Jiang, Yunbin Jiang, Linlin Li, Ke Zheng, Shujuan Yu, Jinyu Li, Cai Yuan, Mingdong Huang
Summary: A novel matriptase targeting carrier (MTC) was designed, showed high specificity and cytotoxicity for matriptase-overexpressing cancer cells in vitro, and demonstrated potential as a highly efficient tumor targeting drug carrier for imaging and therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Applied
Haohui Shi, Na Liang, Jiyang Liu, Siyi Li, Xianfeng Gong, Pengfei Yan, Shaoping Sun
Summary: A novel polymer TPE-bi(SS-CS-Bio) was synthesized for encapsulating PTX with excellent AIE feature and enhanced cellular uptake due to biotin modification. The drug-loaded micelles showed remarkable cytotoxicity against MCF-7 cells and demonstrated potential as a carrier for PTX.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Yilin Wang, Wenjie Wang, Xiaoming Wang, Hao Wu, Weifeng Zhao, Changsheng Zhao
Summary: This study develops low-immunogenicity CM nanoparticles for MRI-guided photothermal therapy using CMC and KMnO4. In vitro and in vivo experiments demonstrate excellent hemocompatibility and low immunogenicity of the proposed nanomaterials, along with outstanding photothermal properties for successful MRI-guided PTT.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Yang Liu, Yi Zhao, Haimei Li, Xiaoyang Zhang, Zichen Wang, Wenyan She, Fenglei Jiang, Yi Liu, Peng Jiang
Summary: In this study, a dual-targeted, multifunctional nanoplatform (FAA@CM) was successfully synthesized for trimodal imaging-guided photothermal/chemodynamic synergistic therapy. The nanoplatform achieved highly precise tumor-specific delivery through dual-targeting capability derived from 4T1 cell membrane cloaking and magnetic targeting. It exhibited trimodal imaging capabilities and enabled complete elimination of 4T1 tumors in mice.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Dong Wang, Zhihao Fan, Xuecheng Zhang, Hui Li, Yawei Sun, Meiwen Cao, Guangcheng Wei, Jiqian Wang
Summary: A novel anticancer prodrug molecule was designed for targeted drug delivery, which could self-assemble into different nanostructures at different pH levels. The self-assemblies demonstrated good cancer cell selectivity, mainly due to their pH-responsive structural transition and folate active targeting effect.
Article
Chemistry, Multidisciplinary
Shaohui Deng, Shiyin Wang, Zecong Xiao, Du Cheng
Summary: A spatially controlled siRNA activation strategy and co-delivery of Ce6 can achieve tumor-specific siRNA therapy with synergistic drug effects.
Article
Biotechnology & Applied Microbiology
S. P. Surya Teja, N. Damodharan, T. Tamilanban, Vetriselvan Subramaniyan, V. Chitra, Suresh V. Chinni, Ling Shing Wong, Neeraj Kumar Fuloria, Mahendran Sekar, Shivkanya Fuloria, Gobinath Ramachawolran, Siddharthan Selvaraj
Summary: The aim of this study was to investigate the influence of excipients on retaining the particle size of methotrexate (MTX) loaded chitosan nanocarriers (CsNP) during lyophilization. The use of mannitol as a lyoprotectant resulted in restricted nanocarrier size and successful tumor targeting. This study demonstrates the potential of chitosan nanocarriers for targeted tumor drug delivery and cancer treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiaoxue Lai, Shuo Wang, Miao Hu, Yiming Sun, Meng Chen, Mengyang Liu, Gang Li, Yihui Deng
Summary: The study developed a new treatment strategy using sialic acid-modified doxorubicin hydrochloride liposome, which effectively inhibited tumor growth while alleviating systemic RA symptoms, providing a new approach for the treatment of comorbid tumors and RA.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Hongyu Long, Weijun Tian, Shuting Jiang, Jianqing Zhao, Jianren Zhou, Qian He, Zhaomin Tang, Wenzhu Shen, Jiajia Wang
Summary: The combination of organic polymers and inorganic nanoparticles to design intelligent nanocarriers is important for delivering anticancer drugs to tumor cells effectively. In this study, a thermo-responsive micelle was prepared as a gatekeeper attached to the surface of mesoporous silica nanoparticle through disulfide bonds. The dual drug delivery platform showed controllable release of drugs and demonstrated high cytocompatibility and cytotoxicity against cancer cells.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Linqi Yun, Kai Li, Cancan Liu, Ligao Deng, Jianbin Li
Summary: This study successfully synthesized biocompatible dual-modified starch micelles and demonstrated their potential as drug delivery vehicles. The results provide reference information for further research in biotechnology and pharmaceutical domains.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Biomaterials
Mingxing Ren, Yuzhou Li, He Zhang, Lingjie Li, Ping He, Ping Ji, Sheng Yang
Summary: A new dual-targeting nanocarrier, CH6-PAMAM-C11, was synthesized by covalently modifying G4.0 PAMAM dendrimer with C11 peptide and CH6 aptamer, showing successful accumulation in bone cells, mineralized areas, and tissues. Both in vitro and in vivo experiments confirmed the efficient bone targeting ability of CH6-PAMAM-C11, suggesting potential for drug delivery to bone tissues for osteoporosis treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Fang Zhang, Kai Cheng, Zhuo-Yao Huang, Xiao-Lin Hou, Xiao-Shuai Zhang, Zi-Tao Zhong, Yong-Guo Hu, Xiao-Ling Lei, Yong Li, Pei-Jie Zhang, Yuan-Di Zhao, Qiu-Ran Xu
Summary: A novel nanocarrier, VC@Lipo, is designed to break the redox balance in tumor cells through embedded VOx nanozyme and photosensitizer Ce6 in liposomes. The nanocarrier, approximately 35 nm in size, can be degraded in the weakly acidic tumor microenvironment. The VOx nanozyme exhibits peroxidase-like activity, generating highly toxic hydroxyl radicals and O-1(2) through Fenton-like reaction and independent of light, while also depleting intracellular glutathione through redox reactions.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Nanoscience & Nanotechnology
Alexander Zheleznyak, Monica Shokeen, Samuel Achilefu
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2018)
Article
Biochemical Research Methods
Rebecca C. Gilson, Rui Tang, Krishna Sharmah Gautam, Dorota Grabowska, Samuel Achilefu
BIOCONJUGATE CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Cong-Lin Liu, Xian Zhang, Jing Liu, Yunzhe Wang, Galina K. Sukhova, Gregory R. Wojtkiewicz, Tianxiao Liu, Rui Tang, Samuel Achilefu, Matthias Nahrendorf, Peter Libby, Junli Guo, Jin-Ying Zhang, Guo-Ping Shi
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Rui Tang, Alexander Zheleznyak, Matthew Mixdorf, Anchal Ghai, Julie Prior, Kvar C. L. Black, Monica Shokeen, Nathan Reed, Pratim Biswas, Samuel Achilefu
Review
Chemistry, Multidisciplinary
Suman B. Mondal, Shaw-Wei D. Tsen, Samuel Achilefu
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Engineering, Biomedical
Jingyi Luan, Anushree Seth, Rohit Gupta, Zheyu Wang, Priya Rathi, Sisi Cao, Hamed Gholami Derami, Rui Tang, Baogang Xu, Samuel Achilefu, Jeremiah J. Morrissey, Srikanth Singamaneni
NATURE BIOMEDICAL ENGINEERING
(2020)
Article
Oncology
Kinan Alhallak, Jennifer Sun, Katherine Wasden, Nicole Guenthner, Julie O'Neal, Barbara Muz, Justin King, Daniel Kohnen, Ravi Vij, Samuel Achilefu, John F. DiPersio, Abdel Kareem Azab
Summary: This study developed nanoparticle-based bispecific T-cell engagers (nanoBiTEs) and nanoparticles targeting multiple cancer antigens (nanoMuTEs), overcoming the major limitations of current T-cell-based immunotherapy. These novel nanoparticles have a long half-life, enabling once-a-week administration while maintaining efficacy, with nanoMuTEs targeting multiple cancer antigens showing greater efficacy in myeloma cells.
Article
Chemistry, Physical
Megan S. Michie, Baogang Xu, Gail Sudlow, Luke E. Springer, Christine T. N. Pham, Samuel Achilefu
Summary: In this study, NIR dye-peptide conjugates were synthesized and it was found that a peptide-driven strategy can alter the aggregation states of molecular probes in aqueous solutions, leading to effective imaging of inflammatory arthritis joints. The results suggest that peptide plays a dominant role in controlling the photophysical properties of these bioconjugates.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Hematology
Sena Kim, Sora Lim, Boram Kim, Julie Ritchey, Kiran Vij, Julie Prior, Lynne Marsala, Alyssa Stoner, Feng Gao, Samuel Achilefu, Matthew L. Cooper, John F. DiPersio, Jaebok Choi
Summary: By blocking the IFNGR signaling pathway, S100A9 is upregulated in T cells and acts as a novel suppressor of graft-versus-host disease (GVHD) while preserving graft-versus-leukemia (GVL) effects. In both mouse models of allo-HSCT and xenogeneic human peripheral blood mononuclear cell transplantation, overexpression of S100A9 or administration of anti-IFNGR antibody improved GVHD without compromising GVL and reduced T-cell trafficking to GVHD target organs.
Article
Rheumatology
Shaw-Wei D. Tsen, Luke E. Springer, Krishna Sharmah Gautam, Rui Tang, Kexian Liang, Gail Sudlow, Amir Kucharski, Christine T. N. Pham, Samuel Achilefu
Summary: LS301 selectively accumulates in regions of joint pathology in mouse models of RA, with a positive correlation with disease severity. Whole-body near-infrared imaging with LS301 allows tracking of spontaneous disease remission and therapeutic response after dexamethasone treatment. Histological analysis shows preferential accumulation of LS301 within chondrocytes and articular cartilage in arthritic mice, with colocalization observed between LS301 and pANXA2 in joint tissue.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anchal Ghai, Alexander Zheleznyak, Matt Mixdorf, Julie O'Neal, Julie Ritchey, Michael Rettig, John DiPersio, Monica Shokeen, Samuel Achilefu
Summary: This study demonstrates the feasibility of [Zr-89]DFO-elotuzumab as a companion diagnostic for CS1-targeted therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Chemistry, Multidisciplinary
Daniel D. Lane, Kvar C. L. Black, Ramesh Raliya, Nathan Reed, Nalinikanth Kotagiri, Rebecca Gilson, Rui Tang, Pratim Biswas, Samuel Achilefu
Article
Chemistry, Multidisciplinary
Rebecca C. Gilson, Kvar C. L. Black, Daniel D. Lane, Samuel Achilefu
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Oncology
Suman B. Mondal, Shengkui Gao, Nan Zhu, LeMoyne Habimana-Griffin, Walter J. Akers, Rongguang Liang, Viktor Gruev, Julie Margenthaler, Samuel Achilefu
ANNALS OF SURGICAL ONCOLOGY
(2017)
Article
Surgery
Victor Bong-Hang Shyu, Chung En Hsu, Chih-Jen Wen, Tze-Chein Wun, Rui Tang, Samuel Achilefu, Fu-Chan Wei, Hui-Yun Cheng
ANNALS OF PLASTIC SURGERY
(2017)
Article
Polymer Science
Paige A. Shaw, Maxime Klausen, Mark Bradley
Summary: A light-responsive polymer capable of controlled release of camptothecin and generation of reactive oxygen species (ROS) was developed, which exhibited high cancer cell killing activity through both camptothecin release and ROS generation.
Article
Polymer Science
Donghui Zhang, Shiqi Liu, Zhihao Cai, Weizhe Luo, Guojian Liu, Runhui Liu
Summary: A straightforward and efficient method for synthesizing NPC monomers has been developed in this study, which enhances the availability of NPC monomers and facilitates the synthesis of polypeptides.