Article
Endocrinology & Metabolism
Jin Ook Chung, Seon-Young Park, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Summary: The study explores the relationship between plasma LRG1 level and urinary albumin excretion in patients with type 2 diabetes. The results show that there is a positive correlation between plasma LRG1 level and urinary albumin excretion, indicating that LRG1 may be associated with increased excretion of urinary albumin in the early stages of diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Eugene Han, Mi Kyung Kim, Byoung Kuk Jang, Hye Soon Kim
Summary: This study in Korean patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease found that hepatic steatosis burden is associated with albuminuria, with a higher prevalence of albuminuria in patients with significant steatosis.
DIABETES & METABOLISM JOURNAL
(2021)
Article
Urology & Nephrology
Juan Chen, Lingfeng Peng, Jian Sun, Jishi Liu, Ling Chu, Bin Yi, Ming Gui, Hao Zhang, Juan Tang
Summary: The study found that Lyn levels are closely correlated with urinary albumin, renal tubular damage, and inflammatory responses in type 2 diabetes patients, making it a strong candidate for predicting albuminuria levels.
Article
Endocrinology & Metabolism
Shuo Zhao, Ming-Li Liu, Bing Huang, Fu-Rong Zhao, Ying Li, Xue-Ting Cui, Rong Lin
Summary: This study found that elevated levels of short-chain acylcarnitine C2 were associated with increased risk of cardiovascular disease in patients with type 2 diabetes mellitus and this association remained significant even after adjusting for potential confounders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Julie Semenchuk, Katie Sullivan, Rahim Moineddin, Farid Mahmud, Allison Dart, Brandy Wicklow, Fengxia Xiao, Thalia Medeiros, James Scholey, Dylan Burger
Summary: The study found that interleukin-9 (IL-9) is associated with podocyte injury in early type 1 diabetes, and there are complex interactions between urinary IL-9, inflammatory cytokines, and ACR (urinary albumin/creatinine ratio, a measure of podocyte injury).
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Katie M. Sullivan, James Scholey, Rahim Moineddin, Etienne Sochett, Brandy Wicklow, Yesmino Elia, Feng Xiao, Thalia Mederios, Pusha Sadi, Dylan Burger, Farid H. Mahmud, Alison B. Dart
Summary: The study found significant associations between podocyte MPE, blood glucose levels and eGFR in youth with type 1 diabetes, but not in those with type 2 diabetes, despite increased renal pathology in the type 2 diabetes cohort.
Article
Endocrinology & Metabolism
Caifeng Shi, Aiqin He, Xiaomei Wu, Lulu Wang, Xueting Zhu, Lei Jiang, Junwei Yang, Yang Zhou
Summary: The urinary levels of IL-18 appear to be associated with greater pulse wave velocity (PWV) in patients with T2D, indicating a link between urinary IL-18 and arterial stiffness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Wei-Hua Tang, Wei-Chin Hung, Chao-Ping Wang, Cheng-Ching Wu, Chin-Feng Hsuan, Teng-Hung Yu, Chia-Chang Hsu, Ya-Ai Cheng, Fu-Mei Chung, Yau-Jiunn Lee, Yung-Chuan Lu
Summary: This study demonstrates that a higher normal urine albumin/creatinine ratio (UACR) is associated with an increased risk of developing chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaoyang Lou, Zhi Yang, Kexia Wu, Weihong Li, Wan Hu, Ronghui Nie, Ping Tu, Peng Duan
Summary: This study aimed to analyze the correlation between serum osteoprotegerin (OPG) level and chronic kidney disease (CKD) in patients with type 2 diabetes. The results showed a negative correlation between serum OPG level and albuminuria and CKD progression risk. The study suggests that increasing OPG levels may delay the progression of CKD.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Tsung-Hui Wu, Li-Hsin Chang, Chia-Huei Chu, Chii-Min Hwu, Harn-Shen Chen, Liang-Yu Lin
Summary: This study investigates the prognostic value of sTNFR2 in patients with type 2 diabetes and early nephropathy. The results suggest that serum sTNFR2 levels are strongly associated with the risk of renal function decline and progressive changes in albuminuria.
Article
Endocrinology & Metabolism
Shanshan Chen, Shuo Li, Xinxin Zhang, Yuxin Fan, Ming Liu
Summary: In this cross-sectional study, higher levels of dehydroepiandrosterone were significantly associated with a lower risk of dyslipidemia in adult men with type 2 diabetes mellitus. However, rising levels of dehydroepiandrosterone sulfate, androstenedione, and total testosterone showed no significant correlations with the risk of dyslipidemia in male patients with T2DM. Further prospective research is needed to confirm the role of dehydroepiandrosterone in the development of dyslipidemia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Aziz Sener, Selin Yildiz, Gulce Kiren, Canan Topcuoglu
Summary: New inflammatory markers are useful in assessing albuminuria in T2DM patients, but not in assessing glycemic control.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Endocrinology & Metabolism
Jens Christian Laursen, Hatice Isik Mizrak, Huda Kufaishi, Sofie Korsgaard Hecquet, Elisabeth Buur Stougaard, Ninna Hahn Tougaard, Marie Frimodt-Moller, Tine Willum Hansen, Christian Stevns Hansen, Peter Rossing
Summary: The study found that hypoxemia is associated with increased prevalence of albuminuria, retinopathy, and neuropathy in type 1 diabetes, but not with cardiovascular disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Dominik Pesta, Tomas Jelenik, Oana-Patricia Zaharia, Pavel Bobrov, Sven Gorgens, Kalman Bodis, Yanislava Karusheva, Nina Krako Jakovljevic, Nebojsa M. Lalic, Daniel F. Markgraf, Volker Burkart, Karsten Mussig, Birgit Knebel, Jorg Kotzka, Jurgen Eckel, Klaus Strassburger, Julia Szendroedi, Michael Roden
Summary: The rs540467 SNP in the NDUFB6 gene is associated with adaptations to exercise training, with a notable impact on individuals with diabetes, particularly those with type 2 diabetes. Additionally, increasing physical activity levels may not always lead to improved insulin sensitivity in diabetes patients, where the polymorphism of the NDUFB6 gene could be a crucial factor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Urology & Nephrology
Yu-Lun Ou, Mei-Yueh Lee, I-Ting Lin, Wei-Lun Wen, Wei-Hao Hsu, Szu-Chia Chen
Summary: This study found significant associations between various obesity-related indices and albuminuria as well as advanced kidney disease in patients with type 2 diabetes mellitus. Screening for these indices may be important for public health programs to prevent complications related to kidney disease.