Article
Chemistry, Physical
Yu-Xi Wang, Yang Li, Shi-Hui Qiao, Jing Kang, Zhi-Li Shen, Ning-Ning Zhang, Zesheng An, Xiaosong Wang, Kun Liu
Summary: A staged-thermal-initiation RAFT polymerization method is reported for the synthesis of polymers with high thiol end-group fidelity, which show high efficiencies for grafting to various gold nanoparticles (GNPs). Experimental proof shows that the decrease of end-group fidelity with molecular weight is caused by the gradual decomposition of the initiator. The positive correlation between end-group fidelity of polymers and grafting-to efficiency is illustrated through grafting-to assays for various GNPs.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Polymer Science
Simeng Liu, Guoqiang Han, Mengmeng Zhang, Bijin Xiong, Jiangping Xu, Jintao Zhu
Summary: Grafting polymer ligands onto gold nanoparticles through gold-sulfur bonds is a common and easy way to produce gold-polymer hybrid nanoparticles. The bonding effects of sulfur-containing end groups on gold nanoparticles were investigated, and it was found that weak bonding between thiolactone-terminated polymers and gold nanoparticles resulted in unstable conjugates. By optimizing the assembly parameters, a superlattice film of gold-polymer conjugates could be constructed.
Article
Polymer Science
Erika Yoshihara, Ahmed Nabil, Shinichi Mochizuki, Michihiro Iijima, Mitsuhiro Ebara
Summary: Temperature-responsive antibody-nanoparticles were prepared by introducing a chain transfer agent into immunoglobulin G and conducting precipitation polymerization of N-isopropylacrylamide in an aqueous medium. The resulting particles showed stability below the LCST and resistance against enzymatic treatment, making them useful for enhancing therapeutic potential of antibody-drug conjugates or immunoassays.
Article
Nanoscience & Nanotechnology
Yen Theng Cheng, Qingbo Xia, Hongwei Liu, Marcello B. Solomon, Emma R. L. Brisson, Lewis D. Blackman, Chris D. Ling, Markus Mullner
Summary: We successfully demonstrated the synthesis of mesoporous carbon-coated anatase nanostructures using a modular approach. Through the combination of polymerization-induced self-assembly (PISA) and reversible addition-fragmentation chain-transfer (RAFT) dispersion polymerization, we fabricated uniform core-shell polymeric nanoreactors with tunable morphologies. The resulting TiO2/C materials possessed a porous structure with large specific surface areas (>85 m2/g) and various carbon contents (20-30 wt %). As anode components in lithium-ion batteries, these TiO2/C nanomaterials showed improved cycling stability, facilitated high overall capacities, and minimized capacity loss compared to their sans carbon counterparts and commercial anatase analogues.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Chemical
Zahra Nadizadeh, Hossein Mahdavi
Summary: In this research, a method was developed to stabilize RAFT initiators on the surface of polyamide NF membranes, followed by successful grafting of a zwitterionic polymer pMEDSAH to reduce irreversible protein adsorption. The prepared grafting membranes showed promising potential for practical applications.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Polymer Science
Gayathri Dev Ammini, Jordan P. P. Hooker, Joren Van Herck, Anil Kumar, Tanja Junkers
Summary: Continuous flow chemistry provides great operational flexibility for photochemical transformations. By using automated inline NMR monitoring with a variable DC power supply and precise control over light intensities, we conducted detailed kinetic investigations of PI-RAFT polymerizations. Our results showed increasing conversion with increasing light intensity until a saturation limit was reached, accompanied by an increase in residual polymer dispersity. However, when appropriate intensities were chosen, the reactions remained living. Additionally, quantitative study of the influence of the RAFT R-group emphasized the importance of selecting the right RAFT agent for photoRAFT polymerization.
Article
Polymer Science
Aaron Priester, Jimmy Yeng, Yuwei Zhang, Risheng Wang, Anthony J. Convertine
Summary: Polymer-Induced Self Assembly (PISA) is a technique that utilizes a macro chain transfer agent (macro-CTA) to induce phase separation during block copolymer formation, resulting in the in situ generation of nanostructures. This study focuses on developing a PISA resin for 3D printing using a difunctional macro-CTA, with the aim of maintaining the shape of printed parts without the need for a crosslinker through physical crosslinks between difunctional macro-CTAs.
Article
Chemistry, Analytical
Qiong Hu, Luofeng Su, Yanyu Huang, Zhuohua Chen, Xiaojing Cao, Yilin Luo, Dongdong Qin, Li Niu
Summary: An ultrasensitive peptide nucleic acid (PNA)-based electrochemical DNA biosensor was reported using coenzyme-mediated electro-grafting of polymers for signal amplification, showing great promise in sequence-specific detection of DNA targets at ultralow concentrations.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Polymer Science
Wangmeng Hou, Zheqi Li, Lu Xu, Yuanchao Li, Yi Shi, Yongming Chen
Summary: The study successfully synthesized well-defined Janus molecular bottlebrushes with high yield using a reversible polymerization technique and a PISA-assisted grafting-from strategy. The approach effectively suppressed radical coupling reactions and achieved the preparation of molecular bottlebrushes at high monomer conversion rates.
Article
Polymer Science
Rambabu Koyilapu, Suchismita Subhadarshini, Shuvra Singha, Tushar Jana
Summary: In this study, in-situ RAFT polymerization of poly(N-vinylimidazole) (PNVI) was successfully carried out in the intergalleries of Cloisite nanoclay to synthesize PNVI of different molecular weights. The PNVI modified clays were used to prepare nanocomposite membranes, with the results showing that the clay containing high molecular weight PNVI demonstrated the most effective enhancement of membrane properties.
Article
Polymer Science
Matthew F. I. Rix, Kyle Collins, Samuel J. Higgs, Eleanor M. Dodd, Simon J. Coles, Nathaniel M. Bingham, Peter J. Roth
Summary: This study demonstrates the various reactions of thionolactone DBT and its ability to introduce a degradable backbone. Additionally, through XRD structure analysis and DFT modeling, the higher reactivity of DBT is explained by its stabilization of the intermediate radical, increased ring strain, and better reinitiating efficiency.
Article
Biochemistry & Molecular Biology
Anastasija D. Jablanovic, Marianna Z. Bekanova, Ekaterina A. Litmanovich, Oleg N. Karpov, Miron A. Bugakov, George A. Shandryuk, Alexander A. Ezhov, Raisa Talroze, Elena Chernikova
Summary: Nanocomposites based on CdSe or CdSe/ZnS quantum dots and PMMA of different molecular weights were synthesized by ligand exchange with RAFT-based PMMA. Comparative study of mono- and telechelics of PMMA revealed telechelics exhibited higher efficiency in forming complexes with quantum dots.
Article
Biophysics
Qiong Hu, Luofeng Su, Yan Mao, Shiyu Gan, Yu Bao, Dongdong Qin, Wei Wang, Yuwei Zhang, Li Niu
Summary: A novel electrochemical sensor is presented for highly specific interrogation of MMP activities at ultralow levels. The sensor is highly selective with a detection limit as low as 0.27 pg mL(-1) and a linear range from 1 pg mL(-1) to 1 ng mL(-1). Its applicability in complex serum samples and screening of MMP inhibitors is satisfactory, showing great promise in drug discovery and disease diagnosis.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Materials Science, Multidisciplinary
Sikai Chen, Qing-Yang Feng, Dong Li, Fei Song, Xiu-Li Wang, Yu-Zhong Wang
Summary: This investigation examines the relationship between the structure and properties of surface-grafted cellulose nanofiber (CNF)-based one-component composites. Key parameters, such as graft density, graft chain length, and interface structure, were systematically adjusted. Increasing the graft density and hydrophobic modification of the CNF surface improved thermal stability. Shorter graft chain length increased the T(g) of the graft chain while hydrophobic modification and longer graft chain length decreased stiffness. Decreasing graft density remarkably enhanced toughness and strength. The interfacial interaction between CNF and grafted polymer played a crucial role in determining the composites' properties, along with graft density.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qingyu Liao, Dong Chen, Xianhong Zhang, Yuhong Ma, Changwen Zhao, Wantai Yang
Summary: A facile synthetic route was developed to prepare a surface-grafted brush layer of poly(vinyl ethers) directly by a radical mechanism, with naked Li+ acting as a catalyst. The grafted polymer layers showed excellent hydrolysis resistance and provided active sites for efficient fixation of bioactive molecules.
Article
Engineering, Biomedical
Halimatu S. Mohammed, Brittany L. Snyder, Damien S. K. Samways, Devon A. Shipp
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2016)
Article
Polymer Science
Farbod Alimohammadi, Chen Wang, Olivia Z. Durham, Hannah R. Norton, Christopher N. Bowman, Devon A. Shipp
Article
Polymer Science
Melodie I. Lawton, Kelly R. Tillman, Halimatu S. Mohammed, Wenbin Kuang, Devon A. Shipp, Patrick T. Mather
Article
Polymer Science
Drazen Pavlovic, Qin Lou, Jeffrey G. Linhardt, Jay F. Kuenzler, Devon A. Shipp
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
(2017)
Article
Engineering, Chemical
Kyle J. Cassidy, Olivia Z. Durham, Devon A. Shipp
MACROMOLECULAR REACTION ENGINEERING
(2019)
Article
Chemistry, Multidisciplinary
Lina Bian, Halimatu S. Mohammed, Devon A. Shipp, Paul J. G. Goulet
Article
Biochemistry & Molecular Biology
Brittany L. Snyder, Halimatu S. Mohammed, Damien S. K. Samways, Devon A. Shipp
MACROMOLECULAR BIOSCIENCE
(2020)
Review
Polymer Science
Olivia Z. Durham, Devon A. Shipp
Summary: Thiol-X polymerizations have been widely used in the production of polymer colloidal particles, offering high yields, rapid synthesis, and compatibility with various monomer species. These reactions have been applied in heterogeneous polymerizations using different methods, showcasing their adaptability and practicality. The step-growth mechanism in thiol-X polymerizations allows for straightforward polymer functionalization and the examples provided demonstrate their potential in creating new technologies.
Article
Immunology
Travis Shute, Eyal Amiel, Noran Alam, Jennifer L. Yates, Katya Mohrs, Elizabeth Dudley, Briana Salas, Chloe Mesa, Adriana Serrata, Daniel Angel, Brandy K. Vincent, Amanda Weyers, Paula A. Lanthier, Emilie Vomhof-Dekrey, Rachel Fromme, Mitchell Laughlin, Olivia Durham, Jianjun Miao, Devon Shipp, Robert J. Linhardt, Kelly Nash, Elizabeth A. Leadbetter
Summary: CD4(+) T cells play a crucial role in facilitating B cell immune protection provided by vaccines, while iNKT cells have been identified as an alternative source of help for B cells in mice. Nanoparticles containing alpha GC and S. pneumoniae polysaccharides activate murine iNKT cells and B cells, inducing robust immune responses and protection against deadly pathogens. However, the potential of these nanoparticles to eliminate B cells under certain conditions suggests the need for further clarification on iNKT cell interactions with B cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qingkai Qi, Gaganjot Sekhon, Richard Chandradat, Nnamdi M. Ofodum, Tianruo Shen, Jan Scrimgeour, Monu Joy, Mario Wriedt, Madhuri Jayathirtha, Costel C. Darie, Devon A. Shipp, Xiaogang Liu, Xiaocun Lu
Summary: A near-infrared mechanophore was incorporated into a polymeric chain to demonstrate force-induced NIR chromism. The mechanophore exhibited NIR mechanochromism in solution, thin-film, and bulk states, with potential applications in mechanical force sensing, damage detection, bioimaging, and biomechanics.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Polymer Science
Ishah H. Alshehri, David Pahovnik, Ema Zagar, Devon A. Shipp
Summary: Gradient copolymers of n-butyl acrylate (nBA) and isobornyl acrylate (IBA) were prepared using reversible addition-fragmentation chain transfer (RAFT) emulsion polymerization. The stepwise monomer addition process allowed for pre-specified gradient compositions to be obtained. H-1 NMR characterization revealed the gradient behavior of the copolymers. Differential scanning calorimetry analysis showed that gradient copolymers had broader glass-transition regions compared to homopolymers and statistical copolymers. The thermal properties of the copolymers can be controlled by the choice of comonomer feed composition and the steepness of the comonomer feed.
Article
Polymer Science
Kyle J. Cassidy, Devon A. Shipp
Summary: This study investigates the impact of various experimental parameters on particle nucleation and growth in radical-mediated thiol-ene polymerizations conducted under typical emulsion polymerization conditions. Four pairs of thiol-ene monomers were used to study the effect of composition on nucleation loci. Kinetic studies were carried out to understand the changes in monomer conversion, molecular weight, and particle size throughout the reaction. The study also discusses the nucleation mechanisms of polymer colloids and how the structure of monomers/polymer influences nucleation processes.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Polymer Science
Arielle L. Santefort, Philip A. Yuya, Devon A. Shipp
Summary: The dynamic covalent exchange of anhydride moieties in highly crosslinked poly(methacrylic anhydride) (PMAA) was investigated through recycling processes. The formation of cyclic anhydrides was observed and confirmed using IR spectroscopy. Computational analysis showed that cyclic anhydrides have higher strain than acyclic anhydrides. The observed cyclization explains the changes in material properties of PMAA.
Article
Polymer Science
Kelly R. Tillman, Rebecca Meacham, Anne N. Rolsma, Mikenzie Barankovich, Ana M. Witkowski, Patrick T. Mather, Tyler Graf, Devon A. Shipp
Article
Chemistry, Multidisciplinary
Olivia Z. Durham, Katie L. Poetz, Devon A. Shipp
AUSTRALIAN JOURNAL OF CHEMISTRY
(2017)
