Article
Polymer Science
Yanping Li, Ke Pan, Yougen Chen
Summary: A new type of degradable poly(beta-trimethylsilyloxy ester) was synthesized by the organocatalyzed Mukaiyama aldol polyaddition. These polyesters showed degradation behavior in the presence of nucleophiles, and the degradation mechanism was influenced by the nature of the catalyst used.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Sajid Iqbal, Alessandro F. Martins, Muhammad Sohail, Jingjing Zhao, Qi Deng, Muhan Li, Zhongxi Zhao
Summary: This study synthesized and characterized poly (beta-amino ester) (P beta AE-447) and evaluated its properties and transfection efficiency as a nanocarrier. The results showed that P beta AE-447 performed better than the commonly used PEI in terms of cell transfection, suggesting its potential for gene delivery.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Azalea Uva, Angela Lin, Helen Tran
Summary: In this study, biodegradable and biobased poly(azomethine)s were synthesized using carotenoid and p-phenylenediamine-based monomers, and solubility was tuned by varying the side chain lengths. The maximum solubilities were quantitatively determined by UV-vis absorption spectroscopy. Acid hydrolysis and artificial sunlight were found to accelerate the degradation of the polymer and generate additional degradation products. Carotenoid monomers are shown to be viable candidates for the design of biobased, degradable, and conjugated polymers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Nanoscience & Nanotechnology
Jiahao Shi, Yuhe Zhang, Bin Ma, Haiyang Yong, Delu Che, Chaolan Pan, Wei He, Dezhong Zhou, Ming Li
Summary: A modular strategy was developed to manipulate the amphiphilicity of PAE/DNA polyplexes by synthesizing hydrophobic and hydrophilic modules and changing their ratio. Using this strategy, the polyplexes with the highest gene transfection efficiency and safety profile were identified.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Guangpu Liu, Hui Jiao, Kaiming Wang, Ping Chang, Yang Jiao
Summary: This study aimed to combine active targeting and pH-responsive drug delivery in cancer therapy using a potential cancer-targeted carrier. The carrier, PEG-PAE-DOMC-FA, showed pH sensitivity and folate-receptor-mediated endocytosis. It successfully loaded and delivered the hydrophobic drug, riccardin D, to tumors, exhibiting improved pharmacokinetics, antitumor efficacy, and reduced toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Nuria Puigmal, Victor Ramos, Natalie Artzi, Salvador Borros
Summary: Nucleic acid vaccines are important in combating emerging infectious diseases and cancer. Delivery of these vaccines via the transdermal route has the potential to enhance their efficacy due to the presence of immune cells in the skin. Researchers have developed a new library of transfection vectors that can specifically target antigen presenting cells in the skin. These vectors have demonstrated high transfection efficiency and the ability to mediate gene transfer when applied to transdermal devices. The use of these efficient vectors derived from PBAEs has the potential to advance nucleic acid vaccination in clinical settings.
Article
Pharmacology & Pharmacy
Jinfeng Xiong, Guannan Li, Xinyu Mei, Jiahui Ding, Hui Shen, Da Zhu, Hui Wang
Summary: Restoring p53 expression and inactivating HPV oncoproteins are crucial for blocking the development of cervical cancer. Our study successfully restored p53 expression and inactivated HPV using nano drugs based on nucleic acid delivery, providing potential applications in the treatment of CIN and cervical cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Polymer Science
Shengtong Guo, Yun Zhu, Qiyong Mei, Guiyou Wang
Summary: The bio-based polyurethane material (PPTR-PU) was successfully prepared by reacting bio-based 1,3-propanediol and 3,6,9-trioxaundecanedioic acid with 1,6-hexamethylene diisocyanate. The PPTR-PU film exhibited high tensile strength and toughness, and it underwent rapid degradation in the presence of HCl and NaOH. Porcine pancreatic lipase accelerated the enzymatic degradation of the film. Measurements revealed that the degradation of PPTR-PU occurred through the hydrolysis of ester groups, resulting in decreased molecular weights and increased hydrogen bonding.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Medicine, Research & Experimental
Yao Jin, Friederike Adams, Lorenz Isert, Domizia Baldassi, Olivia M. Merkel
Summary: This study synthesized new poly(beta-amino ester) polymers, P(BSpBAE) and P(SpBAE), for siRNA delivery. Compared to commonly used PEI polymers, these two polymers showed higher cellular uptake and better release efficiency. The results suggest that these polymers have potential applications in therapeutic siRNA delivery.
MOLECULAR PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Kelley Wiegman, Nicolas J. Briot, J. Zach Hilt, Aron J. Huckaba, Thomas D. Dziubla
Summary: Polymeric prodrugs, such as poly(beta amino esters) (P beta AEs), linking active pharmaceutical ingredients to a polymeric form, have shown great potential in controlled drug delivery. In this study, an antioxidant-P beta AE polymer prodrug that is soluble in organic solutions was synthesized to enhance the processability of the polymer. Curcumin P beta AEs were further processed into nanoparticles and thin films, with control over size and thickness. The processing of the polymer had a significant impact on the release profiles of curcumin, indicating the potential of tuning degradation through polymer processing.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Yitong Zhao, Tao Bo, Chenfei Wang, Dingjin Yao, Chaolan Pan, Weiyi Xu, Hao Zhou, Ming Li, Si Zhang
Summary: This study presents the development of highly branched-linear poly(beta-amino ester)s (H-LPAEs) through a unique oligomer branching strategy for efficient gene transfection. The optimized H-LPAEs show superior gene transfection efficiency compared to the leading commercial gene transfection reagent, Lipofectamine 3000. The H-LPAE(B4-S5-TMPTA) mediated cell apoptosis and inhibited tumor growth, highlighting its potential application in cancer gene therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Parisa Heydari, Jaleh Varshosaz, Mahshid Kharaziha, Shaghayegh Haghjooy Javanmard
Summary: During the study, a biodegradable pH-sensitive and antibacterial hydrogel was synthesized for soft tissue engineering. The Poly-L-ArgMA/P beta AE1.5 sample showed a 1.5-fold increase in swelling ratio under acidic conditions. In addition, different mechanical properties and controllable degradation rate were achieved based on the ratio of P beta AE monomers. The Poly-L-ArgMA/P beta AE1.5 sample also exhibited enhanced antibacterial activities against Escherichia coli and Staphylococcus aureus.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Zheng Li, Yong Shen, Zhibo Li
Summary: Chemical recycling of plastic wastes to convert into value-added products is an attractive strategy to reduce fossil fuel consumption and plastic pollution. This study demonstrates the upcycling of P3HB into valuable monomers and subsequent polymerization to produce degradable and recyclable polymers. The synthesized monomers undergo ring-opening polymerization catalyzed by Sn(Oct)(2) to form amorphous materials, which can be depolymerized back to monomers for closed-loop recycling.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Lesly Dasilva Wandji Djouonkep, Alain Pierre Tchameni, Naomie Beolle Songwe Selabi, Arnaud Kamdem Tamo, Ingo Doench, Zhengzai Cheng, Mario Gauthier, Binqiang Xie, Anayancy Osorio-Madrazo
Summary: Vanillin, a promising aromatic aldehyde, can be used in the design of novel sustainable polymeric materials. A series of poly(ether-ester)s were synthesized using vanillin-derived monomers, showing high molecular weights, semi-crystallinity, excellent thermal and mechanical properties, and good biodegradability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Muhammad Sadeqi Nezhad
Summary: Therapeutic nucleic acids are a promising therapy for treating diseases, but they require a vector for effective and safe delivery to target cells. Synthetic nanoparticle vector PBAE shows great potential for in vivo gene delivery due to its excellent transfection performance and biodegradability.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Polymer Science
Yuanzhang Jiang, Xuyi Wang, Yanting Han, Dakai Gong, Yingchun Gu, Lin Tan
Summary: In this study, FeCl3 and poly(acrylic acid) (PAA) were doped into waterborne polyurethanes (WPUs) to create multifunctional materials with self-healing and antimicrobial properties. WPU/Fe/PAA-5.5, containing 5.5 wt % PAA, exhibited excellent mechanical properties, strong self-healing capabilities, and an impressive antimicrobial rate of over 90%. These supramolecular films were also highly recyclable through hot-pressing.
Article
Polymer Science
Longyu Tian, Min Wang, Guangming Liao, Baoliang Liu, Sujuan Zhang, Yucheng Sun, Zhen Meng, Jintao Zhang, Zaijun Lu
Summary: Two kinds of benzoxazine monomers were synthesized and used to prepare polybenzoxazine anion exchange membranes (AEMs) with quaternary ammonium functionalization. The LQPBZ AEM exhibited better ion conductivity and alkaline stability.
Article
Polymer Science
Claire A. Lemarchand
Summary: This study investigates the shock behavior of three different polymers through molecular dynamics simulations. The results reveal specificities in the shock behavior of polymers, including deviations from the linear relation between shock velocity and particle velocity, as well as differences in shear stress relaxation behind the shock front. It is found that the deviation of the Hugoniot locus is related to the change in the relative contribution of bonding and non-bonding potential energies, while polymers with higher glass transition temperatures exhibit slower shear stress relaxation.
Article
Polymer Science
Zengquan Liu, Xiaochun Yin, He Zhang, Shuo Gao, Qinglin Kuang, Yanhong Feng
Summary: A powder solid-state extension (PSSE) technology was proposed to address the high melt viscosity issue of UHMWPE. By uniaxial extension and sintering in the solid state, a highly self-reinforced material was prepared. X-ray diffraction and scattering techniques were used to study the structural evolution during the PSSE process, and a solid-phase induced transformation model was established.
Article
Polymer Science
Zhike Li, Anyu Luo, Rui Zhou, Xin Li, Haiyan Li
Summary: A novel high temperature resistance IL@SiO2 nanocapsules were successfully prepared and their friction and wear properties in PA6 composites were studied. The addition of IL@SiO2 nanocapsules reduced the friction coefficient and wear rate without affecting the mechanical properties of PA6. The synergy between the IL core and SiO2 wall in the nanocapsules improved the self-lubricating performance of the PA6 composites.
Article
Polymer Science
Xin Liu, Xuhong Guo, Qi Liao
Summary: In this study, an algorithm for accurately estimating viscosity is developed using molecular dynamics simulations and the Green-Kubo formula. This algorithm can be applied to complex systems with long correlations, such as macromolecular and biological simulation systems.
Article
Polymer Science
Hao Pu, Yun-Lei Hou, Jing -Zhou Chen, Dong -Lin Zhao
Summary: The use of modified graphene improves the interfacial adherence of carbon fibers to epoxy resin, resulting in enhanced interfacial and bending properties of CF and matrix in CF/EP composites, as well as increased interlaminar shear strength and flexural strength.
Article
Polymer Science
Wei-Chung Ke, Jin-Wei Lin, Manohar Reddy Busireddy, Yueh-Hsing Lee, Jiun-Tai Chen, Chain-Shu Hsu
Summary: This study introduces a crosslinkable monomer, TAIC, to synthesize three crosslinked polyimide films, which exhibit improved thermal, mechanical, and dielectric properties. The introduction of TAIC enhances the tensile strength, reduces the dielectric constant and dielectric loss, and decreases the coefficient of thermal expansion of the polyimide films.
Article
Polymer Science
Alex Kwasi Kumi, Ruiling Fan, Ye Chen, Yumei Zhang
Summary: The difference in leaching of amylopectin from cellulose/amylopectin/1-butyl-3-methylimidazolium chloride ([Bmim][Cl]) blends during regeneration in water and aqueous ethanol has been studied. Molecular dynamics simulations showed that the dissolution and regeneration mechanisms of amylopectin in [Bmim][Cl] are similar to cellulose in ionic liquids. Water regeneration leads to weak electrostatic interactions, resulting in high leaching of amylopectin. In contrast, ethanol-water interactions enhance electrostatic interactions among amylopectin chains, limiting amylopectin leaching in aqueous ethanol.
Article
Polymer Science
Xi Zeng, Junwei Zhou, Junbiao Peng, Chunsheng Zhang, Danling Wang, Yihu Song, Qiang Zheng
Summary: This study utilizes an oligomer deep eutectic solvent (DES) based on polyethylene glycol to regulate the vulcanization kinetics of rubber. The results show that the DES can accelerate vulcanization at low temperatures without affecting the crosslinking density and Mullins effect.
Article
Polymer Science
Qianqian Yue, Yongfei Peng, Xingjian Liu, Aihua He, Huarong Nie
Summary: The addition of metal deactivators can effectively suppress the aging of TBIR, prolong its lifespan, and have no negative effects on its physical and processing properties. These research findings are of great importance for improving the stability and aging resistance of polymers.
Article
Polymer Science
J. Gomez-Caturla, J. Ivorra-Martinez, R. Tejada-Oliveros, V Moreno, D. Garcia-Garcia, R. Balart
Summary: This work focuses on the development of environmentally friendly PLA formulations by using different esters derived from geraniol as plasticizers. The results show that these esters have good compatibility with PLA, and they can effectively enhance the elongation and plasticity of PLA, reduce its glass transition temperature, and slightly improve its water absorption capabilities.
Article
Polymer Science
Dandan Li, Zhaohui Lu, Zhao Ke, Ke Xu, Fengna Dai, Youhai Yu, Guangtao Qian, Chunhai Chen
Summary: In this study, cross-linked PI aerogel membranes with low dielectric constant and high moisture resistance were prepared by co-polymerization and scraping coating technology. The incorporation of fluorinated blocks and benzimidazole ring structures resulted in novel PI aerogel membranes with fascinating dielectric properties and outstanding moisture resistance.
Article
Polymer Science
Zhaoyang Chu, Qing Zhang, Haihua Luo, Han Zhou, Fapei Zhang, Wei Chen, Wenhua Zhang
Summary: Multi-physical fields solution processing strategy is a universal and facile method for preparing various conjugated polymer films and high-performance devices. In this study, we employed a combined microfluidic flow and ultrasonication strategy (FU) for processing CP solutions, and found a pronounced synergetic effect in promoting the pre-ordering of chains in solution. The conformation order and anisotropy of the solution were revealed through various characterizations. A non-classical nucleation model for polymer crystallization in non-equilibrium solution processing was confirmed. The roles of microfluidic flow and ultrasonication in chain aggregation and crystallization were addressed through multi-physical simulations. Compared to pristine solutions, the FU strategy showed improved solution anisotropy and crystallization kinetics, resulting in higher crystallinity in films and increased mobilities in OFET devices. The FU processing strategy provides a universal approach for regulating chain conformation and aggregation in conjugated polymer solutions.