Article
Chemistry, Physical
David Tetour, Tomas Paska, Veronika Makova, Barbora Nikendey Holubova, Jana Karpiskova, Michal Rezanka, Jiri Brus, Jana Hodacova
Summary: Two hybrid organosilica materials containing bis-cinchonine-phthalazine bridging organic unit were synthesized and used as heterogenized ligands in catalysis of enantioselective Sharpless alkene dihydroxylation. The nanostructured material exhibited higher enantioselectivities than the bulk material and could be used at least five times without loss of enantioselectivity.
JOURNAL OF CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Mingxin Liu, Nguyen Le, Christopher Uyeda
Summary: Nickel catalysts promote nucleophilic cyclopropanation reactions using CH2Cl2 as a methylene source and Mn as a stoichiometric reductant. The substrate scope includes a broad range of alkenes bearing electron-withdrawing substituents, and enantioselective cyclopropanations have been developed using chiral PyBox ligands. Mechanistic studies suggest the intermediacy of a (PyBox)Ni=CH2 species and DFT models provide a rationale for the nucleophilic character of the nickel carbene and the sense of enantioinduction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Johannes Grosskopf, Thorsten Bach
Summary: Upon irradiation with a suitable chiral catalyst, racemic compounds can be converted into enantiopure compounds through a process called photochemical deracemization. This review comprehensively covers the research and current developments in this field, discussing the reactions and mechanistic details underlying the presented reaction. Photochemical deracemization offers a unique opportunity to directly obtain enantiopure compounds from racemates, and short-lived intermediates play a key role in determining the enantioselectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Miguel Sanchez-Fuente, Alberto Lopez-Magano, Alicia Moya, Ruben Mas-Balleste
Summary: Condensation of BINAPO-(PhCHO)(2) and 1,3,5-tris(4-aminophenyl)benzene(TAPB) leads to a new imine-based chiral organic material (COM) that can be post-functionalized through reductive transformation of imine linkers to amines. Although the imine-based material is not stable enough to be used as a heterogeneous catalyst, the reduced amine-linked framework can be efficiently utilized in asymmetric allylation of various aromatic aldehydes. The obtained yields and enantiomeric excesses are comparable to those observed for the molecular BINAP oxide catalyst, with the added advantage of recyclability offered by the amine-based material.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yuki Saito, Shu Kobayashi
Summary: The application of heterogeneous catalysts in continuous-flow enantioselective hydroacylation reactions was studied. Catalysts were prepared by mixing supports and rhodium complexes, and showed excellent activity and enantioselectivity. Under optimized conditions, the catalysts exhibited high turnover numbers and could be applied to various substrates. Furthermore, sequential-flow reactions with other heterogeneous catalysts were demonstrated for the synthesis of biologically active molecules and functional materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Guan-Wu Yin, Shi-Lu Wu, Jun-Hao Yan, Peng-Fei Zhang, Meng-Meng Yang, Li Li, Zheng Xu, Ke-Fang Yang, Li-Wen Xu
Summary: The method of heterogeneous catalysis achieved through swollen-induced in-situ encapsulation can immobilize homogeneous catalysts in cross-linked polymers, allowing for the reusability of inorganic catalysts and showing high potential for practical applications.
MOLECULAR CATALYSIS
(2021)
Article
Chemistry, Physical
Yue Cao, Yong Wu, Yuanteng Zhang, Jing Zhou, Wei Xiao, Dong Gu
Summary: Mesoporous cobalt oxide as a catalyst shows excellent performance in the synthesis of N-heterocycles, with high turnover numbers and easy recyclability for at least six times. Comparative studies reveal that the high surface area of the catalyst plays a crucial role in catalytic reactivity.
Article
Chemistry, Multidisciplinary
Soumyadeep Chakrabortty, Shasha Zheng, Fabian Kallmeier, Eszter Barath, Sergey Tin, Johannes G. de Vries
Summary: A readily available chiral Ru/bisphosphine catalyst was used to achieve the direct asymmetric reductive amination of bio-based levulinic acid (LA) to produce enantioenriched 5-methylpyrrolidinone with excellent enantioselectivity (up to 96% ee) and high isolated yield (up to 89%). Methyl levulinate (ML), a byproduct from the industrial production of 2,5-furandicarboxylic acid (FDCA), can be used as a substitute for LA with similar reactivity and selectivity. Mass spectrometry and isotope labelling studies suggest that the chiral lactam is formed through imine-enamine tautomerization/cyclization followed by asymmetric hydrogenation of the cyclic enamide.
Article
Chemistry, Physical
Junwen Wang, Jun Li, Yan Wang, Sisi He, Hengzhi You, Fen -Er Chen
Summary: In this study, a polymer-supported chiral heterogeneous copper catalyst was reported, which demonstrated high reactivity and enantioselectivity in asymmetric conjugate addition reactions.
Article
Chemistry, Multidisciplinary
Xiao Cai, Yong Liu, Guangjun Li, Weigang Hu, Xu Liu, Mingyang Chen, Weiping Ding, Yan Zhu
Summary: It has been shown that atomically precise metal clusters, such as Pd1Au8(PPh3)(8)(2+), can play a crucial role in the catalytic efficiency of the Suzuki-Miyaura cross-coupling process. The cooperative effect between the central Pd atom and the peripheral Au atoms in the Pd1Au8(PPh3)(8)(2+) cluster has been identified as a key factor in controlling the cross-coupling reaction. By incorporating these clusters into a porous resin, a heterogeneous catalyst called Pd1Au8@Resin has been developed, which demonstrates enhanced catalyst recyclability and continuous performance in the cross-coupling reaction.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Applied
Costanza Leonardi, Arianna Brandolese, Lorenzo Preti, Olga Bortolini, Eleonora Polo, Paolo Dambruoso, Daniele Ragno, Graziano Di Carmine, Alessandro Massi
Summary: This study presents a strategy for immobilizing chiral 2,3-bisaminocyclopropenium salt onto polystyrene and silica supports, and a procedure for converting it into cyclopropenimine superbase catalysts. The silica-supported cyclopropenimine showed superior stability and comparable efficiency in batch tests, and could be used as packing material for fixed-bed reactors. Continuous-flow experiments demonstrated satisfactory long-term stability and unaltered conversion efficiency and enantioselectivity.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Review
Chemistry, Multidisciplinary
Jia-Jun Jiang, Man-Kin Wong
Summary: This review summarizes the rapid development of asymmetric gold catalysis in the past ten years, focusing on newly developed gold-catalyzed enantioselective organic transformations and recent progress in ligand design since 2016, organized according to different types of chiral ligands for asymmetric gold(I) and gold(III) catalysis.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Yuzhu Ma, Kun Lan, Borui Xu, Li Xu, Linlin Duan, Mengli Liu, Liang Chen, Tiancong Zhao, Jun-Ye Zhang, Zirui Lv, Ahmed A. Elzatahry, Xiaomin Li, Dongyuan Zhao
Summary: A novel method for synthesizing streamlined mesoporous nanotadpoles has been reported in this study, which exhibit large inner cavities, high surface areas, and uniform mesopore sizes. By loading Fe3O4 into the nanoparticles, H2O2-driven mesoporous nanomotors with outstanding directionality and a diffusion coefficient of 8.15 μm(2) s(-1) can be designed.
Article
Chemistry, Physical
Zuyun Yin, Jie Liu, Jianing Zhang, Xuebing Ma
Summary: In this paper, a simple and direct strategy for covalently anchoring (S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl dioxide (BINAPO) to hollow mesoporous polystyrene nanospheres (HMPNs) is developed to fabricate HMPNs-supported BINAPO (HMPNs@BINAPO) via one-pot Friedel-Crafts alkylation. HMPNs@BINAPO possesses a nanoscale and spherical morphology with a thin and mesoporous shell suitable for fast mass transfer of reactants and products.
MOLECULAR CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Junjie Meng, Hui He, Qianru Liu, Hanhong Xu, Huicai Huang, Shao-Fei Ni, Zhaodong Li
Summary: A PdII-catalyzed domino enantioselective desymmetrizative coupling of 7-azabenzonorbornadienes with alkynylanilines is described, which generates valuable functionalized compounds with excellent enantio- and diastereo-selectivity. The method allows the construction of multiple covalent bonds and stereocenters in an efficient and atom-economical manner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Liliana P. T. Carneiro, Alexandra M. F. R. Pinto, Adelio Mendes, M. Goreti F. Sales
Summary: This study describes the development of an innovative electrochemical biosensor using a polymer-modified carbon fabric anode electrode and successfully prepares a molecularly imprinted polymer film capable of detecting carcinoembryonic antigen. This all-in-one device is simple to use, highly sensitive, and can be effectively applied in the fabrication of self-powered biosensors.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Helio M. T. Albuquerque, Raquel Nunes da Silva, Marisa Pereira, Andre Maia, Samuel Guieu, Ana Raquel Soares, Clementina M. M. Santos, Sandra Vieira, Artur M. S. Silva
Summary: Reversing protein aggregation within cells is crucial in fighting protein-misfolding disorders, and a new family of cholesterol-quinoline hybrids has been found to effectively inhibit and disaggregate protein aggregation.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Nutrition & Dietetics
Sonia Rocha, Natalia Aniceto, Rita C. Guedes, Helio M. T. Albuquerque, Vera L. M. Silva, Artur M. S. Silva, Maria Luisa Corvo, Eduarda Fernandes, Marisa Freitas
Summary: This study evaluated the inhibitory activity of a panel of 52 structurally related chromone derivatives against glycogen phosphorylase (GP). The results showed that several of the tested compounds exhibited potent inhibitory effects, with hydroxylations at specific positions being the determinants for the inhibitory activity. Molecular docking studies revealed hydrogen bonding patterns that favored the inhibitory effects. Interestingly, the most active compounds showed increased potency with higher glucose concentrations, potentially reducing the risk of hypoglycemia.
Article
Biochemistry & Molecular Biology
Joana L. C. Sousa, Helio M. T. Albuquerque, Armando J. D. Silvestre, Artur M. S. Silva
Summary: Betulinic acid was used as a starting material to synthesize a library of novel BA-derived compounds containing O- and N-heterocycles. Remarkably, the triterpene acts as a diastereoselective inducer in nitromethane conjugate addition reaction, and can also incorporate other heterocycles into its molecular structure using simple synthetic methods.
Article
Chemistry, Organic
Telmo N. Francisco, Joana L. C. Sousa, Samuel Guieu, Artur M. S. Silva, Helio M. T. Albuquerque
Summary: A mild synthesis of 3,5-disubstituted nitrobenzenes from readily available 3-formylchromones is reported. The developed methodology involves a cascade process catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene. The proposed mechanism includes Michael addition reactions and intramolecular cyclization, leading to the formation of three new C-C bonds. The method offers a straightforward and gram-scale synthesis of 3,5-disubstituted nitrobenzenes.
Article
Chemistry, Analytical
Nadia S. Ferreira, Liliana P. T. Carneiro, Christian Viezzer, Maria J. T. Almeida, Ana C. Marques, Alexandra M. F. R. Pinto, Elvira Fortunato, M. Goreti F. Sales
Summary: This work presents an innovative electrochemical biosensor powered by a passive direct methanol fuel cell (DMFC). The biosensor utilizes a molecularly imprinted polymer (MIP) layer on the anode side of the DMFC to selectively detect sarcosine, a potential cancer biomarker. By serially assembling a stack of hybrid DMFC/biosensor devices, the concentration-dependent detection of sarcosine triggers a color change in an external electrochromic cell (EC), making this biosensor a self-controlled and self-signalling device. This approach offers a simple, low-cost solution for autonomous biosensors, suitable for point-of-care analysis.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Environmental
Liliana P. T. Carneiro, Alexandra M. F. R. Pinto, M. Goreti F. Sales
Summary: This work presents a paper-based direct methanol fuel cell platform (PB-DMFC) that serves as both an energy source and a biosensor for point-of-care applications. By assembling the fuel cell components on a treated paper strip, a flexible and self-sufficient biosensor is created, capable of detecting sarcosine. The platform demonstrates stable electrical signals and good reproducibility, with a sensing layer built on the anode electrode for sarcosine detection.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Silvia Carvalho, Rosana V. Pinto, Joao Pires, Joao Rocha, Fernando Antunes, Moises L. Pinto
Summary: Four PEG composites were synthesized and characterized for their adsorption and release performance of hydrogen sulfide (H2S) and nitric oxide (NO). Cytotoxicity studies showed that the PEG composites had no toxicity to human cells.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Beatriz Matos, Mary Batista, Joao Pires
Summary: In the face of global warming and the energy crisis, it is crucial to reduce the emissions of greenhouse gases like CO2 and CH4 and recycle biomethane from landfill biogas. This study demonstrates the potential of converting glycerol, a by-product of biodiesel production, into activated carbon using potassium acetate as an activating agent. The activated carbon exhibits high adsorption capacities for CO2 and CH4, with selectivity values that enable effective separation. Additionally, the study finds that the CO2 emissions produced during activated carbon synthesis can be easily neutralized through their use in small biogas production units.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Mary Batista, Renato Carvalho, Moises L. Pinto, Joao Pires
Summary: Glycerin and dopamine were used as precursors to prepare microporous activated carbon adsorbent materials for the separation of ethane/ethylene and natural gas or landfill gas components. The activated carbons were produced through carbonization and chemical activation, with the introduction of nitrogenated groups to improve selectivity. Methane had the lowest adsorption capacity on the most effective material, followed by carbon dioxide, ethylene, and ethane.
Article
Chemistry, Analytical
Carolina S. Hora, Ana P. M. Tavares, Liliana P. T. Carneiro, Dzmitry Ivanou, Adelio M. Mendes, Goreti F. Sales, M. Goreti F. Sales
Summary: This work proposes an integrated power solution, with an autonomous and self-signaling biosensing device, to detect sarcosine, a known biomarker for prostate cancer. The biosensor is assembled on the counter-electrode of a dye-sensitized solar cell (DSSC), using molecular imprinting to produce the biorecognition element. The device is completely equipment-free and suitable for point-of-care analysis.
Article
Chemistry, Physical
Silvia Carvalho, Joao Pires, Cristina Moiteiro, Moises L. Pinto
Summary: A new imine-linked polymer organic framework with microporosity and temperature stability has been synthesized using inexpensive reagents. The material has a higher capacity to adsorb NO compared to H2S. This study explores the potential use of the framework in the therapeutic release of NO or H2S.
Article
Chemistry, Organic
Daniela Malafaia, Joana L. C. Sousa, Artur M. S. Silva, Helio M. T. Albuquerque
Summary: We report a new 2-SC derivative, 2,2'-[(1E,1'E)-{[hexa-2,4-diyne-1,6-diylbis(oxy)] bis(2,1-phenylene)} bis(ethene-2,1-diyl)] bis(4H-chromen-4-one), which is a dimeric compound formed by linking two units of 2-SC through a 1,3-diyne moiety. The compound was obtained with excellent yield (96%) through the copper-catalyzed homocoupling of two molecules of O-propargyl-2-SC. Its structure was characterized by 1D (H-1 and C-13) and 2D (HSQC and HMBC) NMR techniques as well as HRMS.
Article
Chemistry, Organic
Joana L. C. Sousa, Helio M. T. Albuquerque, Artur M. S. Silva
Summary: A new VN derivative, VN-CHO, was synthesized through photoredox-catalyzed hydroxymethylation reaction followed by oxidation. The introduction of a formyl group in VN structure offers a promising site for further functionalization.
Article
Biochemistry & Molecular Biology
Carina Proenca, Ana Teresa Rufino, Isabela Santos, Helio M. T. Albuquerque, Artur M. S. Silva, Eduarda Fernandes, Jose Miguel P. Ferreira de Oliveira
Summary: This study found that gossypetin, a luteolin derivative, has anti-proliferative and anti-inflammatory properties in osteosarcoma, inhibiting cell growth and the production of proinflammatory cytokines.
Article
Chemistry, Inorganic & Nuclear
Masoume Malmir, Majid M. Heravi, Zahra Yekke-Ghasemi, Masoud Mirzaei
Summary: In this study, a tri-component composite consisting of Fe3O4 nanoparticles, Keggin-type polyoxometalate, and graphene oxide was prepared and investigated as a catalyst for the oxidation of sulfides to sulfoxides. The catalyst showed excellent stability, high yields, and recyclability, making it a promising choice for organic-inorganic hybrid catalytic reactions conducted under mild conditions.
Article
Chemistry, Inorganic & Nuclear
Samuel D. Juarez-Escamilla, Sriloy Dey, Bruno Donnadieu, T. Keith Hollis
Summary: In this study, a bidentate Mo complex was synthesized using metalation and transmetalation methodology. The synthesis was optimized to achieve a high yield. The crystal structure of the bidentate complex was determined. Additionally, alternative forms of ligands were discovered in the reaction.
Article
Chemistry, Inorganic & Nuclear
Mohamed H. Abdel-Rhman, Ghada Samir, Mostafa A. Hussien, Nasser M. Hosny
Summary: This study investigated the dissolution performance of hydrazine carbonate solution on zirconium dibutyl phosphate (Zr-DBP), and found that hydrazine carbonate solution could promote the dissolution of Zr-DBP. The effects of dissolution temperature and hydrogen peroxide concentration on the dissolution efficiency were also explored, and the corrosion effect on stainless steel by hydrazine carbonate solution was studied.
Article
Chemistry, Inorganic & Nuclear
Qiaofang Fu, Fangyu Tan, Wu Ying
Summary: This study successfully prepared vermiculite/g-C3N4/TiO2 composites and found that under specific conditions, the composites exhibited excellent degradation effects, with a high degradation rate for methylene blue. Additionally, the composites were able to enhance surface area, reduce carrier loading rate, improve light energy utilization, and enhance durability.
Article
Chemistry, Inorganic & Nuclear
Annabelle G. W. Hodson, Robert T. Mason
Summary: Functionalised polystyrene resins have been found to be efficient catalysts in the synthesis of specific complexes, with the conversion rate controlled by the polymer structure. The addition of amines or amino acids can further yield substituted 13-butadienyl complexes, which have been analyzed by NMR.
Article
Chemistry, Inorganic & Nuclear
C. Kavitha, S. Anbarasan, P. Subramaniam
Summary: The sulfoxidation of PMAAs by the oxo(salen)chromium(V) complex in aqueous acetonitrile medium was studied. The rate of the reaction is influenced by the polarity of the medium and the substituents on PMAA, with electron donating substituents accelerating the reaction and electron withdrawing substituents retarding the reaction.
Article
Chemistry, Inorganic & Nuclear
Qiang-Qiang Liu, Mithun Kumar Ghosh, Shu-Lan Cai, Xiao-Hong Liu, Lu Lu, Mohd. Muddassir, Tanmay Kumar Ghorai, Jun Wang
Summary: Three newly developed coordination polymers (CPs) with semiconducting properties were synthesized using hydrothermal methods. These CPs exhibit superior photocatalytic activity and can degrade organic pollutants effectively.
Article
Chemistry, Inorganic & Nuclear
Mehrnaz Aliahmadi, Ali Nemati Kharat, Jan Janczak
Summary: This study proposes a method for synthesizing allyl alcohol using cost-effective and renewable bio-resource glycerol. By utilizing catalysts, alcohol as a solvent, and a reducing agent, allyl alcohol with an efficiency of 100% was obtained. The structures of the newly synthesized complexes were determined using X-ray single crystallography.
Article
Chemistry, Inorganic & Nuclear
Ji-Yan Gao, Nan Zhang, Dong-Sheng Huang, Xiang-Rong Liu, Zai-Wen Yang, Shun-Sheng Zhao
Summary: Two new transition metal complexes I and II were synthesized and characterized. The complexes exhibited strong thermal stabilities and showed effective binding to CT-DNA and BSA. Complex II exhibited stronger inhibition activity against P. aeruginosa than gentamicin sulfate. These complexes have potential applications in drug research.
Article
Chemistry, Inorganic & Nuclear
Rishabh Ujjval, Hilal Ahmad Khan, Chinnappan Sivasankar, Natesan Thirupathi
Summary: In this study, a rigid 2-aminobenzimidazole type guanidine and its platinum complexes were synthesized through a series of reactions and characterized by various physical and chemical methods. The reaction mechanism was also explained through DFT calculations.
Article
Chemistry, Inorganic & Nuclear
Marcelo Carpes Nunes, Thais Zaboenco, Vinicius Kemper Melara, Gabriel Barros Baptistella, Andre Luiz Barboza Formiga, Andersson Barison, Fabio Souza Nunes
Summary: A new luminescent molecular thermometer has been developed, which uses the spin-crossover equilibrium of a nickelcyclen derivative to measure temperature. The sensor shows high sensitivity and accuracy.
Article
Chemistry, Inorganic & Nuclear
Yuyu Shan, Zhenqin Zhao, Xia Zhang, Zhan Wu, Xiu-Ling Li
Summary: In this study, a new bridging ligand was synthesized through refluxing, and two mononuclear Cu(I) complexes and two trinuclear Cu(I)-Eu(III) complexes were obtained through self-assembly. The Cu(I) antenna chromophores successfully transferred energy to the Eu(III) centers, achieving sensitized Eu(III) luminescence.
Article
Chemistry, Inorganic & Nuclear
Gabriela Sanchez-Lecuona, Mayra C. Vazquez-Nunez, Bruno Donnadieu, Miguel A. Munoz-Hernandez, Virginia Montiel-Palma
Summary: The reaction of RuHCl(PPh3)3 with GaMe3 has been studied and the obtained complexes were analyzed in detail. The results indicate the formation of a Ru-Ga bond, suggesting the generation of an in situ formed ambiphilic phosphinogallyl ligand. This is of significance for understanding the interaction between metal-halogen bonds and metal-small molecule bonds.
Article
Chemistry, Inorganic & Nuclear
Sevil Sener, Nursel Acar, Fatih Dumludag
Summary: The synthesis, characterization, spectroscopic and bonding features of a new Co (II) phthalocyanine compound containing two thiocarbohydrazone groups were explained. The compound showed semiconductor properties and potential as a temperature sensor.
Article
Chemistry, Inorganic & Nuclear
Ledja B. O. Davi, Aryanna S. P. N. Costa, Mariana S. Silva, Adriana S. Ribeiro, Cintya D. A. E. S. Barbosa, Julio C. S. Da Silva, Dimas J. P. Lima, Daniela S. Anunciacao
Summary: In this study, a dansyl derivative sensor called o-PDDS was prepared and used for the detection of Al3+ ions in water. The o-PDDS sensor exhibited high sensitivity and linear response towards Al3+ ions. Experimental and computational studies confirmed a 1:1 stoichiometry ratio between o-PDDS and Al3+ ions. Real sample analysis demonstrated the selectivity and detection performance of the sensor, indicating its potential for field use.