Article
Chemistry, Inorganic & Nuclear
Mukerrem Findik, Ercan Turkkan, Suray Pehlivanoglu, Ulku Sayin, Umit Ceylan, Emine Guler Akgemci
Summary: A new copper(II) complex, Cu(HPP), with 2-hydroxy-5-methoxyacetophenone thiosemicarbazone (HMAT) was synthesized and characterized. Spectroscopic investigations revealed its intercalative binding mechanism with calf-thymus deoxyribonucleic acid (ct-DNA) and significant binding to bovine serum albumin (BSA). The complex also showed significant cytotoxicity in drug resistant breast cancer cells and has the potential to be a chemotherapeutic agent for breast cancer.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Ahmad Junaid, Chew Hee Ng, Ing Hong Ooi
Summary: This study synthesized and characterized a nanogold-{[(Cu)(phen)(cys)(H2O)]NO3}n conjugate, and evaluated its antiproliferative property against breast cancer cells. The results showed that the nanogold-copper complex conjugate demonstrated selective anticancer activity, highlighting its potential as an anticancer agent.
Article
Biochemistry & Molecular Biology
Zeinab Mirzaei-Kalar, Ali Akbar Khandar, Jonathan M. White, Hoda Abolhasani, Tahereh Komeili Movahhed, Stephen P. Best, Abolghasem Jouyban
Summary: After the accidental discovery of cis-platinum, extensive research has been done on designing metallic compounds for cancer treatment. A solvent-dependent complex of nickel (II) with 1,10-phenanthroline and naproxen has been synthesized and its in vitro DNA binding and cytotoxicity on cancer cells have been studied. The results show that the complex has better inhibition on HT 29 cancer cells compared to cisplatin, but lower inhibition on HEK-293 normal cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Applied
Nourhan Adel Mostafa, Youssef S. Abdelaziz, Sarah Ali Qutb, R. M. Abdel Hameed, Azza A. Shoukry
Summary: This study aimed to design unique metallic drugs with significant therapeutic activity. A mixed ligand Cu (II) complex was fabricated and characterized using IR spectroscopy. The interaction between the complex and CT-DNA was examined through various experiments, suggesting a groove and/or electrostatic interaction mode. The complex exhibited excellent antimicrobial activity against different bacterial types and enhanced cytotoxicity against human tumor cell lines.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Sebastiano Masuri, Maria Grazia Cabiddu, Lukas Moran, Tereza Vessela, Martin Bartosik, Josef Havel, Francesca Meloni, Enzo Cadoni, Petr Vanhara, Tiziana Pivetta
Summary: We synthesized six complexes [Cu(phen)(2)(Lx)](ClO4)(x: 1-6), in which the auxiliary ligand Lx is a coumarin carboxylate derivative with an oxylacetate moiety at the 6th or 7th position and different substituents at the 3rd or 4th position. The complexes exhibit a pentacoordinated geometry around the metal ion. They show affinity towards DNA mainly through electrostatic interactions and groove binding, and the interactions with DNA base pairs are mediated by the auxiliary ligands. The Cu(II) complexes display cytotoxic activity in the micromolar concentration range and can induce the pro-apoptotic branch of the unfolded protein response (UPR) by interfering at the endoplasmic reticulum level. The actin-normalized CHOP to BiP density ratios suggest that the novel compounds preferentially induce the pro-apoptotic UPR signaling driven by CHOP, in a dose-dependent manner and depending on the substituents in the coumarin moiety.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Swarup Kumar Tarai, Arup Tarai, Saikat Mandal, Bhaskar Nath, Ipsita Som, Rituparna Bhaduri, Arka Bagchi, Solanki Sarkar, Arunima Biswas, Sankar Ch. Moi
Summary: The bidentate ligand thiosemicarbazone (H3L) and its Ni(II) complex were synthesized and characterized. The complexes have square planar geometry and show binding abilities with DNA and BSA. The DFT/TD-DFT simulations and theoretical analysis provided insights into the reactivity, bonding mode, and bio-molecular affinity of the compounds. The compounds also demonstrated antiproliferative activity and cell death mechanisms against HEK293 and MCF-7 cell lines.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Shazia Parveen, Farukh Arjmand, Qianfan Zhang, Musheer Ahmad, Arif Khan, Loic Toupet
Summary: In this study, the synthesis and single crystal X-ray structure of Cu(II)-picolinic acid complex, 1 as a potent topoisomerase I inhibitor was reported. Biochemical studies revealed the complex's higher binding propensity towards tRNA, significant inhibitory effect on enzyme catalytic activity, and strong antimicrobial potential. Additionally, DFT and molecular docking studies provided insights into electronic transitions and specific binding preferences at the target site.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Inorganic & Nuclear
Radoslaw Kotuniak, Paulina Szczerba, Dobromila Sudzik, Marc J. F. Strampraad, Peter-Leon Hagedoorn, Wojciech Bal
Summary: We investigated the kinetics of Cu(ii) binding to ACTUN peptides using modified/substituted GGH analogues. Rules for rate modulation by 1(st) and 2(nd) sphere interactions were established, providing crucial insight into the elucidation of the reaction mechanism and its contribution to biological copper transport.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
R. Fouad, Ibrahim A. Shaaban, Tarik E. Ali, Mohammed A. Assiri, S. S. Shenouda
Summary: Novel and stable coordinating compounds were successfully isolated and characterized through various techniques. Experimental data matched well with theoretical calculations, indicating the bidentate nature of MCMT as a ligand forming chelates with metal ions. Thermal analysis and optical property studies further confirmed the structure and properties of the complexes.
Article
Chemistry, Multidisciplinary
Maryam Hasanzadeh Esfahani, Farshad Boorboor Ajdari, Elaheh B. Poormohammadi, Alireza Abbasi, Mahdi Behzad
Summary: A new mixed-ligand Cu(II) complex has been synthesized, showing high specific capacity and promising energy storage characteristics in a battery-like system. Electrochemical evaluations demonstrated its effectiveness, with a maximum specific capacity of 483 C g(-1) in a three-electrode system. Overall, the pyrazolone-based compound presents potential for further energy storage applications.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Applied
Nimya Ann Mathews, M. R. Prathapachandra Kurup
Summary: This study synthesized new ternary complexes derived from multisubstituted thiosemicarbazone ligands and characterized their properties using various spectroscopic and analytical methods. The complexes showed strong interactions with DNA, cleaving DNA without external agents, and exhibited potential cytotoxicity against human breast cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Muhammad Iqbal, Amir Karim, Saeed Ullah, Saqib Ali, Muhammad Nawaz Tahir
Summary: Three new mononuclear mixed ligand copper(II) and zinc(II) complexes were synthesized and characterized. The complexes showed stable interaction ability with DNA and exhibited potential biological activities. Additionally, these complexes showed potential anti-diabetic activity.
Article
Chemistry, Medicinal
Zizhen Zhao, Xiaorong Li, Zhihong Cui, Tingting Tong, Yingying Zhang, Yuping Zhang, Xiaoxi Yang, Rajendiran Keerthiga, Chen Fu, Ailing Fu
Summary: The synthesized hemiprotonic compounds in this study have selective antitumor, antibacterial, and antifungal activities, possibly exerting antitumor effects by specific inhibition of transcription factor PLAGL2, and showing sensitivity to drug-resistant bacteria.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Mukerrem Findik, Burak Kuzu, Suray Pehlivanoglu, Serdal Kaya, Ulku Sayin, Emine Guler Akgemci, Ahmet Ozgur Saf
Summary: In this study, the synthesis and characterization of 9-ethyl-3-carbazolecarboxaldehyde-4-ethyl-thiosemicarbazone (ECCAET) and its copper(II) complex (Cu(ECCAET)2) were conducted. Experimental evidence revealed that Cu(ECCAET)2 interacts with DNA through intercalative binding mode and binds strongly to BSA. Molecular docking studies supported the bonding mechanism of ECCAET and Cu(ECCAET)2 with DNA and BSA. In addition, Cu(ECCAET)2 exhibited higher cytotoxic and antiproliferative properties compared to its ligand (ECCAET), demonstrating its potential as a drug candidate against gynecologic cancer diseases.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
E. Halevas, S. Matsia, A. Hatzidimitriou, E. Geromichalou, T. A. Papadopoulos, G. Katsipis, A. Pantazaki, G. Litsardakis, A. Salifoglou
Summary: Quercetin is a bioactive flavonoid with limited solubility and bioavailability, but a synthetic ternary compound Ce(III)-quercetin-(1,10-phenanthroline) has shown enhanced bioavailability and bioactivity. Physicochemical characterization revealed its properties and biological studies demonstrated its toxicity-suppressing potential and cell metabolism inhibition. In silico studies provided insight into its mechanism of action at the molecular level. This work highlights the importance of metal-flavonoid compounds in enhancing the role of flavonoids in physiology and disease.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Masoume Malmir, Majid M. Heravi, Zahra Yekke-Ghasemi, Masoud Mirzaei
Summary: In this study, a tri-component composite consisting of Fe3O4 nanoparticles, Keggin-type polyoxometalate, and graphene oxide was prepared and investigated as a catalyst for the oxidation of sulfides to sulfoxides. The catalyst showed excellent stability, high yields, and recyclability, making it a promising choice for organic-inorganic hybrid catalytic reactions conducted under mild conditions.
Article
Chemistry, Inorganic & Nuclear
Samuel D. Juarez-Escamilla, Sriloy Dey, Bruno Donnadieu, T. Keith Hollis
Summary: In this study, a bidentate Mo complex was synthesized using metalation and transmetalation methodology. The synthesis was optimized to achieve a high yield. The crystal structure of the bidentate complex was determined. Additionally, alternative forms of ligands were discovered in the reaction.
Article
Chemistry, Inorganic & Nuclear
Mohamed H. Abdel-Rhman, Ghada Samir, Mostafa A. Hussien, Nasser M. Hosny
Summary: This study investigated the dissolution performance of hydrazine carbonate solution on zirconium dibutyl phosphate (Zr-DBP), and found that hydrazine carbonate solution could promote the dissolution of Zr-DBP. The effects of dissolution temperature and hydrogen peroxide concentration on the dissolution efficiency were also explored, and the corrosion effect on stainless steel by hydrazine carbonate solution was studied.
Article
Chemistry, Inorganic & Nuclear
Qiaofang Fu, Fangyu Tan, Wu Ying
Summary: This study successfully prepared vermiculite/g-C3N4/TiO2 composites and found that under specific conditions, the composites exhibited excellent degradation effects, with a high degradation rate for methylene blue. Additionally, the composites were able to enhance surface area, reduce carrier loading rate, improve light energy utilization, and enhance durability.
Article
Chemistry, Inorganic & Nuclear
Annabelle G. W. Hodson, Robert T. Mason
Summary: Functionalised polystyrene resins have been found to be efficient catalysts in the synthesis of specific complexes, with the conversion rate controlled by the polymer structure. The addition of amines or amino acids can further yield substituted 13-butadienyl complexes, which have been analyzed by NMR.
Article
Chemistry, Inorganic & Nuclear
C. Kavitha, S. Anbarasan, P. Subramaniam
Summary: The sulfoxidation of PMAAs by the oxo(salen)chromium(V) complex in aqueous acetonitrile medium was studied. The rate of the reaction is influenced by the polarity of the medium and the substituents on PMAA, with electron donating substituents accelerating the reaction and electron withdrawing substituents retarding the reaction.
Article
Chemistry, Inorganic & Nuclear
Qiang-Qiang Liu, Mithun Kumar Ghosh, Shu-Lan Cai, Xiao-Hong Liu, Lu Lu, Mohd. Muddassir, Tanmay Kumar Ghorai, Jun Wang
Summary: Three newly developed coordination polymers (CPs) with semiconducting properties were synthesized using hydrothermal methods. These CPs exhibit superior photocatalytic activity and can degrade organic pollutants effectively.
Article
Chemistry, Inorganic & Nuclear
Mehrnaz Aliahmadi, Ali Nemati Kharat, Jan Janczak
Summary: This study proposes a method for synthesizing allyl alcohol using cost-effective and renewable bio-resource glycerol. By utilizing catalysts, alcohol as a solvent, and a reducing agent, allyl alcohol with an efficiency of 100% was obtained. The structures of the newly synthesized complexes were determined using X-ray single crystallography.
Article
Chemistry, Inorganic & Nuclear
Ji-Yan Gao, Nan Zhang, Dong-Sheng Huang, Xiang-Rong Liu, Zai-Wen Yang, Shun-Sheng Zhao
Summary: Two new transition metal complexes I and II were synthesized and characterized. The complexes exhibited strong thermal stabilities and showed effective binding to CT-DNA and BSA. Complex II exhibited stronger inhibition activity against P. aeruginosa than gentamicin sulfate. These complexes have potential applications in drug research.
Article
Chemistry, Inorganic & Nuclear
Rishabh Ujjval, Hilal Ahmad Khan, Chinnappan Sivasankar, Natesan Thirupathi
Summary: In this study, a rigid 2-aminobenzimidazole type guanidine and its platinum complexes were synthesized through a series of reactions and characterized by various physical and chemical methods. The reaction mechanism was also explained through DFT calculations.
Article
Chemistry, Inorganic & Nuclear
Marcelo Carpes Nunes, Thais Zaboenco, Vinicius Kemper Melara, Gabriel Barros Baptistella, Andre Luiz Barboza Formiga, Andersson Barison, Fabio Souza Nunes
Summary: A new luminescent molecular thermometer has been developed, which uses the spin-crossover equilibrium of a nickelcyclen derivative to measure temperature. The sensor shows high sensitivity and accuracy.
Article
Chemistry, Inorganic & Nuclear
Yuyu Shan, Zhenqin Zhao, Xia Zhang, Zhan Wu, Xiu-Ling Li
Summary: In this study, a new bridging ligand was synthesized through refluxing, and two mononuclear Cu(I) complexes and two trinuclear Cu(I)-Eu(III) complexes were obtained through self-assembly. The Cu(I) antenna chromophores successfully transferred energy to the Eu(III) centers, achieving sensitized Eu(III) luminescence.
Article
Chemistry, Inorganic & Nuclear
Gabriela Sanchez-Lecuona, Mayra C. Vazquez-Nunez, Bruno Donnadieu, Miguel A. Munoz-Hernandez, Virginia Montiel-Palma
Summary: The reaction of RuHCl(PPh3)3 with GaMe3 has been studied and the obtained complexes were analyzed in detail. The results indicate the formation of a Ru-Ga bond, suggesting the generation of an in situ formed ambiphilic phosphinogallyl ligand. This is of significance for understanding the interaction between metal-halogen bonds and metal-small molecule bonds.
Article
Chemistry, Inorganic & Nuclear
Sevil Sener, Nursel Acar, Fatih Dumludag
Summary: The synthesis, characterization, spectroscopic and bonding features of a new Co (II) phthalocyanine compound containing two thiocarbohydrazone groups were explained. The compound showed semiconductor properties and potential as a temperature sensor.
Article
Chemistry, Inorganic & Nuclear
Ledja B. O. Davi, Aryanna S. P. N. Costa, Mariana S. Silva, Adriana S. Ribeiro, Cintya D. A. E. S. Barbosa, Julio C. S. Da Silva, Dimas J. P. Lima, Daniela S. Anunciacao
Summary: In this study, a dansyl derivative sensor called o-PDDS was prepared and used for the detection of Al3+ ions in water. The o-PDDS sensor exhibited high sensitivity and linear response towards Al3+ ions. Experimental and computational studies confirmed a 1:1 stoichiometry ratio between o-PDDS and Al3+ ions. Real sample analysis demonstrated the selectivity and detection performance of the sensor, indicating its potential for field use.
