Journal
POLYHEDRON
Volume 28, Issue 3, Pages 637-645Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2008.12.013
Keywords
Synthesis; X-ray structure; Cytotoxic effect; Pyrazole ligands; Platinum(II), Palladium(II), Copper(II)) complexes; 9-Methylguanine
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Funding
- Medical University of Lodz [502-13-629]
- DAAD for fellowship [A/07/01244]
- Department of Pharmaceutical Biochemistry at Medical University of Lodz [503-3015-2]
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The new pyrazole ligand 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-phosphonic acid dimethyl ester (2a) has been used to obtain a series of platinum(II), palladium(II) and copper(II) complexes (3a-7a) as potential anticancer compounds. The molecular structures of the platinum(II) and copper(II) complexes 3a and 6a have been determined by X-ray crystallography. The cytotoxicity of the phosphonic ligand 2a and its carboxylic analog 2b as well as their complexes has been evaluated on leukemia and melanoma cell lines. Copper(II) complexes were found to be more efficient in the induction of melanoma cell death than the platinum(II) or palladium(H) complexes. Cytotoxic effectiveness of compound 7b against melanoma WM-115 cells was two times better than that of cisplatin. The reaction of compound 5b with 9-methylguanine has been studied. (C) 2008 Elsevier Ltd. All rights reserved.
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