Journal
POLYHEDRON
Volume 27, Issue 2, Pages 537-546Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2007.10.006
Keywords
crystal structures; 3-Nitro-4-hydroxybenzoic acid ligand; Zn(II) and Co(II) complexes; anticonvulsant activity
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Purposes of these studies were to synthesize Zn(II) and Co(II) complexes of 3-nitro-4-hydroxybenzoic acid, determine their structures through X-ray crystallography, and obtain their anticonvulsant activities. Thermogravimetric, differential scanning calorimetry, impedance of aqueous solutions and magnetic properties analyses were also determined. Anticonvulsant and related activities of these complexes as well as Zn(II), Co(II), Ni(II) and Mg(II) (5-nitrosalicylato) complexes were determined by the National Institutes of Health, Antiepileptic Development Program. Results of these analyses are presented to document unique bonding features and physical properties of these compounds and their anticonvulsant activities. It is concluded that these compounds have chemical and physical properties that can be used to account for their anticonvulsant activities. (c) 2007 Elsevier Ltd. All rights reserved.
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