The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling

Collective transcriptomic deregulation of hypertrophic and dilated cardiomyopathy – Importance of fibrotic mechanism in heart failure

(2018) Beutline Malgija et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

(2018) Stefan Frantz et al.   EUROPEAN JOURNAL OF HEART FAILURE

Fibromodulin reduces scar size and increases scar tensile strength in normal and excessive-mechanical-loading porcine cutaneous wounds

(2018) Wenlu Jiang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Myocardial fibrosis: biomedical research from bench to bedside

(2017) Mariann Gyöngyösi et al.   EUROPEAN JOURNAL OF HEART FAILURE

Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease

(2017) Nikos K. Karamanos   FEBS Journal

Heart failure

(2017) Marco Metra et al.   LANCET

A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling

(2017) Leonardo Schirone et al.   Oxidative Medicine and Cellular Longevity

The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart

(2017) Kate Herum et al.   Journal of Clinical Medicine

Fibromodulin Is Essential for Fetal-Type Scarless Cutaneous Wound Healing

(2016) Zhong Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Syndecans in heart fibrosis

(2016) Ida G. Lunde et al.   CELL AND TISSUE RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase

(2016) Sebastian Kalamajski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs)

(2016) Ruijie Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling

(2016) Arne O. Melleby et al.   PLoS One

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart

(2015) Kate M. Herum et al.   CARDIOVASCULAR RESEARCH

Immune Cell and Other Noncardiomyocyte Regulation of Cardiac Hypertrophy and Remodeling

(2015) R. A. Frieler et al.   CIRCULATION

Shedding of syndecan-4 promotes immune cell recruitment and mitigates cardiac dysfunction after lipopolysaccharide challenge in mice

(2015) Mari E. Strand et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly

(2015) Loren E. Dupuis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

Myocardial Extracellular Matrix

(2014) Marieke Rienks et al.   CIRCULATION RESEARCH

Fibromodulin-Deficiency Alters Temporospatial Expression Patterns of Transforming Growth Factor-β Ligands and Receptors during Adult Mouse Skin Wound Healing

(2014) Zhong Zheng et al.   PLoS One

Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart

(2013) Mari E. Strand et al.   FEBS Journal

Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli

(2013) Kristin V. T. Engebretsen et al.   FEBS Journal

The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly

(2013) Shoujun Chen et al.   FEBS Journal

Biological interplay between proteoglycans and their innate immune receptors in inflammation

(2013) Helena Frey et al.   FEBS Journal

Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice

(2012) Haruya Ohmura et al.   HYPERTENSION RESEARCH

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress

(2012) Kate M. Herum et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fibromodulin, an Oxidative Stress-Sensitive Proteoglycan, Regulates the Fibrogenic Response to Liver Injury in Mice

(2011) Elisabetta Mormone et al.   GASTROENTEROLOGY

Small Leucine-Rich Proteoglycans in Kidney Disease

(2011) L. Schaefer   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload

(2011) Anne Waehre et al.   PLoS One

Syndecan-4 Is Essential for Development of Concentric Myocardial Hypertrophy via Stretch-Induced Activation of the Calcineurin-NFAT Pathway

(2011) Alexandra V. Finsen et al.   PLoS One

Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects

(2010) Begoña López et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload

(2010) J. L. Bjornstad et al.   EUROPEAN HEART JOURNAL

Delayed Wound Closure in Fibromodulin-Deficient Mice Is Associated with Increased TGF-β3 Signaling

(2010) Zhong Zheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The role of small leucine-rich proteoglycans in collagen fibrillogenesis

(2010) Sebastian Kalamajski et al.   MATRIX BIOLOGY

Homologous Sequence in Lumican and Fibromodulin Leucine-rich Repeat 5-7 Competes for Collagen Binding

(2008) Sebastian Kalamajski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY