Article
Medicine, General & Internal
Nutjaree Jeenduang, Boonnisa Sangkaew
Summary: This study investigated the relationship between vitamin D status and serum lipids in Southern Thai subjects. The results showed that vitamin D sufficiency could reduce the risk of hypertriglyceridaemia and reduced HDL-C, especially in women. This suggests that vitamin D may have beneficial effects on lipids and a decreased risk for cardiovascular diseases in Thai women.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Nutrition & Dietetics
Limin Yang, Miori Sato, Mayako Saito-Abe, Minaho Nishizato, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada, Yukihiro Ohya
Summary: The study found no association between early-life 25-hydroxyvitamin D levels and the risk of developing childhood atopic dermatitis (AD).
Article
Endocrinology & Metabolism
Li Liu, Mingming Xu, Hang Zhou, Xuexue Hao, Xiangyu Chen, Xiaoqiang Liu
Summary: The study found that decreased serum 25-hydroxyvitamin D levels were associated with stress urinary incontinence and mixed urinary incontinence in elderly men.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Jun-Hyuk Lee, Yu-Jin Kwon, Hye Sun Lee, Jee Hye Han, Boyoung Joung, Sung Jin Kim
Summary: This study confirms an inverse dose-dependent association between serum 25-hydroxyvitamin D levels and elevated intraocular pressure (EIOP) in a large sample of 15,338 individuals. Each unit increase in serum 25-hydroxyvitamin D is associated with a 3% decrease in the odds of having EIOP. Compared to individuals deficient in 25-hydroxyvitamin D, those with insufficiency and sufficiency have a 28% and 49% lower odds of EIOP, respectively. Therefore, clinical assessment of intraocular pressure may be helpful in the treatment and prevention of glaucoma in patients with insufficient 25-hydroxyvitamin D.
Article
Medicine, General & Internal
Munachimso Kizito Mbata, Mireille Hunziker, Anja Makhdoomi, Giorgia Luethi-Corridori, Maria Boesing, Stephanie Giezendanner, Juergen Muser, Anne B. Leuppi-Taegtmeyer, Joerg D. Leuppi
Summary: This study aimed to explore the possible association between serum 25-hydroxyvitamin D levels and the severity of COVID-19 in hospitalized patients. The results showed no significant association between serum 25-hydroxyvitamin D levels and COVID-19 severity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Nutrition & Dietetics
Benchao Li, Buyun Liu, Wei Bao, Shuang Rong
Summary: This study aimed to examine the association between serum 25(OH)D concentrations and respiratory infection. The findings showed that individuals with lower serum 25(OH)D concentrations had a higher risk of respiratory infection, particularly head or chest cold, as well as influenza, pneumonia, and ear infections. Lower serum 25(OH)D concentrations were associated with a higher risk of head or chest cold in obese adults. This study highlights the potential protective effect of vitamin D on respiratory health.
JOURNAL OF NUTRITION
(2023)
Article
Medicine, General & Internal
Seok-Hoon Lee, Nam-Seok Joo
Summary: This study aimed to investigate the effect of NBUVB-LED exposure on serum 25(OH)D concentrations. The results indicated that NBUVB-LED exposure might increase serum 25(OH)D levels. However, further research is needed to validate these findings.
Article
Nutrition & Dietetics
Ewelina A. Dziedzic, Jakub S. Gasior, Agnieszka Tuzimek, Marek Dabrowski, Waclaw Kochman
Summary: This study investigated the differences in monocyte-to-HDL ratio (MHR) and serum 25-hydroxyvitamin D (25(OH)D) concentration between male patients with different diagnoses of chronic coronary syndrome (CCS), and analyzed the correlation between 25(OH)D and MHR in this group. The results showed significant differences in 25(OH)D and MHR between acute coronary syndrome (ACS) patients and CCS patients, with the highest HDL and serum 25(OH)D concentrations observed in patients with CCS, and the highest value of MHR observed in patients with ST-elevation myocardial infarction (STEMI). There was also a significant correlation observed between 25(OH)D, HDL, and MHR.
Review
Nutrition & Dietetics
Patrick J. McCullough, William P. McCullough, Douglas Lehrer, Jeffrey B. Travers, Steven J. Repas
Summary: Vitamin D, sunshine, and UVB phototherapy have been reported to effectively treat psoriasis, controlling the disease without complications. Changes in serum 25(OH)D concentrations before and after treatment are crucial for assessing the therapeutic effects. Further research is needed to fully understand the impact of these treatments on psoriasis patients.
Article
Medicine, General & Internal
Qingqing Xiao, Bin Cai, Anwen Yin, Huanhuan Huo, Keke Lan, Guo Zhou, Linghong Shen, Ben He
Summary: Nonlinear associations between serum 25(OH)D levels and all-cause and cardiovascular disease (CVD) mortality were observed in American patients with osteoarthritis (OA). The thresholds of 27.70 and 54.40 nmol/L for CVD and all-cause mortality, respectively, may represent intervention targets for lowering the risk of premature death and cardiovascular disease.
Article
Oncology
Zhen Teng, Meiyu Wei
Summary: The study revealed that the decrease in serum 25(OH)D level and increase in IL-6 level in patients with CHD are associated with the severity of CHD, providing valuable insights for clinical diagnosis, treatment, and prognosis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Guowei Li, Likang Li, Jonathan D. Adachi, Ruoting Wang, Zebing Ye, Xintong Liu, Lehana Thabane, Gregory Y. H. Lip
Summary: This study found a quasi J-shaped relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history. The lowest risk of recurrent stroke was observed at a 25(OH)D level of approximately 60 nmol/L, which was associated with a 48% reduction in risk compared to a level of 10 nmol/L.
Article
Endocrinology & Metabolism
Meng Gao, Minghui Liu, Jinbo Chen, Zewu Zhu, Hequn Chen
Summary: The study investigated the correlation between serum 25(OH)D concentrations and all-cause mortality in patients with kidney stone disease. Higher levels of 25(OH)D were associated with lower levels of cardiovascular risk factors and better overall health. Insufficient serum 25(OH)D concentrations in kidney stone patients increased the risk of all-cause mortality.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Ping Li, Yanru Zhao, Xinna Fan, Jia Wang, Wenqi Lu, Xiaoyan Zheng
Summary: This study found a negative association between serum 25-hydroxyvitamin D3 and depressive symptoms in US females, as well as an inverted U-shaped relationship between 25-hydroxyvitamin D2 and depressive symptoms with an inflection point at 56.2 nmol/L.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Maria Klatka, Izabela Rysz, Anna Hymos, Agnieszka Polak, Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Ewelina Grywalska
Summary: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia due to abnormal insulin secretion or action. Type 1 diabetes mellitus is the most common type in children and adolescents, and its development is influenced by genetic predisposition, environmental factors, and immune response. Recent research has focused on the role of Epstein-Barr virus (EBV) in the pathogenesis of type 1 diabetes. This study aimed to evaluate the effect of EBV infection on immune cell activation, fructosamine levels, and HbA1c levels in children with type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jolanta Smok-Kalwat, Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Aleksandra Kozinska, Filip Koszalka, Wojciech Kwasniewski, Ewelina Grywalska, Stanislaw Gozdz
Summary: Lung cancer is a major threat to modern society, with increasing numbers of new cases and deaths each year. Despite extensive research, the mechanisms of lung cancer development and progression, particularly the role of the immune system, remain unclear. This literature review emphasizes the importance of immune system disorders and cell signaling changes in the pathogenesis of lung cancer. It suggests that future studies should focus on analyzing tumor microenvironmental immune checkpoints and genetic susceptibilities to lung cancer, which may lead to the development of personalized therapies and improved prognoses for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Walczak, Karolina Szalast, Dorota Krasowska
Summary: The aim of this study was to investigate the molecular mechanism of KYN's antiproliferative activity on human epidermal melanocytes. The results showed that KYN significantly inhibited the metabolic activity of HEMa cells by decreasing the levels of cyclin D1 and cyclin-dependent kinase 4 (CDK4) through the aryl hydrocarbon receptor (AhR) pathway. These findings suggest that KYN might play a role in regulating physiological and pathological processes mediated by melanocytes.
Review
Biochemistry & Molecular Biology
Katarzyna Walczak, Agnieszka Gerkowicz, Dorota Krasowska
Summary: Peroxisome proliferator-activated receptors (PPARs) are involved in various processes in the skin, including melanoma, and there may be potential interactions between the PPAR signaling pathway and the kynurenine pathway. The kynurenine pathway is a major pathway of tryptophan metabolism and produces metabolites that have biological activity in cancer cells. Although the relationship between PPAR and the kynurenine pathway has not been reported in melanoma, there are indications of potential involvement in melanoma initiation, progression, and metastasis. The PPAR signaling pathway may also have effects on the tumor microenvironment and immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Karolina Kielbik, Ewelina Grywalska, Andrzej Glowniak, Grazyna Mielnik-Niedzielska, Izabela Korona-Glowniak
Summary: The genetic mechanisms, resistance patterns, and clonal composition of pneumococcal strains from healthy children in Poland were analyzed. Certain clonal groups were found to be resistant to erythromycin, clindamycin, and tetracycline. Capsular switching was observed in certain clones. The study highlights the role of nasopharyngeal carriage in the spread of drug-resistant pneumococcal clones after vaccination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Klatka, Agnieszka Polak, Paulina Mertowska, Sebastian Mertowski, Jakub Lyczba, Anna Hymos, Izabela Korona-Glowniak, Ewelina Grywalska
Summary: Chronic lymphocytic thyroiditis, or HD, is a common thyroid disorder. Research has focused on the role of Toll-like receptors (TLRs), particularly TLR2, in the pathogenesis of HD. This study found a significant increase in TLR2 expression on immune cells and a higher concentration of soluble TLR2 in plasma in HD patients compared to healthy individuals. TLR2 expression also correlated with thyroid function indicators. These findings suggest that TLR2 may be involved in the immunopathogenesis of HD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marek Majewski, Kamil Torres, Paulina Mertowska, Sebastian Mertowski, Izabela Korona-Glowniak, Jan Korulczyk, Witold Zgodzinski, Ewelina Grywalska
Summary: Gastric cancer is a common type of cancer worldwide. Toll-like receptors (TLRs) expressed on immune cells play a role in the pathogenesis of gastric cancer. This study found that patients with gastric cancer had a higher percentage of immune cells expressing TLR2 compared to the control group. Additionally, there was a significant association between TLR2 expression and the stage of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bartlomiej Barczynski, Karolina Fraszczak, Ewelina Grywalska, Jan Kotarski, Izabela Korona-Glowniak
Summary: According to recent data, changes in the vaginal microbiota could impact the risk of gynaecological cancers. In women with endometrial cancer, there are notable changes in the composition of the cervicovaginal microbiota. A study was conducted to characterize the cervicovaginal microbiota of women undergoing hysterectomy for different conditions. The presence of various microorganisms was detected, and certain microorganisms were found to be more common in cancer patients, suggesting their potential role as co-factors for endometrial cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
D. Krasowska, T. Gambichler, C. Cortes, A. Horev, N. Compagno, S. S. Dahale, P. Papanastasiou, D. Keefe
Summary: This study investigated the long-term (104 weeks) efficacy and safety of secukinumab in pediatric patients with severe chronic plaque psoriasis. The results showed that secukinumab demonstrated sustained efficacy and a favorable safety profile up to 2 years of treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Medicine, General & Internal
Jaroslaw Sobieszczanski, Sebastian Mertowski, Katarzyna Sarna-Bos, Piotr Stachurski, Ewelina Grywalska, Renata Chalas
Summary: The oral cavity has a specific microenvironment, and dental structures are constantly exposed to chemical and biological factors. Trauma to the teeth, particularly the pulp and root canal system, can lead to severe local inflammation caused by external and opportunistic pathogens. Long-term inflammation not only affects local tissues but also impacts the immune system, potentially triggering a systemic reaction. This literature review highlights the connection between root canal infections and their impact on the oral microenvironment, specifically focusing on the influence of immune system disorders in selected diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anna Michalak-Stoma, Katarzyna Walczak, Michal Adamczyk, Malgorzata Kowal, Dorota Krasowska
Summary: Psoriasis is a complex systemic disease with multifactorial pathogenesis. It is associated with increased cardiovascular disease risk and comorbidities such as obesity. This study found decreased levels of certain miRNAs in psoriatic patients, which are consistent with cardiovascular disease levels, indicating their impact on cardiovascular disease risk in psoriatic patients. miR-22 and miR-146a may be contributing factors in the obesity-cardiovascular disease-psoriasis network.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Peet Brecht, James Curtis Dring, Felipe Yanez, Agnieszka Slyczen, Paulina Mertowska, Sebastian Mertowski, Ewelina Grywalska
Summary: Cardiovascular diseases (CVDs) are the leading cause of death globally, with numerous risk factors such as genetic factors, age, sex, lifestyle, and nutrition-related issues contributing to their incidence. This review focuses on the role of minerals, vitamins, and intestinal microorganisms in the development and progression of CVDs in both adults and children. The article emphasizes the importance of promoting healthy eating habits and increasing awareness to reduce the risk of CVDs.
Article
Oncology
Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Marcin Pasiarski, Jolanta Smok-Kalwat, Stanislaw Gozdz, Ewelina Grywalska
Summary: This study focuses on primary immunodeficiencies, specifically antibody deficiencies with near-normal immunoglobulin levels or hyperimmunoglobulinemia. It explores the role of immune checkpoints and Epstein-Barr virus (EBV) reactivation in the context of these disorders, highlighting their impact on the clinical picture of patients and potential contribution to the development of cancer, particularly hematological malignancies.
Article
Oncology
Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Gabriela Kita, Katarzyna Guz, Aleksandra Kita, Marcin Pasiarski, Jolanta Smok-Kalwat, Stanislaw Gozdz, Ewelina Grywalska
Summary: This study compares immune factors and EBV in chronic lymphocytic leukemia (CLL) and common variable immunodeficiency (CVID), finding a potential link between immune issues, EBV, and cancer in individuals with weakened immunity. The study suggests management strategies for these risks but further research is needed.
Article
Oncology
Marek Majewski, Paulina Mertowska, Sebastian Mertowski, Kamil Torres, Ewelina Grywalska
Summary: TLR-9 is significantly involved in the progression of gastric cancer and its connection to EBV infection is investigated. By analyzing specific T and B immune cell groups that express TLR-9, along with the levels of soluble TLR-9 in the blood, this study compares these factors between individuals with gastric cancer and healthy volunteers. The research sheds light on the interplay between TLR-9, immune cell populations, and EBV in gastric cancer development.