Review
Oncology
Zhuang Li, Penglin Liu, Ziying Wang, Zhaoyang Zhang, Zhongshao Chen, Ran Chu, Guiju Li, Qiuyue Han, Yong Zhao, Li Li, Jinwei Miao, Beihua Kong, Kun Song
Summary: This systematic review and meta-analysis aimed to examine the pooled prevalence of HPV DNA and p16INK4a positivity in vulvar cancer and vulvar intraepithelial neoplasia worldwide. The study found that HPV16 and HPV33 were the most predominant genotypes in vulvar cancer and vulvar intraepithelial neoplasia, and double positivity for HPV DNA and p16INK4a had potential clinical significance in vulvar neoplasms.
Review
Virology
Sasidharanpillai Sabeena, Nagaraja Ravishankar
Summary: Prophylactic HPV vaccination before the age of 27 years leads to a significant decline in vHPV types among young women, as indicated by a systematic review and meta-analysis.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Virology
Farideh Aghaeipour, Hamid Salehiniya, Hamid Abbaszadeh
Summary: The prevalence of HPV in oral lesions in Iran was found to be 21%, with the highest rates in Rasht (50%) and lip lesions (40%), and the lowest in normal mucosa (8%). The highest prevalence was observed in precancerous lesions (29%) and hairy leukoplakia (70%). Considering the fairly high prevalence of HPV, it is recommended to pay more attention to vaccination and treatment for HPV in Iran.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Virology
Ali Ardekani, Mahdi Sepidarkish, Abolfazl Mollalo, Parivash Afradiasbagharani, Safoura Rouholamin, Mahroo Rezaeinejad, Maryam Farid-Mojtahedi, Sanaz Mahjour, Mustafa Almukhtar, Malihe Nourollahpour Shiadeh, Ali Rostami
Summary: This study evaluated the global prevalence of HPV infection among pregnant women and found significant variations in prevalence rates across different regions. Countries in Africa had the highest prevalence rates, while countries in Europe and the Eastern Mediterranean had the lowest rates. Pregnant women living with HIV and those with pregnancy disorders had higher prevalence rates, and younger ages for first intercourse and pregnancy, multiple lifetime sexual partners, and lower education levels were identified as primary risk factors for HPV infection.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Review
Immunology
Jorge Bartolome, Consolacion Molto, Javier David Benitez-Fuentes, Gonzalo Fernandez-Hinojal, Aranzazu Manzano, Pedro Perez-Segura, Abhenil Mittal, Faris Tamimi, Eitan Amir, Alberto Ocana
Summary: Through a systematic review and meta-analysis, this study found that HLA-G expression is associated with overall survival (OS) in solid tumor patients, particularly in gastric, pancreatic, and colorectal cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Critical Care Medicine
Tingting Jiang, Taiping Lin, Xiaoyu Shu, Quhong Song, Miao Dai, Yanli Zhao, Li Huang, Xiangping Tu, Jirong Yue
Summary: This review aimed to investigate the prevalence and prognostic value of preexisting sarcopenia in mechanically ventilated (MV) patients. The results showed that sarcopenia was associated with increased mortality, longer duration of MV, longer days of ICU stay, and hospital stay in MV patients.
Review
Microbiology
Lisa Pagan, Roos A. M. Ederveen, Bertine W. Huisman, Jan W. Schoones, Romy D. Zwittink, Frank H. J. Schuren, Robert Rissmann, Jurgen M. J. Piek, Mariette I. E. van Poelgeest
Summary: This systematic review explores the relationship between microbiome and vulvar (pre)malignant disease, revealing differences in vulvar microbiome composition between healthy and diseased states. Although promising, there is limited data with low evidence levels.
Review
Obstetrics & Gynecology
Devika Nandwana, Kenna Hawes, Christina Farr Zuend, Rachel Pope
Summary: Objective: This study aimed to assess the prevalence of high-risk human papillomavirus (hrHPV) and human papillomavirus (HPV)-associated abnormalities in the neovaginas of postvaginoplasty transfeminine patients. The current body of research demonstrates that transfeminine individuals may develop neovaginal HPV infection with associated cytologic abnormalities or grossly apparent lesions after vaginoplasty. However, there is limited high-grade evidence to draw broader conclusions about neovaginal HPV prevalence in this population. More rigorous prevalence research is needed to inform preventative care guidelines for transfeminine individuals at risk of developing HPV-related neovaginal complications.
OBSTETRICS AND GYNECOLOGY
(2023)
Review
Environmental Sciences
Stefano Palma, Timo Gnambs, Richard Crevenna, Galateja Jordakieva
Summary: The review found that medical staff conducting ablation procedures, especially with lasers and LEEP, may be at increased risk of HPV transmission from lesions. High-risk HPV genotypes were detected in the airways of medical staff following ablations, and cases of HPV-associated upper airway neoplasms were documented. Simple safety measures can greatly reduce HPV contamination and transmission risk.
ENVIRONMENTAL RESEARCH
(2021)
Review
Oncology
Angela Santoro, Giuseppe Angelico, Antonio Travaglino, Frediano Inzani, Damiano Arciuolo, Michele Valente, Nicoletta D'Alessandris, Giulia Scaglione, Alessia Piermattei, Federica Cianfrini, Patrizia Straccia, Roberta Benvenuto, Antonio Raffone, Giorgia Garganese, Valerio Gallotta, Gian Franco Zannoni
Summary: This study conducted a systematic review and metanalysis to determine the prognostic role of perineural invasion (PNI) in vulvar squamous cell carcinoma (VSCC). The results showed that PNI is associated with unfavorable prognosis in VSCC patients. PNI should be included in the pathological report and considered in prognostic assessment and adjuvant treatment planning.
Review
Nutrition & Dietetics
Qianqian Gao, Kaiyan Hu, Jing Gao, Yi Shang, Fan Mei, Li Zhao, Fei Chen, Bin Ma
Summary: This study conducted a systematic review and meta-analysis to estimate the prevalence and prognostic value of sarcopenic obesity (SO) in cancer patients. The results showed that SO is common among cancer patients and is significantly associated with poor outcomes.
Review
Oncology
Aino Niinivirta, Tuula Salo, Pirjo Astrom, Krista Juurikka, Maija Risteli
Summary: This study systematically evaluated the prognostic value of dysadherin in cancer and summarized the current knowledge on the subject. The results showed that high levels of tumoral FXYD5 are associated with increased risk of death, metastatic behavior of cancer, and inverse correlation with E-cadherin level.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Yan-Ling Chen, Xiao-Lin Liu, Ling Li
Summary: The meta-analysis showed that lower miR-34a expression is significantly associated with poorer overall survival and disease-free/progression-free/recurrence-free survival in gastrointestinal cancer patients. The expression level of miR-34a is relatively lower in patients with lymph node metastasis, and decreased miR-34a expression is linked to poor tumor differentiation and late TNM stage. MiR-34a may serve as a new factor for prognosis prediction and progression in gastrointestinal cancers.
Review
Oncology
Ping Zeng, Meng Si, Rui-xia Sun, Xu Cheng, Xiao-yang Li, Min-bin Chen
Summary: This meta-analysis revealed a strong association between decreased CD9 expression and poor prognosis in solid tumors, particularly in lung cancer and head and neck cancer patients. CD9 may serve as a valuable prognostic predictive biomarker and potential therapeutic target in human solid tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaoyu Yang, Yunhong Xia, Shuomin Wang, Chen Sun
Summary: This meta-analysis evaluated the relationship between SPARC expression and prognosis in patients with HCC. The results showed that elevated levels of SPARC expression are associated with a lower survival rate in HCC patients, but not with disease-free survival.
