Extensive recoding of dengue virus type 2 specifically reduces replication in primate cells without gain-of-function in Aedes aegypti mosquitoes

Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure

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Limits of variation, specific infectivity, and genome packaging of massively recoded poliovirus genomes

(2017) Yutong Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Philippines halts dengue immunisation campaign owing to safety risk

(2017) Owen Dyer   BMJ-British Medical Journal

Philippines halts dengue immunisation campaign owing to safety risk

(2017) Owen Dyer   BMJ-British Medical Journal

Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets

(2016) Andrew J. Broadbent et al.   VACCINE

The burden of chikungunya in the Pacific

(2015) T.X. Nhan et al.   CLINICAL MICROBIOLOGY AND INFECTION

Dermal CD14 + Dendritic Cell and Macrophage Infection by Dengue Virus Is Stimulated by Interleukin-4

(2015) Evelyne Schaeffer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Synonymous Deoptimization of Foot-and-Mouth Disease Virus Causes AttenuationIn Vivowhile Inducing a Strong Neutralizing Antibody Response

(2015) Fayna Diaz-San Segundo et al.   JOURNAL OF VIROLOGY

Reply to Simmonds et al.: Codon pair and dinucleotide bias have not been functionally distinguished

(2015) Bruce Futcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference

(2015) Sam H. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recoding of the Vesicular Stomatitis Virus L Gene by Computer-Aided Design Provides a Live, Attenuated Vaccine Candidate

(2015) Bingyin Wang et al.   mBio

The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication

(2014) Nicky J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

High-Throughput Quantitative Proteomic Analysis of Dengue Virus Type 2 Infected A549 Cells

(2014) Han-Chen Chiu et al.   PLoS One

Attenuation of human respiratory syncytial virus by genome-scale codon-pair deoptimization

(2014) C. Le Nouen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computer-aided codon-pairs deoptimization of the major envelope GP5 gene attenuates porcine reproductive and respiratory syndrome virus

(2014) Yan-Yan Ni et al.   VIROLOGY

Dengue Viruses Are Enhanced by Distinct Populations of Serotype Cross-Reactive Antibodies in Human Immune Sera

(2014) Ruklanthi de Alwis et al.   PLoS Pathogens

Deliberate reduction of hemagglutinin and neuraminidase expression of influenza virus leads to an ultraprotective live vaccine in mice

(2013) Chen Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells

(2013) Antoine Nougairede et al.   PLoS Pathogens

ZAP-mediated mRNA degradation

(2011) Yiping Zhu et al.   RNA Biology

From research to phase III: Preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine

(2011) Bruno Guy et al.   VACCINE

Synthetic Poliovirus and Other Designer Viruses: What Have We Learned from Them?

(2010) Eckard Wimmer et al.   Annual Review of Microbiology

The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti

(2010) Cynthia CH Khoo et al.   BMC MICROBIOLOGY

Live attenuated influenza virus vaccines by computer-aided rational design

(2010) Steffen Mueller et al.   NATURE BIOTECHNOLOGY

The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages

(2010) Marc Daigneault et al.   PLoS One

C6/36 Aedes albopictus Cells Have a Dysfunctional Antiviral RNA Interference Response

(2010) Doug E. Brackney et al.   PLoS Neglected Tropical Diseases

Putting Synthesis into Biology: A Viral View of Genetic Engineering through De Novo Gene and Genome Synthesis

(2009) Steffen Mueller et al.   CHEMISTRY & BIOLOGY

The Aedes aegypti cell line CCL-125 is dengue virus permissive

(2009) Nitwara Wikan et al.   JOURNAL OF VIROLOGICAL METHODS

Genetic Inactivation of Poliovirus Infectivity by Increasing the Frequencies of CpG and UpA Dinucleotides within and across Synonymous Capsid Region Codons

(2009) C. C. Burns et al.   JOURNAL OF VIROLOGY

Synthetic viruses: a new opportunity to understand and prevent viral disease

(2009) Eckard Wimmer et al.   NATURE BIOTECHNOLOGY

Virus-Host Coevolution: Common Patterns of Nucleotide Motif Usage in Flaviviridae and Their Hosts

(2009) Francisco P. Lobo et al.   PLoS One

Genome-scale relationships between cytosine methylation and dinucleotide abundances in animals

(2008) Martin W. Simmen   GENOMICS

T7 RNA polymerase-dependent and -independent systems for cDNA-based rescue of Rift Valley fever virus

(2008) M. Habjan et al.   JOURNAL OF GENERAL VIROLOGY

Attenuation by a Thousand Cuts

(2008) John M. Coffin   NEW ENGLAND JOURNAL OF MEDICINE

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE