Article
Biochemistry & Molecular Biology
Marwin A. Farrugia, Maena Le Corvec, Christophe Renou, Jean-Baptiste J. Nousbaum, Dann J. Ouizeman, Olivier Sire, Olivier Loreal, Hugues Tariel, Jerome Bernard, Thierry Piche, Albert Tran, Hafid Ait-Oufella, Luce Landraud, Philippe Gual, Rodolphe Anty
Summary: This study aimed to evaluate the diagnostic value of a rapid and easy-to-use mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out spontaneous bacterial peritonitis (SBP). The results showed that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP.
Article
Gastroenterology & Hepatology
Ryuta Shigefuku, Motoh Iwasa, Akiko Eguchi, Yasuyuki Tamai, Kyoko Yoshikawa, Ryosuke Sugimoto, Yoshiyuki Takei
Summary: The study found that serum copeptin levels are associated with liver and renal function, increase with the progression of liver disease, and are also linked to hepatic encephalopathy. Serum copeptin, albumin-bilirubin score, and hepatocellular carcinoma are independent predictors of PSS formation and reduced survival rates. Serum copeptin and albumin-bilirubin scores are independent predictors of ascites retention, and are negatively correlated with mortality rates.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Paolo Caraceni, Manuel Tufoni, Giacomo Zaccherini, Oliviero Riggio, Paolo Angeli, Carlo Alessandria, Sergio Neri, Francesco G. Foschi, Fabio Levantesi, Aldo Airoldi, Loredana Simone, Gianluca Svegliati-Baroni, Stefano Fagiuoli, Giacomo Laffi, Raffaele Cozzolongo, Vito Di Marco, Vincenzo Sangiovanni, Filomena Morisco, Pierluigi Toniutto, Antonio Gasbarrini, Rosanna De Marco, Salvatore Piano, Silvia Nardelli, Chiara Elia, Andrea Roncadori, Maurizio Baldassarre, Mauro Bernardi
Summary: Baseline serum albumin concentration closely correlates with 18-month mortality in untreated patients; on-treatment serum albumin levels are strongly associated with outcomes, especially at 1 month after treatment. Long-term albumin administration improves patient survival even if the serum albumin level does not normalize.
JOURNAL OF HEPATOLOGY
(2021)
Article
Chemistry, Analytical
Andrey Bogomolov, Tatiana Sakharova, Iskander Usenov, Camillo Mizaikoff, Valeria Belikova, Stanislav Perevoschikov, Viacheslav Artyushenko, Olga Bibikova
Summary: A multispectral fiber optic probe has been developed for simultaneous analysis of various liquid and solid samples using attenuated total reflection mid-infrared spectroscopy and fluorimetry. Technical evaluation has confirmed its output signal quality comparable to single-method probes, demonstrating the capability to deliver complementary chemical information. The qualitative analysis of biological tissue is highlighted as one of the key applications of this developed multispectral probe.
ANALYTICAL CHEMISTRY
(2021)
Article
Physics, Applied
Mohit Kumar, Pawan Kumar, Andres Vega, Maximilian A. Weissflog, Thomas Pertsch, Frank Setzpfandt
Summary: By tuning the pump wavelength, we have successfully achieved phase matching for nondegenerate photon pair generation in a silver gallium sulfide AgGaS2 crystal, generating photon pairs in the mid-infrared and visible spectral ranges. Additionally, we demonstrated photon pair generation with broad spectral bandwidth.
APPLIED PHYSICS LETTERS
(2021)
Article
Gastroenterology & Hepatology
Yasunari Hiramine, Hirofumi Uto, Seiichi Mawatari, Shuji Kanmura, Yasushi Imamura, Takuya Hiwaki, Akiko Saishoji, Manei Oku, Koichi Tokushige, Shigeho Maenohara, Akio Ido
Summary: In patients with hepatic ascites, the incidence of AKI is high and is associated with a significantly worse prognosis. The use of tolvaptan (TLV) in combination with diuretics may reduce the risk of AKI and have a synergistic therapeutic effect on hepatic ascites.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
I van den Berg, P. N. Ho, T. D. W. Luke, M. Haile-Mariam, S. Bolormaa, J. E. Pryce
Summary: Breeding objectives in the dairy industry have shifted to include fertility, animal health, and environmental impact, in addition to production. Utilizing milk mid-infrared spectroscopic predictions of biomarkers can enhance genomic prediction accuracy for these traits, showing potential for more comprehensive breeding strategies.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Chemistry, Analytical
Hanwen Qu, Wei Wu, Chen Chen, Ziwei Yan, Wenjia Guo, Chunzhi Meng, Xiaoyi Lv, Fangfang Chen, Cheng Chen
Summary: The study aims to classify glioma patients using serum mid-infrared spectroscopy combined with ensemble learning method. Different base classifiers were used and AdaBoost integration was introduced to improve accuracy. The final classification accuracy of the test set reached 94.29%, showing great potential for non-invasive and precise identification of glioma patients as well as intelligent diagnosis of other diseases.
ANALYTICAL METHODS
(2021)
Article
Computer Science, Artificial Intelligence
Kejing Zhu, Jie Shen, Wen Xu, Keyu Yue, Liying Zhu, Yulin Niu, Qing Wu, Wei Pan
Summary: This study explores the potential application of mid-infrared spectroscopy combined with machine learning for the differentiation of breast and lung cancers. By collecting blood samples, separating serum, and training classification models, significant differences were found in certain intervals, which may reflect the absorption of key chemical bonds in protein molecules. The results show that the prediction model trained based on fine KNN has the best performance and can achieve 100% prediction on the test set samples. This method may help reduce the cancer burden through early detection and appropriate treatment and care in underserved areas.
INTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS
(2023)
Article
Food Science & Technology
Stephen E. Holroyd, Elizabeth Nickless, Philip Watkinson
Summary: Infrared spectroscopy and Raman spectroscopy were used to analyze food samples and study their chemical structure. This research focused on the effects of ageing on the protein structure in Cheddar cheese using Raman and mid-infrared (MIR) spectroscopy combined with chemometrics approaches. The results demonstrate the potential of Raman confocal imaging and MIR spectroscopy in understanding chemical changes in complex dairy matrices.
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Natalie Harris, Claudia Gonzalez Viejo, Christopher Barnes, Sigfredo Fuentes
Summary: Due to the increasing rates of wine fraud, it is important to develop non-invasive techniques to assess wine quality and provenance. This study used near-infrared spectroscopy to analyze unopened bottles of Shiraz wines from Australia and developed accurate machine learning models to predict wine vintage, sensory descriptors, and volatile aromatic compounds. The proposed method allows for the assessment of wine traits without opening the bottle, which can be used to detect fraud and provenance.
FERMENTATION-BASEL
(2023)
Article
Optics
Yujie Cai, Yu Chen, Xiaoning Xin, Kun Huang, E. Wu
Summary: This study demonstrates a broadband mid-infrared (MIR) single-photon frequency upconversion spectroscopy method. By utilizing the temporal-spectral quantum correlation of non-degenerate photon pairs, the signal is extracted from the noise caused by strong pump, achieving single-photon-level MIR spectral measurement. The system features non-destructive and robust operation, making it an appealing option for biochemical applications.
PHOTONICS RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Sander De Bruyne, Marijn M. Speeckaert
Summary: Traditional renal biomarkers are insensitive for early detection of kidney disease. Infrared spectroscopy offers a label-free and non-destructive method for quick and inexpensive diagnosis of kidney disorders. This review provides an overview of the applications of near- and mid-infrared spectroscopy in patients with acute kidney injury and chronic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Analytical
Md Rejvi Kaysir, Jiaqi Song, Shazzad Rassel, Abdulrahman Aloraynan, Dayan Ban
Summary: The prevalence of diabetes is increasing worldwide, leading to severe health complications. The development of non-invasive techniques for blood glucose measurement based on photoacoustic spectroscopy (PAS) has shown great promise. However, there are challenges with penetration depth and interference from other components in blood. This review paper describes the basics of PAS in the MIR region, recent developments, challenges, and proposes improvements, including incorporating machine learning, to enhance glucose detection sensitivity.
Article
Multidisciplinary Sciences
Angelos Xomalis, Xuezhi Zheng, Rohit Chikkaraddy, Zsuzsanna Koczor-Benda, Ermanno Miele, Edina Rosta, Guy A. E. Vandenbosch, Alejandro Martinez, Jeremy J. Baumberg
Summary: Optomechanical interactions enable coherent interconversion of signals between optical and mechanical domains. Extreme light-matter coupling at nanoscale mode volumes allows single mid-infrared (MIR) photon sensitivity. This study demonstrates frequency upconversion by utilizing infrared absorption and Raman activity of molecular vibrations in plasmonic nanocavities, showing potential for low-cost and large-scale infrared detectors and spectroscopic techniques.
Article
Physiology
Kevin Nay, David Martin, Luz Orfila, Dany Saligaut, Brice Martin, Mathieu Horeau, Thibaut Cavey, Moussa Kenawi, Marie-Laure Island, Martine Ropert, Olivier Loreal, Christelle Koechlin Ramonatxo, Frederic Derbre
Summary: This study investigated the effects of simulated microgravity on iron metabolism in rats, finding that exposure to microgravity leads to iron misdistribution and durable reduction in iron availability. The upregulation of hepcidin in response to microgravity is not a transient adaptation, and skeletal muscle may not play a key role in the iron misdistribution that occurs in this environment.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Noemie Le Tallec-Esteve, Chloe Rousseau, Benoit Desrues, Olivier Loreal, Ronan Thibault
Summary: The study found that serum iron parameters were positively associated with the severity of OSAS and time spent under hypoxia, indicating a potential impact of OSAS-induced hypoxia on iron metabolism in obese patients.
CLINICAL NUTRITION
(2021)
Article
Rheumatology
Jean-David Albert, Maena Le Corvec, Olivia Berthoud, Claire David, Xavier Guennoc, Emmanuel Hoppe, Sandrine Jousse-Joulin, Benoit Le Goff, Hugues Tariel, Olivier Sire, Anne Jolivet-Gougeon, Guillaume Coiffier, Olivier Loreal
Summary: The study demonstrates that mid-infrared fibre evanescent wave spectroscopy can effectively differentiate septic from non-septic synovial fluids in a multicentre cohort, and is particularly useful in ruling out septic arthritis.
Article
Critical Care Medicine
Xavier Mariette, Olivier Hermine, Pierre Louis Tharaux, Matthieu Resche-Rigon, Raphael Porcher, Philippe Ravaud, Serge Bureau, Maxime Dougados, Annick Tibi
Summary: The study aimed to determine the effectiveness of anakinra in improving outcomes of patients with mild-to-moderate COVID-19 pneumonia, but the results showed that anakinra did not show improvement in patient outcomes. Further studies are needed to assess the efficacy of anakinra in other selected groups of patients with more severe COVID-19.
LANCET RESPIRATORY MEDICINE
(2021)
Review
Hematology
Eolia Brissot, Marie-Berengere Troadec, Olivier Loreal, Pierre Brissot
Summary: Iron plays a crucial role in hematopoiesis, including thrombopoiesis, directing the lineage commitment of progenitor cells. While iron deficiency can lead to thrombocytosis and potentially favor vascular thrombosis, severe iron deficiency anemia can also cause thrombocytopenia. The relationship between iron and platelet function remains debated, with different conditions like iron overload or sequestration leading to diverse effects on platelet counts and functioning.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Chemistry, Physical
Ellyn A. King, Sabyasachi Sen, Wataru Takeda, Catherine Boussard-Pledel, Bruno Bureau, Jean-Pierre Guin, Pierre Lucas
Summary: Germanium selenide glasses aged for up to 20 years at room temperature exhibit structural relaxation as observed through Raman spectroscopy, with changes in the ratio of tetrahedral units and configurational entropy. The non-reversing enthalpy obtained by MDSC is not a reliable measure of the ability of a glass to relax.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Chemistry, Inorganic & Nuclear
Claudia Goncalves, Raphael Mereau, Virginie Nazabal, Catherine Boussard-Pledel, Claire Roiland, Eric Furet, Michael Deschamps, Bruno Bureau, Marc Dussauze
Summary: The study on the Ge-Te-Se glassy system utilizes multi-techniques such as solid-state NMR, Raman and infrared spectroscopies, and DFT calculations to provide insights into its structural organization and interconnections, with a focus on mixed structural units. This experimental/theoretical approach is applied to both selenium and tellurium rich parts of the glassy system.
JOURNAL OF SOLID STATE CHEMISTRY
(2021)
Review
Microbiology
Thomas Gautier, Sandrine David-Le Gall, Alaa Sweidan, Zohreh Tamanai-Shacoori, Anne Jolivet-Gougeon, Olivier Loreal, Latifa Bousarghin
Summary: The global pandemic caused by the emergence of SARS CoV-2 has led to significant health impacts, with no specific treatment available yet. Alterations in gut microbiota in COVID-19 patients have drawn attention to the potential use of probiotics as alternative therapies.
Article
Chemistry, Physical
Yaroslav Shpotyuk, Pavlo Demchenko, Oleh Shpotyuk, Valentina Balitska, Catherine Boussard-Pledel, Bruno Bureau, Zdenka Lukacova Bujnakova, Peter Balaz
Summary: The impact of high-energy milling on glassy arsenic monoselenide g-AsSe is studied with X-ray diffraction, revealing changes in intermediate- and extended-range ordering. The reamorphization of the molecular-to-network under nanomilling results in a breakdown of intermediate-range ordering and changes in extended-range ordering. The microstructure scenarios are identified using an ab initio quantum-chemical cluster modeling code.
Article
Biochemistry & Molecular Biology
Laura E. Diepeveen, Gaby Stegemann, Erwin T. Wiegerinck, Rian Roelofs, Myrthe Naber, Olivier Loreal, Bart Smeets, Frank Thevenod, Dorine W. Swinkels, Rachel P. L. van Swelm
Summary: Hemolysis can cause acute kidney injury, and the iron regulatory hormone hepcidin plays a protective role during this process. The synthesis of renal hepcidin is induced by iron and hemin through the Nrf2 pathway. Kidney-specific mechanisms of hepcidin regulation exist, highlighting the complexity of iron regulatory mechanisms during AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
David Martin, Kevin Nay, Francois Robin, Amelie Rebillard, Luz Orfila, Brice Martin, Patricia Leroyer, Pascal Guggenbuhl, Suzanne Dufresne, Philippe Noirez, Martine Ropert, Olivier Loreal, Frederic Derbre
Summary: This study investigates the impact of iron excess on skeletal muscle structure and metabolic adaptations. The results suggest that skeletal muscle can protect itself from the deleterious effects of iron overload under pathophysiological conditions.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Gastroenterology & Hepatology
Amandine Landemaine, Houda Hamdi-Roze, Severine Cunat, Veronique Loustaud-Ratti, Xavier Causse, Si Nafa Si Ahmed, Bernard Drenou, Christophe Bureau, Gilles Pelletier, Caroline De Kerguenec, Nathalie Ganne-Carrie, Stephane Durupt, Fabrice Laine, Olivier Loreal, Martine Ropert, Lenaick Detivaud, Jeff Morcet, Patricia Aguilar-Martinez, Yves M. Deugnier, Edouard Bardou-Jacquet
Summary: Based on the derivation cohort study of ferroportin disease, we have developed a simple and readily available scoring system that can be used for screening in routine clinical practice. The scoring system has good diagnostic performance for identifying patients with ferroportin disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Immunology
Guillaume Coiffier, Emmanuelle Ducasse, Arthur Keraudren, Emilie Prat, Hortense Modeste, Jean-David Albert, Olivier Loreal, Pascal Guggenbuhl, Anne Jolivet-Gougeon
Summary: The performance of different types of blood culture vials was compared in osteoarticular specimens. The use of these vials shortened the positive detection time, and there was no significant difference in the positivity rate between different vials. It is crucial to use both aerobic and anaerobic vials simultaneously to maximize the positive detection time during diagnostic procedures.
MICROBIAL PATHOGENESIS
(2022)
Review
Medicine, General & Internal
Pierre Allaume, Noemie Rabilloud, Bruno Turlin, Edouard Bardou-Jacquet, Olivier Loreal, Julien Calderaro, Zine-Eddine Khene, Oscar Acosta, Renaud De Crevoisier, Nathalie Rioux-Leclercq, Thierry Pecot, Solene-Florence Kammerer-Jacquet
Summary: This study provides a systematic review of applications and performances of deep neural network algorithms in liver pathology. The results show that DNN models have diverse applications in this field, but most studies have a high risk of bias. Therefore, DNN models in liver pathology present both opportunities and limitations.
Article
Nutrition & Dietetics
Kevin Nay, Mathieu Horeau, Olivier Loreal, Frederic Derbre
Summary: This study discusses the regulation of iron metabolism and the potential harm of iron misdistribution on health under microgravity or bedrest, proposing new ways to improve nutritional care for astronauts and bedridden patients.
CAHIERS DE NUTRITION ET DE DIETETIQUE
(2021)