TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets
Authors
Keywords
Macrophages, Phagocytosis, Cytokines, Cloning, Flow cytometry, Lymphoma cells, Chemokines, CD coreceptors
Journal
PLoS One
Volume 12, Issue 10, Pages e0187262
Publisher
Public Library of Science (PLoS)
Online
2017-10-31
DOI
10.1371/journal.pone.0187262
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
- (2016) Penka S. Petrova et al. CLINICAL CANCER RESEARCH
- New insights into the multidimensional concept of macrophage ontogeny, activation and function
- (2016) Florent Ginhoux et al. NATURE IMMUNOLOGY
- Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo
- (2016) Michael Zhang et al. PLoS One
- Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk
- (2015) Mingye Feng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of Fc R-mediated phagocytosis by IVIg is independent of IgG-Fc sialylation and Fc RIIb in human macrophages
- (2014) S. Q. Nagelkerke et al. BLOOD
- Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
- (2014) Peter J. Murray et al. IMMUNITY
- The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target
- (2013) A. Neil Barclay et al. Annual Review of Immunology
- Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells
- (2013) Sandra Redlich et al. Journal of Neuroinflammation
- The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications
- (2012) Mark P Chao et al. CURRENT OPINION IN IMMUNOLOGY
- Phenotypic characterization of lung macrophages in asthmatic patients: Overexpression of CCL17
- (2012) Karl J. Staples et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction
- (2012) G. Zizzo et al. JOURNAL OF IMMUNOLOGY
- Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy
- (2011) Takami Sato et al. IMMUNOLOGIC RESEARCH
- An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
- (2011) Anca Sindrilaru et al. JOURNAL OF CLINICAL INVESTIGATION
- Functional Characteristics of the High Affinity IgG Receptor, Fc RI
- (2011) C. E. van der Poel et al. JOURNAL OF IMMUNOLOGY
- Macrophage regulation of tumor angiogenesis: Implications for cancer therapy
- (2011) Mario Leonardo Squadrito et al. MOLECULAR ASPECTS OF MEDICINE
- Cytokine-induced immune complex binding to the high-affinity IgG receptor, Fc RI, in the presence of monomeric IgG
- (2010) C. E. van der Poel et al. BLOOD
- Macrophage Diversity Enhances Tumor Progression and Metastasis
- (2010) Bin-Zhi Qian et al. CELL
- Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion
- (2009) A. Varin et al. BLOOD
- Toll-Like Receptor Stimulation Enhances Phagocytosis and Intracellular Killing of Nonencapsulated and Encapsulated Streptococcus pneumoniae by Murine Microglia
- (2009) S. Ribes et al. INFECTION AND IMMUNITY
- M2 Macrophages Phagocytose Rituximab-Opsonized Leukemic Targets More Efficiently than M1 Cells In Vitro
- (2009) M. Leidi et al. JOURNAL OF IMMUNOLOGY
- CD36 and TLR Interactions in Inflammation and Phagocytosis: Implications for Malaria
- (2009) L. K. Erdman et al. JOURNAL OF IMMUNOLOGY
- Expression of the Inhibitory CD200 Receptor Is Associated with Alternative Macrophage Activation
- (2009) Nathalie Koning et al. Journal of Innate Immunity
- Specificity and affinity of human Fc receptors and their polymorphic variants for human IgG subclasses
- (2008) P. Bruhns et al. BLOOD
- High tumour islet macrophage infiltration correlates with improved patient survival but not with EGFR mutations, gene copy number or protein expression in resected non-small cell lung cancer
- (2008) D-W Kim et al. BRITISH JOURNAL OF CANCER
- Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer
- (2008) M. Ryder et al. ENDOCRINE-RELATED CANCER
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started