Review
Oncology
Courtney Hoskinson, Rachel Yutong Jiang, Leah T. Stiemsma
Summary: The mammary microbiome and gut microbiome are associated with breast cancer, with unique microbial signatures and dysbiosis occurring in these areas. Specific breast and gut microbes can influence host immune responses and chemotherapies affect the microbiome. Understanding the role of the microbiome using multi-omic approaches and animal models is important for improving strategies for breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min Chen, Shizhao Li, Itika Arora, Nengjun Yi, Manvi Sharma, Zhenhai Li, Trygve O. Tollefsbol, Yuanyuan Li
Summary: This study aimed to investigate the effects of maternal exposure to genistein (GE), a natural isoflavone enriched in soybean products, on the prevention of overnutrition-induced breast cancer later in life. The results showed that maternal dietary GE treatment improved metabolic functions and delayed mammary tumor development in offspring mice. The study suggested that maternal GE consumption could effectively intervene in early-life obesity-related metabolic disorders and breast cancer by influencing the interplay between early-life gut microbiota, microbial metabolite profiles, and offspring epigenome.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Pajau Vangay, Tonya Ward, Sarah Lucas, Lalit K. Beura, Dominique Sabas, Max Abramson, Lisa Till, Susan L. Hoops, Purna Kashyap, Ryan C. Hunter, David Masopust, Dan Knights
Summary: In this study, the differential effects of human gut microbiota from the United States and rural Thailand on the murine gut mucosa and immune system were assessed. The results suggest that Western-associated human gut microbes contribute to a pro-inflammatory immune response.
Article
Nutrition & Dietetics
Jacquelyn Cheng, Nikolai Kolba, Philip Sisser, Sondra Turjeman, Carmel Even, Omry Koren, Elad Tako
Summary: This study investigated the effects of genistein administration on trace mineral status, BBM functionality, intestinal morphology, and intestinal microbiome in Gallus gallus. The results showed that intraamniotic administration of 2.5% genistein improved villus surface area, acidic goblet cells, and hemoglobin levels. Genistein exposure also downregulated DcytB and upregulated hepcidin expression, and positively altered the composition and function of the intestinal microbiota.
Article
Nutrition & Dietetics
Alessio Cardilli, Ibrahim Hamad, Aleksandra Dyczko, Sofie Thijs, Jaco Vangronsveld, Dominik N. Mueller, Stephan P. Rosshart, Markus Kleinewietfeld
Summary: This article investigates the effect of a high-salt diet on the gut microbiota of laboratory and wild mice. The results show that the high-salt diet leads to a decrease in microbial diversity and significant changes in microbial composition in laboratory mice, while the gut microbiota of wild mice remains relatively unaffected. This finding has important implications for future translational microbiome research.
Article
Gastroenterology & Hepatology
Naoyoshi Nagata, Tadashi Takeuchi, Hiroaki Masuoka, Ryo Aoki, Masahiro Ishikane, Noriko Iwamoto, Masaya Sugiyama, Wataru Suda, Yumiko Nakanishi, Junko Terada-Hirashima, Moto Kimura, Tomohiko Nishijima, Hiroshi Inooka, Tohru Miyoshi-Akiyama, Yasushi Kojima, Chikako Shimokawa, Hajime Hisaeda, Fen Zhang, Yun Kit Yeoh, Siew C. Ng, Naomi Uemura, Takao Itoi, Masashi Mizokami, Takashi Kawai, Haruhito Sugiyama, Norio Ohmagari, Hiroshi Ohno
Summary: This study investigates the interrelationships among gut microbes, metabolites, and cytokines in COVID-19 and its complications, and validates the results with follow-up data. The results show multiple correlations between COVID-19-related microbes, gut metabolites, and inflammatory cytokine dynamics, especially in severe disease and pneumonia. The study also confirms the concordance of altered metabolites in COVID-19 with their corresponding microbial functional genes.
Article
Cell Biology
Noemi Cabre, Yi Duan, Cristina Llorente, Mary Conrad, Patrick Stern, Dennis Yamashita, Bernd Schnabl
Summary: The bile acid sequestrant colesevelam was found to alleviate ethanol-induced liver steatosis in mice, although it did not significantly impact liver injury and inflammation.
Article
Oncology
Yiqi Fan, Qing Su, Junxiao Chen, Yong Wang, Shuai He
Summary: This study evaluated the relationship between gut microbiome (GM) and glioma and found that an imbalance in GM promotes glioma growth, while a balanced GM can delay glioma development. In particular, an increased abundance of Bacteroidia is associated with accelerated glioma progression.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Raghad Khalid AL-Ishaq, Alena Liskova, Peter Kubatka, Dietrich Busselberg
Summary: Consumption of flavonoids impact GI cancer positively, with 90% undergoing enzymatic metabolism by gut microbiome. Efforts to combine specific flavonoids with current treatments are needed to evaluate their effects on cancer progression. Studies on standardizing flavonoid administration methods are required for further research.
Review
Nutrition & Dietetics
Hala Elzayat, Ghaidaa Mesto, Farah Al-Marzooq
Summary: Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic inflammation of the gastrointestinal tract (GIT). Recent research has shown the significant role of the oral and gut microbiome in the development and progression of IBD and their impact on overall gut health. The interconnected oral and gut microbiome, as complex microbial communities, are implicated in IBD pathogenesis, and understanding their relationship can provide insights into disease management and prevention strategies.
Review
Biochemistry & Molecular Biology
Aravind Thavamani, Iman Salem, Thomas J. Sferra, Senthilkumar Sankararaman
Summary: Cystic fibrosis is a deadly genetic disorder that affects fluid regulation and pH balance in the body, as well as gut dysbiosis. Due to the use of antibiotics and inherent dysfunction of CFTR, gut dysbiosis can have an impact on various symptoms of cystic fibrosis.
Article
Gastroenterology & Hepatology
Antonio Rubio-Del-Campo, Roberto Gozalbo-Rovira, Eva M. Moya-Gonzalvez, Juan Alberola, Jesus Rodriguez-Diaz, Maria J. Yebra
Summary: The study showed that different disaccharides have varying effects on infant gut microbiota, with 3FN demonstrating physiological and immunomodulatory effects on the colon.
Article
Immunology
Ji Hye Jeong, Sujin Park, Sangyeon Lee, Yeounhee Kim, In Kyong Shim, Seong-Yun Jeong, Eun Kyung Choi, Jinju Kim, Eunsung Jun
Summary: A pancreatic cancer model using humanized mice was constructed to monitor tumor growth and investigate the correlation between immune cell count and tumor ECM density. Tumor-derived cells and organoids with continuous passage capacity were isolated from the model for testing the efficacy of targeted immunotherapeutic agents.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Anja Kathrin Wege, Eva-Maria Rom-Jurek, Paul Jank, Carsten Denkert, Peter Ugocsai, Christine Solbach, Jens-Uwe Blohmer, Bruno Sinn, Marion Mackelenbergh, Volker Moebus, Andreas Trumpp, Elisabetta Marangoni, Nicole Pfarr, Christoph Irlbeck, Jens Warfsmann, Bernhard Polzer, Florian Weber, Olaf Ortmann, Sibylle Loibl, Valentina Vladimirova, Gero Brockhoff
Summary: The study aimed to discover and validate biomarkers associated with tumor progression and clinical outcome in Luminal breast cancer, with findings showing that an elevated mdm2 gene was linked to tumor growth and metastasis in mice, as well as correlated with prognosis and treatment response in patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Microbiology
Rosana Wiscovitch-Russo, Aji Mary Taal, Claire Kuelbs, Lauren M. Oldfield, MohanKumar Ramar, Harinder Singh, Alexey V. Fedulov, Norberto Gonzalez-Juarbe
Summary: This study examined the changes in the gut and lung microbiome during pregnancy in mice. The results showed differences in the microbial composition of the gut and lung between pregnant and non-pregnant mice. Pregnancy significantly contributed to the variance in both the lung and stool microbiome. However, after removing common gut-associated bacteria from the lung dataset, no microbial differential abundance was observed between the pregnant and non-pregnant lung microbiota.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Mohammad Mijanur Rahman, Trygve O. Tollefsbol
Summary: Cancer therapeutics is constantly evolving, with CRISPR-dCas9 emerging as a promising precision cancer treatment option that can modify cancer epigenetic features. Challenges such as off-target effects and lack of efficient delivery systems need to be addressed when targeting cancer with sgRNA-dCas9.
Article
Biochemical Research Methods
Shizhao Li, Trygve O. Tollefsbol
Summary: DNA methylation plays a crucial role in epigenetic regulation in eukaryotes, impacting various biological processes in health and disease. Research has shown that DNA methylation extends beyond promoter regions of genes to gene bodies, repeat sequences, and transcriptional start sites. Advances in DNA methylation analysis technologies have enabled a more comprehensive understanding of its patterns and distribution in the genome.
Article
Biochemical Research Methods
Itika Arora, Trygve O. Tollefsbol
Summary: The field of epigenetics plays a crucial role in regulating genomic interactions and has significant implications for diseases such as cancer. Researchers analyze epigenetics data through genome-wide studies and high-throughput methods, utilizing bioinformatics tools to identify key modifications. Next-generation sequencing technology is used for high-throughput genomic profiling, allowing researchers to understand various epigenetic modifications accurately and in parallel.
Article
Oncology
Min Chen, Shizhao Li, Vinodh Srinivasasainagendra, Manvi Sharma, Zhenhai Li, Hemant Tiwari, Trygve O. Tollefsbol, Yuanyuan Li
Summary: Maternal exposure to genistein from soybean products has a time-dependent effect on early-life breast cancer development in offspring mice, potentially through inherited epigenetic changes in candidate genes.
Article
Oncology
Tomi Akinyemiju, Taofik Oyekunle, Omolola Salako, Anjali Gupta, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, April Deveaux, Allison Hall, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna Arnett, Michael J. Muehlbauer, Christopher B. Newgard, Adetola Daramola
Summary: In a case-control study of 555 West African women, metabolic syndrome was strongly associated with breast cancer and the aggressive triple-negative molecular subtype. Clinical and lifestyle interventions targeting metabolic syndrome are needed to reduce breast cancer risk in this population.
CLINICAL BREAST CANCER
(2022)
Article
Multidisciplinary Sciences
Itika Arora, Manvi Sharma, Shizhao Li, Michael Crowley, David K. Crossman, Yuanyuan Li, Trygve O. Tollefsbol
Summary: This study demonstrates that maternal exposure to a Broccoli sprouts (BSp) diet can prevent mammary tumor development in offspring. The study also identifies key genes with differential expression and DNA methylation patterns in the offspring mammary tumor. Additionally, the study reveals an impact of maternal BSp treatment on DNA methyltransferase and histone deacetylases activity.
Article
Oncology
Manvi Sharma, Trygve O. Tollefsbol
Summary: Dietary phytochemicals have the ability to prevent cancer by regulating the epigenome. Some natural botanicals, when combined at optimal concentrations, can synergistically decrease cellular viability and inhibit tumor growth in breast cancer cell lines. These combinations also down-regulate the levels of enzymes involved in epigenetic modifications and induce global changes in chromatin modifications. This study suggests that combined use of these dietary compounds may have implications in breast cancer therapy.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Min Chen, Shizhao Li, Itika Arora, Nengjun Yi, Manvi Sharma, Zhenhai Li, Trygve O. Tollefsbol, Yuanyuan Li
Summary: This study aimed to investigate the effects of maternal exposure to genistein (GE), a natural isoflavone enriched in soybean products, on the prevention of overnutrition-induced breast cancer later in life. The results showed that maternal dietary GE treatment improved metabolic functions and delayed mammary tumor development in offspring mice. The study suggested that maternal GE consumption could effectively intervene in early-life obesity-related metabolic disorders and breast cancer by influencing the interplay between early-life gut microbiota, microbial metabolite profiles, and offspring epigenome.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Anjali Gupta, Veeral Saraiya, April Deveaux, Taofik Oyekunle, Klarissa D. Jackson, Omolola Salako, Adetola Daramola, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna Arnett, Michael J. Muehlbauer, Christopher B. Newgard, Tomi Akinyemiju
Summary: There is a relationship between lipid biomarkers and breast cancer in African women, with low-density lipoprotein and high-density lipoprotein associated with different subtypes of breast cancer.
SCIENTIFIC REPORTS
(2022)
Review
Microbiology
Huixin Wu, Sebanti Ganguly, Trygve O. Tollefsbol
Summary: Breast cancer is the most common cancer in women in the United States. Recent studies have shown that microbiota composition is a new risk factor for breast cancer, and alterations in gut and breast microbiota are associated with prognosis. Nutritional treatment with probiotics and prebiotics is an emerging and promising strategy for prevention and treatment of breast cancer, as they can modulate microbiota population.
Article
Oncology
Andrew Brane, Itika Arora, Trygve O. O. Tollefsbol
Summary: Certain life stages, known as critical periods, during growth and development are thought to be important for later-life breast cancer initiation and progression. Nutritional factors, especially those found in plant-based diets, are believed to be key to the impact of these critical periods on cancer. In this study, nutritional intervention during the critical period of puberty was found to reduce tumor size and incidence while delaying latency, with significant alterations in gene expression patterns and methylation profiles.
Article
Cell Biology
Itika Arora, Shizhao Li, Michael R. Crowley, Yuanyuan Li, Trygve O. Tollefsbol
Summary: Combined treatment with broccoli sprouts and green tea polyphenols shows more efficacy in inhibiting the growth of breast tumors and regulating epigenetic modifications and tumor-related genes compared to individual treatments.
Article
Biochemistry & Molecular Biology
Fang Zhang, Mert Icyuz, Trygve Tollefsbol, Paul Alan Cox, Sandra Anne Banack, Liou Y. Sun
Summary: Neurodegenerative diseases involve changes in cognition, anxiety and autism-like behaviors, which are affected by epigenetic alterations. This study found that L-serine administration in GHRH-KO mice improved anxiety symptoms and behavioral deficits, while upregulating epigenetic markers and mRNA expression related to anxiety, cognition and autism-like behaviors. These findings offer new insights into the beneficial effects of L-serine intervention on neuropsychological impairments.
Article
Biochemistry & Molecular Biology
Huixin Wu, William J. Van Der Pol, Laura G. Dubois, Casey D. Morrow, Trygve O. Tollefsbol
Summary: Breast cancer is highly prevalent in women in the US, and diet and nutrition supplementation play a role in its onset and progression. In this study, the effect of inulin-supplemented diet on preventing estrogen receptor-negative mammary carcinoma was investigated in a mouse model. The results showed that inulin supplementation significantly inhibited tumor growth and delayed tumor latency. The mice consuming inulin had a distinct gut microbiome and higher diversity of gut microbial composition compared to the control. These findings suggest that modulating microbial composition through inulin consumption could be a promising strategy for breast cancer prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Shizhao Li, Huixin Wu, Min Chen, Trygve O. Tollefsbol
Summary: The study investigates the transgenerational influence and epigenetic regulation of paternal consumption of combined sulforaphane and epigallocatechin-3-gallate on the prevention of estrogen receptor-negative mammary cancer in transgenic mice. The results suggest that the combination of SFN and EGCG can synergistically suppress tumor growth and regulate gene expression related to tumorigenesis, showing potential for preventing ER(-) mammary cancer through transgenerational effects.
JOURNAL OF NUTRITION
(2023)