Review
Chemistry, Multidisciplinary
James Oyim, Calvin A. Omolo, Edith K. Amuhaya
Summary: The reduction of available drugs effective against microbes is worsening due to global antimicrobial resistance crisis. Innovative strategies, like Photodynamic Antimicrobial Chemotherapy (PACT), are needed to combat this. PACT utilizes light, oxygen, and a photosensitizer to destroy a wide spectrum of microorganisms, including resistant strains, showing promise in addressing antimicrobial resistance.
FRONTIERS IN CHEMISTRY
(2021)
Article
Polymer Science
Abdechakour Elkihel, Charlotte Vernisse, Tan-Sothea Ouk, Romain Lucas-Roper, Vincent Chaleix, Vincent Sol
Summary: This study presents a synthesis method for light-triggered antibacterial hydrogels based on xylan chains chemically bound to meso-tetra(4-carboxyphenyl)porphyrin (TCPP). TCPP not only acts as an efficient photosensitizer against Gram-positive bacteria, but also serves as a cross-linking agent for the hydrogels. The hydrogels were characterized using infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), and swelling and rheological tests. Under visible light irradiation, the hydrogels showed interesting antimicrobial activity against Staphylococcus aureus and Bacillus cereus, suggesting their potential for the treatment of skin bacterial infections through photodynamic antimicrobial chemotherapy (PACT).
Review
Chemistry, Inorganic & Nuclear
Balaji Babu, John Mack, Tebello Nyokong
Summary: Photodynamic therapy is a cancer treatment that involves a nontoxic photosensitizer, a light source, and ground-state molecular oxygen. Activation of the photosensitizer by light generates reactive oxygen species, which destroy cancer cells.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Patricia Santos, Ana T. P. C. Gomes, Leandro M. O. Lourenco, Maria A. F. Faustino, Maria G. P. M. S. Neves, Adelaide Almeida
Summary: The photodynamic action of three cationic porphyrins towards viruses was evaluated and compared with methylene blue. The study found that these porphyrins were more effective than methylene blue in the photoinactivation of viruses in plasma, and also had a moderate inactivation effect in whole blood. Therefore, these porphyrin compounds are promising and safe photosensitizers for photoinactivation of viruses in blood plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Taiga Yamada, Teruyuki Komatsu
Summary: Photodynamic therapy (PDT) utilizes visible-light irradiation of photosensitizers (PSs) to induce apoptosis in tumors and microbial cells. However, macrocyclic compounds tend to agglutinate and lose photochemical activity in aqueous environments. Encapsulation within liposomes and polymer micelles can overcome this limitation. Hemoproteins and serum albumin have shown potential as hosts for porphyrin PS molecules. This concept paper provides a comprehensive review of recent developments and trends of protein-porphyrin complex PSs for anticancer and antimicrobial PDT applications.
Article
Biochemistry & Molecular Biology
Ashish Kumar Yadav, Virendra Singh, Rajesh Kushwaha, Dependu Dolui, Rohit Rai, Prodyut Dhar, Arnab Dutta, Biplob Koch, Samya Banerjee
Summary: Four new Co-II complexes with different ligands were designed and synthesized. The photoactivity of these complexes was tuned by varying the pi conjugation in the ligands. Curcumin complexes showed intense absorption and fluorescence, which were useful for studying their intracellular uptake and localization in breast cancer cells. Furthermore, these complexes exhibited significant apoptotic photocytotoxicity and antibacterial activity under light exposure.
Article
Chemistry, Multidisciplinary
Maged S. Al-Fakeh, Samir Osman Mohammed Osman, Malek Gassoumi, Mokded Rabhi, Mohamed Omer
Summary: Palladium nanoparticles (Pd-NPs) synthesized using Saudi propolis exhibit environmental, fast, controlled, and cost-effective characteristics; the average particle size of Pd-NPs ranges from 3.14 to 4.62 nm, at the quantum scale; Saudi propolis-derived Pd-NPs demonstrate enhanced antimicrobial and anticancer activities.
Article
Chemistry, Multidisciplinary
Kayode Sanusi, Odunayo C. Atewolara-Odule, Nurudeen O. Sanyaolu, Adeola A. Ibikunle, Phindile B. Khoza, Nafisat O. Fatomi, Similoluwa A. Fasanya, Hope E. Abuka, Esther O. Jesugbile, Yusuf Yilmaz, Umit Ceylan
Summary: The adsorption properties and solubility behaviors of 18 porphyrin derivatives in different solvents were predicted using density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations. It was found that the photovoltaic properties were enhanced when the substituent of the parent porphyrin was -CO2H and acetonitrile (AcCN) or dichloromethane (DCM) was used as the solvent. The correlation between the adsorption properties on the TiO2 surface and the solubility properties in the selected solvents was poor, which was attributed to the porphyrin-solvent-TiO2 interaction.
STRUCTURAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Bhavya Khurana, Tan-Sothea Ouk, Romain Lucas, Mathias O. Senge, Vincent Sol
Summary: The number of drug-resistant bacteria is on the rise, and antimicrobial PDT offers an efficient and cost-effective way to eliminate these bacteria without causing resistance.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2022)
Article
Environmental Sciences
Fabien Aujoulat, Rose Ragot, Mylene Toubiana, Chrystelle Bancon-Montigny, Patrick Monfort, Christian Salles, Agnes Masnou, Sophie Delpoux, Marlene Rio, Marie-George Tournoud, Pierre Marchand, Estelle Jumas-Bilak, Patricia Licznar-Fajardo
Summary: Aquatic ecosystems under anthropic pressures, such as in the city of Montpellier, face challenges of antimicrobial resistance due to strong demographic pressures. The study utilized a method combining cultural and molecular approaches to explore antimicrobial resistance, revealing a significant increase in cultivable bacterial community, fecal bacteria from human origin, and prevalence of beta-lactamases and extended-spectrum beta-lactamases encoding-genes in urban rivers. Urban rivers in developed areas are shown to contribute to the dissemination of antimicrobial resistance, highlighting the importance of considering these environments as reservoirs for resistant bacteria.
Article
Biotechnology & Applied Microbiology
Solmaz Saghebasl, Hassan Amini, Abbas Nobakht, Sanya Haiaty, Hesam Saghaei Bagheri, Parisa Hasanpour, Morteza Milani, Sepideh Saghati, Ozra Naturi, Mehrdad Farhadi, Reza Rahbarghazi
Summary: This study investigated a nanofibrous matrix for promoting wound healing, which showed good cytocompatibility, antibacterial activity, and enhanced healing potential. The addition of an antibacterial agent and a drug release system improved the therapeutic effect of the matrix.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Anna Lewandowska-Andralojc, Ewelina Gacka, Tomasz Pedzinski, Gotard Burdzinski, Aleksandra Lindner, Jessica M. O'Brien, Mathias O. Senge, Aleksandra Siklitskaya, Adam Kubas, Bronislaw Marciniak, Justyna Walkowiak-Kulikowska
Summary: Two graphene oxide nanoassemblies, covalently and noncovalently bonded with TPPNH2, were fabricated. The noncovalent assembly showed enhanced photoinduced electron transfer efficiency from porphyrin to GO, while the covalent assembly generated singlet oxygen with comparable efficiency to free TPPNH2.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Pinar Sen, Rodah Soy, Sithi Mgidlana, John Mack, Tebello Nyokong
Summary: The emergence of antimicrobial resistance has made the development of photodynamic therapy (PDT) related applications essential, since microorganisms cannot develop resistance to this method. This study focuses on the synthesis, characterization, and evaluation of the utility of palladium porphyrins and their chitosan inclusion complexes as photosensitizer dye in photodynamic antimicrobial therapy (PACT). The photophysical-chemical studies showed that the immobilization of the porphyrins into the chitosan influenced their properties. Furthermore, the PACT activity of cationic porphyrin and its chitosan immobilization form were found to be effective in decreasing the number of viable cells up to 100% in vitro.
Article
Chemistry, Organic
Y. Shyma Mary, Yohannan Sheena Mary, Renjith Thomas, B. Narayana
Summary: The spectroscopic and chemical properties of three acetamide derivatives were experimentally and theoretically investigated, revealing detailed functional group assignments and interactions. Frontier orbital studies showed a delocalization of the LUMO in mono substituted phenyl rings, while the HOMO was found over the pyrazole ring and acetamide group with changes in polarity. The electron localization function indicated localization of electrons in specific C-H bonds adjacent to C-Cl bonds in the aromatic ring. Additionally, the compounds were suggested to have inhibitory activity against antitumor protein-chromophore complexes.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Yiting Deng, Shuhan Ma, Jiayu Li, Bowen Zheng, Zhibin Lv
Summary: Anticancer peptides (ACPs) are a promising new therapeutic approach in cancer treatment, as they can selectively target cancer cells. This study utilized machine learning algorithms to predict potential ACP sequences based on physicochemical features extracted from peptide sequences. By using feature selection methods, 19 key amino acid physicochemical properties were identified that can predict the likelihood of a peptide sequence functioning as an ACP. The study aims to enhance the efficiency of designing peptide sequences for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Urszula K. Komarnicka, Alessandro Niorettini, Sandra Koziel, Barbara Pucelik, Agata Barzowska, Daria Wojtala, Aleksandra Ziolkowska, Monika Lesiow, Agnieszka Kyziol, Stefano Caramori, Marina Porchia, Alina Bienko
Summary: In this study, two novel phosphine ligands and their corresponding metal complexes were synthesized and characterized. The copper(I) complexes were found to be highly unstable, while the ruthenium(II) and iridium(III) complexes showed promising cytotoxicity towards cancer cells. Further analysis revealed that these metal complexes effectively accumulated inside cancer cells, inducing apoptosis and altering the cell cycle. Additionally, the complexes exhibited low genotoxicity towards DNA and were able to generate reactive oxygen species. Furthermore, efficient anticancer action was demonstrated on multicellular tumor spheroids.
Article
Chemistry, Medicinal
Stanislaw Malicki, Barbara Pucelik, Edyta Zyla, Malgorzata Benedyk-Machaczka, Wojciech Galan, Anna Golda, Alicja Sochaj-Gregorczyk, Marta Kaminska, Joao Crispim Encarnacao, Barbara Chruscicka, Hans-Peter Marti, Tony Jialiang Chen, Katarzyna Magiera-Mularz, Bartosz Zieba, Tad A. Holak, Janusz M. Dabrowski, Anna Czarna, Joanna Koziel, Piotr Mydel, Grzegorz Dubin
Summary: In this study, a molecular probe based on aptamer was developed, which specifically recognizes human PD-L1. The probe showed excellent potential in cancer imaging in both in vitro and in vivo experiments.
Article
Chemistry, Multidisciplinary
Claire Donohoe, Fabio A. Schaberle, Fabio M. S. Rodrigues, Nuno P. F. Goncalves, Christopher J. Kingsbury, Mariette M. Pereira, Mathias O. Senge, Ligia C. Gomes-da-Silva, Luis G. Arnaut
Summary: The challenge of large molecules crossing cell membranes has hindered the development of new medicines. However, this study shows that altering the atropisomers of a drug can improve cell uptake and therapeutic efficacy. The most effective atropisomer is able to optimize hydrogen bonding with membrane phospholipids, leading to increased cellular uptake and phototoxicity. These findings highlight the importance of atropisomerism in drug development and provide new insights for designing efficient cell-penetrating drugs.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Giusi Piccirillo, Nidia Maldonado-Carmona, Diana L. Marques, Nicolas Villandier, Claude A. Calliste, Stephanie Leroy-Lhez, M. Ermelinda S. Eusebio, Mario J. F. Calvete, Mariette M. Pereira
Summary: This study demonstrates the successful degradation of highly prescribed antibiotics (TMP and SMX) using a new photocatalyst, which has significant potential for improving the removal of pollutants from water.
Article
Radiology, Nuclear Medicine & Medical Imaging
Peter J. Gawne, Sara M. A. Pinto, Karin M. Nielsen, George P. Keeling, Mariette M. Pereira, Rafael T. M. de Rosales
Summary: Manganese porphyrins have a wide range of therapeutic and imaging applications, and can be used as radioprotectants and MRI contrast agents. The use of microwave heating allows for fast and efficient synthesis and labeling of [Mn-52]Mn-porphyrins, which show promising labeling efficiency and cellular stability. This technique has potential for in vivo imaging and quantification of Mn-porphyrin therapeutics.
NUCLEAR MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Lucas D. Dias, Fernanda Alves, Hilde H. Buzza, Vanderlei S. Bagnato
Summary: In this study, detergents loaded with curcumin were prepared and showed efficient antibacterial photodynamic effects against pathogenic microorganisms. They also demonstrated effective decontamination of material surfaces and treatment of skin infections.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Chemistry, Multidisciplinary
Rafael T. Aroso, Giusi Piccirillo, Lucas D. Dias, Sara M. A. Pinto, Luis G. Arnaut, Mariette M. Pereira
Summary: The combination of photodynamic therapy with antibiotics or antimicrobial peptides for bacteria inactivation has shown a synergistic effect. Tetrapyrrolic macrocycles have been found to be the most promising photosensitizers. While there are review articles on the microbiological results of this dual inactivation, none of them focus on the synthetic processes and chemical versatility of these photosensitizers. Therefore, this review presents an overview on synthetic methodologies of tetrapyrrolic macrocycles and their conjugates with antibiotics or antimicrobial peptides, for use in dual bacteria inactivation.
Article
Chemistry, Applied
Fabio M. S. Rodrigues, Vitaliy Masliy, Madalena F. C. Silva, Alexandre P. Felgueiras, Rui M. B. Carrilho, Mariette M. Pereira
Summary: Catalytic multi-step processes were optimized and developed under continuous-flow conditions to transform eugenol into potential new fragrances. One approach involved the direct catalytic conversion of eugenyl acetate into a cyclic carbonate, while the other approach utilized a hydroformylation/acetalization sequential process. These methods demonstrated high productivities of 7.68 g/day and 10.02 g/day, respectively.
Article
Biochemistry & Molecular Biology
Fabio M. S. Rodrigues, Iuri Tavares, Rafael T. Aroso, Lucas D. Dias, Carolina V. Domingos, Clara M. G. de Faria, Giusi Piccirillo, Teresa M. R. Maria, Rui M. B. Carrilho, Vanderlei S. Bagnato, Mario J. F. Calvete, Mariette M. Pereira
Summary: Herein, the design and application of natural curcumin ester and ether derivatives as potential bioplasticizers in photosensitive phthalate-free PVC-based materials are described. The preparation of PVC-based films incorporating newly synthesized curcumin derivatives and their characterization is also discussed. The results showed that the plasticizing effect of the curcumin derivatives in PVC materials was similar to that observed in PVC-phthalate materials. Furthermore, these new materials exhibited strong antibacterial activity against S. aureus under low irradiation intensities.
Review
Chemistry, Multidisciplinary
Rui M. B. Carrilho, Mario J. F. Calvete, Gabor Mikle, Laszlo Kollar, Mariette M. Pereira
Summary: This review critically analyzes the literature of the past 10 years on the use of carbon monoxide (CO) as a renewable feedstock for fine chemicals production, with a focus on various catalytic reactions. The review highlights notable examples of CO utilization as a C1 building block in the synthesis of important compounds and known pharmaceuticals.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Luis G. Arnaut, Mariette M. Pereira
Summary: This article offers a personal account of the discovery and development of a photosensitizer for photodynamic therapy of cancer. It focuses on the chemical aspects of drug discovery and development, including the chemical landscape at the time of discovery, the breakthrough offered by stable bacteriochlorins, challenges in synthesizing high purity products for preclinical studies, the relationship between molecular structure and pharmacology in PDT, and the interpretation of preclinical data and management of unexpected results. Special attention is given to the implications of atropisomerism and immune responses in PDT.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Maria Ines P. Mendes, Carlos D. F. Coelho, Fabio A. Schaberle, Maria Joao Moreno, Mario J. F. Calvete, Luis G. Arnaut
Summary: The explosive vaporization of nanodroplets triggered by laser pulses can generate large volume changes and intense photoacoustic waves. Nanodroplets have the potential to be used as contrast agents in photoacoustic tomography, and their performance can be improved with proper design.
Article
Materials Science, Biomaterials
Piotr Jablonski, Agnieszka Kyziol, Dominika Pawcenis, Barbara Pucelik, Marek Hebda, Monika Migdalska, Halina Krawiec, Manuel Arruebo, Karol Kyziol
Summary: In this study, electrostatic self-assembly was used to fabricate biopolymer-based coatings on titanium alloy surfaces. The resulting coatings showed good corrosion resistance, antioxidant properties, biocompatibility, and antibacterial activity, making them suitable for implant functionalization.
BIOMATERIALS ADVANCES
(2022)
Meeting Abstract
Endocrinology & Metabolism
A. Barzowska, B. Pucelik, A. Czarna
DIABETES TECHNOLOGY & THERAPEUTICS
(2022)
