Article
Medicine, General & Internal
Guanrong Wu, Baoyi Liu, Qiaowei Wu, Changting Tang, Zijing Du, Ying Fang, Yijun Hu, Honghua Yu
Summary: The study found that the expression of various angiogenesis and inflammation mediators in the vitreous fluid of eyes with proliferative diabetic retinopathy (PDR) was significantly increased, and there were correlations between these mediators. The levels of these mediators were also correlated with kidney damage, indicating potential common pathways in diabetic retinopathy and nephropathy.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Sarah R. Weber, Yuanjun Zhao, Christopher Gates, Jingqun Ma, Felipe da Veiga Leprevost, Venkatesha Basrur, Alexey I. Nesvizhskii, Thomas W. Gardner, Jeffrey M. Sundstrom
Summary: Vitreous fluid has emerged as a valuable medium for studying retinal diseases, with proteomic analysis providing insights into proliferative diabetic retinopathy. Despite the lack of standardized methodology, there have been numerous studies utilizing mass spectrometry for vitreous proteomic analysis. Moving forward, addressing common pitfalls and proposing next steps is crucial for advancing this field.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Irene Andres-Blasco, Alex Gallego-Martinez, Ximena Machado, Javier Cruz-Espinosa, Salvatore Di Lauro, Ricardo Casaroli-Marano, Victor Alegre-Ituarte, Jose Fernando Arevalo, Maria Dolores Pinazo-Duran
Summary: The study aimed to evaluate the molecules related to oxidative stress, inflammation, angiogenesis, and apoptosis in patients with proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME). By investigating their correlation in the plasma and vitreous body, as well as examining ophthalmological examination data, the study found that oxidative stress and inflammation were increased in the plasma and vitreous samples from patients with PDR/DME, while antioxidant capacity was decreased. The study suggests that exploring the relationship between these potential biomarkers in the plasma and vitreous may help detect early molecular changes in PDR/DME and monitor therapeutic outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sara Rezzola, Jessica Guerra, Adwaid Manu Krishna Chandran, Alessandra Loda, Anna Cancarini, Piergiuseppe Sacristani, Francesco Semeraro, Marco Presta
Summary: Proliferative diabetic retinopathy (PDR) is a major complication of diabetes mellitus, resulting from inflammation among endothelial cells, neurons, and glia. While anti-vascular endothelial growth factor (VEGF) interventions are the current therapeutic option for PDR, their impact on Muller cell activation remains unclear. Additional modulators besides VEGF have been found to play a role in Muller cell activation, suggesting potential for novel therapeutic strategies in PDR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Manqiao Wang, Linni Wang, Yi Gong, Qingbo Li, Yan Shao, Xiaorong Li
Summary: The study investigates the effects of different anti-VEGF drugs on fibrovascular membranes (FVM) in proliferative diabetic retinopathy (PDR), using an in vitro model to simulate intraocular fibroblasts barrier and assess drug penetration. The results show that all three anti-VEGF drugs significantly reduce vascular area and density on the proliferating membranes, and the small molecule drug has better penetration and faster movement across membranes in the in vitro cell model.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Ophthalmology
Evy Lefevere, Inge Van Hove, Jurgen Sergeys, David H. W. Steel, Reinier Schlingemann, Lieve Moons, Ingeborg Klaassen
Summary: The study suggests that PDGF may play a role in retinal neurite outgrowth associated with the formation of FVMs in PDR, as indicated by the abundant expression of PDGF receptors in FVMs.
CURRENT EYE RESEARCH
(2022)
Article
Ophthalmology
Jesse M. Smith, Nikhil Mandava, Vanessa Tirado-Gonzalez, Rodrigo Garcia-Santisteban, Matthew D. Geiger, Jennifer L. Patnaik, Ashley Frazer-Abel, Anne M. Lynch, Naresh Mandava, V. Michael Holers, Brandie D. Wagner, Idaira Sanchez-Santos, Daniela Meizner, Hugo Quiroz-Mercado, Alan G. Palestine
Summary: This study found a strong correlation between complement levels in aqueous and vitreous samples in patients with diabetic eye disease. The results suggest that the analysis of aqueous specimens can accurately sample the intraocular complement, allowing for the rapid and safe measurement of experimental complement targets and treatment response.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Biochemical Research Methods
Junwei Fang, Hanying Wang, Tian Niu, Xin Shi, Xindan Xing, Yuan Qu, Yujuan Liu, Xinyi Liu, Yu Xiao, Tianyu Dou, Yinchen Shen, Kun Liu
Summary: This study analyzed the vitreous cavity fluid of patients with proliferative diabetic retinopathy (PDR) and control subjects without diabetes to identify metabolic and lipid differences. The results revealed significant differences in metabolism and lipids between PDR and control groups. Pathway analysis identified 8 metabolic processes associated with PDR development and 14 altered lipid species in PDR patients. Additionally, fatty acid desaturase 2 (FADS2) was identified as a potential contributor to the pathogenesis of PDR.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Jinfeng Qu, Xiuju Chen, Qinghuai Liu, Fang Wang, Mingxin Li, Qiong Zhou, Jin Yao, Xiaoxin Li
Summary: This study aimed to evaluate the effects of preoperative intravitreal aflibercept (IVA) injection on the incidence of postoperative vitreous hemorrhage (VH) in patients with proliferative diabetic retinopathy (PDR). The results showed that the VH incidence was significantly lower in the IVA group compared to the control group, and it also improved visual acuity. Therefore, prophylactic use of aflibercept can reduce the risk of postoperative hemorrhage in patients with PDR.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Ophthalmology
San-Ni Chen, Shih-Jen Chen, Tsung-Tien Wu, Wei-Chi Wu, Chang-Hao Yang, Chung-May Yang
Summary: Pars plana vitrectomy (PPV) has been widely used in the treatment of severe diabetic retinopathy, and new technologies have expanded its applications. This article reviews the applications of new technologies for PPV in eyes with diabetic retinopathy, based on the experiences with Asian patients, and highlights important procedures and entities not commonly mentioned in the literature.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Yusuke Kameda, Tadashiro Saeki, Ko Hanai, Yuta Suzuki, Yasuko Uchigata, Tetsuya Babazono, Shigehiko Kitano
Summary: Chronic kidney disease may increase the risk of post-vitrectomy vitreous hemorrhage and neovascular glaucoma in patients with proliferative diabetic retinopathy. A reduced estimated glomerular filtration rate is the significant variable associated with postoperative complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Siyan Li, Enzhong Jin, Xuan Shi, Yi Cai, Hui Zhang, Mingwei Zhao
Summary: This study identified a highly expressed proteome in vitreous humor of PDR patients, with majority of proteins involved in complement and coagulation cascades. Transcription factors PPAR-alpha, RXR, LXR were identified as possible upstream regulators of these proteins in disease progression. Further study is required to explore their role in PDR.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yohei Tomita, Gael Cagnone, Zhongjie Fu, Bertan Cakir, Yumi Kotoda, Masaki Asakage, Yoshihiro Wakabayashi, Ann Hellstrom, Jean-Sebastien Joyal, Saswata Talukdar, Lois E. H. Smith, Yoshihiko Usui
Summary: The study identified a set of metabolites altered in the vitreous humour of PDR patients compared with non-diabetic controls, including both previously identified changes and novel dysregulated metabolites. By investigating the association of creatine with retinal NV and conducting oral supplementation experiments in a mouse model, the study suggests that metabolites in vitreous humour may provide insights into pathways influencing retinopathy, and that creatine supplementation could potentially be beneficial in suppressing NV in PDR.
Article
Ophthalmology
Ze-Yu Liang, Yi-Peng Wang, Jing Li, Wen-Chao Yang, Yong-Fang Tu, Yue Zhang, Song Chen
Summary: This study assessed the effects of intravitreal ranibizumab (IVR) on angiogenesis and glial activity of the fibrovascular membrane (FVM) in patients with proliferative diabetic retinopathy (PDR). The results showed that IVR can reduce angiogenesis and glial activity of FVM, promote glial-fibrotic transformation, but does not decrease cell density.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Endocrinology & Metabolism
Yan Yang, Wenyun Yue, Nan Wang, Zicong Wang, Bingyan Li, Jun Zeng, Shigeo Yoshida, Chun Ding, Yedi Zhou
Summary: This study identified altered tsRNAs and miRNAs in vitreous humor samples of proliferative diabetic retinopathy (PDR) patients. The differential expression of these molecules may play important roles in the pathogenesis of PDR and could serve as potential therapeutic targets for the treatment of PDR.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
David H. H. Steel, Brendan Geraghty, Victoria Kearns, Boris Stanzel, David Wong
Summary: We describe a novel technique modification of subretinal injection to reduce the risk of foveal dehiscence during subretinal tissue plasminogen activator delivery for submacular haemorrhage, using a perfluorocarbon liquid filled vitreous cavity and an eccentric injection point, with a viscous fluid injector system controlled injection.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Lucinda J. Teoh, Ameenat Lola Solebo, Jugnoo S. Rahi
Summary: This study investigates the changing epidemiology of severe visual impairment (SVI) and blindness (BL) in children in the UK in the 21st century. The overall incidence rates remained stable, with higher rates in infancy. Mortality among children diagnosed in infancy declined, despite an increase in the overall proportion with non-ophthalmic impairments/disorders. The relative contribution of different groups of disorders changed over time, with an increase in cerebral visual impairment and hereditary conditions. The study highlights the increasing complexity and heterogeneity of childhood visual disability.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Timothy L. Jackson, Cristina Soare, Caroline Petrarca, Andrew Simpson, James E. Neffendorf, Robert Petrarca, Katherine Alyson Muldrew, Tunde Peto, Usha Chakravarthy, Luke Membrey, Richard Haynes, Mark Costen, David H. W. Steel, Riti Desai
Summary: This study assessed the long-term safety and efficacy of epimacular brachytherapy (EMB) for chronic neovascular age-related macular degeneration (nAMD). The results showed that EMB did not reduce the number of injections and was associated with worse visual acuity compared to anti-VEGF monotherapy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Mariantonia Ferrara, Vito Romano, Claudio Iovino, Mustafa R. Kadhim, Elon H. C. van Dijk, Camiel J. F. Boon, Piergiacomo Grassi, Sibel Demirel, Cristian Cartes, Mario R. Romano
Summary: This study aimed to identify the preferences of audience and faculty in digital education sessions in ophthalmology. The survey results showed that most respondents preferred digital education sessions to last 30-60 minutes without a break, to be held in the evening time-slot of a weekday. The availability of webinars and recorded surgical videos/clinical cases, associated with live discussion, were considered the most important opportunities in digital educational channels.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Mariantonia Ferrara, Mo Al-Zubaidy, Anna Song, Peter Avery, D. Alistair Laidlaw, Tom H. Williamson, David Yorston, David H. W. Steel
Summary: Age has an influence on the clinical characteristics of primary rhegmatogenous retinal detachments (RRD), with different age groups showing distinct phenotypical differences. This study reveals the existence of various subtypes of RRD.
Review
Ophthalmology
Julian E. Klaas, Jakob Siedlecki, David H. Steel, D. Alistair H. Laidlaw, Siegfried Priglinger
Summary: This article reviews the existing literature on the preoperative assessment and nomenclature of foveal status in macula involving retinal detachment (MIRD). The results suggest wide variability and inconsistencies in the preoperative assessment, diagnostic modalities, and nomenclature used to describe the foveal status in eyes with macula-off RRD. There is a need for an updated nomenclature and standardized reporting of preoperative OCT findings in MIRD.
Review
Ophthalmology
Anusha Yoganathan, Teresa Sandinha, Mohith Shamdas, Asterios Diafas, David Steel
Summary: This review systematically examines the use of Patient Reported Outcome Measures (PROMs) in Vitreoretinal surgery and recommends a preferred PROM-tool for clinical practice. The adoption of PROMs in Vitreoretinal surgery is lagging behind other ophthalmic subspecialties. The review considers the precision and responsiveness of generic-health PROMs and vision-related PROMs following vitreoretinal surgery and also emphasizes the importance of standardizing clinical outcomes in vitreoretinal clinical trials.
Article
Ophthalmology
Lindsay Prior, Noemi Lois
Summary: This study explores the acceptability of a new surveillance pathway for patients with previously treated and stable diabetic macular oedema (DMO) and/or proliferative diabetic retinopathy (PDR) from the perspectives of patients and healthcare professionals. The study finds that patients are concerned about the expertise of professionals, the quality of interactions with professionals, and the need for holistic treatment. Ophthalmologists tend to overlook the deeper implications of patient concerns for the organization of services, focusing on patient education as the solution.
Article
Ophthalmology
Heidi Laviers, Evangelia Papavasileiou, Charlotte Bruce, Laura Maubon, Meera Radia, Nikolaos Dervenis, Benjamin Zuckerman, Graeme K. K. Loh, Olga Theodorou, Abdel Douiri, Hadi Zambarakji, Teresa Sandinha, David H. H. Steel, Varo Kirthi, Cordelia McKechnie, Rahila Zakir, Graham Duguid, Timothy L. L. Jackson
Summary: The purpose of this study was to assess the effect of ethnicity on surgical macular hole closure. A retrospective cohort study was conducted in five UK National Health Service Hospitals, and the results showed that Black ethnicity is associated with an approximately twofold greater risk of failed FTMH surgery, highlighting the need for further investigation into the reasons for this difference.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Mariantonia Ferrara, Antonio Rivera-Real, Roxane J. Hillier, Maged Habib, Mustafa R. Kadhim, Maria T. Sandinha, Katie Curran, Alyson Muldrew, David H. W. Steel
Summary: This study compared the effects of using atraumatic ILM forceps and standard forceps on anatomical and functional changes after ILM peeling. The results showed no significant differences in terms of final visual acuity, visual field mean deviation, pick-up-related retinal haemorrhages, swelling of arcuate nerve fibre layer lesions, dissociated optic nerve fibre layer lesions, inner retina defects, and inner retinal volumes between the two groups. The study provided estimates for future studies in this field.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joseph Collin, Megan S. R. Hasoon, Darin Zerti, Sarah Hammadi, Birthe Dorgau, Lucy Clarke, David Steel, Rafiqul Hussain, Jonathan Coxhead, Steven Lisgo, Rachel Queen, Majlinda Lako
Summary: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries, resulting from the degeneration of retinal photoreceptors, retinal pigment epithelium (RPE), and choroidal endothelial cells. The molecular processes underlying the development of these cell types and the progression of AMD from early to advanced stages are not fully understood. This study used single-cell RNA sequencing to analyze human fetal and adult RPE-choroidal tissues, uncovering changes in gene expression and identifying possible loss of RPE cells and melanocytes in patients with intermediate AMD. However, further validation is needed due to the limitations of the single-cell RNA sequencing technique.
HUMAN MOLECULAR GENETICS
(2023)
Article
Ophthalmology
Raffaele Raimondi, Dina Ghazal, David H. Steel
Article
Ophthalmology
Mariantonia Ferrara, Anna Song, Mohaimen Al-Zubaidy, Peter Avery, Alistair Laidlaw, Tom H. Williamson, David Yorston, David H. W. Steel
Summary: This study retrospectively analyzed data from two online datasets to assess the effect of sex and laterality on clinical features of primary RRD. The results showed a male predominance and a higher number of right eyes. Males were more commonly pseudophakic and presented with baseline posterior vitreous detachment. Females were associated with myopia, retinal holes, and isolated inferior RD. Right eyes had more foveal involvement and larger retinal tears, while left eyes were more myopic and presented with isolated nasal RD.
Article
Ophthalmology
David Yorston, Paul H. J. Donachie, D. A. Laidlaw, David H. Steel, G. W. Aylward, Tom H. Williamson
Summary: This study aimed to identify factors associated with anatomical outcome after vitrectomy and internal tamponade for rhegmatogenous retinal detachment. The results showed that age, location and extent of retinal breaks, density of silicone oil, and presence of proliferative vitreoretinopathy were associated with increased risk of failure, while C2F6 tamponade, cryotherapy, and 25 G vitrectomy were associated with reduced risk. The risk stratification model indicated that a large portion of patients are at low or moderate risk of failure.
Article
Ophthalmology
Mario R. Romano, Mariantonia Ferrara, Rosa M. Coco-Martin, Annekatrin Rickmann, Martin S. Spitzer, David H. W. Steel, J. Carlos Pastor
Summary: The purpose of this study is to propose a grading system for the assessment of silicone oil (SiO) emulsion, applicable in a routine clinical setting and validated through an expert-led consensus procedure. Based on literature review and questionnaire survey, a final grading system was developed, allowing for the homogenous collection of data on SiO emulsion.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
