Article
Medicine, General & Internal
Kazuhiko Fukushima, Haruhito A. Uchida, Yasuko Fuchimoto, Tomoyo Mifune, Mayu Watanabe, Kenji Tsuji, Katsuyuki Tanabe, Masaru Kinomura, Shinji Kitamura, Yosuke Miyamoto, Sae Wada, Taisaku Koyanagi, Hitoshi Sugiyama, Takumi Kishimoto, Jun Wada
Summary: Close attention is needed, particularly for respiratory system events and infectious diseases, when treating patients with silica-associated SLE.
Review
Immunology
Haeun Ko, Chan Johng Kim, Sin-Hyeog Im
Summary: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that mainly affects women in their reproductive years. Type 2 immune responses are involved during the pathology of SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Wenyan Fu, Yu Liu, Fangjie Liu, Chenghua Liu, Jingjing Li, Jiali Niu, Peng Han, Dan Xu, Jiaojiao Hou, Yuanfang Ma, Jiannan Feng, Zhanguo Li, Rong Mu, Guang Yang
Summary: A conserved peptide HU1 from bacterial biofilms was specifically recognized by approximately 47% of SLE patients' sera, showing a significant positive correlation with lupus nephritis development. Antibodies against HU1 aggravated lupus nephritis in mice and inhibited the activity of protein disulfide isomerase on renal cells. These findings reveal a novel mechanism linking bacterial biofilms to the development of lupus nephritis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Benjamin Y. F. So, Desmond Y. H. Yap, Tak Mao Chan
Summary: MicroRNAs (miRs) are non-coding small RNAs that play a crucial role in the pathogenesis of lupus nephritis (LN). They are involved in regulating immune cells and inflammatory pathways, and their dysregulation can lead to abnormal immune responses and kidney abnormalities in LN patients. While miRs show promise for various clinical applications in LN, further research is needed to fully understand their clinical utility and address potential safety concerns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Meiying Wang, Tatsuya Ishikawa, Yupeng Lai, Dhiraj Nallapothula, Ram Raj Singh
Summary: NETosis is a form of neutrophil cell death associated with lupus. Aberrant NETosis can play diverse roles, including autoantibody production, inflammation, and tissue damage, at different stages of lupus pathogenesis. Targeting NETosis as a treatment approach for lupus is being studied.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yusuke Murakami, Ryutaro Fukui, Reika Tanaka, Yuji Motoi, Atsuo Kanno, Ryota Sato, Kiyoshi Yamaguchi, Hirofumi Amano, Yoichi Furukawa, Hitoshi Suzuki, Yusuke Suzuki, Naoto Tamura, Naomi Yamashita, Kensuke Miyake
Summary: The study showed that anti-TLR7 monoclonal antibody protected lupus-prone mice from nephritis by reducing IgG deposition in glomeruli through inhibiting autoantibody production. In addition, the antibody also suppressed the increase of lupus-associated patrolling monocytes in circulation, spleen, and glomeruli. These findings suggest that targeting TLR7 could be a promising therapeutic approach for lupus nephritis by regulating autoantibody production and monocytosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiao-Ling Liu, Ying Tan, Feng Yu, Shang-Rong Ji, Ming-Hui Zhao
Summary: This study aimed to investigate the prevalence and clinicopathological associations between anti-C1qA08 antibodies and anti-monomeric CRP (mCRP) a.a.35-47 antibodies, as well as the interaction between C1q and mCRP. The results showed that the combination of anti-C1qA08 and anti-mCRP a.a.35-47 autoantibodies could predict a poor renal outcome. The key linear epitopes of the combination were C1qA08 and a.a.35-47.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Liang Liang, Qingyun Zhou, Lujia Feng
Summary: The study revealed that miR-155 regulates the production of TNF-alpha, IL-6, and IL-1 beta by DCs through the Akt/mTOR signaling pathway and by affecting the process of autophagy.
ARTHRITIS RESEARCH & THERAPY
(2021)
Article
Genetics & Heredity
Sesha L. Paluri, Matthew Burak, Alireza G. Senejani, Madison Levinson, Tania Rahim, Kaylyn Clairmont, Michael Kashgarian, Isabel Alvarado-Cruz, Rithy Meas, Marina Cardo-Vila, Caroline Zeiss, Stephen Maher, Alfred L. M. Bothwell, Erdem Coskun, Melis Kant, Pawel Jaruga, Miral Dizdaroglu, R. Stephen Lloyd, Joann B. Sweasy
Summary: The Polb gene encodes DNA polymerase beta, which plays a role in base excision repair and microhomology-mediated end-joining. Mice with Pol beta-Y265C mutation develop lupus, but mice lacking Ogg1 and Neil1 DNA glycosylases show less severe renal disease due to higher levels of IgM antibodies in their sera.
Article
Immunology
Elena Litvinova, Carine Bounaix, Guillaume Hanouna, Jennifer Da Silva, Laura Noailles, Lucie Beaudoin, Michael Padden, Nessrine Bellamri, Agnes Lehuen, Eric Daugas, Renato C. Monteiro, Heloise Flament
Summary: This study found that the frequency of MAIT cells is significantly reduced in the blood of patients with severe lupus nephritis (LN), and these cells also undergo changes in function and phenotype. The study also found that patients who achieve complete renal remission after immunosuppressive therapy have higher frequencies of MAIT cells and lower expression of proliferation marker Ki-67 and granzyme B (GzB).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Umesh Kumar Dhawan, Andreas Margraf, Maciej Lech, Manikandan Subramanian
Summary: Hypercholesterolemia exacerbates autoimmune response and accelerates the progression of autoimmune disorders. The impaired DNase response in hypercholesterolemic mice is associated with increased anti-nuclear antibody levels and renal immune complex deposition. Treatment with DNase1 decreases autoantibody levels and renal pathology in hypercholesterolemic mice and humans, suggesting its potential as a therapeutic strategy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Masashi Morita, Masayuki Mizui, Satoshi Masuyama, George C. Tsokos, Yoshitaka Isaka
Summary: The study compares the efficacy and mechanisms of action of conventional anti-CD3 antibodies and non-mitogenic anti-CD3 antibodies. It demonstrates that non-mitogenic anti-CD3 antibodies can effectively suppress the development of lupus by reducing surface TCR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Eunkyeong Jang, Somi Cho, Sungjin Pyo, Jin-Wu Nam, Jeehee Youn
Summary: The study found that spleen-derived CD11b(+)Gr-1(+) myeloid cells promote the accumulation of splenic long-lived plasma cells in lupus-prone mice, contributing to the development of autoimmune diseases. By establishing a positive feedback loop between CD4(+) T cells and SDMCs, it exacerbates the autoimmune response in lupus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mario Gaudino, Katia Audisio, Mohamed Rahouma, N. Bryce Robinson, Giovanni J. Soletti, Gianmarco Cancelli, Ruth M. Masterson Creber, Alastair Gray, Belinda Lees, Stephen Gerry, Umberto Benedetto, Marcus Flather, David P. Taggart, Arterial Revascularization Trial Arterial Revascularizat Trial Investigators
Summary: This study evaluated the association between sternal wound complications (SWC) and long-term mortality in the Arterial Revascularization Trial. The results showed that postoperative SWC was significantly associated with long-term mortality and increased rates of major adverse cardiovascular events.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Clara Hoebart, Attila Kiss, Patrick M. Pilz, Petra L. Szabo, Bruno K. Podesser, Michael J. M. Fischer, Stefan Heber
Summary: This study aims to investigate the effects of TRPA1 activation, inhibition, or absence on infarcts and explore the underlying mechanisms. In vivo experiments showed no significant differences in infarct size among different TRPA1 activation or inhibition groups compared to the control group. In vitro experiments demonstrated that the presence of sensory neurons, partly dependent on TRPA1, increased the survival probability of cardiomyocytes challenged by ischemia-reperfusion. These findings raise doubts about the potential of TRPA1 as a promising target for reducing myocardial damage within a 24-hour period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fabian Dorninger, Attila Kiss, Peter Rothauer, Alexander Stiglbauer-Tscholakoff, Stefan Kummer, Wedad Fallatah, Mireia Perera-Gonzalez, Ouafa Hamza, Theresa Koenig, Michael B. Bober, Tiscar Cavalle-Garrido, Nancy E. Braverman, Sonja Forss-Petter, Christian Pifl, Jan Bauer, Reginald E. Bittner, Thomas H. Helbich, Bruno K. Podesser, Hannes Todt, Johannes Berger
Summary: The deficiency in ether lipids can cause severe symptoms in humans and the mouse model has been used to study the pathophysiology of the disease. However, the exact role of ether lipids in the cardiac tissue is still unknown. This study found that ether lipid deficiency can lead to cardiac abnormalities in both mice and human patients, but the manifestations are heterogeneous and differ between the two.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Bettina Kronsteiner, Max Haberbusch, Philipp Aigner, Anne-Margarethe Kramer, Patrick M. Pilz, Bruno K. Podesser, Attila Kiss, Francesco Moscato
Summary: To understand the cardiac responses to vagus nerve stimulation (VNS), an ex-vivo Langendorff-perfused rabbit heart model with intact vagal innervation was used. This model demonstrated nerve excitability for about 5 hours ex-vivo. The charges required for HR reduction were lower in the ex-vivo model compared to in-vivo experiments, indicating the feasibility of this model to study the cardiac effects of VNS.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Marta Sarkoezy, Simon Watzinger, Zsuzsanna Z. A. Kovacs, Eylem Acar, Fanni Marvanykoevi, Gergo Szucs, Gulsum Yilmaz Lauber, Zsolt Galla, Andrea Siska, Imre Foldesi, Attila Fintha, Andras Kriston, Ferenc Kovacs, Peter Horvath, Bence Kovari, Gabor Cserni, Tibor Krenacs, Petra Lujza Szabo, Gabor Tamas Szabo, Peter Monostori, Karin Zins, Dietmar Abraham, Tamas Csont, Peter Pokreisz, Bruno K. Podesser, Attila Kiss
Summary: Chronic kidney disease is a prevalent health issue affecting 10% to 12% of the global population. In the context of uremic cardiomyopathy, dysregulation of neuregulin-10 signaling in the heart has been identified as a contributing factor to heart failure. A study using a nephrectomy-induced model of chronic kidney disease demonstrated that systemically administered recombinant human neuregulin-10 for a duration of 10 days could alleviate the progression of uremic cardiomyopathy and kidney dysfunction. These promising preclinical findings call for further clinical studies to validate the beneficial effects of recombinant human neuregulin-10 in patients with chronic kidney disease.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Physiology
Petra Lujza Szabo, Jessica Marksteiner, Janine Ebner, Christopher Dostal, Bruno K. Podesser, Jakob Sauer, Helmut Kubista, Hannes Todt, Benjamin Hackl, Xaver Koenig, Attila Kiss, Karlheinz Hilber
Summary: The study showed that the muscular dystrophies caused by dystrophin deficiency can lead to impaired cardiac function and arrhythmias, increasing disease morbidity and mortality. Impaired calcium handling in ventricular cardiomyocytes has been identified as a causal factor for complications in the dystrophic heart, and the drug ivabradine has been found to improve calcium handling and contractile performance in dystrophic cardiomyocytes. The administration of ivabradine significantly improved cardiac function and increased intracellular calcium transients in dystrophin-deficient rats.
PHYSIOLOGICAL REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Florian Falkner, Simon Andreas Mayer, Benjamin Thomas, Sarah Onon Zimmermann, Sonja Walter, Patrick Heimel, Wilko Thiele, Jonathan Paul Sleeman, Amir Khosrow Bigdeli, Herbert Kiss, Bruno Karl Podesser, Ulrich Kneser, Helga Bergmeister, Karl Heinrich Schneider
Summary: This study evaluated the use of decellularized submillimeter vascular grafts from the human placenta for vascular replacement. The grafts were modified to prevent thrombotic events and implanted into rats for evaluation. The grafts showed a patency rate of 71% and induced no immunological responses, indicating their potential for use as super-microsurgical vascular replacements.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Zsofia Onodi, Petra Lujza Szabo, Daniel Kucsera, Peter Pokreisz, Christopher Dostal, Karlheinz Hilber, Gavin Y. Oudit, Bruno K. Podesser, Peter Ferdinandy, Zoltan V. Varga, Attila Kiss
Summary: Duchenne muscular dystrophy (DMD) is a muscle wasting disease characterized by difficulty moving and premature death, mainly due to heart failure. Inflammation is thought to play a role in the disease progression, but the specific mechanisms are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Simon Aberger, Nicolas Kozakowski, Zoltan Prohazka, Thomas Pleininger, Hermann Salmhofer
Summary: This study reports a case of severe hantavirus disease with coinciding SARS-CoV-2 infection, presenting as thrombotic microangiopathy with rapid response to eculizumab. These findings support a disease model involving virus-associated endothelial injury and complement activation.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Transplantation
Rhea Jabbour, Andreas Heinzel, Roman Reindl-Schwaighofer, Mariella G. Gregorich, Heinz Regele, Nicolas Kozakowski, Johannes Klaeger, Gottfried Fischer, Alexander Kainz, Jan U. Becker, Chris Wiebe, Rainer Oberbauer
Summary: This retrospective cohort study aimed to investigate the association between HLA histocompatibility and the progression of chronic histologic lesions in kidney allografts. The results showed that HLA mismatch scores were not associated with the progression of histologic lesions, except for arteriolar hyalinosis, specifically HLA-EMMA DRB1. However, the established associations of dnDSA formation with HLA mismatch and microvascular inflammation were confirmed in the cohort.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Geriatrics & Gerontology
Hoa Dinh, Zsuzsanna Z. A. Kovacs, Merse Kis, Klaudia Kupecz, Anita Sejben, Gergo Szucs, Fanni Marvanykovi, Andrea Siska, Marah Freiwan, Szonja Polett Posa, Zsolt Galla, Katalin Eszter Ibos, Eva Bodnar, Guelsuem Yilmaz Lauber, Ana Isabel Antunes Goncalves, Eylem Acar, Andras Kriston, Ferenc Kovacs, Peter Horvath, Zsolt Bozso, Gabor Toth, Imre Foeldesi, Peter Monostori, Gabor Cserni, Bruno K. Podesser, Andrea Lehoczki, Peter Pokreisz, Attila Kiss, Laszlo Dux, Krisztina Csabafi, Marta Sarkozy
Summary: This study investigated the impact of KP-13 on the trajectory of CKD and uremic cardiomyopathy. The results showed that KP-13 increased blood pressure, accentuated diastolic dysfunction, and intensified CKD-associated markers. However, KP-13 did not exacerbate circulatory uremic toxin levels, renal inflammation, or fibrosis markers, while the higher dose of KP-13 correlated with reduced heart wall thickness and increased expression of inflammatory, fibrosis, and apoptosis markers.
Review
Cardiac & Cardiovascular Systems
Michael Kest, Andras Agoston, Gabor Tamas Szabo, Attila Kiss, Aron Uveges, Daniel Czuriga, Andras Komocsi, Istvan Hizoh, Zsolt Koszegi
Summary: This study aims to identify and analyze angiography-derived indices of microvascular resistance that have been validated against an invasive reference method. The study finds that combined angiography- and pressure-based methods provide a more reliable assessment of microvascular resistance compared to methods relying solely on angiography.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)