Article
Peripheral Vascular Disease
Boyang Xiang, Yujia Zhou, Xiaoguang Wu, Xiang Zhou
Summary: This study aimed to investigate the long-term benefits of physical activity for individuals with hypertension. The findings suggested that moderate-intensity physical activity was associated with a lower risk of cardiovascular events and all-cause mortality. However, higher intensities of physical activity did not provide additional benefits.
Article
Cardiac & Cardiovascular Systems
Ashish Verma, Anand Vaidya, Sonu Subudhi, Sushrut S. Waikar
Summary: The study found that higher serum aldosterone levels are independently associated with an increased risk for kidney disease progression in individuals with chronic kidney disease, regardless of concomitant diabetes. This suggests a potential role for mineralocorticoid receptor antagonists in delaying CKD progression even in those without diabetes.
EUROPEAN HEART JOURNAL
(2022)
Article
Health Care Sciences & Services
Victor Martinez-Majolero, Belen Urosa, Sonsoles Hernandez-Sanchez, David Arroyo
Summary: This study explores the impact of physical exercise on the quality of life in patients with end-stage renal disease, considering the most common associated diseases such as diabetes and hypertension. The findings suggest that implementing appropriate intensity of physical exercise and avoiding sedentary lifestyles have positive effects on the quality of life in end-stage renal disease patients.
Article
Cardiac & Cardiovascular Systems
Chou-Pin Kuo, Ming-Tsun Tsai, Kuo-Hua Lee, Yao-Ping Lin, Shao-Sung Huang, Chin-Chou Huang, Wei-Cheng Tseng, Der-Cherng Tarng
Summary: This study investigated the dose-response effects of physical activity on mortality and major cardiorenal events in chronic kidney disease patients. The results showed that physical activity of 7.5 to <15 MET-h/week was associated with lower risks of adverse cardiorenal outcomes.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Merve Firat, Naciye Vardar-Yagli, Melda Saglam, Tolga Yildirim, Yunus Erdem
Summary: This study compared the quality of life, physical activity, fear of COVID-19, and mental health in patients with chronic kidney disease (CKD) and healthy individuals during the pandemic. It was found that CKD patients had worse quality of life and lower levels of physical activity compared to healthy individuals. These patients also had fear of COVID-19 and poor mental health. Therefore, psychosocial and physical activity interventions may be beneficial for both groups during the COVID-19 pandemic.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Article
Medicine, General & Internal
Ji Hye Kim, Young Youl Hyun, Kyu-Beck Lee, Sung Woo Lee, Hayne Cho Park, Wookyung Chung, Joongyub Lee, Yun Kyu Oh, Kook-Hwan Oh, Dong-Wan Chae, Curie Ahn
Summary: This study found that for adults with chronic kidney disease, an adequate amount of moderate-vigorous physical activity is associated with a lower risk of all-cause death, cardiovascular events, and end-stage kidney disease. Age and sex also play a role in modifying the relationships between physical activity and clinical outcomes. Physical activity plans should be tailored for individual adults with CKD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Min-Kuang Tsai, Wayne Gao, Kuo-Liong Chien, Chih-Cheng Hsu, Chi-Pang Wen
Summary: A study found that sustained leisure-time physical activity, particularly with vigorous intensity, significantly lowered the risk of ESRD, even among individuals with comorbidities such as diabetes or hyperlipidemia.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Urology & Nephrology
Nanbo Zhu, Suvi Virtanen, Hong Xu, Juan Jesus Carrero, Zheng Chang
Summary: This study used data from the SCREAM project to investigate the relationship between depression and clinical outcomes in patients with CKD not receiving dialysis. The study found that depression was consistently associated with adverse clinical outcomes, including hospitalization, CKD progression, major adverse cardiovascular events, and all-cause mortality. The study emphasizes the need for future research on managing depression in early-stage CKD.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Carmine Zoccali, Francesca Mallamaci, Marcin Adamczak, Rodrigo Bueno de Oliveira, Ziad A. Massy, Pantelis Sarafidis, Rajiv Agarwal, Patrick B. Mark, Peter Kotanko, Charles J. Ferro, Christoph Wanner, Michel Burnier, Raymond Vanholder, Andrzej Wiecek
Summary: Chronic kidney disease (CKD) is a progressive condition that increases the risk of cardiovascular diseases. Traditional and non-traditional risk factors contribute to the progression of cardiovascular complications in CKD patients. Arterial disease in CKD patients is characterized by calcification and vascular stiffness. Recent clinical trials have shown promising potential treatments for CKD patients, including hypoxia-inducible factor prolyl hydroxylase inhibitors, intravenous iron for treating anemia, and sodium/glucose cotransporter-2 inhibitors. However, more research is needed in this area.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Chieh-Li Yen, Pei-Chun Fan, Cheng-Chia Lee, Jia-Jin Chen, George Kuo, Yi-Ran Tu, Pao-Hsien Chu, Hsiang-Hao Hsu, Ya-Chung Tian, Chih-Hsiang Chang
Summary: This study evaluated the cardiovascular and renal outcomes in patients with stage 3 chronic kidney disease with different LDL-C levels during statin treatment. Patients with LDL-C levels between 70-100 mg/dL had lower risks of major adverse cardiac and cerebrovascular events and new-onset end-stage renal disease requiring chronic dialysis compared to other LDL-C groups.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Sue K. Park, Yong-Soo Kim, Yeong Hoon Kim, Kyu Hun Choi, Kook-Hwan Oh, Seong Kwon Ma, Soo Wan Kim
Summary: High body weight variability is associated with adverse cardiovascular outcomes in patients with pre-dialysis chronic kidney disease, even in the absence of significant weight gain or loss.
Article
Medicine, General & Internal
Chi-Chih Hung, Pei-Hua Yu, Sheng-Wen Niu, I-Ching Kuo, Jia-Jung Lee, Feng-Ching Shen, Jer-Ming Chang, Shang-Jyh Hwang
Summary: The study explores the relationship between obesity and renal outcomes in patients with chronic kidney disease. It suggests that CKD stage and anemia may explain the obesity paradox observed in renal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Hosam Alzahrani, Najlaa Alotaibi, Adel Alshahrani, Khalid M. Alkhathami, Yasir S. Alshehri, Msaad Alzhrani, Fahad H. Alshehri, Rania Almeheyawi, Ibrahim Saeed Aljulaymi, Muhsen Alsufiany, Kabir P. Sadarangani, Hatem H. Allam, Barbara Barcaccia
Summary: This study investigated the relationship between physical activity and health-related quality of life in individuals with chronic diseases, and found a curvilinear association and dose-response relationship.
Article
Environmental Sciences
Masashi Kanai, Kazuhiro P. Izawa, Hiroki Kubo, Masafumi Nozoe, Kyoshi Mase, Shinichi Shimada
Summary: This study investigated the association between health utility score and physical activity outcomes in stroke survivors, finding that the health utility score was significantly associated with the number of steps taken, but not with the duration of moderate-to-vigorous physical activity (MVPA).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Urology & Nephrology
Tzu-Heng Huang, Hsuan Chiu, Pei-Yu Wu, Jiun-Chi Huang, Ming-Yen Lin, Szu-Chia Chen, Jer-Ming Chang
Summary: This study found that increased left atrial diameter (LAD), ratio of left ventricular mass to body surface area (LVM/BSA), ratio of LVM to height(2.7) (LVM/ht(2.7)), and ratio of observed to predicted LVM (o/p LVM) were associated with eGFR slope, while left ventricular ejection fraction (LVEF) was not. Furthermore, specific measurements of LAD, LVM/BSA, and LVM/ht(2.7) were correlated with progression to dialysis in patients with CKD stage 3-5.
Article
Urology & Nephrology
Ming-Yen Lin, Sheng-Wen Niu, Wei-Ming Li, Huei-Lan Lee, Li-Tzong Chen, Wen-Jeng Wu, Shang-Jyh Hwang
Summary: The study assessed temporal patterns and regional differences in the incidence rate of urinary tract urothelial carcinoma, finding that women had a significantly higher incidence rate than men and the prevalence of diabetes among patients was increasing. Local Moran's I statistic identified new high incidence cluster areas apart from the previously known endemic area of blackfoot disease. Additionally, older age, male sex, end-stage kidney disease, and higher tumor grade were associated with lower survival probabilities.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Medicine, General & Internal
Jia-Jung Lee, Jer-Ming Chang, Lii-Jia Yang, Chih-Cheng Hsu, Ming-Huang Lin, Ming-Yen Lin
Summary: This study analyzed the infection status of hepatitis B, hepatitis C, and tuberculosis in the dialysis population using data from the Taiwan National Health Insurance Research Database. The results showed an increasing trend of treated hepatitis B and hepatitis C cases and a mildly decreasing trend of treated tuberculosis cases. Male patients had higher rates of treated hepatitis B and tuberculosis, liver malignancy, and liver-related mortality.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Ming-Yen Lin, Min-Yu Chang, Pei-Yu Wu, Ping-Hsun Wu, Ming-Huang Lin, Chih-Cheng Hsu, Jer-Ming Chang, Shang-Jyh Hwang, Yi-Wen Chiu
Summary: The study found that the universal pay-for-performance program implemented by the Taiwanese government has achieved certain effectiveness in providing better care for patients with late-stage CKD, including more appropriate medication prescriptions and improved survival outcomes. Further efforts are needed to expand the program's coverage and enrollment.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Ping-Hsun Wu, Ming-Yen Lin, Teng-Hui Huang, Tien-Ching Lee, Sung-Yen Lin, Chung-Hwan Chen, Mei-Chuan Kuo, Yi-Wen Chiu, Jer-Ming Chang, Shang-Jyh Hwang
Summary: This study aimed to investigate the safety, treatment adherence, renal function effect, and mortality of denosumab in CKD patients. The results showed that high adherence users had better renal function and no decline in renal function. The all-cause mortality rate was lower in high adherence users compared to low adherence users in both the overall cohort and CKD subcohort.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Thaminda Liyanage, Tadashi Toyama, Carinna Hockham, Toshiharu Ninomiya, Vlado Perkovic, Mark Woodward, Masafumi Fukagawa, Kunihiro Matsushita, Kearkiat Praditpornsilpa, Lai Seong Hooi, Kunitoshi Iseki, Ming-Yen Lin, Heide A. Stirnadel-Farrant, Vivekanand Jha, Min Jun
Summary: The burden of chronic kidney disease (CKD) varies greatly in different regions of Asia, with China and India having the highest number of CKD cases. Urgent collaborative action is needed in Asia to prevent and manage CKD and its complications.
Article
Clinical Neurology
Hsiu-Yu Ho, Ming-De Chen, Chiu-Chin Tsai, Hui-Mei Chen
Summary: This study investigated the effects of computerized cognitive training (CCT) on stroke survivors' cognition, activity, and participation, comparing it with conventional cognitive training. The results showed that CCT significantly improved cognitive function in stroke survivors, but had no significant effect on activities and participation. Additionally, the improvements in cognitive function were immediate and sustained at the 4-week follow-up after CCT.
NEUROREHABILITATION
(2022)
Article
Genetics & Heredity
Chih-Chuan Yu, An-Fu Lee, Stefen Kohl, Ming-Yen Lin, Siao Muk Cheng, Chi-Chih Hung, Jer-Ming Chang, Yi-Wen Chiu, Shang-Jyh Hwang, Edgar A. Otto, Friedhelm Hildebrandt, Daw-Yang Hwang
Summary: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common inherited adult kidney disease with complex genetic heterogeneity. A research study on 920 families in Taiwan identified multiple disease-causing mutations and provided evidence of a founder effect in the ADPKD population.
NPJ GENOMIC MEDICINE
(2022)
Article
Medicine, General & Internal
Pei-Yu Wu, Ming-Yen Lin, Shang-Jyh Hwang, Yi-Wen Chiu
Summary: For incident PD patients with PD duration no longer than 4 years, neither PD duration nor glucose exposure amount increases the long-term mortality risk.
FRONTIERS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Ming-Hsien Tsai, Ming-Yen Lin, Chen-Yang Hsu, Amy Ming-Fang Yen, Tony Hsiu-Hsi Chen, Sherry Yueh-Hsia Chiu, Shang-Jyh Hwang
Summary: Understanding the risk factors associated with renal function state transitions in community residents is crucial for appropriate preventive and care actions. Factors such as estimated glomerular filtration rate, proteinuria, and diabetes mellitus were found to be significantly linked to state transitions, emphasizing the importance of personalized screening plans and services.
FRONTIERS IN PUBLIC HEALTH
(2022)
Editorial Material
Public, Environmental & Occupational Health
Ming-Yen Lin, Marco Fiorentino, I-Wen Wu
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Cheng-Yin Chung, Shang-Yu Wu, Huei-Hsuan Chiu, Tzu-Ning Wu, Your-Tong Wang, Ming-Yen Lin
Summary: This longitudinal cohort study found no significant linear and non-linear associations between air pollutant exposures and long-term kidney function changes in patients with chronic kidney disease (CKD).
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Ming-Yen Lin, Yi-Wen Chiu, Yu-Hsuan Lin, Yihuang Kang, Ping-Hsun Wu, Jeng-Huei Chen, Hsing Luh, Shang-Jyh Hwang
Summary: The concept of chronic kidney disease (CKD) originated in the 2000s, with an estimated 850 million patients worldwide. This review examines the burden, existing care models, effectiveness, challenges, and developments of CKD care. Multidisciplinary teams show potential profits in achieving comprehensive and preferable outcomes. In addition, a novel CKD care structure using modern technologies, biosensors, data visualization, machine learning algorithms, and mobile care is proposed to reduce human contact and protect the vulnerable population from infectious diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Urology & Nephrology
Ming-Yen Lin, Chia-Te Liao, Ming-Huang Lin, Hsiao-Ting Wu, Mai-Szu Wu, Yung-Ho Hsu, Chih-Cheng Hsu
Summary: The Taiwan Renal Data System (TWRDS) is crucial in reducing the incidence and mortality of kidney disease and improving kidney health and care policymaking. It plays a significant role in kidney disease surveillance, providing research materials, and achieving precision prevention and care through complex algorithms. TWRDS can also contribute to building a resilient society against communicable disease threats and promoting equitable distribution of healthcare resources.
Meeting Abstract
Clinical Neurology
Wen-Ching Chen, Ping-Hsun Wu, Yi-Ting Lin, Ming-Yen Lin, Teng-hui Huang, Yi-Wen Chiu, Jer-Chia Tsai, Shang-Jyh Hwang
CEREBROVASCULAR DISEASES
(2022)
Article
Urology & Nephrology
Ming -Yen Lin, Yi-Wen Chiu, Yung -Ho Hsu, Mai-Szu Wu, Jer-Ming Chang, Chih-Cheng Hsu, Chih-Wei Yang, Wu -Chang Yang, Shang-Jyh Hwang
Summary: The implementation of universal CKD care programs in Taiwan has significantly reduced the long-term trends in the incidence of maintenance dialysis.