Article
Biochemistry & Molecular Biology
D. K. Wosniaki, A. M. Marin, G. S. Soares, D. L. Zanette, L. Blanes, E. C. Munhoz, M. Aoki
Summary: Deletion of GSTM1 and GSTT1 genes may cause reduced glutathione S-transferase activity, leading to increased risk of leukemia. The frequency of GSTM1-null and GSTT1-null genotypes was significantly higher in Brazilian leukemia patients, especially in chronic leukemia.
GENETICS AND MOLECULAR RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Giovana Nakanishi, Laisa S. Bertagnolli, Murilo Pita-Oliveira, Mariana M. Scudeler, Sabrina Torres-Loureiro, Thais Almeida-Dantas, Maria Laura C. Alves, Heithor S. Cirino, Fernanda Rodrigues-Soares
Summary: GSTM1 and GSTT1 deletions show significant frequency differences among distinct ethnic groups, with East Asians having the highest frequencies and Sub-Saharan Africans having the lowest, indicating a strong influence of ethnicity. Further studies on the impact of admixture on the frequency values of these genes are needed.
DRUG METABOLISM REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Baiming Jin, Siyuan Wan, Michael Boah, Jie Yang, Wenjing Ma, Man Lv, Haonan Li, Kewei Wang
Summary: This study found a significant negative correlation between the GSTM1 null genotype and susceptibility to arsenic poisoning, while the GSTT1 single null genotype and GSTM1-GSTT1 dual-null genotype were not associated with the risk of arsenic poisoning. Individuals with the GSTM1 null genotype may have lower susceptibility to arsenic poisoning.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Environmental Sciences
Aneela Shoukat, Syed Muhammad Nurulain, Sabir Hussain, Sosan Andleeb Khan, Hussain Ahmed, Zahid Muneer, Syed Tahir Abbas Shah, Saqlain Raza, Syed Ali Musstjab Shah Eqani
Summary: Chronic exposure to e-waste can lead to liver toxicity due to the presence of heavy metals and organic pollutants. The study found that individuals exposed to e-waste showed abnormal liver enzymes, indicating a potential risk of liver toxicity. Furthermore, analysis of GSTM1, GSTT1, and GSTP1 genes suggested that they may serve as risk factors for liver toxicity in chronic e-waste exposure.
ENVIRONMENTAL POLLUTION
(2023)
Article
Oncology
Simona Jurkovic Mlakar, Chakradhara Rao Uppugunduri Satyanarayana, Tiago Nava, Vid Mlakar, Hadrien Golay, Shannon Robin, Nicolas Waespe, Mohamed-Ali Rezgui, Yves Chalandon, Jaap Jan Boelens, Robert G. M. Bredius, Jean-Hugues Dalle, Christina Peters, Selim Corbacioglu, Henrique Bittencourt, Maja Krajinovic, Marc Ansari
Summary: The GSTM1/GSTT1 double null genotype is an independent risk factor for post-HSCT relapse. GSTM1 status modulates BU-induced cell death, while GSTT1 is proposed to be involved in baseline cell proliferation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ezeldine K. Abdalhabib, Denise E. Jackson, Badr Alzahrani, Elyasa M. Elfaki, Alneil Hamza, Fehaid Alanazi, Elryah Ali, Abdulrahman Algarni, Ibrahim Khider Ibrahim, Muhammad Saboor
Summary: The study revealed that GSTT1, GSTM1, and XPD gene polymorphisms are associated with the risk of developing chronic myeloid leukemia (CML), with significant differences observed in GST null polymorphisms and XPD genotypes. GSTT1 null polymorphism was found to be related to CML phases, while age and gender were not associated with the studied polymorphisms.
PHARMACOGENOMICS & PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tanya Tacheva, Shanbeh Zienolddiny-Narui, Dimo Dimov, Denitsa Vlaykova, Iva Miteva, Tatyana Vlaykova
Summary: This study investigated the relationship between GSTM1 and GSTT1 gene polymorphisms and COPD risk, finding that the GSTM1 null genotype may be involved in leucocyte telomere shortening and contribute to the pathogenesis of COPD.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Giovana Nakanishi, Murilo Pita-Oliveira, Laisa S. Bertagnolli, Sabrina Torres-Loureiro, Mariana M. Scudeler, Heithor S. Cirino, Maria Laura Chaves, Bruno Miwa, Fernanda Rodrigues-Soares
Summary: Glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) enzymes play a significant role in susceptibility or resistance to human diseases and detoxification processes. The deletion of these genes can vary among different ethnicities and populations, impacting drug safety and efficacy. This systematic review highlights the knowledge gap in considering non-European populations and diseases related to GSTM1 and GSTT1 variations. To achieve global precision/personalized medicine, it is important to fill this research gap and understand the clinical implications of GSTM1 and GSTT1 null genotypes.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2022)
Article
Oncology
Abozer Y. Elderdery, Hadeil M. E. Idris, Entesar M. Tebien, Nada Abdalfatah Diab, Siddiqa M. A. Hamza, Bandar A. Suliman, Abdulaziz H. Alhamidi, Nawal Eltayeb Omer, Jeremy Mills
Summary: The study found a strong correlation between GSTT1 polymorphism and the development of Ph-ve CML, while GSTM1 polymorphism did not play a role in the initial development of the disease. Further research is needed to clarify the roles of other genes in disease development.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Biochemistry & Molecular Biology
Leticia Madureira Pacholak, Rodrigo Kern, Stefania Tagliari de Oliveira, Leia Carolina Lucio, Marla Karine Amarante, Roberta Losi Guembarovski, Maria Angelica Ehara Watanabe, Carolina Panis
Summary: The study found that polymorphisms in GSTM1 and GSTT1 genes were not associated with breast cancer susceptibility, and did not have a significant impact on GSH levels in patients. Further research is needed to understand the relationship between these polymorphisms and breast cancer.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Respiratory System
Jong-Uk Lee, Ji-Yeon Jeong, Min Kyung Kim, Sun A. Min, Jong-Sook Park, Choon-Sik Park
Summary: This study found that the GSTM1 null genotype may be associated with TDI-induced occupational asthma (TDI-OA), and the genetic effect of the GSTM1 null genotype may be enhanced synergistically by the GSTT1 null genotype. The GSTM1 and GSTT1 genotypes may be useful diagnostic markers for TDI-OA.
CANADIAN RESPIRATORY JOURNAL
(2022)
Article
Environmental Sciences
Beibei Sun, Jie Song, Ya Wang, Jing Jiang, Zhen An, Juan Li, Yange Zhang, Gui Wang, Huijun Li, Neil E. Alexis, Ilona Jaspers, Weidong Wu
Summary: This study found that short-term exposure to PM2.5 is associated with nasal inflammation, oxidative stress, and reduced lung function in retired adults. The reduction in lung function and inflammation were more pronounced among subjects with the GSTT1-null genotype.
ENVIRONMENTAL POLLUTION
(2021)
Article
Multidisciplinary Sciences
Harriet Cullen, Saskia Selzam, Konstantina Dimitrakopoulou, Robert Plomin, A. David Edwards
Summary: The study found that individuals with a higher genetic risk for schizophrenia and bipolar disorder are more vulnerable to the negative effects of early gestational age at birth on brain development, which affects cognitive function at four years old. Better understanding of gene-environment interactions can help inform more effective risk-reducing interventions for this vulnerable population.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Noppadol Chanhom, Sukanya Wattanapokayakit, Nusara Satproedprai, Supharat Suvichapanich, Surakameth Mahasirimongkol, Usa Chaikledkaew, Wanvisa Udomsinprasert, Taisei Mushiroda, Jiraphun Jittikoon
Summary: The study revealed that GSTT1 null and GSTM1/GSTT1 double null genotypes were associated with an increased risk of ATDILI, especially in Thai TB patients carrying the CYP2E1 wild type phenotype.
Review
Pharmacology & Pharmacy
Shimeng Jiao, Ting Cao, Hualin Cai
Summary: This review provides an update on peripheral biomarkers of treatment-resistant schizophrenia (TRS), focusing on genetic and related factors associated with TRS. Although the current evidence regarding biomarkers in TRS is limited, it can help to better understand the neurobiological interface of clinical phenotypes and psychiatric symptoms, enabling individualized prediction and therapy for TRS in the long term.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Rheumatology
Martin Sebastian Winkler, Peter Korsten, Claudia Binder, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Oncology
Yi Liao, Senmao Li, Hao Chen, Chunyu Chen, Jintuan Huang, Feng Lin, Jianping Wang, Zuli Yang
Summary: A risk prediction system combining FIT and risk factors was developed to improve the sensitivity of colonoscopy screening. The system effectively stratified participants into high risk and low risk groups, with better predictive ability for colorectal neoplasia compared to using FIT alone.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente Martin, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia
Summary: This study aimed to examine the association between height and risk of gastric cancer. Through a large pooled analysis of case-control studies, the study found no significant association between adult height and gastric cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Maria A. Karalexi, Marina Servitzoglou, Vassilios Papadakis, Denis Kachanov, Maja Cesen Mazic, Margaret Baka, Maria Moschovi, Maria Kourti, Sofia Polychronopoulou, Eftichia Stiakaki, Emmanuel Hatzipantelis, Helen Dana, Kalliopi Stefanaki, Astero Malama, Marios S. Themistocleous, Katerina Strantzia, Tatyana Shamanskaya, Panagiota Bouka, Paraskevi Panagopoulou, Maria Kantzanou, Evangelia Ntzani, Nick Dessypris, Eleni Th. Petridou
Summary: The prognosis of children with neuroblastoma varies depending on the stage and biology of the tumor, and early-stage neuroblastoma has a better prognosis. Treatment with anti-GD2 antibody can improve the prognosis of high-risk patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Review
Clinical Neurology
Christoph Eckhard Heyde, Ulrich Josef Albert Spiegl, Anna Voelker, Nicolas von der Hoeh, Jeanette Henkelmann
Summary: The prevalence of nonspecific pyogenic spondylodiskitis has increased, causing high morbidity and mortality. The diagnosis is often delayed due to nonspecific clinical manifestations at the early stage. CT can assess the bony condition, while MRI is still the gold standard for diagnosis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Agriculture, Dairy & Animal Science
Julyana M. S. Martins, Lindolfo D. dos Santos Neto, Sarah Sgavioli, Itallo C. S. Araujo, Angela A. S. Reis, Rodrigo S. Santos, Eugenio G. de Ara, Nadja S. M. Leandro, Marcos B. Cafe
Summary: This study aimed to evaluate the effects of glycosaminoglycan supplementation in broiler diets on gene expression, synthesis of proteins and minerals, and macroscopic characteristics of bones and cartilage. The results showed that the inclusion of chondroitin and/or glucosamine sulfates in the feed improved the expression of genes related to cartilage metabolism, as well as the structure and mineralization of bone and cartilage. These findings suggest that chondroitin and glucosamine sulfates can contribute to the development of a healthy locomotor system in broilers.
Review
Health Care Sciences & Services
Pedro Henrique Costa Matos da Silva, Kamilla de Faria Santos, Laura da Silva, Caroline Christine Pincela da Costa, Rodrigo da Silva Santos, Angela Adamski da Silva Reis
Summary: This study conducted a systematic review to identify miRNAs associated with gestational diabetes mellitus (GDM) and build a panel of miRNAs. Fifty-five studies were included, and 82 altered miRNAs in GDM were identified, with mir-16-5p, mir-20a-5p, mir-222-3p, and mir-330-3p being the most frequently dysregulated miRNAs. Dysregulation of these miRNAs is associated with cell cycle homeostasis, growth and proliferation of pancreatic β cells, glucose uptake and metabolism, insulin secretion, and resistance.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Health Care Sciences & Services
Aline Ruilowa de Pinho Coelho, Luciana Carvalho Silveira, Kamilla de Faria Santos, Rodrigo da Silva Santos, Angela Adamski da Silva Reis
Summary: This study used a systematic review and meta-analysis to investigate the relationship between the ACE gene (I/D) polymorphism and the development and progression of DR in type 2 diabetic patients. The results showed no significant association between the polymorphism and DR risk, indicating that the I/D polymorphism is not involved in the susceptibility to and progression of DR in type 2 diabetic patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Genetics & Heredity
Rayana Pereira Dantas de Oliveira, Elisangela Gomes da Silva, Kamilla de Faria Santos, Rodrigo da Silva Santos, Angela Adamski da Silva Reis
Summary: This genetic association study found that both GSTM1 and GSTT1 null and mutant genotypes (677TT) conferred risk to hypertension susceptibility in hypertensive diabetic patients. The combined genotypes (MTHFR:GSTT1:GSTM1) revealed a significant association, suggesting an oxidative hypothesis for the development of hypertension in diabetic patients. Imbalance in antioxidant enzymes and homocysteine metabolism may contribute to the establishment of oxidative stress in these patients.
Review
Biochemistry & Molecular Biology
J. O. Costa, C. C. P. Costa, N. S. Lima, K. F. Santos, A. A. S. Reis, R. S. Santos
Summary: This study conducted a systematic review and meta-analysis to investigate the association between polymorphisms in the VEGF-A gene and ALS and MS. The results suggest that VEGF-A gene polymorphisms may not be major risk factors for ALS and MS development, but they may become strong susceptibility factors when associated with specific factors such as sex or haplotype combinations.
GENETICS AND MOLECULAR RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
J. V. A. Neves, N. S. Lima, C. C. P. Costa, K. F. Santos, A. A. S. Reis, R. S. Santos
Summary: The folate cycle is crucial for the nervous system, with the MTHFR, MTR, and SLC19A1 genes playing important roles in its regulation. This study investigated the association of polymorphisms in these genes with ALS and MS, finding that the C677T polymorphism was associated with a 1.5-fold increased risk of MS. However, most polymorphisms were not associated with ALS and MS susceptibility. Further research is needed to understand the role of folate pathway gene polymorphisms in these neurodegenerative diseases.
GENETICS AND MOLECULAR RESEARCH
(2023)