Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Public, Environmental & Occupational Health
Feiteng Zhu, Hemu Zhuang, Shujuan Ji, Er Xu, Lingfang Di, Zhengan Wang, Shengnan Jiang, Haiping Wang, Lu Sun, Ping Shen, Yunsong Yu, Yan Chen
Summary: The study found that in households of CA-MRSA infected patients in China, most MRSA isolates belonged to epidemic CA-MRSA clones, while no MRSA was detected in the control group households. The research revealed that the home environment is an important reservoir for MRSA.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Microbiology
Monika Kumaraswamy, Kamilla Wiull, Bishnu Joshi, George Sakoulas, Armin Kousha, Gustav Vaaje-Kolstad, Mona Johannessen, Kristin Hegstad, Victor Nizet, Fatemeh Askarian
Summary: This study revealed that MRSA-derived MVs are capable of reducing the pathogen's susceptibility to VAN, thereby increasing its resistance to treatment, particularly in interactions with human neutrophils. Additionally, the elevated expression of proteins associated with antibiotic resistance in MVs may further impact MRSA's resistance.
Article
Infectious Diseases
Cheng-En Tsai, Chia-Jui Yang, Yu-Chung Chuang, Jann-Tay Wang, Wang-Huei Sheng, Yee-Chun Chen, Shan-Chwen Chang
Summary: This study aimed to determine the synergistic effects of combining CPT with DAP, VAN, or LNZ against different MRSA strains. The results showed that the CPT-DAP combination exhibited significant synergistic bactericidal effects, while the CPT-VAN and CPT-LNZ combinations did not show synergistic activity. Therefore, DAP may be a better choice for combination therapy with CPT in the treatment of MRSA infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Jin Liang, Yuanfang Hu, Mingxia Fu, Na Li, Fengxia Wang, Xiaojun Yu, Bing Ji
Summary: The study investigated the molecular epidemiology of Staphylococcus aureus (S. aureus) in patients from the Yellow River Delta region and examined antibiotic resistance profiles in different genetic backgrounds. Antibiotic susceptibility testing, spa typing, and agr typing were conducted on all 204 strains. The results identified 39 MRSA strains and 22 hVISA isolates. The majority of MRSA isolates belonged to agrI and were associated with type IV SCCmec. The most common genotypes among MRSA population were ST59-t437-agrI-IVa and ST72-t2431-agrI-IVF. The study highlights the genetic diversity and drug resistance patterns among MSSA strains exhibiting phenotypic hVISA.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biotechnology & Applied Microbiology
Rong Huang, Guang-Qing Cai, Jian Li, Xi-Sheng Li, Hai-Ting Liu, Xue-Ling Shang, Jian-Dang Zhou, Xin-Min Nie, Rong Gui
Summary: A novel nano-drug delivery system, PLT@Ag-MOF-Vanc, was constructed for the treatment of MRSA infections, showing good antibacterial activity, biocompatibility, and targeting capabilities. It killed MRSA through multiple approaches and demonstrated superior anti-infective effects in a mouse MRSA pneumonia model compared to free vancomycin.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Fateme Eskandari, Hossein Mofidi, Bahar Asheghi, Fateme Mohammadi, Ahmad Gholami
Summary: Nowadays, there is a growing concern about the inadequacy of new antimicrobials and the rise of antimicrobial resistance. In this study, the antimicrobial properties of zinc oxide nanoparticles (ZnONPs) were improved by coupling them with imidazolium (IM@ZnONPs). The results showed that IM@ZnONPs exhibited stronger antibacterial activities, especially against antimicrobial-resistant pathogens, compared to ZnONPs and zinc ions.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Pathology
Jill Parkes-smith, Haakon Bergh, Patrick N. A. Harris
Summary: Staphylococcus aureus bacteraemia has high morbidity and mortality, and timely use of effective antibiotics is crucial. Molecular diagnostics can shorten the time from blood culture positivity to identification of MRSA or MSSA.
Article
Immunology
Yifei Lu, Yingran Wang, Jing Wang, Yan Zhao, Qiu Zhong, Gang Li, Zhifeng Fu, Shuguang Lu
Summary: Endolysin LysP108 demonstrates promising antibacterial potential as it can lyse bacterial cell walls, inhibit bacterial biofilms, and work synergistically with vancomycin to reduce abscess size in MRSA-infected mice. The results indicate strong bactericidal effects against MRSA and the ability to significantly reduce subcutaneous abscess size when used in combination with vancomycin.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nur Najihah Izzati Mat Rani, Xiang Yi Chen, Zahraa M. Al-Zubaidi, Hanisah Azhari, Tzar Mohd Nizam Khaitir, Pei Yuen Ng, Fhataheya Buang, Geok Chin Tan, Yin Ping Wong, Mazlina Mohd Said, Adeel Masood Butt, Azmy A. Hamid, Mohd Cairul Iqbal Mohd Amin
Summary: This study focused on the encapsulation of vancomycin into liposomes coated with a red blood cell membrane with a targeting ligand, and successfully achieved targeted drug delivery to bacterial cells. The conjugation of the targeting ligand was confirmed through various analyses, and the formulation exhibited controlled drug release. In vitro and in vivo experiments demonstrated the high antibacterial efficacy of the formulation against MRSA, with low toxicity to mammalian cells and human erythrocytes.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Immunology
Marin L. Schweizer, Kelly Richardson, Mary S. Vaughan Sarrazin, Michihiko Goto, Daniel J. Livorsi, Rajeshwari Nair, Bruce Alexander, Brice F. Beck, Michael P. Jones, Mireia Puig-Asensio, Daniel Suh, Madeline Ohl, Eli N. Perencevich
Summary: Among patients with methicillin-resistant Staphylococcus aureus bloodstream infections, switching to daptomycin is associated with lower 30-day mortality, especially when done within 3 days of initial vancomycin receipt. However, switching to daptomycin at any time during the first hospitalization did not significantly affect 30-day mortality.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Mengli Jin, Shuyue Zhu, Yating Tang, Xiangri Kong, Xingye Wang, Yufen Li, Shuang Jiang, Lin Wei, Chunjie Hu, Bingmei Wang, Wu Song
Summary: Antimicrobial resistance (AMR) is a global health threat, and there is a need for new anti-infective agents. Ayanin, a flavonoid extracted from Callicarpa nudiflora, was found to be an inhibitor of MRSA ClpP, suggesting its potential therapeutic effect against MRSA infections.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Masakazu Kitahara, Shin Takayama, Tetsuya Akaishi, Akiko Kikuchi, Tadashi Ishii
Summary: This study demonstrated that administration of HET in acute stroke patients can effectively prevent MRSA colonization and reduce the incidence of infectious diseases, leading to improved rehabilitation outcomes within three months.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Sumalee Kondo, Pimonwan Phokhaphan, Sissades Tongsima, Chumpol Ngamphiw, Worawich Phornsiricharoenphant, Wuthiwat Ruangchai, Areeya Disratthakit, Pholawat Tingpej, Surakameth Mahasirimongkol, Aroonlug Lulitanond, Anucha Apisarnthanarak, Prasit Palittapongarnpim
Summary: MRSA is a significant causative agent of hospital-acquired infections, and rigorous surveillance of MRSA strains is necessary to prevent its potential spread.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Pooi Yin Chung, Pey Lin Narissa Loh, Hui-min Neoh, Ramliza Ramli
Summary: Staphylococcus aureus is a significant threat to human health and has developed resistance to conventional antimicrobials. The presence of biofilms complicates treatment for infections caused by multi-drug resistant S. aureus. Alpha-amyrin has been shown to reduce biomass and inhibit metabolic activity of S. aureus. This study demonstrates that alpha-amyrin can reduce biofilm biomass of MSSA, MRSA, and VISA isolates, suggesting its potential as a therapeutic agent for chronic S. aureus infections.
Article
Public, Environmental & Occupational Health
Charles E. Marvil, Ahmed Babiker, Aaron Preston, Andrew S. Webster, Jeannette Guarner, Kari Love, Elham Ghonim, Paulina A. Rebolledo, Yun F. Wang, Robert A. Arthur, H. Richard Johnston, Jesse J. Waggoner, Anne Piantadosi, Jesse T. Jacob
Summary: In this study, an epidemiological investigation and genome sequencing were performed to determine the source and scope of an outbreak of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) in a cluster of hospitalized patients. Lack of appropriate respiratory hygiene during a single hemodialysis session resulted in transmission of SARS-CoV-2 to patients and healthcare workers, highlighting the importance of infection prevention precautions.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Katie J. Suda, Alfredo Traversa, Ursula Patel, Linda Poggensee, Margaret A. Fitzpatrick, Geneva M. Wilson, Charlesnika T. Evans
Summary: This study assessed the treatment trends for patients with CRE from 2012 to 2018. The findings revealed a decrease in the utilization of aminoglycosides and colistin, while there was an increase in the use of extended-spectrum cephalosporins and ceftazidime-avibactam. Moreover, significant uptake of ceftazidime-avibactam, a newly approved antibiotic, was observed for treating CRE infections.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
L. McKinley, C. C. Goedken, E. Balkenende, G. Clore, Sherlock S. Hockett, R. Bartel, S. Bradley, J. Judd, Goedken Lyons, C. Rock, M. Rubin, C. Shaughnessy, H. S. Reisinger, E. Perencevich, N. Safdar
Summary: This study used a mixed methods approach to examine daily environmental cleaning practices in healthcare facilities. The results revealed low cleaning rates, especially in the presence of patients and in semi-private rooms. Standardized cleaning practices are needed to address these barriers and improve cleaning rates.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Public, Environmental & Occupational Health
Sandra N. Bulens, Hannah E. Reses, Uzma A. Ansari, Julian E. Grass, Clayton Carmon, Valerie Albrecht, Adrian Lawsin, Gillian McAllister, Jonathan Daniels, Yeon-Kyeng Lee, Sarah Yi, Isaac See, Jesse T. Jacob, Chris W. Bower, Lucy Wilson, Elisabeth Vaeth, Ruth Lynfield, Paula Snippes Vagnone, Kristin M. Shaw, Ghinwa Dumyati, Rebecca Tsay, Erin C. Phipps, Wendy Bamberg, Sarah J. Janelle, Zintars G. Beldavs, P. Maureen Cassidy, Marion Kainer, Daniel Muleta, Jacquelyn T. Mounsey, Alison Laufer-Halpin, Maria Karlsson, Joseph D. Lutgring, Maroya Spalding Walters
Summary: Carbapenem-resistant Enterobacterales (CRE) are increasingly being detected in the community, with 10% of cases being community-associated (CA). Some CA cases were found to carry carbapenemase genes. Therefore, continued surveillance of CRE in the community is crucial to monitor the emergence of the disease outside traditional healthcare settings.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Immunology
Daniel J. Morgan, Erik R. Dubberke, Tiffany Hink, Carey Ann D. Burnham, Lisa Pineles, Larry Magder, J. Kristie Johnson, Surbhi Leekha, M. B. Mph, Anthony D. Harris
Summary: Universal gown and glove use in medical and surgical ICUs did not decrease acquisition of C. difficile.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Alexandre R. Marra, Gosia S. Clore, Erin Balkenende, Cassie Cunningham Goedken, Daniel J. Livorsi, Michihiko Goto, Mary S. Vaughan-Sarrazin, Ann Broderick, Eli N. Perencevich
Summary: This study aimed to estimate antibiotic use during the last 6 months of life for hospitalized patients under hospice or palliative care and identify potential targets for antibiotic stewardship. The data showed that within 14 days of placement or consultation, 41% of hospice patients and 48% of palliative care patients received at least one antibiotic.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Public, Environmental & Occupational Health
Satoshi Kakiuchi, Eli N. Perencevich, Daniel J. Livorsi, Michihiko Goto
Summary: The optimal metric for outpatient antimicrobial stewardship should consider both the number of prescriptions and the duration of therapy.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Benjamin R. Griffin, Mary Vaughan-Sarrazin, Eli Perencevich, Masaaki Yamada, Melissa Swee, Meenakshi Sambharia, Saket Girotra, Heather S. Reisinger, Diana Jalal
Summary: This study developed a mortality prediction model using Veterans Health Administration data to predict the risk of death following acute kidney injury. It found that traditional renal variables contributed less to the risk of death compared to non-kidney factors. This research is significant for the care and management of patients with acute kidney injury.
AMERICAN JOURNAL OF MEDICINE
(2023)
Editorial Material
Immunology
Michihiko Goto, Eli N. Perencevich
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Roy H. Perlis, Jacob Kendall-Taylor, Kamber Hart, Ishani Ganguli, Jesse A. Berlin, Steven M. Bradley, Sebastien Haneuse, Sharon K. Inouye, Elizabeth A. Jacobs, Arden Morris, Olugbenga Ogedegbe, Eli Perencevich, Lawrence N. Shulman, N. Seth Trueger, Stephan D. Fihn, Frederick P. Rivara, Annette Flanagin
Summary: Although the viability of peer review has been questioned during the COVID-19 pandemic, this study found that the speed and quality of peer reviews in an open-access medical journal improved modestly during the initial year of the pandemic.
Article
Immunology
Shinya Hasegawa, Daniel J. Livorsi, Eli N. Perencevich, Jonas N. Church, Michihiko Goto
Summary: Conventional hospital antibiograms have limited accuracy in predicting antimicrobial resistance (AMR) for individual patients, indicating limited utility for guiding empiric therapy. Our study provides a comprehensive evaluation of the diagnostic accuracies of antibiograms in predicting AMR among Escherichia coli and Klebsiella spp, finding mostly poor accuracy and substantial trade-offs in sensitivity and specificity.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Alessandra A. Pratt, Grant D. Brown, Eli N. Perencevich, Daniel J. Diekema, Matthew W. Nonnenmann
Summary: The study found that there was a significant reduction in virus and particle concentrations on the inside compared to the outside of the plastic face shield. However, viable virus was still measured in the breathing zone of the simulated healthcare personnel, indicating the need for additional exposure control methods to prevent transmission from virus aerosol.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Eli P. P. Wilber, Ahmed Babiker, Jessica Howard-Anderson, Jill E. E. Holdsworth, Eileen M. M. Burd, M. Jeremy Eldridge, Jesse T. T. Jacob
Summary: Initial specimen diversion devices (ISDDs) are effective in reducing blood-culture contamination rates, as shown by sustained reduction for over 18 months. However, no clinically significant reduction in inpatient vancomycin usage was observed.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Margaret Carrel, Gosia S. Clore, Michihiko Goto, Seungwon Kim, Eli N. Perencevich, Mary Vaughan-Sarrazin
Summary: Using geocoded electronic health records and flood maps, this study examines the impact of Hurricane Matthew and flooding on infectious outcomes and antimicrobial prescribing in North Carolina veterans. The results indicate a decline in outpatient visits and antimicrobial prescribing in the weeks immediately after the hurricane, followed by an increase in antimicrobial prescribing in the subsequent weeks. Overall, the study suggests that hurricane and flood exposure had minor effects on infectious outcomes and antimicrobial prescribing.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2023)
Article
Public, Environmental & Occupational Health
Kerri A. Thom, Clare Rock, Gwen L. Robinson, Heather R. S. Reisinger, Jure Baloh, Emily Chasco, Yuanyuan Liang, Shanshan Li, Daniel J. Diekema, Loreen A. Herwaldt, J. Kristie Johnson, Anthony D. Harris, Eli N. Perencevich
Summary: Applying ABHR directly to gloved hands can effectively reduce contamination compared to usual care, but it is slightly less effective than the gold standard. Therefore, the Centers for Disease Control and Prevention and the World Health Organization should consider advising healthcare personnel to use ABHR for decontamination during single-patient encounters.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)