Article
Multidisciplinary Sciences
Mareike Grotheer, Mona Rosenke, Hua Wu, Holly Kular, Francesca R. Querdasi, Vaidehi S. Natu, Jason D. Yeatman, Kalanit Grill-Spector
Summary: In this study, the development of white matter in infants from 0 to 6 months was investigated using diffusion MRI and quantitative MRI measurements. The researchers found that the longitudinal relaxation rate (R1) of white matter increased over time, with faster development in less mature areas of white matter in newborns.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Jiao Li, Guo-Rong Wu, Bing Li, Feiyang Fan, Xiaopeng Zhao, Yao Meng, Peng Zhong, Siqi Yang, Bharat B. Biswal, Huafu Chen, Wei Liao
Summary: The study explores the variations in white matter functional connectivity in healthy individuals and identifies genetic basis and macroscale imaging related to these variabilities. Results indicate that inter-individual differences in gene expression in different brain regions are associated with neuronal activities and psychiatric disorders, while genes overexpressed in certain regions are linked to glial cells and neurological diseases. This research sheds light on how transcriptomic and cellular signatures relate to macroscale brain specialization.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Sebastien Naze, Timothee Proix, Selen Atasoy, James R. Kozloski
Summary: Recent studies have shown that local gray matter connections play a crucial role in the formation of connectome harmonic patterns, which is consistent across different cortical surface templates and resolutions. Alterations of local and long-range connectivity matrices can affect the spatial patterns of connectome harmonics.
Article
Biology
Victor Nozais, Stephanie J. Forkel, Laurent Petit, Lia Talozzi, Maurizio Corbetta, Michel Thiebaut de Schotten, Marc Joliot
Summary: Resting-state functional magnetic resonance imaging has shown that functional connectivity within and between networks is related to cognitive states and pathologies. However, the white matter connections supporting this connectivity have only been partially described. A new method has been developed to map the white and grey matter contributing to each resting-state network, demonstrating the overlap between networks and the potential impact of white matter lesions on network communication. An atlas and open-source software have been provided to facilitate the study of white matter damage to resting-state networks, with initial application showing promising results in identifying impacted networks in stroke patients.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kara E. Garcia, Xiaojie Wang, Christopher D. Kroenke
Summary: The article discusses a new theoretical framework regarding the physical processes of cerebral cortex folding, proposing that cortical folding may induce subcortical fiber growth and organization. Through simulations and experiments, it is demonstrated that subcortical stresses resulting from folding are sufficient to induce stereotyped fiber organization beneath gyri and sulci, supporting the viewpoint of cortical growth-induced folding.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Xie Tang, Yuanchao Zhang, Daihong Liu, Yixin Hu, Liling Jiang, Jiuquan Zhang
Summary: The study found cortical gyrification and white matter microstructural changes in patients with the akinetic-rigid subtype of Parkinson's disease, while patients with tremor-dominant subtype showed no significant changes. These results suggest that cortical gyrification changes in PD may be related to the microstructural abnormalities of underlying white matter tracts.
Article
Neurosciences
Lea Roumazeilles, Frederik J. Lange, R. Austin Benn, Jesper L. R. Andersson, Mads F. Bertelsen, Paul R. Manger, Edmund Flach, Alexandre A. Khrapitchev, Katherine L. Bryant, Jerome Sallet, Rogier B. Mars
Summary: Comparative neuroimaging of ring-tailed lemurs, black-capped squirrel monkeys, and rhesus macaques revealed differences in frontal projections and white matter architecture. The results suggest that squirrel monkeys and rhesus macaques have expanded frontal projections compared to ring-tailed lemurs, while ring-tailed lemurs have reduced connectivity in the parietal region. Furthermore, squirrel monkeys have a specific occipito-parietal anatomy.
Article
Biology
Guozheng Feng, Rui Chen, Rui Zhao, Yuanyuan Li, Leilei Ma, Yanpei Wang, Weiwei Men, Jiahong Gao, Shuping Tan, Jian Cheng, Yong He, Shaozheng Qin, Qi Dong, Sha Tao, Ni Shu
Summary: By analyzing longitudinal diffusion MRI data, researchers have discovered the multiscale developmental pattern of the human white matter connectome from childhood to adolescence and revealed its potential transcriptomic and cellular mechanisms.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jiefeng Jiang, Joel Bruss, Woo-Tek Lee, Daniel Tranel, Aaron D. Boes
Summary: Cognitive control is crucial for adaptive behavior and is modulated by distributed neural computations. However, little is known about the anatomy of white matter tracts that coordinate these computations. In this study, the authors found that lesions in white matter connecting left frontoparietal regions reliably predicted deficits in cognitive control performance. These findings improve our understanding of the white matter correlates of cognitive control and provide a method for predicting deficits after lesions through network disconnection.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Xinyang Liu, Mattis Geiger, Changsong Zhou, Andrea Hildebrandt
Summary: This study explores the associations between microstructural properties of brain fibers and face processing ability. It finds significant linear associations between specific fiber properties in the face network and face processing ability. Furthermore, the microstructural properties of the face processing brain system tend to differentiate from global brain fibers with increasing ability.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Chase R. Figley, Teresa D. Figley, Kaihim Wong, Md Nasir Uddin, Rodrigo Dalvit Carvalho da Silva, Jennifer Kornelsen
Summary: The UManitoba-JHU functionally defined human white matter (WM) atlas in ICBM152 template space contains specific WM pathways and general WM regions underlying 12 functional brain networks. This study compared intersecting regions of periventricular and juxtacortical WM (PVWM and JCWM) with the WM networks and found that most WM networks showed lower spatial similarity with PVWM and all showed lower spatial similarity with JCWM. This suggests that these WM networks can still be used to explore network-specific WM changes, even in patient populations with known predispositions toward PVWM and/or JCWM damage.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Layla Banihashemi, Vanessa J. Schmithorst, Michele A. Bertocci, Alyssa Samolyk, Yicheng Zhang, Joao Paulo Lima Santos, Amelia Versace, Megan Taylor, Gabrielle English, Jessie B. Northrup, Vincent K. Lee, Richelle Stiffler, Haris Aslam, Ashok Panigrahy, Alison E. Hipwell, Mary L. Phillips
Summary: The neural basis of infant positive and negative emotionality can be identified through functional interactions among large-scale networks. These interactions influence the relationship between white matter microstructure and emotional behavior in infancy.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biology
Arian Ashourvan, Preya Shah, Adam Pines, Shi Gu, Christopher W. Lynn, Danielle S. Bassett, Kathryn A. Davis, Brian Litt
Summary: The study accurately predicted the activation patterns and correlations of intracranial EEG electrodes, and demonstrated that the estimated interaction weights could significantly predict structural connectivity and strength across frequencies, beyond what is expected based solely on the distance between sampled regions. The pairwise maximum entropy model offers a framework for explaining functional connectivity in intracranial EEG and sheds light on how the brain's structural connectome leads to large-scale activation patterns through promoting co-activation between connected structures.
COMMUNICATIONS BIOLOGY
(2021)
Article
Cell Biology
Jodie H. K. Man, Charlotte A. G. H. van Gelder, Marjolein Breur, Daniel Okkes, Douwe Molenaar, Sophie van der Sluis, Truus Abbink, Maarten Altelaar, Marjo S. van der Knaap, Marianna Bugiani
Summary: This study comprehensively analyzed the cortex of vanishing white matter (VWM) patients using high-resolution mass spectrometry-based proteomics and immunohistochemistry. The findings revealed a large number of differentially expressed proteins in the VWM cortex, forming a major protein interaction network. Gene ontology analysis further indicated enrichment for cellular metabolism, particularly mitochondrial activity. Importantly, the study identified astrocytic involvement in the cortical pathology of VWM, with morphological changes and decreased complexity observed in VWM cortical astrocytes compared to control cells. These astrocytes were found to be immature and non-reactive. These insights into cortical involvement in VWM have significant implications for the development of therapeutic strategies.
Article
Neurosciences
Stella M. Sanchez, Aki Tsuchiyagaito, Rayus Kuplicki, Heekyeong Park, Ivan Postolski, Michael Rohan, Martin P. Paulus, Salvador M. Guinjoan
Summary: This study provides evidence that there are differences in white matter connectivity patterns between participants with high and low repetitive negative thinking (RNT) in major depressive disorder (MDD), which may be related to reward mechanisms and psychomotor activity.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
N. Ceren Askin Incebacak, Yao Sui, Laura Gui Levy, Laura Merlini, Joana Sa de Almeida, Sebastien Courvoisier, Tess E. Wallace, Antoine Klauser, Onur Afacan, Simon K. Warfield, Petra Huppi, Francois Lazeyras
Summary: The study compares the image quality of 2D high-resolution image acquisition with 3D reconstruction from low-resolution images in neonatal subjects, finding that they have comparable quality for clinical and morphometric assessments, with no loss of anatomical details and similar edge definition. Quantitative assessments show the reconstructed images accurately detect fine anatomical structures and allow for comparable morphometric measurements.
JOURNAL OF NEUROIMAGING
(2022)
Review
Pediatrics
Elodie Zana-Taieb, Jacques Sizun, Pierre Kuhn, Audrey Reynaud
Summary: This article investigates the impact of neonatal unit design on the neurodevelopment of hospitalized neonates and the well-being of parents and healthcare staff. It provides recommendations regarding the minimum area required for a hospital room for a single neonate and their family.
Article
Neurosciences
Ingrid Dudink, Petra S. Huppi, Stephane V. Sizonenko, Margie Castillo-Melendez, Amy E. Sutherland, Beth J. Allison, Suzanne L. Miller
Summary: Fetal growth restriction (FGR) is mainly caused by suboptimal placental function, leading to limited nutrient and oxygen supply to the developing fetus, particularly affecting brain development. FGR results in altered brain morphology, disrupted connectivity, and region-specific brain network disturbances, which are associated with cognitive and behavioral impairments.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Serafeim Loukas, Lara Lordier, Djalel-Eddine Meskaldji, Manuela Filippa, Joana Sa de Almeida, Dimitri Van de Ville, Petra S. Hueppi
Summary: Research indicates that even during the newborn period, familiar music and unfamiliar music are processed differently by the brain. After music listening, functional connectivity between brain regions in all newborns is modulated. Premature infants exposed to music experience enhanced functional connectivity between brain regions after listening to music.
HUMAN BRAIN MAPPING
(2022)
Letter
Pediatrics
Juliane Schneider, Vania Sandoz, Lucile Equey, Joanne Williams-Smith, Antje Horsch, Myriam Bickle Graz
Article
Neuroimaging
Rosanne Govaarts, Emma Beeldman, Matteo Fraschini, Alessandra Griffa, Marjolein M. A. Engels, Michael A. van Es, Jan H. Veldink, Leonard H. van den Berg, Anneke J. van der Kooi, Yolande A. L. Pijnenburg, Marianne de Visser, Cornelis J. Stam, Joost Raaphorst, Arjan Hillebrand
Summary: This study aimed to investigate if there are similarities in resting-state brain activity and functional connectivity between patients with early symptomatic amyotrophic lateral sclerosis (ALS) and behavioral variant frontotemporal dementia (bvFTD). The findings showed differences in brain activity and connectivity between ALS and bvFTD patients, contributing to our understanding of these diseases.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Giulia Bommarito, Valentina Garibotto, Giovanni B. Frisoni, Federica Ribaldi, Sara Stampacchia, Frederic Assal, Stephane Armand, Gilles Allali, Alessandra Griffa
Summary: This pilot study used a multimodal imaging approach to explore the biological substrate of the Motoric Cognitive Risk (MCR) syndrome in a Memory Clinic cohort. The results showed that MCR+ patients had increased ventricular volume and altered diffusion parameters, suggesting that ventricular enlargement and microstructural damage of the surrounding white matter tracts could contribute to MCR pathophysiology.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Alessandra Griffa, Giulia Bommarito, Frederic Assal, Maria Giulia Preti, Rachel Goldstein, Stephane Armand, Francois R. Herrmann, Dimitri Van De Ville, Gilles Allali
Summary: This study aimed to assess whether gait, neuropsychological, and multimodal MRI parameters can predict short-term symptom reversal after cerebrospinal fluid tap test in patients with idiopathic normal pressure hydrocephalus (iNPH). The results showed that none of the individual parameters could predict the outcome, but a multivariable approach achieved modest prediction accuracy and could be included in patient-screening procedures. Further exploration of their value in predicting shunting outcome, particularly in relation to gait and white-matter parameters, is needed.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Alessandra Griffa, Enrico Amico, Raphael Liegeois, Dimitri Van de Ville, Maria Giulia Preti
Summary: This study explores the specificity of structure-function coupling in different brain states and individual identification. The results demonstrate that structure-function coupling measures accurately classify task decoding and fingerprinting, with key information found in the liberal portion of functional signals.
Article
Pediatrics
Oriane Lovey, Myriam Bickle-Graz, Mathilde Morisod Harari, Antje Horsch, Juliane Schneider
Summary: This study aimed to evaluate the impact of a standardised joint observation (JOIN) on the neurodevelopment of preterm infants at six months corrected age, but results showed no significant improvement in neurodevelopment between the intervention and control groups.
Article
Neurosciences
Philippe Voruz, Alexandre Cionca, Isabele Jacot de Alcantara, Anthony Nuber-Champier, Gilles Allali, Lamyae Benzakour, Patrice H. Lalive, Karl O. Lovblad, Olivia Braillard, Mayssam Nehme, Matteo Coen, Jacques Serratrice, Jean-Luc Reny, Jerome Pugin, Idris Guessous, Radek Ptak, Basile N. Landis, Dan Adler, Alessandra Griffa, Dimitri Van De Ville, Frederic Assal, Julie A. Peron
Summary: The neuropsychological deficits and brain damage following SARS-CoV-2 infection have been investigated in this study. 116 patients with different disease severities were tested for neuropsychological performance, olfactory function, completed questionnaires, and underwent functional magnetic resonance imaging. Severe patients showed poorer verbal episodic memory, while moderate patients had reduced mental flexibility. Neuroimaging revealed different patterns of functional brain connectivity alterations. The severity of the infection in the acute phase predicted the neuropsychological performance six to nine months later. SARS-CoV-2 infection causes long-term memory and executive dysfunctions related to functional brain connectivity alterations.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Nigel Colenbier, Ekansh Sareen, Tamara del-Aguila Puntas, Alessandra Griffa, Giovanni Pellegrino, Dante Mantini, Daniele Marinazzo, Giorgio Arcara, Enrico Amico
Summary: The use of human brain connectivity data as a fingerprint for individual identification has become a popular area of research in neuroscience. Recent studies have found that brain signatures can be extracted from resting-state MEG recordings, but their effectiveness in task-related conduct is still uncertain. This study demonstrates that identification improves during tasks compared to resting-state, particularly in controlled tasks, and the brain regions contributing to identification also change during task activities.
Editorial Material
Pediatrics
Petra S. Huppi, Manuela Filippa
PEDIATRIC RESEARCH
(2023)
Proceedings Paper
Acoustics
Alessandra Griffa, Maria Giulia Preti
Summary: This study investigates structure-function coupling at different temporal scales in the brain and its specificity to individuals. Using resting-state magnetoencephalography (MEG), the researchers found a spatial gradient of the SDI between different task regions and high accuracy in individual classification. These findings reveal individual differences in the resting state of the brain.
2022 30TH EUROPEAN SIGNAL PROCESSING CONFERENCE (EUSIPCO 2022)
(2022)
Article
Clinical Neurology
Philippe Voruz, Alexandre Cionca, Isabele Jacot de Alcantara, Anthony Nuber-Champier, Gilles Allali, Lamyae Benzakour, Marine Thomasson, Patrice H. Lalive, Karl-Olof Lovblad, Olivia Braillard, Mayssam Nehme, Matteo Coen, Jacques Serratrice, Jerome Pugin, Idris Guessous, Basile N. Landis, Dan Adler, Alessandra Griffa, Dimitri Van de Ville, Frederic Assal, Julie A. Peron
Summary: Lack of awareness of cognitive impairment, specifically anosognosia, plays a key role in distinguishing between different phenotypes of post-COVID-19 conditions. The prevalence of anosognosia for memory impairment varies based on the severity of the infection. Anosognosic patients show different cognitive and psychiatric profiles compared to nosognosic patients, and there are differences in brain functional connectivity between the two groups.
BRAIN COMMUNICATIONS
(2022)
