Article
Oncology
He-Yang Zhang, Hai-Lun Xie, Guo-Tian Ruan, Qi Zhang, Yi-Zhong Ge, Xiao-Yue Liu, Meng Tang, Meng-Meng Song, Shi-Qi Lin, Ming Yang, Xiao-Wei Zhang, Hong-Xia Xu, Chun-Hua Song, Han-Ping Shi
Summary: This study aimed to accurately clarify the prognostic value of various inflammatory markers in patients with stage IV cancer. The results showed that the lymphocyte C-reactive protein ratio (LCR) was the most accurate prognostic predictor and could predict long-term survival in patients.
Article
Cell Biology
Wenrong Cheng, Guoqin Wang, Weiyi Guo, Lijun Sun, Xiaoyi Xu, Hongrui Dong, Suhua Ye, Yanqiu Geng, Hong Cheng
Summary: Primary membrane nephropathy (PMN) and IgA nephropathy (IgAN) are the most common glomerular diseases in China. In this study, the clinicopathological characteristics of PMN/IgAN patients were analyzed, and the presence of galactose-deficient IgA1 (KM55) and M-type Phospholipase A2 Receptor (PLA2R) in circulation and renal tissues was detected. It was found that PMN/IgAN patients with glomerular KM55 positivity showed characteristics of both PMN and IgAN, and this positivity may indicate a poorer prognosis. Further investigation is needed to understand the mechanism behind this finding.
Article
Endocrinology & Metabolism
Siqing Wang, Aiya Qin, Lingqiu Dong, Jiaxing Tan, Xiaoyuan Zhou, Wei Qin
Summary: This retrospective study aimed to evaluate whether obesity is a risk factor for IgA nephropathy (IgAN) patients. The results showed that compared to patients with normal body weight, obese patients had more severe renal dysfunction, higher risk of metabolic disorders, and unhealthy behaviors. Although obesity was not confirmed as an independent risk factor for IgAN patients, it increased the risk when combined with hypertension. Therefore, the importance of obesity in IgAN patients needs to be emphasized.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Sonia Zambrano, Liqun He, Toshiki Kano, Ying Sun, Emmanuelle Charrin, Mark Lal, Christer Betsholtz, Yusuke Suzuki, Jaakko Patrakka
Summary: The study reveals the key role of endothelial cells in the early pathogenesis of IgAN through single-cell RNA sequencing analysis, identifying important cell-cell crosstalk pathways and providing novel insights into the pathogenesis of IgAN.
KIDNEY INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Evangeline Pillebout
Summary: Many authors have suggested that IgA Vasculitis and IgA Nephropathy may be two different clinical manifestations of the same disease, but larger clinical studies are needed to explore further. Limited studies have been conducted on these two diseases, and therapeutic trials often exclude patients with both conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Transplantation
Patrick J. Gleeson, Michelle M. O'Shaughnessy, Jonathan Barratt
Summary: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease with a high risk of kidney failure. The pathogenesis of IgAN involves immune complexes and specific O-glycoforms of IgA1. Kidney biopsy is the gold-standard diagnostic test, and histological features can predict outcome. Proteinuria and blood pressure are modifiable risk factors. There is currently no specific biomarker for diagnosis, prognosis, or therapy response tracking. Recent research has focused on treatments for IgAN, with supportive care and non-immunomodulatory drugs as the main management options. Reno-protective medications are expanding beyond renin-angiotensin-aldosterone system blockade. Systemic immunosuppression can improve kidney outcomes, but there are concerns about side effects. Ongoing studies explore approaches targeting the mucosal immune compartment, B-cell promoting cytokines, and the complement cascade. This review discusses current treatment standards and novel developments in the pathophysiology, diagnosis, outcome prediction, and management of IgAN.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Shaomin Gong, Shi Jin, Yang Li, Wuhua Jiang, Zhen Zhang, Ziyan Shen, Jialin Wang, Huili Zhou, Xiao Liu, Xialian Xu, Xiaoqiang Ding, Yiqin Shi, Hong Liu
Summary: The study found that higher levels of urinary sCD163 (u-sCD163) in patients with IgA nephropathy (IgAN) were associated with greater severity of histological lesions, more proteinuria, poorer renal function, and infiltration of tubulointerstitial CD163(+) macrophages. High u-sCD163 levels were also linked to a 2.66-fold greater risk for IgAN remission failure. Additionally, adding u-sCD163 levels to the model significantly improved the risk prediction of IgAN remission status.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Urology & Nephrology
Xingchen Yao, Yaling Zhai, Huanping An, Jingge Gao, Yazhuo Chen, Wenhui Zhang, Zhanzheng Zhao
Summary: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, and there is a lack of effective non-invasive diagnostic methods. Recent studies have shown that microRNAs (miRNAs) play important roles in the occurrence and development of IgAN, and can help predict prognosis.
Article
Immunology
Siqing Wang, Lingqiu Dong, Gaiqin Pei, Zheng Jiang, Aiya Qin, Jiaxing Tan, Yi Tang, Wei Qin
Summary: The study found that a high NLR value is closely related to the deterioration of renal function, worsening of pathological lesions, renal progression, and prognosis in patients with IgAN. Patients with a high NLR value are more likely to have hypertension and a poorer prognosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Lijie He, Hanmin Wang, Peng He, Yali Jiang, Feng Ma, Jing Wang, Jinping Hu
Summary: Research has shown that serum H19 expression is significantly downregulated in patients with IgA nephropathy, and a high level of H19 is associated with better renal outcome within 5 years.
JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Yngvar Lunde Haaskjold, Njal Gjaerde Lura, Rune Bjorneklett, Lars Sigurd Bostad, Thomas Knoop, Leif Bostad
Summary: Random forest survival analysis was used to identify predictors of end-stage kidney disease in patients with IgAN. Reporting tubular atrophy/interstitial fibrosis as a continuous variable, reporting subtypes of segmental glomerular sclerosis, and the number of normal glomeruli could improve the prognostic information in IgAN.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Terje Apeland, Anastasia Ushakova, Mohammad A. Mansoor, Jessica Furriol, Grete Jonsson, Hans-Peter Marti
Summary: This study identified prognostic biomarkers related to the rate of eGFR-loss in IGAN, which may help identify patients at risk of progressive disease. AOPP, oxidized free cysteine, TNFR1, and osteopontin are promising prognostic biomarkers in IGAN.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Xutong Wang, Zuishuang Guo, Bo Huang, Minhua Xie, Jingjing Ren, Yuze Zhu, Haonan Guo, Yongli Wang, Dan Yu, Junjun Zhang, Linqi Zhang
Summary: The study investigated the clinicopathological features, causes, and prognosis of newly diagnosed IgA nephropathy (IgAN) patients with acute kidney disease (AKD). The results showed that AKD is not rare among IgAN patients and is an independent risk factor for short-term and long-term prognosis. AKD resulting from different causes has different effects on prognosis.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Aiya Qin, Jiaxing Tan, Siqing Wang, Lingqiu Dong, Zheng Jiang, Dandan Yang, Huan Zhou, Xiaoyuan Zhou, Yi Tang, Wei Qin
Summary: This study found that an elevated TyG index is associated with an increased risk of renal progression in IgA nephropathy (IgAN).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Xia Wang, Nannan Yang, Chunyu Lu, Feng Xu, Jinquan Wang
Summary: This study retrospectively analyzed the clinical and pathological characteristics of 7 patients with renal biopsy-proven IgAN associated with PV. The results showed that PV associated with IgAN mainly occurs in males and is often accompanied by hematuria and mild-to-moderate renal insufficiency. Most patients had a good long-term prognosis, with only a few progressing relatively quickly to end-stage renal disease.
Review
Integrative & Complementary Medicine
Cai-Yu-Zhu Wen, Ya-Fei Liu, Li Zhou, Hong-Xing Zhang, Sheng-Hao Tu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2015)
Letter
Rheumatology
Ya-Fei Liu, Cai-Yu-Zhu Wen, Sheng-Hao Tu
JOURNAL OF RHEUMATOLOGY
(2015)
Article
Integrative & Complementary Medicine
Ya-Fei Liu, Cai-Yu-Zhu Wen, Zhe Chen, Yu Wang, Ying Huang, Yong-Hong Hu, Sheng-Hao Tu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2016)
Article
Biotechnology & Applied Microbiology
Ya-Fei Liu, Cai-Yu-Zhu Wen, Zhe Chen, Yu Wang, Ying Huang, Sheng-Hao Tu
BIOMED RESEARCH INTERNATIONAL
(2016)
Review
Integrative & Complementary Medicine
Ya-Fei Liu, Ying Huang, Cai-Yu-Zhu Wen, Jun-Jun Zhang, Guo-Lan Xing, Sheng-Hao Tu, Zhe Chen
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2017)
Article
Medicine, Research & Experimental
Yu Wang, Zhe Chen, Ying Huang, Liu Yafei, Shenghao Tu
MEDICAL SCIENCE MONITOR
(2018)
Review
Integrative & Complementary Medicine
Ya-Fei Liu, Zhe Zhang, Jun-Jun Zhang, Zhe Chen, Sheng-Hao Tu, Guo-Lan Xing
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Cell Biology
Ya-Fei Liu, Guo-Lan Xing, Zhe Chen, Sheng-Hao Tu
Summary: This study revealed that lncRNA HOTAIR suppresses inflammatory cytokine secretion by upregulating miR-20b and downregulating NLRP3, thereby alleviating ankle swelling in patients with gouty arthritis.
Review
Multidisciplinary Sciences
Ya-Fei Liu, Zhe Zhang, Xiao-Li Pan, Guo-Lan Xing, Ying Zhang, Zhang-Suo Liu, Sheng-Hao Tu
Summary: The study indicates that patients with severe COVID-19 are more likely to have chronic kidney disease (CKD) and complications of acute kidney injury (AKI). Continuous renal replacement therapy (CRRT) is more frequently used in severe patients, and the risk of AKI is higher in the critical group.
Article
Urology & Nephrology
Yin-Hong Geng, Zhe Zhang, Jun-Jun Zhang, Bo Huang, Zui-Shuang Guo, Xu-Tong Wang, Lin-Qi Zhang, Song-Xia Quan, Rui-Min Hu, Ya-Fei Liu
Summary: The study systematically evaluated the relationship between hyperuricemia and IgA nephropathy. The findings indicate that hyperuricemia exacerbates the clinical and pathological outcomes of IgA nephropathy, leading to worse prognosis.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Review
Immunology
Liang Han, Zhe Chen, Kun Yu, Jiahui Yan, Tingting Li, Xin Ba, Weiji Lin, Yao Huang, Pan Shen, Ying Huang, Kai Qin, Yinhong Geng, Yafei Liu, Yu Wang, Shenghao Tu
Summary: IL-27 plays an important role in regulating inflammatory responses, but its function in rheumatoid arthritis (RA) is still debated. IL-27 can modulate the development of RA through various mechanisms, but its specific role in RA treatment requires further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ya-Fei Liu, Huan-Huan Wang, Yin-Hong Geng, Liang Han, Sheng-Hao Tu, Hui Wang
Summary: The prevalence of metabolic syndrome (MetS) is increasing worldwide, leading to MetS-associated kidney disease. Traditional theories suggest using multiple medications to control blood pressure, lipid levels, blood glucose, and obesity, as well as improve insulin resistance. However, this approach may reduce patients' compliance and increase adverse reactions. Therefore, complementary and alternative medicine, such as berberine (BBR), is being explored for its potential efficacy and safety in addressing MetS through various pathways and targets. This article elaborates on the effects and mechanisms of BBR on different aspects of MetS and kidney diseases, highlighting the need for further clinical trials.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Urology & Nephrology
Yin-Hong Geng, Zhe Zhang, Jun-Jun Zhang, Bo Huang, Zui-Shuang Guo, Xu-Tong Wang, Lin-Qi Zhang, Song-Xia Quan, Rui-Min Hu, Chun-Dong Song, Feng-Yang Duan, Ya-Fei Liu
Summary: A novel nomogram model was constructed to predict the risk of hyperuricemia incidence in IgA nephropathy (IgAN). The model included 8 independent risk factors and exhibited moderate prediction ability. It may be useful in predicting the risk of hyperuricemia in IgAN.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Yin-Hong Geng, Jia-Hui Yan, Liang Han, Zhe Chen, Sheng-Hao Tu, Lin-Qi Zhang, Chun-Dong Song, Feng-Yang Duan, Ya-Fei Liu
Summary: A network pharmacology integrated molecular docking strategy was used to predict the molecular mechanism of Ermiao san in treating hyperuricemia and gout. The study identified 46 active compounds and their targets in Ermiao san. It was found that Ermiao san regulates various biological processes, cellular compounds, and molecular functions, as well as targets specific proteins and pathways related to hyperuricemia and gout. The results of molecular docking analyses also confirmed the binding affinity between the active compounds of Ermiao san and the core protein receptors.