Article
Medicine, General & Internal
Xinyu Hao, Dongying Zheng, Muhanmmad Khan, Lixia Wang, Timo Hamalainen, Fengyu Cong, Hongming Xu, Kedong Song
Summary: This study aimed to develop predictive models using machine learning techniques to explore more information from medical records of pregnant women with SLE for predicting adverse outcomes. After analysis and selection, 18 variables showed statistical differences and 40 variables were identified as contributing predictors. The Random Forest algorithm demonstrated the best discrimination ability for overall predictive models and achieved the best performance in real-time predictive accuracy assessment. Machine learning models could overcome the limitations of statistical methods in the presence of small sample sizes and numerous variables, and the RF classifier performed well in such structured medical records.
Article
Endocrinology & Metabolism
Yu Deng, Yiran Zhou, Jiangcheng Shi, Junting Yang, Hong Huang, Muqiu Zhang, Shuxian Wang, Qian Ma, Yingnan Liu, Boya Li, Jie Yan, Huixia Yang
Summary: Through gene expression data analysis and machine learning methods, this study identified SEZ6, NRAD1, and LPAR4 as potentially useful genetic biomarkers for predicting APO risk during early and mid-pregnancy in women with SLE.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Worawit Louthrenoo, Thananant Trongkamolthum, Nuntana Kasitanon, Antika Wongthanee
Summary: Adverse pregnancy outcomes (APOs) remain a concern for Thai pregnant SLE patients. Renal involvement and SLE flares are associated with an increased risk of APOs.
Article
Rheumatology
Anika Lucas, Amanda M. Eudy, Dafna Gladman, Michelle Petri, Murray Urowitz, Christina M. Wyatt, Megan E. B. Clowse
Summary: This study analyzed cohorts of pregnant women with SLE and found that LN was associated with fetal loss and preeclampsia. Active nephritis was associated with poor pregnancy outcome and fetal loss.
Article
Rheumatology
Kensuke Irino, Yojiro Arinobu, Masahiro Ayano, Shotaro Kawano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: The study retrospectively analyzed 64 pregnancies in 39 cases of lupus patients at Kyushu University Hospital from October 2002 to July 2018. The results showed that 29.7% of patients experienced lupus flare during pregnancy, with discontinuation of immunosuppressants being a significant risk factor. Additionally, fetal stillbirth rates were significantly higher in cases with lower C3 levels at 12 weeks of gestation compared to before conception.
Article
Medicine, General & Internal
Petronela Vicoveanu, Ingrid-Andrada Vasilache, Dragos Nemescu, Alexandru Carauleanu, Ioana-Sadiye Scripcariu, Dorina Rudisteanu, Alexandra Burlui, Elena Rezus, Demetra Socolov
Summary: This study provides a comprehensive analysis of the most important predictors for adverse pregnancy outcomes in pregnant patients with SLE, which could serve as a basis for further research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Massimo Radin, Irene Cecchi, Francesca Crisafulli, Evandro Mendes Klumb, Guilherme Ramires de Jesus, Marcela Ignacchiti Lacerda, Miguel Angel Saavedra, Geraldine Vanessa Reyes-Navarro, Luca Iaccarino, Maddalena Larosa, Gabriella Moroni, Francesco Tamborini, Dario Roccatello, Laura Andreoli, Savino Sciascia, Cecilia Beatrice Chighizola
Summary: A network meta-analysis of 19 studies found that complement levels, specifically C3 and C4, gradually increased during gestation in lupus pregnant women. However, patients with lupus nephritis and gestational flares had significantly lower complement levels at all timepoints. Particularly in early gestation, a reduction or smaller increase in C3 and C4 levels, even within the normal range, may predict gestational flares.
AUTOIMMUNITY REVIEWS
(2023)
Article
Rheumatology
Alexandra Legge, Alicia Malone, John G. Hanly
Summary: The SLICC frailty index (SLICC-FI) has been validated in a prevalent cohort of individuals with longstanding SLE, showing that higher baseline SLICC-FI values are associated with increased mortality risk and damage accrual.
Article
Rheumatology
Abir Mokbel, Doaa H. S. Attia, Hania S. Zayed, Nahlaa Eesa Naeem, Geilan Mahmoud, Rafat Riad, Soumaya Abou Elewa, Mohamed Youssef, Hisham Haggag, Sally S. Mohamed
Summary: This study aims to describe the pregnancy outcomes of SLE patients and identify predictors of adverse maternal and fetal outcomes. The study included 201 singleton pregnancies of 123 women with SLE. The study found that pregnancy planning, disease flares, and secondary antiphospholipid syndrome were predictors of adverse pregnancy outcomes.
Article
Rheumatology
Cigdem Cetin, Tugba Sarac-Sivrikoz, Muege Ates-Tikiz, Sibel Zarali, Aysenur Ersoy, Yasemin Yalcinkaya, Ahmet Gul, Murat Inanc, Recep Has, Ibrahim Kalelioglu, Bahar Artim Esen
Summary: The postpartum six-month period has the highest risk for disease flares during SLE pregnancies. Disease activity during pregnancy increases the risk of adverse pregnancy outcomes. Regular follow-up of patients is necessary to achieve a positive pregnancy outcome and lower maternal morbidity.
Article
Rheumatology
Catherine A. Sims, Amanda M. Eudy, Jayanth Doss, Jennifer L. Rogers, Rebecca E. Sadun, Lisa Criscione-Schreiber, Kai Sun, Megan E. B. Clowse
Summary: Women with active SLE or on teratogens are at a higher risk of poor pregnancy outcomes. The HOP-STEP Intervention effectively identifies pregnancy interest, allowing rheumatologists to optimize disease control and medication regimens before conception.
Article
Medicine, General & Internal
Nuria Banos, Aleida Castellanos, Giuseppe Barilaro, Francesc Figueras, Gema Lledo, Marta Santana, Gerard Espinosa
Summary: A prospective study was conducted on pregnant women with SLE, antiphospholipid syndrome, or non-criteria obstetric antiphospholipid syndrome to develop a predictive tool for adverse pregnancy outcomes. Baseline characteristics and certain biomarkers were found to be predictive of adverse outcomes, highlighting the need for better biomarkers for pregnant women with autoimmune diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Tsuyoshi Murata, Hyo Kyozuka, Toma Fukuda, Naoya Toba, Aya Kanno, Shun Yasuda, Akiko Yamaguchi, Yasuhisa Nomura, Takashi Kanno, Kiyoshi Migita, Keiya Fujimori
Summary: The study evaluated the association between disease activity, serological activity, and adverse pregnancy outcomes in pregnant women with SLE, finding that high disease activity and serological activity are significantly associated with adverse pregnancy outcomes. Proper disease control and close management for low complements are crucial for better perinatal outcomes.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Rheumatology
Ji-Won Kim, Ju-Yang Jung, Hyoun-Ah Kim, Jeong Yang, Dong W. Kwak, Chang-Hee Suh
Summary: This study aimed to examine the frequency and risk factors of complications during pregnancy in women with systemic lupus erythematosus (SLE). The results showed that pregnant women with SLE have a higher risk of adverse pregnancy outcomes and pregnancies should be delayed until achieving LLDAS and should be closely monitored with the lowest possible dose of CS.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Immunology
Wenran Zhang, Zhaoyang Tang, Yanjun Shi, Long Ji, Xueyu Chen, Yanru Chen, Xiaohui Wang, Meng Wang, Wei Wang, Dong Li
Summary: The study found that GGT and TBIL have opposite effects in the progression of SLE. High GGT levels may be a risk factor for SLE aggravation, while low TBIL levels may also be a risk factor for SLE aggravation. Additionally, high GGT levels and low TBIL levels have a subadditive effect on the increased risk of SLE aggravation.
FRONTIERS IN IMMUNOLOGY
(2021)