GATA2 Inhibition Sensitizes Acute Myeloid Leukemia Cells to Chemotherapy

Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells

(2016) Yahui Ding et al.   Journal of Hematology & Oncology

An update of current treatments for adult acute myeloid leukemia

(2015) H. Dombret et al.   BLOOD

A Targetable GATA2-IGF2 Axis Confers Aggressiveness in Lethal Prostate Cancer

(2015) Samuel J. Vidal et al.   CANCER CELL

Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia

(2014) M Celton et al.   LEUKEMIA

Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis

(2014) M R Corces-Zimmerman et al.   LEUKEMIA

Elevated TIM3+ hematopoietic stem cells in untreated myelodysplastic syndrome displayed aberrant differentiation, overproliferation and decreased apoptosis

(2014) Jing-lian Tao et al.   LEUKEMIA RESEARCH

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Gata2cis-element is required for hematopoietic stem cell generation in the mammalian embryo

(2013) Xin Gao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gata2is required for HSC generation and survival

(2013) Emma de Pater et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia

(2013) Daniel J. DeAngelo et al.   LEUKEMIA RESEARCH

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia

(2012) P. A. Greif et al.   BLOOD

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia

(2012) M. Luesink et al.   BLOOD

A historical perspective on the development of the cytarabine (7days) and daunorubicin (3days) treatment regimen for acute myelogenous leukemia: 2013 the 40th anniversary of 7+3

(2012) Marshall A. Lichtman   BLOOD CELLS MOLECULES AND DISEASES

The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer

(2012) Madhu S. Kumar et al.   CELL

Resistance of leukemic stem-like cells in AML cell line KG1a to natural killer cell-mediated cytotoxicity

(2011) Miaorong She et al.   CANCER LETTERS

GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia

(2011) Neil P. Rodrigues et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle

(2009) A. J. Tipping et al.   BLOOD

GATA-1 and GATA-2 binding to 3′ enhancer of WT1 gene is essential for its transcription in acute leukemia and solid tumor cell lines

(2009) A Furuhata et al.   LEUKEMIA

GATA-2 Reinforces Megakaryocyte Development in the Absence of GATA-1

(2009) Z. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Erlotinib and gefitinib for the treatment of myelodysplastic syndrome and acute myeloid leukemia: A preclinical comparison

(2008) Simone Boehrer et al.   BIOCHEMICAL PHARMACOLOGY

Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-b signaling

(2008) Tomohiko Sato et al.   CANCER SCIENCE

Evi-1 Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells

(2008) Susumu Goyama et al.   Cell Stem Cell

AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1

(2008) M Takeshita et al.   LEUKEMIA