Article
Endocrinology & Metabolism
T-H Yan, C-H Ma, N. Peng, Y-E Li, Q-Y Li, H. Wang
Summary: The study revealed that LINC00665 plays a role in cerebral ischemia-reperfusion (CI/R) injury, and can affect cell viability and apoptosis by regulating miR-744-5p.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Biotechnology & Applied Microbiology
Guoning Su, Yan Qu, Gang Li, Min Deng
Summary: The study found that SEV has a protective effect on cerebral ischemia/reperfusion injury (CIRI) by modulating the miR-30 c-5p-HIPK1 axis. Inhibition of HIPK1 can reverse the effect of reduced miR-30 c-5p on CIRI.
Article
Medicine, Research & Experimental
Shanshan Qiao, Dexin Yang, Xiaofeng Li, Weiping Li, Yuan Zhang, Wenlan Liu
Summary: The study reveals the crucial role of PAQR3 in ischemia/reperfusion injury, showing that silencing PAQR3 protects neuronal cells and improves cell survival by inhibiting the apoptosis pathway. Knockdown of PAQR3 significantly attenuates apoptosis and increases cell viability, offering a novel therapeutic target for preventing cerebral ischemia/reperfusion injury.
Article
Pharmacology & Pharmacy
Ruirui Xue, Shuang Gao, Yayun Zhang, Xuejun Cui, Wen Mo, Jinhai Xu, Min Yao
Summary: The objective of this study was to evaluate the neuroprotective effect of resveratrol (RES) in rat models of cerebral ischemia/reperfusion (I/R) injury. The results showed that RES significantly reduced cerebral infarct volume, decreased brain water content, and improved neurological function. It also decreased oxidative stress levels. The findings suggest that RES has a good therapeutic effect on cerebral I/R injury and can be used as a neuroprotective agent.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Shengyuan Wang, Na Li, Xiangen Meng
Summary: In this study, the role of circ_Arhgap5 in cerebral ischemia/reperfusion-induced nerve injury in PC12 cells and its associated mechanism were explored. The silence of circ_Arhgap5 protected PC12 cells from ischemia/reperfusion-induced injury by mediating the miR-29a-3p/Rock1 axis.
METABOLIC BRAIN DISEASE
(2023)
Article
Medicine, Research & Experimental
Li Yu, Yangyang Zhang, Qianqian Chen, Yu He, Huifen Zhou, Haitong Wan, Jiehong Yang
Summary: Formononetin has anti-inflammatory effects and may exert a protective effect against cerebral ischemia-reperfusion injury by inhibiting relevant targets in the JAK2/STAT3 signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jiarui Feng, Lilong Zhang, Enfu Xue, Zhendong Qiu, Ning Hu, Kunpeng Wang, Yingru Su, Weixing Wang
Summary: In this study, the role of the celiac ganglion (CG) in hepatic ischemia-reperfusion injury (HIRI) was investigated. The results showed that silencing Bmal1 expression in the CG can reduce liver fat reserve, hepatocyte apoptosis, and liver fibrosis, and increase liver glycogen accumulation. Furthermore, the downregulation of Bmal1 can suppress the levels of hepatic neurotransmitters norepinephrine and neuropeptide Y, as well as sympathetic nerve activity in HIRI. Additionally, decreased Bmal1 expression in the CG can reduce inflammation, oxidative stress, and increase glutathione levels in the liver. These findings suggest that reducing Bmal1 expression in the CG can improve hepatocyte injury in HIRI.
Article
Biochemistry & Molecular Biology
Yu Wu, Xiaomei Fan, Sha Chen, Ling Deng, Lu Jiang, Shaonan Yang, Zhi Dong
Summary: The aim of this study was to investigate the protective mechanism of geraniol against cerebral ischemia-reperfusion injury (CIRI). The results showed that geraniol effectively attenuated cerebral infarction and pathological injury, reduced ER-stress-related protein expression and apoptosis occurrence, and increased anti-apoptotic protein expression, suggesting a protective effect against CIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bei Sun, Hao Ou, Fei Ren, Yujiao Guan, Ye Huan, Hongwei Cai
Summary: Propofol shows neuroprotective effects in cerebral ischemia-reperfusion injury by inhibiting the expression of SNHG14 through the p38 MAPK signaling pathway. This mechanism may involve the competitive binding of SNHG14 to miR-30b-Sp to promote autophagy and exacerbate CI/R injury.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Yu Zheng, Yingying Tao, Xiaobo Zhan, Qi Wu
Summary: The NR4A1/LKB1/AMPK axis is a new protective pathway involved in hepatocyte ischemia-reperfusion injury (IRI). It can improve cell viability, reduce oxidative stress and inflammation through negative regulation on the LKB1/AMPK pathway, while inducing apoptosis and autophagy.
Article
Endocrinology & Metabolism
Xuexin Wang, Lingling Jiang
Summary: This study aimed to evaluate the role of PDCD10 in uterine ischemia/reperfusion injury (IRI) in rats. The results showed that silencing PDCD10 could ameliorate uterine IRI through inhibition of fibrosis, inflammation, and apoptosis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Cell Biology
An-Qi Zhang, Lu Wang, Yi-Xiu Wang, Shan-Shan Hong, Yu-Shan Zhong, Ru-Yi Yu, Xin-Lu Wu, Bing-Bing Zhou, Qi-Min Yu, Hai-Feng Fu, Shuang-Dong Chen, Yun-Chang Mo, Qin-Xue Dai, Jun-Lu Wang
Summary: miR-324-3p is decreased in patients with acute ischemic stroke and in in vitro and in vivo models of ischemic stroke. Overexpression of miR-324-3p potentiates ischemic brain damage, while inhibition of miR-324-3p attenuates the damage. Silencing miR-324-3p increases A1R expression through regulation of GATA2.
NEURAL REGENERATION RESEARCH
(2022)
Article
Peripheral Vascular Disease
Hongyun Wang, Rusitanmujiang Maimaitiaili, Jianhua Yao, Yuling Xie, Sujing Qiang, Fan Hu, Xiang Li, Chao Shi, Peng Jia, Haotian Yang, Meng Wei, Juan Zhao, Zheng Zhou, Jinxin Xie, Jizong Jiang, Haidong Cai, Joost P. G. Sluijter, Yawei Xu, Yi Zhang, Junjie Xiao
Summary: Plasma circulating extracellular vesicles have potential therapeutic benefits for ischemic diseases, but the delivery method is crucial. Studies using large animal and murine models, as well as human embryonic stem cells or rat cardiomyocytes, identified the role and delivery methods of EVs in ischemia-reperfusion injury. Additionally, the crucial molecule miR-486 within EVs was found to confer cardioprotective effects.
Article
Biochemistry & Molecular Biology
Bangkun Yang, Ying Nie, Lesheng Wang, Wenping Xiong
Summary: The study found that pre-treatment with flurbiprofen axetil (FPA) can alleviate neurological injury, cerebral edema, oxidative stress, inflammatory response, and cerebral pathological changes in a rat model of cerebral ischemia/reperfusion injury (CIRI). FPA improves CIRI by up-regulating miR-30c-5p expression and reducing SOX9 expression.
CHEMICAL BIOLOGY & DRUG DESIGN
(2022)
Article
Immunology
Jiefu Zhu, Yafei Zhang, Lang Shi, Yao Xia, Hongchu Zha, Huimin Li, Zhixia Song
Summary: This study reveals the protective role of RP105 in ischemic and septic acute kidney injury (AKI). Overexpression of RP105 alleviated renal structural injuries and dysfunction caused by ischemic and septic AKI. RP105 suppressed inflammatory responses mediated by the TLR4 signaling pathway. These findings suggest that RP105 could be a potential target for preventing and treating ischemic and septic AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)