A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall muscles

The struggle by Caenorhabditis elegans to maintain proteostasis during aging and disease

(2016) Elise A. Kikis   Biology Direct

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Aggregation Behavior of Chemically Synthesized, Full-Length Huntingtin Exon1

(2014) Bankanidhi Sahoo et al.   BIOCHEMISTRY

Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission

(2014) P. Hemachandra Reddy   DRUG DISCOVERY TODAY

Novel Polyglutamine Model Uncouples Proteotoxicity from Aging

(2014) Nakeirah T. M. Christie et al.   PLoS One

Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A

(2014) K. P. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

(2014) Cendrine Tourette et al.   PLOS BIOLOGY

Skeletal muscle pathology in Huntington's disease

(2014) Daniel Zielonka et al.   Frontiers in Physiology

Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease

(2013) Tali Gidalevitz et al.   BMC BIOLOGY

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons

(2012) François-Xavier Lejeune et al.   BMC GENOMICS

Integration of  -Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity

(2012) J. A. Parker et al.   JOURNAL OF NEUROSCIENCE

Small-molecule proteostasis regulators for protein conformational diseases

(2011) Barbara Calamini et al.   Nature Chemical Biology

Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins

(2011) V. Prahlad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cellular perspective on conformational disease: the role of genetic background and proteostasis networks

(2010) Tali Gidalevitz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease

(2010) Christian Landles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of overexpression of Huntingtin proteins on mitochondrial integrity

(2008) Hongmin Wang et al.   HUMAN MOLECULAR GENETICS

Heat Shock Transcription Factor 1-activating Compounds Suppress Polyglutamine-induced Neurodegeneration through Induction of Multiple Molecular Chaperones

(2008) Nobuhiro Fujikake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY