A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity
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Title
A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity
Authors
Keywords
Fluorescence imaging, HT29 cells, Enzyme assays, Aldehydes, SW480 cells, Small molecules, Isozymes, Robotics
Journal
PLoS One
Volume 12, Issue 1, Pages e0170937
Publisher
Public Library of Science (PLoS)
Online
2017-01-28
DOI
10.1371/journal.pone.0170937
References
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Note: Only part of the references are listed.- Diaphorase Coupling Protocols for Red-Shifting Dehydrogenase Assays
- (2016) Mindy I. Davis et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
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- (2014) Klaus Pors et al. DRUG DISCOVERY TODAY
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- (2014) S Condello et al. ONCOGENE
- Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities
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- Cancer Stem Cells: The ‘Achilles Heel’ of Chemo-Resistant Tumors
- (2014) In-Sun Hong et al. Recent Patents on Anti-Cancer Drug Discovery
- Development and Validation of a 96-Well Cellular Assay for the Discovery of ALDH1A1 Inhibitors
- (2013) Wenyu Ming et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Aldehyde dehydrogenases: From eye crystallins to metabolic disease and cancer stem cells
- (2012) Vasilis Vasiliou et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Retinaldehyde Dehydrogenase 1 Coordinates Hepatic Gluconeogenesis and Lipid Metabolism
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- (2012) Florian W Kiefer et al. NATURE MEDICINE
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- Low expression of aldehyde deyhdrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer
- (2011) Christoph Kahlert et al. BMC CANCER
- The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance
- (2011) Jan S. Moreb et al. CHEMICO-BIOLOGICAL INTERACTIONS
- A Novel Aldehyde Dehydrogenase-3 Activator Leads to Adult Salivary Stem Cell Enrichment In Vivo
- (2011) A. Banh et al. CLINICAL CANCER RESEARCH
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- Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use–dependent inhibitor of dopamine synthesis
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- Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis
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- (2009) Maria P. Arolfo et al. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
- Molecular Cloning and Oxidative Modification of Human Lens ALDH1A1: Implication in Impaired Detoxification of Lipid Aldehydes
- (2009) Tianlin Xiao et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
- Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
- (2008) Satori A Marchitti et al. Expert Opinion on Drug Metabolism & Toxicology
- Structure of Daidzin, a Naturally Occurring Anti-Alcohol-Addiction Agent, in Complex with Human Mitochondrial Aldehyde Dehydrogenase§
- (2008) Edward D. Lowe et al. JOURNAL OF MEDICINAL CHEMISTRY
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